BBS Faculty Member - Joseph Majzoub

Joseph Majzoub

Chief, Division of Endocrinology

Boston Children's Hospital
Center for Life Sciences Bldg, Rm 16028
300 Longwood Ave.
Boston, MA 02115
Tel: 617-919-2930
Fax: 617-730-0244

The specific aims of the Majzoub laboratory's studies are to analyze beneficial and detrimental effects, and the regulation of, the mammalian stress response, particularly within the brain. Current research focuses on the behavioral and neuroendocrine roles of corticotropin-releasing hormone (CRH), the regulation of CRH gene transcription by silencing factors, and the role of Mrap2 to modulate energy balance during stress.

Last Update: 8/5/2015


For a complete listing of publications click here.



Asai M, Ramachandrappa S, Joachim M, Shen Y, Zhang R, Nuthalapati N, Ramanathan V, Strochlic D, Ferket P, Linhart K, Ho, C, Novoselova TV, Garg S, Ridderstråle M, Marcus C, Hirschhorn JN, Keogh JM, O’Rahilly S, Chan LF, Clark AJ, Farooqi IS, Majzoub JA. Loss of Function of the Melanocortin 2 Receptor Accessory Protein 2 Is Associated with Mammalian Obesity. Science 2013. 341:275-8.

Freedman BD, Bukovac-Kempna P, Carlone DL, Shah M, Guagliardo NA, Barrett PQ, Gomez-Sanchez CE,
Majzoub JA, Breault DT. Adrenocortical zonation results from lineage conversion of differentiated zona glomerulosa cells. Developmental Cell 2013 26:666-73.

Thomas JL, Rajapaksha M, Mack VL, DeMars GA,
Majzoub JA, Bose HS. Regulation of human 3β-hydroxysteroid dehydrogenase type 2 by adrenal corticosteroids and product-feedback by androstenedione in human adrenarche. J Pharmacol Exp Ther. 2015 352:67-76.

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