BBS Faculty Member - Victor Hsu

Victor Hsu

Department of Medicine

Brigham and Women's Hospital
Building for Transformative Medicine, 6016J
60 Fenwood Road
Boston, MA 02115
Tel: 617-525-1103
Fax: 617-525-1104
Lab Members: 3 postdoctoral fellows, 2 instructors

We are interested in understanding mechanisms of intracellular transport. Coat proteins play a key role in this process by initiating the formation of transport carriers. We have been elucidating how coat proteins cooperate with key lipids to form the two general classes of transport carriers, vesicles and tubules. We have also identified a novel coat complex that acts in endocytic recycling, a pathway critical for many cellular events. The fundamental mechanisms that we have elucidated have also led us to shed key insights into energy metabolism, cancer, diabetes, and viral pathogenesis.

Last Update: 1/19/2017


For a complete listing of publications click here.



Bai, M., Gad, H., Turacchio, G., Cocucci, E., Yang, J., Li, J., Beznoussenko, G.V., Nie, Z., Luo, R., Fu, L., Collawn, J.F., Kirchhausen, T., Luini, A., Hsu, V.W. ARFGAP1 promotes AP-2-dependent endocytosis. Nature Cell Biology 2011; 13: 559-67.

Li, J., Malaby, A.W., Famulok, M., Sabe, H., Lambright, D.G., and Hsu, V.W. Grp1 plays a key role in linking insulin signaling to glut4 recycling.
Developmental Cell 2012; 22: 1286-98.

Pang, X., Fan, J., Zhang, Y., Zhang, K., Gao, B., Ma, J., Li, J., Deng, Y., Zhou, Q., Egelman, E.H., Hsu, V.W., and Sun F. A PH Domain in ACAP1 Possesses Key Features of the BAR Domain in Promoting Membrane Curvature.
Developmental Cell 2014; 31: 73-86.

Park, S.Y., Yang, J.S., Schmider, A.B., Soberman, R.J., and Hsu, V.W. Coordinated regulation of bidirectional COPI transport at the Golgi by cdc42.
Nature 2015; 521: 529-32.

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of Harvard College