BBS Faculty Member - David Breault

Faculty Listing

David Breault

Department of Pediatrics

Boston Children's Hospital
Division of Endocrinology, CLS 16026
300 Longwood Ave
Boston, MA 02115
Tel: 617-919-2863
Fax: 617-730-0244
Email: david.breault@childrens.harvard.edu
Visit my lab page here.

As a physician-scientist caring for children with chronic disease I am acutely aware of the burden caused by these conditions and the need for improved therapeutic treatment options. Regenerative medicine offers enormous hope for the treatment of many conditions either through the directed differentiation of pluripotent stem cells or through the activation of endogenous tissue stem cells. My laboratory is pursuing various strategies to direct stem cell differentiation and to identify self-renewing progenitor/stem cells from a variety of mouse tissues with regenerative potential. Recent work has lead to the discovery of several populations of slowly-cycling tissue stem cells, including an elusive intestinal stem cell. We are now investigating the basic mechanisms regulating this population, including their response to physiological and pathological stress as well as their role in establishing cancer.

Last Update: 8/9/2013

Publications

For a complete listing of publications click here.

Stadtfeld M, Maherali N, Breault DT, Hochedlinger C. Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell 2: 1–11, 2008. PMID: 18371448

Breault DT*, Min IM, Carlone DL, Henderson DE, Algra S, Montgomery RK, Wagers AJ, Hole N. Generation of mTert-GFP Mice as a Model to Identify and Study Tissue Stem Cells. Proc Natl Acad Sci U S A. 105(30):10420-10425, 2008. PMID: 18650388 * Corresponding Author

Montgomery RK, Carlone DL, Richmond, CA, Farilla L, Kranendonk MEG, Henderson DE, Baffour-Awuah NY, Ambruzs DM, Fogli LK, Algra S, Breault DT*. Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells. Proc Natl Acad Sci U S A 108(1):179-84, 2011. PMID: 21173232 *Corresponding Author

Carlone DL, Breault DT. Tales from the Crypt: The expanding role of slowly cycling Intestinal Stem Cells. Cell Stem Cell. 2012 10(1):2-4 PMID 22226346