BBS Faculty Member - Soumya Raychaudhuri

Soumya Raychaudhuri

Division of Genetics and Rheumatology
Department of Medicine, BWH

Harvard Medical School
NRB Building, Room 250, 255
77 Avenue Louis Pasteur
Boston, MA 02115
Tel: 617-525-4484
Fax: 617-525-4488
Visit my lab page here.

Immune-mediated diseases such as lupus or rheumatoid arthritis are not caused by an isolated insult resulting in a single dysfunctional gene or pathway, but rather a systemic
dysregulation of multiple genes and pathways. Our group uses methods in bioinformatics, and human genetics, and human immunology to better understand the critical elements of dysregulation within the immune system that results in human diseases. We are specifically interested in gene discovery, fine-mapping disease alleles, and integrative functional genomics of autoimmune diseases.

Our group focuses particularly on rheumatoid arthritis, type I diabetes, and tuberculosis. We are interested in (1) using genomics and genetics to identify germline and somatic mutations that predispose to immune-mediated diseases, (2) using those same mutations to identify common pathways, biological processes, and cell-types that play a key role in disease predisposition, and (3) defining the role of those systems within immune cells. For each of these broad goals, the group heavily emphasizes statistical and computational methods.

Last Update: 7/29/2015


For a complete listing of publications click here.



Hu X, Deutsch AJ, Lenz TL, Onengut-Gumuscu S, Han B, Chen W-M, et al. Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis. Nature Genetics. In Press. 2015.

Lenz T, Deutsch AJ, Han B, Hu X, et al. Pervasive non-additive and interaction effects in the HLA modulate the risk of autoimmune diseases.
Nature Genetics. In Press 2015.

Trynka G, Sandor C, Han B, Xu H, Stranger BE, et al. Chromatin marks identify critical cell-types for fine-mapping complex trait variants.
Nature Genetics. 45: 124-30, 2013.

Seddon J, Yu Y, Miller E, Reynolds R, et al. Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration. Nature Genetics. 45:1366-1370, 2013.

Stahl EA, Wegmann D, Trynka G, Gutierrez-Achury J, Do R, et al. (2012) Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis. Nat Genet 44: 483-489.

Raychaudhuri S, Sandor C, Stahl EA, Freudenberg J, Lee HS, et al. (2012) Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis. Nat Genet 44: 291-296.

Raychaudhuri S, Iartchouk O, Chin K, Tan PL, Tai AK, et al. (2011) A rare penetrant mutation in CFH confers high risk of age-related macular
degeneration. Nat Genet 43: 1232-1236.

Raychaudhuri S (2011) Mapping rare and common causal alleles for complex human diseases. Cell 147: 57-69.

Hu X, Kim H, Stahl E, Plenge R, Daly M, et al. (2011) Integrating autoimmune risk Loci with gene expression data identifies specific pathogenic
immune cell subsets. Am J Hum Genet 89: 496-506.

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