PiN Faculty Member - Joseph Majzoub, MD

Joseph Majzoub, MD

Thomas Morgan Rotch Professor of Pediatrics and Medicine

Boston Children's Hospital
Karp Family Research Building, Room 04-125
1 Blackfan Circle
Boston, MA 02115
Tel: 617-919-2930
Fax: 617-730-0244

Our lab's research focuses on how normal physiological responses to various common stressors including psychological stress (Nature, 1995; Mol Psychiatry, 2017) enhance health, and on how these same systems cause disease when dysregulated. We have found corticotropin releasing hormone (CRH) released from the same hypothalamic neurons may control both the endocrine and behavioral responses to stress, acting both as a neuroendocrine releasing factor and a neurotransmitter. We have discovered (Science, 2013) a new gene that regulates the melanocortin pathway by interacting with the melanocortin 4 receptor (Mc4r), and whose deficiency in mice and humans leads to obesity, possibly by affecting the efficiency of energy extraction from food via changes in the gut microbiota.

Last Update: 9/16/2020


For a complete listing of publications click here.



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