BBS Faculty Member - Fei Chen

Fei Chen

Assistant Professor

Broad Institute of MIT and Harvard

415 Main Street
Cambridge, MA 02141
Email: chenf@fas.harvard.edu
Visit my lab page here.



Cells in complex mammalian tissues, such as the brain, are spatially organized and dynamic, yet almost all genomic tools lack temporal and spatial resolution. Our laboratory, at the Broad institute, sets out to build a set of tools which will bridge single-cell genomics with space and time – to enable discoveries of where cell types are localized within intact tissues, when relevant transcriptional modules are active. To do this, we are developing novel technologies at the intersection of microscopy, genomics, synthetic biology, and bioinformatics. We are applying these tools to learn organizational principles governing neurodevelopment, and cellular mechanisms of disorganization during neuronal injury and disease.



Last Update: 8/10/2020



Publications

Rodriques S.G.†, Stickels R.R.†, Goeva A., Martin C.A., Murray E., Vanderburg C.R., Welch J., Chen L.M., Chen F.*††, Macosko E.Z.*†† (2019) Slide-seq: A Scalable Technology for Measuring Genome-Wide Expression at High Spatial Resolution, Science (†, ††, equal contribution; *, Corresponding Author)

Chen H., Liu S., Padula S., Griswold K., Lin A., Zhao T., Marshall J.L., Chen F.* (Nature Biotechnology, 2020) TRACE: a pseudo-random DNA editor for efficient and continuous nucleotide diversification in human cells. (*, Corresponding Author)

Rodriques S.G.*, Chen L.M*., Liu S., Zhong E.D., Scherrer J.R., Boyden E.S.*†, Chen F.*† Recording the age of RNA with Deamination (Nature Biotechnology 2020) (†, equal contribution; *, Corresponding Author)

Chen F.*, Tillberg P.W.*, Boyden E.S. (2015) Expansion Microscopy. Science. PMC4312537 (*, equal contribution)



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