BBS Faculty Member - Marsha Moses

Marsha Moses

Julia Dyckman Andrus Professor, Harvard Medical School
Director, Vascular Biology Program, Children's Hospital Boston
Department of Surgery, Harvard Medical School and Boston Children's Hospital



Boston Children's Hospital
Karp Family Research Laboratories 12.129
300 Longwood Ave.
Boston, MA 02115-5737
Tel: 617-919-2207
Fax: 617-730-4655
Email: marsha.moses@childrens.harvard.edu



Dr. Marsha A. Moses is the Julia Dyckman Andrus Professor at Harvard Medical School and the Director of the Vascular Biology Program at Boston Children's Hospital. She has made significant contributions to our understanding of the biochemical and molecular mechanisms that underlie the regulation of tumor development and progression. Dr. Moses and her laboratory have discovered several inhibitors of these processes that function at both the transcriptional and translational level, some of which are being developed for potential clinical use in a variety of human diseases. Named a pioneer in the field of Biomarker Medicine by the Journal of the National Cancer Institute, she created a Proteomics Initiative at Boston Children’s Hospital, has utilized its resources, including an extensive human biorepository and has leveraged her significant expertise in proteomics, to discover and validate a number of novel, non-invasive biomarkers for a variety of human cancers and non-neoplastic diseases. Several of these biomarkers are being used in clinical trials. Recently, she and her team have also engineered novel non-toxic, targeted nanomedicines for the treatment of human cancers and their metastases. These drug delivery systems are engineered to deliver a variety of therapeutic agents including siRNAs, gene editing systems and chemotherapies. A number of these diagnostics and potential therapeutics are included in Dr. Moses’ significant patent portfolio composed of both US and foreign patents.

Dr. Moses’ basic and translational work has been published in such journals as Science, The New England Journal of Medicine, Cell, PNAS and Nature Communications, among others. She received a Ph.D. in Biochemistry from Boston University and completed a National Institutes of Health postdoctoral fellowship at Boston Children's Hospital and MIT in the laboratory of Dr. Robert Langer. Dr. Moses is the recipient of a number of NIH and foundation grants and numerous awards and honors. She has been recognized with both of Harvard Medical School's mentoring awards, the A. Clifford Barger Mentoring Award and the Joseph B. Martin Dean’s Leadership Award for the Advancement of Women Faculty. Marsha has received the Excellence in Mentoring Award from the Postdoc Association of Boston Children’s Hospital and has also received their Award for Exceptional Mentorship. She has also received the Honorary Member Mentoring Award from the Association of Women Surgeons of the American College of Surgeons. Dr. Moses has been elected to the Institute of Medicine (National Academy of Medicine) of the National Academies of the United States, the National Academy of Inventors, the American Institute for Molecular and Biological Engineering and is a Fellow of the American Association for the Advancement of Science.



Last Update: 3/9/2020



Publications

For a complete listing of publications click here.

 


 

Jia D, Hasso SM, Chan J, D’Amore, Zurakowski D, Rodig SJ, Moses MA. Transcriptional repression of VEGF by ZNF24: mechanistic studies and vascular consequences in vivo. Blood. 2012 Dec 3; Epub ahead of print. PMCID: In Process.

Roy R, Rodig S, Bielenberg D, Zurakowski D, Moses MA. ADAM12 transmembrane and secreted isoforms promote breast tumor growth and metastasis. J Biol Chem 2011 Apr 14; Epub ahead of print. PMCID: In Process.

Fernandez CA, Roy R, Lee S, Yang J, Panigrahy D, Van Vliet KJ, Moses MA. The anti-angiogenic peptide, Loop 6, binds IGF-IR. J Biol Chem. 2010 Oct 12; Epub ahead of print. PMID: 20940305

Yang J., Bielenberg D.R., Rodig S.J., Doiron R., Clifton M.C., Kung A.L., Strong R.K., Zurakowski D., Moses M.A. (2009) Lipocalin 2 promotes breast cancer progression. PNAS, 106(10):3913-8.

Harper J., Yan L., Louriero R., Wu I., Fang J., D'Amore P., Moses M.A. (2007) Repression of VEGF expression by the zinc finger transcription factor ZNF24. Cancer Res., 67(18):8736-41.

Pories S.E., Zurakowski D., Roy R., Lamb C.C., Raza S., Exarhopoulos A., Scheib R.G., Schumer S., Lenahan C., Borges V., Louis G.W., Anand A., Isakovich N., Hirschfield-Bartek J., Wewer U., Lotz M.M., Moses M.A. (2008) Urinary metalloproteinases: noninvasive biomarkers of breast cancer risk assessment. Cancer Epidemiol Biomarkers Prev., 17(5):1034-42.

Smith E.R., Manfredi M., Scott R.M., Black P., Moses M.A. (2007) A recurrent craniopharyngioma illustrates the potential usefulness of urinary matrix metalloproteinases as noninvasive biomarkers: case report. Neurosurgery, 60(6):E1148-9.



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