BBS Faculty Member - Vijay Sankaran

Vijay Sankaran

Department of Pediatrics, HMS
Division of Hematology/Oncology, Boston Children's Hospital

Boston Children's Hospital
CLS Building, Room 03001
3 Blackfan Circle
Boston, MA 02115
Tel: 617-919-6270
Email: sankaran@broadinstitute.org
Visit my lab page here.



Our laboratory utilizes human genetic approaches to gain insight into blood cell production (hematopoiesis) and how this process is perturbed in disease states. We study rare genetic blood disorders and the genetics underlying variation in hematopoiesis in large population-based studies. We also perform mechanistic functional studies in primary human hematopoietic cells to obtain a deeper understanding of hematopoiesis. We are particularly interested in gaining insight into the genetic basis of a variety of blood disorders, obtaining a deeper understanding of the developmental regulation of hemoglobin switching, and in developing tools that can be used for functional follow up of human genetic studies.



Last Update: 6/14/2017



Publications

For a complete listing of publications click here.

 


 

Basak, A., Hancarova, M., Ulirsch, J.C., Balci, T.B., Trkova, M., Pelisek, M., Vlckova, M., Muzikova, K., Cermak, J., Trka, J., Dyment, D.A., Orkin, S.H., Daly, M.J., Sedlacek, Z., and Sankaran, V.G. BCL11A deletions result in fetal hemoglobin persistence and neurodevelopmental alterations. The Journal of Clinical Investigation 2015, 125(6), 2363-2368.

Ulirsch, J.C., Nandakumar, S.K., Wang, L., Giani, F.C., Zhang, X., Rogov, P., Melnikov, A., McDonel, P., Do, R., Mikkelsen, T.S.,
Sankaran, V.G. Systematic Functional Dissection of Common Genetic Variation Affecting Red Blood Cell Traits. Cell. 2016, 165(6):1530-1545.

Guo, M.H., Nandakumar, S.K., Ulirsch, J.C., Zekavat, S.M., Buenrostro, J.D., Natarajan, P., Salem, R.M., Chiarle, R., Mitt, M., Kals, M., Pärn, K., Fischer, K., Milani, L., Mägi, R., Palta, P., Gabriel, S.B., Metspalu, A., Lander, E.S., Kathiresan, S., Hirschhorn, J.N., Esko, T.,
Sankaran, V.G. Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms. Proc Natl Acad Sci U S A. 2017, 114(3):E327-E336.

Kim, A.R., Ulirsch, J.C., Wilmes, S., Unal, E., Moraga, I., Karakukcu, M., Yuan, D., Kazerounian, S., Abdulhay, N.J., King, D.S., Gupta, N., Gabriel, S.B., Lander, E.S., Patiroglu, T., Ozcan, A., Ozdemir, M.A., Garcia, K.C., Piehler, J., Gazda, H.T., Klein, D.E.,
Sankaran, V.G.‡ Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation. Cell. 2017, 168(6):1053-1064.



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