BBS Faculty Member - Ruth Franklin

Ruth Franklin

Assistant Professor, Department of Stem Cell and Regenerative Biology

Harvard Medical School
New Research Building, Room 929
77 Avenue Louis Pasteur
Boston, MA 02115
Tel: 617-432-8245
Email: ruthfranklin@fas.harvard.edu
Visit my lab page here.



Cells of the immune system defend us against a variety of insults, including infection by pathogens. However, it is now clear that immune cells also have important functions during development, tissue repair, and homeostasis. We use mouse models of infection, fibrosis, and cancer to investigate how immune cells sense and respond to both subtle changes in the tissue environment and extreme perturbations that drive inflammation. Our lab is particularly interested in the central role of macrophages and other innate immune cells in this process. We also aim to understand how cells of the immune system communicate with non-immune cell types within tissues, including fibroblasts and neurons, to elicit both local and systemic responses during homeostasis and disease.



Last Update: 7/29/2020



Publications

1) Zhou, X.*, Franklin, R.A.*, Adler, M.*, Jacox, J.B., Bailis, W., Shyer, J.A., Flavell, R.A., Mayo, A., Alon, U., Medzhitov, R. (2018) Circuit design features of a stable two-cell system. Cell. 172(4): 744-757.*contributed equally

2) Adler, M., Mayo, A.E., Zhou, X., Franklin, R.A., Jacox, J.B., Medzhitov, R., Alon, U. (2018) Endocytosis as a stabilizing mechanism for tissue homeostasis. Proc Natl Acad Sci USA. 115(8): E1926-E1935.

3) Franklin, R.A. and Li, M.O. (2016) Ontogeny of Tumor-associated Macrophages and Its Implication in Cancer Regulation. Trends Cancer. 2(1): 20-34.

4) Franklin, R.A., Liao, W., Sarkar, A., Kim, M.V., Bivona, M.R., Liu, K., Pamer, E.G., Li, M.O. (2014) The cellular and molecular origin of tumor-associated macrophages. Science. 344(6186): 921-925. 



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