BBS Faculty Member - Jordan Kreidberg

Jordan Kreidberg

Department of Pediatrics

Boston Children's Hospital
Division of Nephrology, Karp Bldg. 6215
300 Longwood Avenue
Boston, MA 02115 - 5737
Tel: 617-919-2959
Fax: 617-730-0129
Email: jordan.kreidberg@childrens.harvard.edu
Lab Members: 6 postdoctoral fellows



Our research focuses on how stem cell and progenitor populations in developing organs are regulated by signaling networks. Important areas of study include how transcription factors and chromatin modification proteins are involved in organ development. We have taken a genome-wide approach to identifying targets of the Wilms’ tumor-1 transcription factor (WT1) using chromatin immunoprecipitation, using chromatin from embryonic kidneys. These studies have provided evidence that WT1 regulates chromatin modification in development, and future studies will examine histone modifications in development and disease models that are regulated by WT1.

We are also studying the role of microRNAs in kidney progenitor cells, and we have begun to identify microRNAs required to maintain progenitor populations and molecular pathways regulated by microRNAs.

Our studies on organ development are being extended to several disease models. Polycystic Kidney Disease (PKD) is one of the most common genetic diseases. We are investigating roles for integrins and receptor tyrosine kinases in the pathogenesis of PKD. These studies have identified a role for Wnt signaling in PKD that we are continuing to investigate. We are also using high throughput sequencing to characterize changes in global microRNA expression in PKD, that will elucidate new roles for microRNAs in human disease.



Last Update: 4/9/2014



Publications

For a complete listing of publications click here.

 


 

Pandey, P., Qin, S., Ho, J. Zhou, J. and Kreidberg, J.A. Systems biology approach to identify transcriptional reprogramming and microRNA targets during progression of Polycystic Kidney Disease. (In Press, BMC System Biology 2011 Apr 25;5:56. PMID: 21518438

Qin, S., Taglienti, M., Nauli, S.M., Contrino, L.,Takakura, A., Zhou, J. and Kreidberg, J.A. Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease J. Clinical Investigation 2010 120(10):3617-3628

Hartwig, S., Ho, J., Pandey, P., MacIsaac, K., Taglienti, M., Xiang, M., Alterovitz, G., Ramoni, M., Fraenkel. E., and Kreidberg, J.A. . Genomic Characterization of Wilms’ Tumor Suppressor-1 Targets in Nephron Progenitor Cells during Kidney Development. Development. 2010 137:1189-1203



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