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Keith G. Mansfield , D.V.M

Associate Director for Resource and Collaborative Affairs
Associate Professor of Pathology
Chair, Division of Primate Resources

Research in the Division of Primate Resources has focused principally on the recognition of spontaneously occurring infectious diseases of nonhuman primates and their development into novel animal models to investigate disease pathogenesis. The division has been involved in the initial description of several pathogens not previously recognized in nonhuman primates including Enterocytozoon bieneusi, enteropathogenic E. coli and rhesus rhadinovirus.> Recognition of such agents is critical in promoting colony health and in the development of novel animal models of human infectious diseases. Of particular interest to the division has been the study of opportunistic infections in simian AIDS and elucidating their impact on gastrointestinal function, body composition and disease progression.

The Division's collaborative research program is a vital and dynamic component of the overall research effort of the New England Primate Research Center and enables investigators from other institutions to pursue their primate oriented research goals. This program encompasses a broad range of research projects involving investigators from throughout the nation and the world. We maintain an exemplary record in fulfilling the mission of serving as a national resource to the biomedical research community. In the years 1993-1997, 908 scientists representing 429 different institutions utilized the Center's resources.

Goldin BR, Li W, Mansfield K, Woods M, Wanke C, Freeman L, Shevitz A, Gualtieri L, Bussell S, Gorbach SL. The effect of micronutrient supplementation of disease progression and death in SIV-infected juvenile male rhesus macaques. J Infect Dis 2005; 192:311-18.

Greenough TC, Carville A, Coderre J, Somasundaran M, Sullivan JL, Luzuriaga K, Mansfield KG. Pneumonitis and multi-organ system disease in common marmosets (Callithrix jacchus) infected with the severe acute respiratory syndrome-associated coronavirus. Am J Pathol. 2005;167:455-63.

Yearly J, Pearson C, Carville A, Shannon R, Mansfield KG, SIV-Associated Myocarditis: Viral and Cellular Correlates of Inflammation Severity. Journal of AIDS and Human Retroviruses 2006;22:529-40.

Yearley J, Pearson C, Shannon RP, Mansfield KG. Phenotypic variation in myocardial macrophage populations suggests a role for macrophage activation in SIV-associated cardiac disease. Journal of AIDS and Human Retroviruses 2007;23:515-24.

Mansfield KG, Angela Carville A, Lynn Wachtman L, Barry R. Goldin BR, Yearley J, Li W, Woods M, Gualtieri L, Shannon R, and Wanke C. A Diet high in saturated fat and cholesterol accelerates SIV disease progression. J Infect Dis 2007;196:1202-10.

Wachtman LM, Gualtieri L, Wanke C, Shannon R, Mansfield KG. Viral and host correlates of serum resistin in simian AIDS. J AIDS and Hum Retroviruses, 2008 in press.
 
 

 
 
 
             
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