David A. Sinclair, Ph.D., A.O. is a Professor in the Department of Genetics at Harvard Medical School, best known for his work on understanding why we age and how to slow its effects. The Sinclair lab was the first to identify a role for NAD biosynthesis in the regulation of lifespan and first showed that sirtuins are involved in CR’s benefits in mammals and identified the first small molecules that activate sirtuins (STACs). His lab is also working on epigenetic changes as a driver of aging and the use of reprogramming factors to reset the age of cells and tissues. He has published over 200 scientific papers, is a co-inventor on over 50 patents, co-founded biotech and consumer companies, four of which have gone public, and is the author of the New York Times bestselling book Lifespan: Why We Age and Why We Don’t Have To. He serves as co-chief editor of the scientific journal Aging and has received more than 35 honors including the Australian Medical Research Medal, the NIH Director’s Pioneer award and was on TIME magazine’s lists of the “100 most influential people in the world” and the “Top 50 people in Healthcare”. In 2018, he became an Officer of the Order of Australia (AO).
For publications, see PubMed.ncbi.nih.gov
Harvard Medical School
Department of Genetics
77 Avenue Louis Pasteur
Boston MA 02115 USA
Lab Website: http://genetics.med.harvard.edu/sinclair/