Immunology Faculty Member - Robert Anthony, PhD

Robert Anthony, PhD

Massachusetts General Hospital
Center for Immunology and Inflammatory Diseases
149 13th Street, Room 8.307
Charlestown, MA 02129
Tel: 617-724-4245
Fax: 617-726-5651
Email: robert.anthony@mgh.harvard.edu



The Anthony Laboratory explores the role and regulation of IgG and IgE glycosylation in health and disease. These antibody classes are arguably the two most clinically relevant antibodies. Our interests stem from well-known clinical paradoxes that are associated with these antibody classes. IgG is highly effective at triggering inflammation and is essential for defense from infections and cancer. However, in the form of high dose intravenous immunoglobulin (IVIG), IgG exerts anti-inflammatory activity and is used to treat a number of autoimmune and inflammatory diseases.  Allergen-specific IgE is absolutely required for allergic symptoms and disease, yet not all individuals with allergen-specific IgE suffer from allergies. Work from our group has shown that glycan on IgG and IgE contribute to these paradoxically effectors. The overarching goal of the laboratory is development of strategies that target and modulate glycans on antibodies, enabling antibody engineering in vivo.



Last Update: 6/8/2020



Publications

For a complete listing of publications click here.

 


 

Sialylation of immunoglobulin E is a determinant of allergic pathogenicity.
Shade KT, Conroy ME, Washburn N, Kitaoka M, Huynh DJ, Laprise E, Patil SU, Shreffler WG, Anthony RM. Nature 2020. https://doi.org/10.1038/s41586-020-2311-z

Engineered Sialylation of Pathogenic Antibodies In Vivo Attenuates Autoimmune Disease.
Pagan JD, Kitaoka M, Anthony RM. Cell. 2018 Jan 25;172(3):564-577.e13. doi: 10.1016/j.cell.2017.11.041. Epub 2017 Dec 21.PMID: 29275858 

A single glycan on IgE is indispensable for initiation of anaphylaxis.
Shade KT, Platzer B, Washburn N, Mani V, Bartsch YC, Conroy M, Pagan JD, Bosques C, Mempel TR, Fiebiger E, Anthony RM. J Exp Med. 2015 Apr 6;212(4):457-67. doi: 10.1084/jem.20142182. Epub 2015 Mar 30.PMID: 25824821 



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