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Ortho
Journal at HMS
Journal Club
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Research Opportunities
With the resources of four major teaching hospitals and two world-class
universities at our fingertips, the possibilities for research projects
as a member of the Harvard Combined Orthopedic Residency Program are
quite literally limited only by imagination and motivation. Residents
in previous years have conducted studies ranging from the molecular
biology of osteotropism in metastatic breast cancer, to guided tissue
regeneration of the ACL, to and prospective outcomes studies on pediatric
distal radius fractures. Residents have also won funding awards for
research from organizations such as the National Institutes of Health,
the sOrthopaedic Research and Education Foundation, and the American
Orthopaedic Association.
Research groups are active in multiple areas of orthopaedic basic
science at every institution. What follows is a brief summary, but
it does not do justice to the breadth of orthopedic basic science
research that thrives in the Harvard community. Opportunities also
abound in the industrial sector, as residents have also performed
research projects at several of the numerous orthopaedic and biotechnology
companies located in the greater Boston area, such as Smith and Nephew,
and Genzyme. Moreover, clinical research activities, are also thriving
as the emphasis on clinical outcomes and evidence-based medicine continues
to increase in orthopaedics. We encourage you to investigate further
if your interest is piqued.
Brigham
and Women’s Hospital
Cartilage Repair Center
Tom Minas, MD
- Clinical outcomes of cartilage repair procedures and joint
preserving osteotomies.
- Optimizing the performance of tissue engineered cartilage via
pressure perfusion variation in culture duration, perfusion pressures,
and graft polarity.
- Enhancing cartilage repair by ultrasound frequency and nutritional
supplementation.
Center for Molecular Orthopaedics
Chris Evans, PhD
- Gene therapies in musculoskeletal disease.
Optical Coherence Tomography Laboratory
Mark Brezinski, MD, PhD
- In-vivo evaluation of articular cartilage.
Orthopaedic Research Laboratory
Myron Spector, PhD
- Tissue engineering and biomaterials, application of novel surface
chemistries to permanent biomaterials, biology of contractile
cells in musculoskeletal tissues.
Anuj Bellare, PhD
- Biomaterials and nanotechnology.
Sonya Shortkroff, PhD
- Role of inflammatory cytokines in rheumatoid synovium.
Skeletal Biology Laboratory
Julie Glowacki, PhD
- Skeletal aging, principles underlying cartilage and bone repair,
methods for tissue regeneration.
- Chondrocyte differentiation, distraction osteogenesis, tissue
and joint engineering.
Shiuchi Mizuno, PhD
- Tissue engineering reactor for cell-based therapy.
Karen Yates, PhD
- Molecular biology, chondrocyte differentiation.
Children’s
Hospital Boston
Bone Cell Biology Laboratory
Peter Hauschka, PhD; Keith R. Solomon, PhD
- Osteoblast and osteoclast cell communication and control, membrane
signaling mechanisms, bone cell responses to mechanical forces
– strain and shear. Osteoinduction and growth factors, molecular
mechanisms of skeletal metastasis, osteoprogenitor cells and calcification.
Laboratory for the Study of Skeletal Disorders and Rehabilitation
Melvin Glimcher, MD; Kevin P. McHugh, PhD
- Transcriptional regulation of osteoclast differentiation, cell
- matrix interactions and signaling in bone cells and osteolysis.
Orthopaedic Research Laboratory
Frederic Shapiro, MD
- Light and electron microscopic studies of embryologic development
of limbs and spine, gap junctions in bone cell communication,
and bone/cartilage abnormalities in human skeletal dysplasias.
- Histology-MRI correlations in avascular necrosis of femoral
head in piglet model and human DDH.
Massachusetts
General Hospital
Biomaterials Research Laboratory
Arun Shanbhag, PhD
- Periprosthetic osteolysis, genetic markers for arthritis, and
the anabolic effects of bisphosphonates.
Biomotion Laboratory
David Krebs, PhD
- Mechanical and neural constraints of human locomotion.
Joint Kinematics Laboratory
Guoan Li, PhD; Harry Rubash, PhD; Thomas Gill,
MD
- Kinematics and biomechanics of the musculoskeletal system.
Musckuloskeletal Tissue Engineering Lab
Tom Gill M.D., Mark Randolph, M.D.
- Tissue Engineering - biologic repair techniques for meniscus
and articular cartilage.
Orthopaedic Biology and Oncology Laboratory
Henry Mankin, MD; Christine Towle, PhD; Francis
Hornicek, MD PhD; Mark Gebhardt, MD
- Cartilage metabolism, role of IL-1 in osteoarthritis.
- Genetic markers and drug-resistance mechanisms of bone and
soft-tissue sarcomas.
Orthopedic Biomechanics Laboratory
William H. Harris, MD; Harry Rubash, MD
- Development of highly cross-linked polyethylene.
- Osteogenic substances and repair of osseous defects.
- Development of relational Intranet database for prospective
collection of patient outcomes data.
Shoulder Biomechanics Group
Jon JP Warner, MD
- 3D evaluation of rotator cuff tendon repair, tendon transfers,
proximal humerus anatomy in arthroplasty
Beth
Israel Deaconess Medical Center
Orthopedic Biomechanics Laboratory
Brian Snyder, MD, PhD
- Bone density and fracture risk prediction, fracture risk in
pathologic defects.
- Non-invasive fracture risk prediction in osteoporosis, and
growth factors for the acceleration of fracture healing.
- Spinal biomechanics, instrumentation and biomaterials.
- Biomechanics of benign and metastatic defects in the appendicular
skeleton, radiological predictors of pathological fracture risk.
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