Immunology Faculty Member - Michael Goldberg, Ph.D.

Michael Goldberg, Ph.D.

Dana Farber Cancer Institute
Dept. of Cancer Immunology & AIDS
1 Jimmy Fund Way, SM770C
Boston, MA 02215
Tel: 617-582-9840
Fax: 617-582-9610

Our laboratory is interested to develop and deliver novel therapeutics to improve antitumor immunity. The majority of cancer research focuses on cancer cells, but the tumor microenvironment is a critical determinant of patient outcomes. Harsh side effects aside, conventional therapeutic approaches that attempt to kill cancer cells directly select for resistant clones that lead to relapse. In contrast, the immune system can generate a specific, proliferative, coordinated, adaptive, and memory antitumor response.

We apply nanotechnology to stimulate cytotoxic T lymphocytes and to remove physical mediators of immunosuppression in the tumor microenvironment. Working at the interface of bioengineering, cancer biology, chemistry, immunology, and materials science allows us to probe tumors in unconventional ways. The resultant insights into the mechanisms underlying tumor immune evasion enable us to develop innovative therapies for improved, durable responses.

Last Update: 1/5/2015


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