HMS Virology

Virology Faculty Member - Dana Gabuzda

Dana Gabuzda

Professor of Neurology, (Microbiology and Molecular Genetics)

Dana Farber Cancer Institute
CLS 1010
44 Binney Street
Boston, MA 2115
Tel: 617-632-2154
Fax: 617-632-4338
Visit my lab page here.

Our lab studies molecular mechanisms of HIV replication and pathogenesis, and their role in mediating pathogen-host interactions, immune responses, and disease outcomes. Using biological, genetic, biochemical, metabolomic, systems biology, and computational approaches, current projects include studies in several areas of virology and immunology: 1) HIV replication and pathogenesis in the immune system, gut, liver, and central nervous system; 2) mechanisms and pathways underlying differences in host responses to viral infection, antiretroviral therapy, and aging; 3) role of exosomes in immune cell communication, stress responses, and disease pathophysiology;  4) mechanisms underlying HIV-associated neurological disorders, accelerated aging, and susceptibility to cancer. The lab uses new technologies, bioinformatics, and computational approaches to generate, visualize, analyze, and interpret large data sets, and broad variety of software and R packages for data integration, network and pathway analysis, and modeling.

Last Update: 9/21/2016


For a complete listing of publications click here.



Mukerji J, Olivieri KC, Misra V, Agopian KA, Gabuzda D. Proteomic analysis of HIV-1 Nef cellular binding partners reveals a role for exocyst complex proteins in mediating enhancement of intercellular nanotube formation. Retrovirology. 2012;9:33.

Kamat A, Misra V, Cassol E, Ancuta P, Yan Z, Li C, Morgello S, Gabuzda D. A plasma biomarker signature of immune activation in HIV patients on antiretroviral therapy. PLoS One. 2012;7(2):e30881.

Cassol E, Misra V, Holman A, Kamat A, Morgello S, Gabuzda D. Plasma metabolomics identifies lipid abnormalities linked to markers of inflammation, microbial translocation, and hepatic function in HIV patients receiving protease inhibitors. BMC Infectious Diseases 2013;13:203.

Yen PJ, Mefford ME, Hoxie JA, Williams KC, Desrosiers RC, Gabuzda D. Identification and characterization of a macrophage-tropic SIV envelope glycoprotein variant in blood from early infection in SIVmac251-infected macaques. Virology 2014; 458-459:53-68.

Yen PJ, Herschhorn A, Haim H, Salas I, Gu C, Sodroski J, Gabuzda D. Loss of a conserved N-linked glycosylation site in the simian immunodeficiency virus envelope glycoprotein V2 region enhances macrophage tropism by increasing CD4-independent cell-to-cell transmission. J Virol 2014; 88:5014-28.

Mefford ME, Kunstman K, Wolinsky SM, Gabuzda D. Bioinformatic analysis of neurotropic HIV envelope sequences identifies polymorphisms in the gp120 bridging sheet that increase macrophage-tropism through enhanced interactions with CCR5. Virology 2015;481:210-22.

Pery E, Sheehy A, Nebane NM, Brazier AJ, Misra V, Rajendran KS, Buhrlage SJ, Mankowski MK, Rasmussen L, White EL, Ptak RG, Gabuzda D. Identification of a novel HIV-1 inhibitor targeting Vif-dependent degradation of human APOBEC3G protein. J Biol Chem 2015;290:10504-17.

Pery E, Sheehy A, Miranda Nebane N, Misra V, Mankowski MK, Rasmussen L, Lucile White E, Ptak RG, Gabuzda D. Redoxal, an inhibitor of de novo pyrimidine biosynthesis, augments APOBEC3G antiviral activity against human immunodeficiency virus type 1. Virology 2015;484:276-287.

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