PiN Faculty Member - Xandra Breakefield, PhD

Xandra Breakefield, PhD

Professor of Neurology

Massachusetts General Hospital
Neurogenetics Unit, CNY 6216
149 13th St
Charlestown, MA 2129
Tel: 617-726-5728
Fax: 617-724-1537
Visit my lab page here.

Our laboratory focuses on understanding genetic mechanisms underlying diseases of the nervous system and developing therapies and biomarkers for these diseases. Longstanding work has focused on genes causing movement disorders, including early onset torsion dystonia
(DYT1) and X-linked dystonia parkinsonism (XDP).

A major emphasis has also been on brain tumors, especially glioma/glioblastoma, as well as on tumor suppressor syndromes – neurofibromatosis type 1 & 2 and tuberous sclerosis type 1 & 2. We have developed preclinical mouse models for these tumors and used a number of viral vectors for gene therapy.

Our recent work has also focused on characterization of extracellular vesicles (exosomes and microvesicles) released by brain tumor cells, including their use as biomarkers, their ability to modify cells in their microenvironment in favor of tumor growth, and their potential as therapeutic
delivery vehicles in the nervous system.

Last Update: 9/16/2020


For a complete listing of publications click here.



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