Immunology Faculty Member - Richard Blumberg, MD

Richard Blumberg, MD

Vice Chair of Medicine for Research
Department of Medicine
Division Chief, Gastroenterology, Hepatology & Endoscopy Brigham and Women's Hospital Jerry S. Trier Professor of Medicine Harvard Medical School



Brigham and Women's Hospital
New Research Building, Room 641
77 Avenue Louis Pasteur
Boston, MA 02115
Tel: 617-732-6917
Fax: 617-264-5815
Email: Rblumberg@BWH.Harvard.Edu
Lab Members: 4 Postdoctoral Fellows, 4 Instructors,and 1 research scientist



The laboratory studies mucosal immunity and focuses on several pathways that are especially relevant to the physiologic processes and diseases related to these compartments. As such, the laboratory has a particular interest in the manner in which aberrations of these physiologic processes lead to the development of inflammation, the management of the luminal microbial ecology, intestinal barrier dysfunction and cancer, among others.

The laboratory has four major areas of interest:
(1) Characterization of the neonatal MHC class I-related Fc receptor (FcRn) in epithelial cells and dendritic cells; (2) understanding carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1) as a regulatory molecule on T and NK cells; (3) determining the role of the nonclassical MHC class I-related molecule, CD1d, and microsomal triglyceride transfer protein in mucosal immunity; and (4) evaluation of ER stress pathways in intestinal inflammation.









Last Update: 6/9/2020



Publications

For a complete listing of publications click here.

 


 

1. Nieuwenhuis EE, Matsumoto T, Exley M, Schleipman RA, Glickman J, Bailey DT, Corazza N, Colgan SP, Onderdonk AB, Blumberg RS. CD1d-dependent macrophage-mediated clearance of Pseudomonas aeruginosa from lung. Nat Med. 2002 Jun;8(6):588-93.
2. Olszak T, An D, Zeissig S, Vera MP, Richter J, Franke A, Glickman JN, Siebert R, Baron RM, Kasper DL, and Blumberg RS. Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function. Science 2012; 336:489-493. PMC3437652.
3. Olszak T, Neves JF, Dowds CM, Baker K, Glickman J, Davidson NO, Lin CS, Jobin C, Brand S, Sotlar K, Wada K, Katayama K, Nakajima A, Mizuguchi H, Kawasaki K, Nagata K, Muller W, Snapper SB, Schreiber S, Kaser A, Zeissig S, and Blumberg RS. Protective mucosal immunity mediated by epithelial CD1d and IL-10. Nature 2014; 509:497-502. PMC4132962. Iyer SS, Gensollen T, Gandhi A, Oh SF, Neves JF, Collin F, Lavin R, Serra C, Glickman J, de Silva P, Sartor RB, Besra G, Maxwell A, Hauser R, Llebaria A, Blumberg RS. Dietary and Microbial Oxazoles Induce Inflammation by Modulating Epithelial Derived AhR Responses. Cell 2018; 173:1123-1134. PMC6119676Nagaishi TPao LLin SHIijima HKaser AQiao SWChen ZGlickman JNajjar SMNakajima ANeel BGBlumberg RS. SHP1 phosphatase-dependent T cell inhibition by CEACAM1 adhesion molecule isoforms. Immunity. 2006 Nov;25(5):769-81.
4. Chen L, Chen Z, Baker K, Halvorsen EM, da Cunha AP, Flak MB, Gerber G, Huang YH, Hosomi S, Arthur JC, Dery KJ, Nagaishi T, Beauchemin N, Holmes KV, Ho JW, Shively JE, Jobin C, Onderdonk AB, Bry L, Weiner HL, Higgins DE, and
Blumberg RS. The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction. Immunity 2012; 37:930-46. PMC3516394.
5. Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, and
Blumberg RS. CEACAM1 regulates TIM-3-mediated tolerance and exhaustion. Nature 2015; 517:386-90. PMC4297519.
6.
Gandhi AK, Kim WM, Sun ZJ, Huang YH, Bonsor DA, Sundberg EJ, Kondo Y, Wagner G, Kuchroo VK, Petsko G, Blumberg RS. High resolution X-ray and NMR structural study of human T-cell immunoglobulin and mucin domain containing protein-3. Sci Rep. 2018 Nov 30;8(1):17512. PMC6269442
7.
Kaser A, Lee AH, Franke A, Glickman JN, Zeissig S, Tilg H, Nieuwenhuis EE, Higgins DE, Schreiber S, Glimcher LH, Blumberg RS. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell. 2008 Sep 5;134(5):743-56. PMC2586148.
8. Adolph TETomczak MFNiederreiter LKo HJBöck JMartinez-Naves EGlickman JNTschurtschenthaler MHartwig JHosomi SFlak MBCusick JLKohno KIwawaki TBillmann-Born SRaine TBharti RLucius RKweon MNMarciniak SJChoi AHagen SJSchreiber SRosenstiel PKaser ABlumberg RS. Paneth cells as a site of origin for intestinal inflammation. Nature. 2013 Nov 14;503(7475):272-6. PMC3862182
9. Hosomi S, Grootjans J, Tschurtschenthaler M, Krupka N, Matute JD, Flak MB, Martinez-Naves E, Gomez Del Moral M, Glickman JN, Ohira M, Lanier LL, Kaser A, Blumberg R. Intestinal epithelial cell endoplasmic reticulum stress promotes MULT1 up-regulation and NKG2D-mediated inflammation. J Exp Med. 2017 Oct 2;214(10):2985-2997. PMC5626394
10. Grootjans J, Krupka N, Hosomi S, Matute JD, Hanley T, Saveljeva S, Gensollen T, Heijmans J, Li H, Limenitakis JP, Ganal-Vonarburg SC, Suo S, Luoma AM, Shimodaira Y, Duan J, Shih DQ, Conner ME, Glickman JN, Fuhler GM, Palm NW, de Zoete MR, van der Woude CJ, Yuan GC, Wucherpfennig KW, Targan SR, Rosenstiel P, Flavell RA, McCoy KD, Macpherson AJ, Kaser A, Blumberg RS. Epithelial endoplasmic reticulum stress orchestrates a protective IgA response. Science. 2019 Mar 1;363(6430):993-998. PMC6637967
11. Qiao SW, Kobayashi K, Johansen FE, Sollid LM, Andersen JT, Milford E, Roopenian DC, Lencer WI, and Blumberg RS. Dependence of antibody-mediated presentation of antigen on FcRn. Proc Natl Acad Sci U S A 2008 Jul 8; 105:9337-42. PMC2453734
12. Baker K, Qiao SW, Kuo TT, Aveson VG, Platzer B, Andersen JT, Sandlie I, Chen Z, de Haar C, Lencer WI, Fiebiger E, and
Blumberg RS. Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells. Proc Natl Acad Sci U S A 2011 Jun 14; 108:9927-32. PMC3116387
13. Baker K, Rath T, Flak MB, Arthur JC, Chen Z, Glickman JN, Zlobec I, Karamitopoulou E, Stachler MD, Odze RD, Lencer WI, Jobin C, and
Blumberg RS. Neonatal Fc receptor expression in dendritic cells mediates protective immunity against colorectal cancer. Immunity 2013; 39:1095-107. PMC3902970.
14. Pyzik M, Rath T, Kuo TT, Win S, Baker K, Hubbard JJ, Grenha R, Gandhi A, Krämer TD, Mezo AR, Taylor ZS, McDonnell K, Nienaber V, Andersen JT, Mizoguchi A, Blumberg L, Purohit S, Jones SD, Christianson G, Lencer WI, Sandlie I, Kaplowitz N, Roopenian DC, Blumberg RS. Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury. Proc Natl Acad Sci U S A. 2017 Apr 4; 114(14): E2862-E2871.PMC5389309
15. Hubbard JJ, Pyzik M, Rath T, Kozicky LK, Sand KM, Gandhi AK, Grevys A, Foss S, Menzies SC, Glickman JN, Fiebiger E, Roopenian DC, Sandlie I, Andersen JT, Sly LM, Baker K,
Blumberg RS. FcRn is a CD32a co-receptor that determines susceptibility to IgG immune complex-driven autoimmunity. J Exp Med 2020, In press



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of Harvard College