BBS Faculty Member - Franziska Michor

Franziska Michor

Department of Biostatistics, Harvard School of Public Health

Dana Farber Cancer Institute
CLS Building, Room 11029
3 Blackfan Circle
Boston, MA 02215
Tel: 617-632-5045
Email: michor@jimmy.harvard.edu
Visit my lab page here.



Cancer represents one of the biggest problems for modern societies. In 2010, there were 1.53 million new cancer cases and 570,000 cancer-related deaths in the US, leading to an overall cost of $264 billion. By 2020, cancer deaths worldwide could reach 10 million. Therefore, an important goal of life science research is to improve tumor diagnostics and anti-cancer treatment options to alleviate cancer-related morbidity and mortality. We are interested in using the tools of theoretical evolutionary biology, applied mathematics, statistics, and computational biology to address important questions in cancer research. Current projects include the following:

(1) Which genetic and epigenetic alterations cause cancer?

(2) In which order do oncogenic alterations arise?

(3) Where do oncogenic alterations arise?

(4) How do oncogenic alterations arise?

(5) What do we do about it?

For more information, please visit michorlab.dfci.harvard.edu



Last Update: 8/4/2014



Publications

Leder K, Pitter K, LaPlante Q, Hambardzumyan D, Ross BD, Chan TA, Holland EC, Michor F (2014) Mathematical modeling of PDGF-driven glioblastoma reveals optimized radiation dosing schedules. Cell 156, 603-616.

Haeno H, Gonen M, Davis MB, Herman JM, Iacobuzio-Donahue CA, Michor F (2012) Computational modeling of pancreatic cancer progression reveals dynamics of growth and dissemination and suggests optimum treatment strategies. Cell
148, 362-375.

De S, Michor F (2011) DNA replication timing and long-range DNA interactions predict mutational landscapes of cancer genomes. Nature Biotechnology
29, 1103-1108.

De S, Michor F (2011) DNA secondary structures and epigenetic determinants of cancer genome evolution. Nature Structural and Molecular Biology
18, 950-955.



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