PiN Faculty Member - Mariella Filbin, MD, PhD

Mariella Filbin, MD, PhD

Assistant Professor of Pediatrics

Dana Farber Cancer Institute
360 Longwood Ave
Boston, MA 02215
Tel: 617-632-5993
Email: mariella.filbin@childrens.harvard.edu
Visit my lab page here.



My research focuses on pediatric brain tumors, particularly high-grade gliomas and other malignant brain tumors that are in greatest need of therapeutic improvements. I am especially interested in how the specific developmental and cellular contexts in which tumorigenic mutations arise shape the cellular hierarchy of the resulting tumors. This developmental “fingerprint” can then be used to design novel therapies that either enable differentiation of tumor cells so they are no longer proliferating or induce tumor cell death. In my studies I am combining single-cell genetics and transcriptomics with gene editing-, epigenetic-, stem cell- and pharmacologic methods to identify these cellular states, hierarchies and networks underlying tumorigenesis, with the goal of establishing new druggable targets.



Last Update: 10/2/2020



Publications

For a complete listing of publications click here.

 


 



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