BBS Faculty Member - Paul Anderson

Paul Anderson

Division of Rheumatology, Immunology and Allergy

Brigham and Women's Hospital
Smith Building, Room 652C
75 Francis Street
Boston, MA 02115
Tel: 617-525-1202
Fax: 617-525-1310
Email: panderson@rics.bwh.harvard.edu
Visit my lab page here.



Messenger RNA is in constant flux between different locations and states -- the nucleus and cytoplasm, activation and silencing, translation and decay. Classical nuclear bodies such as nucleoli and nuclear speckles are self-generated RNA structures whose morphology and function are inextricably linked: altered morphology reflects altered function. Cytoplasmic RNA structures such as stress granules (SGs) and processing bodies (PBs) have been revealed as functional byproducts of mRNA metabolism. Stress granules (SGs) and processing bodies (PBs) share substrate mRNA, dynamic properties and many proteins, but also house separate components and independent functions. Each can exist without the other, but when coordinately induced they are often tethered together in a cytosolic dance. Work in the laboratory is focused on understanding the role of subcellular localization in the control of mRNA translation/decay.




















Last Update: 8/9/2013



Publications

For a complete listing of publications click here.

 


 

Ohn T, Kedersha N, Hickman T, Tisdale S, Anderson P. A functional RNAi screen links O-GlcNAc modification of ribosomal proteins to stress granule and processing body assembly. Nat Cell Biol 2008Oct;10(10):1224-31.

Yamasaki S, Ivanov P, Hu GF, Anderson P. Angiogenin cleaves tRNA and promotes stress-induced translational repression. J Cell Biol 2009 Apr 6;185(1):35-42. PMCID: PMC2700517

Anderson P, Kedersha N. RNA granules: post-transcriptional and epigenetic modulators of gene expression [review]. Nat Rev Mol Cell Biol 2009 June; 10(6):430-6.

Anderson P. Post-transcriptional regulons coordinate the initiation and resolution of inflammation [review]. Nat Rev Immunol 2010 Jan 10; (1):24-35.

Emara MM, Ivanov P, Hickman T, Dawra N, Tisdale, S, Kedersha N, Guo-Fu H, Anderson P. Angiogenin-induced tiRNAs promote stress-induced stress granule assembly. J Biol Chem 2010 Apr 2;285(14):10959-68. PMCID: PMC2856301

Ivanov P, Emara M, Villen J, Gygi SP, Anderson P. Angiogenin-induced tRNA fragments inhibit translation initiation. Mol Cell 2011 Aug 19;43:613-23. PMCID: PMC3160621

Simarro M, Giannattasio G, Xing W, Lundequist EM, Stewart S, Stevens RL, Orduna A, Boyce JA, Anderson P. The translational repressor T-cell intracellular antigen-1 (TIA-1) is a key modulator of th2 and th17 responses driving pulmonary inflammation induced by exposure to house dust mite. Immunol Lett 2012 Aug 30;146(1-2):8-14. PMCID: PMC3407291



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