Publications
For a complete listing of publications click here.
Yeap, L.S., Hwang, J.K., Du, Z., Meyers, R.M., Meng, F-L., Jakubauskaite, A., Liu, M., Mani, V., Neuberg, D., Kepler, T.B., Wang, J.H. and Alt, F.W. (2015) Sequence-intrinsic mechanisms that target AID mutational outcomes on antibody genes, Cell, 163, 1124-1137. PMC4751889
Hu, J., Zhang, Y., Zhao, L., Frock, R.L., Du, Z., Meyers, R.M., Meng, F-L., Schatz, D.G. and Alt, F.W. (2015) Chromosomal loop domains direct the recombination of antigen receptor genes. Cell, 163, 947-959. PMC4660266
Dong, J., Panchakshari, R.A., Zhang, T., Zhang, Y., Hu, J., Volpi, S.A.. Meyers, R.M., Ho, Y-J., Du, Z., Robbiani, D.F., Meng F., Gostissa, M., Nussenzweig, M.C., Manis, J.P. and Alt, F.W. (2015) Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching. Nature, 525, 134-139. PMC4592165
Wei, P-C., Chang, A.N., Kao, J., Du, Z., Meyers, R.M., Alt, F.W. and Schwer, B. (2016) Long neural genes harbor recurrent DNA break clusters in neural stem/progenitor cells. Cell, 164, 644-655. PMC4752721
Tian, M., Cheng, C., Chen, X., Duan, H., Cheng, H-L., Dao, M., Sheng, Z., Kimble, M., Wang, L., Lin, S., Schmidt, S.D., Du, Z., Joyce, G., Chen, Y., DeKosky, B.J., Chen, Y., Normandin, E., Cantor, E., Chen, R., Doria-Rose, N.A., Zhang, Y., Shi, W., Kong, W-P., Choe, M., Georgiev, I.S., Huang, H-Y., Jain, S., McGuire, A.T., Georgeson, E., Menis, S., Schief, W.R., Stamatatos, L., Kwong, P.D., Shapiro, L., Haynes, B.F., Mascola, J.R. and Alt, F.W. (2016) Induction of HIV neutralizing antibody lineages in mice with diverse precursor repertories. Cell. 166, 1471–1484. PMC5103708
Hwang, J.K., Wang, C., Du, Z., Meyers, R.M., Kepler, T.B., Neuberg, D., Kwong, P.D., Mascola, J.R., Joyce, M.G., Bonsignori, M., Haynes, B.F., Yeap, L-S. and Alt, F.W. (2017) Sequence intrinsic somatic mutation mechanisms contribute to affinity maturation of VRC01-class HIV-1 broadly neutralizing antibodies. Proc. Natl. Acad. Sci. USA. 114, 8614-8619. PMC5559054.
Panchakshari, R.A., Zhang, X., Kumar, V, Du, Z., Wei, P.C., Kao, J., Dong, J. and Alt, F.W. (2018) DNA double-strand break response factors influence end-joining features of IgH class switch and general translocation junctions. Proc. Natl. Acad. Sci. U S A. 115, 762-767. PMC5789958
Jain, S., Ba, Z., Zhang, Y., Dai, H-Q and Alt, F.W. CTCF-binding elements mediate accessibility of RAG substrates during chromatin scanning. Cell May 18. pii: S0092-8674(18)30566-X. doi: 10.1016/j.cell.2018.04.035. [Epub ahead of print]