Publications

2016

Abudayyeh OO, Gootenberg JS, Konermann S, Joung J, Slaymaker IM, Cox DB, Shmakov S, Makarova KS, Semenova E, Minakhin L, Severinov K, Regev A, Lander ES, Koonin EV, Zhang F. C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector. Science. 2016 Jun 2. pii: aaf5573. [Epub ahead of  print] PubMed PMID: 27256883.

 

Dahlman JE, Abudayyeh OO, Joung J, Gootenberg JS, Zhang F, Konermann S. Corrigendum: Orthogonal gene knockout and activation with a catalytically active  Cas9 nuclease. Nat Biotechnol. 2016 Apr 7;34(4):441. doi: 10.1038/nbt0416-441a. PubMed PMID: 27054997.

 

Hirano H, Gootenberg JS, Horii T, Abudayyeh OO, Kimura M, Hsu PD, Nakane T, Ishitani R, Hatada I, Zhang F, Nishimasu H, Nureki O. Structure and Engineering of Francisella novicida Cas9. Cell. 2016 Feb 25;164(5):950-61. doi:

10.1016/j.cell.2016.01.039. Epub 2016 Feb 11. PubMed PMID: 26875867; PubMed Central PMCID: PMC4899972.

 

Kim JW, Botvinnik OB, Abudayyeh O, Birger C, Rosenbluh J, Shrestha Y, Abazeed  ME, Hammerman PS, DiCara D, Konieczkowski DJ, Johannessen CM, Liberzon A, Alizad-Rahvar AR, Alexe G, Aguirre A, Ghandi M, Greulich H, Vazquez F, Weir BA, Van Allen EM, Tsherniak A, Shao DD, Zack TI, Noble M, Getz G, Beroukhim R, Garraway LA, Ardakani M, Romualdi C, Sales G, Barbie DA, Boehm JS, Hahn WC, Mesirov JP, Tamayo P. Characterizing genomic alterations in cancer by complementary functional associations. Nat Biotechnol. 2016 May;34(5):539-46. doi: 10.1038/nbt.3527. Epub 2016 Apr 18. PubMed PMID: 27088724; PubMed Central PMCID: PMC4868596.

 

Sanguansak T, Morley K, Morley M, Kusakul S, Lee R, Shieh E, Yospaiboon Y, Bhoomibunchoo C, Chai-Ear S, Joseph A, Agarwal I. Comparing smartphone camera adapters in imaging post-operative cataract patients. J Telemed Telecare. 2016 Feb 4. pii: 1357633X15625400. [Epub ahead of print] PubMed PMID: 26851243.

 

Fuchsberger C, Flannick J, Teslovich TM, Mahajan A, Agarwala V,, et. al. The geneticarchitecture of type 2 diabetes. Nature. 2016 Aug 4;536(7614):41-7. PubMed PMID:  27398621.

 

Alkaitis MS, Ackerman HC. Tetrahydrobiopterin Supplementation Improves Phenylalanine Metabolism in a Murine Model of Severe Malaria. ACS Infect Dis. 2016 Sep 27. [Epub ahead of print] PubMed PMID: 27641435.

 

Anahtar MN, Bowman BA, Kwon DS. Efficient Nucleic Acid Extraction and 16S rRNA Gene Sequencing for Bacterial Community Characterization. J Vis Exp. 2016 Apr 14;(110). doi: 10.3791/53939. PubMed PMID: 27168460; PubMed Central PMCID: PMC4941931.

 

Sekar A, Bialas AR, de Rivera H, Davis A, Hammond TR, Kamitaki N, Tooley K, Presumey J, Baum M, Van Doren V, Genovese G, Rose SA, Handsaker RE; Schizophrenia Working Group of the Psychiatric Genomics Consortium, Daly MJ, Carroll MC, Stevens B, McCarroll SA. Schizophrenia risk from complex variation of complement  component 4. Nature. 2016 Jan 27. doi: 10.1038/nature16549. [Epub ahead of print] PubMed PMID: 26814963.

 

Bell JS. A PIECE OF MY MIND. Osler in Jail. JAMA. 2016 Jun 21;315(23):2523-4.  doi: 10.1001/jama.2016.1823. PubMed PMID: 27327797.

 

Bell JS, Wilson RI. Behavior Reveals Selective Summation and Max Pooling among Olfactory Processing Channels. Neuron. 2016 Jun 30. pii: S0896-6273(16)30264-1. doi: 10.1016/j.neuron.2016.06.011. [Epub ahead of print] PubMed PMID: 27373835.

 

Bent EH, Gilbert LA, Hemann MT. A senescence secretory switch mediated by PI3K/AKT/mTOR activation controls chemoprotective endothelial secretory responses. Genes Dev. 2016 Aug 15;30(16):1811-21. doi: 10.1101/gad.284851.116. PubMed PMID: 27566778; PubMed Central PMCID: PMC5024680.

 

Gonzalez Castro LN, Colorado RA, Botelho AA, Freitag SK, Rabinov JD, Silverman SB. Carotid-Cavernous Fistula: A Rare but Treatable Cause of Rapidly Progressive  Vision Loss. Stroke. 2016 Aug;47(8):e207-9. doi: 10.1161/STROKEAHA.116.013428. Epub 2016 Jul 12. PubMed PMID: 27406104

 

Masuda T, Wang X, Maeda M, Canver MC, Sher F, Funnell AP, Fisher C, Suciu M, Martyn GE, Norton LJ, Zhu C, Kurita R, Nakamura Y, Xu J, Higgs DR, Crossley M, Bauer DE, Orkin SH, Kharchenko PV, Maeda T. Transcription factors LRF and BCL11A  independently repress expression of fetal hemoglobin. Science. 2016 Jan 15;351(6270):285-9. doi: 10.1126/science.aad3312. PubMed PMID: 26816381.

 

Brendel C, Guda S, Renella R, Bauer DE, Canver MC, Kim YJ, Heeney MM, Klatt D, Fogel J, Milsom MD, Orkin SH, Gregory RI, Williams DA. Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype. J Clin Invest. 2016 Oct 3;126(10):3868-3878. doi: 10.1172/JCI87885. PubMed PMID: 27599293.

 

Pinello L, Canver MC, Hoban MD, Orkin SH, Kohn DB, Bauer DE, Yuan GC. Analyzing CRISPR genome-editing experiments with CRISPResso. Nat Biotechnol. 2016 Jul 12;34(7):695-7. doi: 10.1038/nbt.3583. PubMed PMID: 27404874.

 

Kim PG, Canver MC, Rhee C, Ross SJ, Harriss JV, Tu HC, Orkin SH, Tucker HO, Daley GQ. Interferon-α signaling promotes embryonic HSC maturation. Blood. 2016 Jul 14;128(2):204-16. doi: 10.1182/blood-2016-01-689281. Epub 2016 Apr 19. PubMed PMID: 27095787; PubMed Central PMCID: PMC4946201.

 

Canver MC, Orkin SH. Customizing the genome as therapy for the β-hemoglobinopathies. Blood. 2016 May 26;127(21):2536-45. doi: 10.1182/blood-2016-01-678128. Epub 2016 Apr 6. Review. PubMed PMID: 27053533; PubMed Central PMCID: PMC4882803.

 

Zhang B, Chang K, Ramkissoon S, Tanguturi S, Bi WL, Reardon DA, Ligon KL, Alexander BM, Wen PY, Huang RY. Multimodal MRI features predict isocitrate dehydrogenase genotype in high-grade gliomas. Neuro Oncol. 2016 Jun 26. pii: now121. [Epub ahead of print] PubMed PMID: 27353503.

 

Chang K, Zhang B, Guo X, Zong M, Rahman R, Sanchez D, Winder N, Reardon DA, Zhao B, Wen PY, Huang RY. Multimodal imaging patterns predict survival in recurrent glioblastoma patients treated with bevacizumab. Neuro Oncol. 2016 May4. pii: now086. [Epub ahead of print] PubMed PMID: 27257279.

 

Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu-Remaileh M, Shaul YD, Liu CM, Zhou M, Koh MJ, Chung H, Davidson SM, Luengo A, Wang AQ, Xu X,  Yasgar A, Liu L, Rai G, Westover KD, Vander Heiden MG, Shen M, Gray NS, Boxer MB, Sabatini DM. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nat Chem Biol. 2016 Jun;12(6):452-8. doi: 10.1038/nchembio.2070. Epub 2016 Apr 25. PubMed PMID: 27110680; PubMed Central PMCID: PMC4871733.

 

Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R,  Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu MR, Shaul YD, Liu CM, Zhou M, Koh MJ, Chung H, Davidson SM, Luengo A, Wang AQ, Xu X, Yasgar A,  Liu L, Rai G, Westover KD, Heiden MG, Shen M, Gray NS, Boxer MB, Sabatini DM. Corrigendum: A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nat Chem Biol. 2016 Jul 19;12(8):656. doi: 10.1038/nchembio0816-656. PubMed PMID: 27434767.

 

Chen WW, Freinkman E, Wang T, Birsoy K, Sabatini DM. Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism. Cell. 2016 Aug 25;166(5):1324-1337.e11. doi: 10.1016/j.cell.2016.07.040. PubMed PMID: 27565352; PubMed Central PMCID: PMC5030821.

 

Roffman JL, Tanner AS, Eryilmaz H, Rodriguez-Thompson A, Silverstein NJ, Ho NF, Nitenson AZ, Chonde DB, Greve DN, Abi-Dargham A, Buckner RL, Manoach DS, Rosen BR, Hooker JM, Catana C. Dopamine D1 signaling organizes network dynamics underlying working memory. Sci Adv. 2016 Jun 3;2(6):e1501672. doi: 10.1126/sciadv.1501672. eCollection 2016 Jun. PubMed PMID: 27386561; PubMed Central PMCID: PMC4928887.

 

Chen KT, Izquierdo-Garcia D, Poynton CB, Chonde DB, Catana C. On the accuracy and reproducibility of a novel probabilistic atlas-based generation for calculation of head attenuation maps on integrated PET/MR scanners. Eur J Nucl Med Mol Imaging. 2016 Aug 29. [Epub ahead of print] PubMed PMID: 27573639.

 

Abudayyeh OO, Gootenberg JS, Konermann S, Joung J, Slaymaker IM, Cox DB, Shmakov S, Makarova KS, Semenova E, Minakhin L, Severinov K, Regev A, Lander ES, Koonin EV, Zhang F. C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector. Science. 2016 Jun 2. pii: aaf5573. [Epub ahead of  print] PubMed PMID: 27256883.

 

De Los Angeles A, Ferrari F, Xi R, Fujiwara Y, Benvenisty N, Deng H, Hochedlinger K, Jaenisch R, Lee S, Leitch HG, Lensch MW, Lujan E, Pei D, Rossant  J, Wernig M, Park PJ, Daley GQ. Corrigendum: Hallmarks of pluripotency. Nature. 2016 Mar 17;531(7594):400. doi: 10.1038/nature16470. Epub 2015 Dec 16. PubMed PMID: 26675727.

 

Del Castillo-Calcáneo J, Donoghue JA. A Novel Method for 3-Dimensional Printing a Brain That Feels and Looks Like One: The Next Step in the Search of the Perfect Neurosurgical Simulator. World Neurosurg. 2016 Jul;91:620-2. doi: 10.1016/j.wneu.2016.03.086. Epub 2016 Apr 5. PubMed PMID: 27062917.

 

Barrett KT, Dosumu-Johnson RT, Daubenspeck JA, Brust RD, Kreouzis V, Kim JC, Li A, Dymecki SM, Nattie EE. Partial Raphe Dysfunction in Neurotransmission Is Sufficient to Increase Mortality after Anoxic Exposures in Mice at a Critical Period in Postnatal Development. J Neurosci. 2016 Apr 6;36(14):3943-53. doi: 10.1523/JNEUROSCI.1796-15.2016. PubMed PMID: 27053202; PubMed Central PMCID: PMC4821907.

 

Zangi L, Oliveira MS, Ye LY, Ma Q, Sultana N, Hadas Y, Chepurko E, Später D, Zhou B, Chew WL, Ebina W, Abrial M, Wang QD, Pu WT, Chien KR. An IGF1R-Dependent  Pathway Drives Epicardial Adipose Tissue Formation After Myocardial Injury. Circulation. 2016 Nov 1. pii: CIRCULATIONAHA.116.022064. [Epub ahead of print] PubMed PMID: 27803039.

 

Powers JT, Tsanov KM, Pearson DS, Roels F, Spina CS, Ebright R, Seligson M, de Soysa Y, Cahan P, Theißen J, Tu HC, Han A, Kurek KC, LaPier GS, Osborne JK, Ross  SJ, Cesana M, Collins JJ, Berthold F, Daley GQ. Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma. Nature. 2016 Jul 6;535(7611):246-51. doi: 10.1038/nature18632. PubMed PMID: 27383785; PubMed Central PMCID: PMC4947006.

 

Eshel N, Tian J, Bukwich M, Uchida N. Dopamine neurons share common response function for reward prediction error. Nat Neurosci. 2016 Mar;19(3):479-86. doi: 10.1038/nn.4239. Epub 2016 Feb 8. PubMed PMID: 26854803; PubMed Central PMCID: PMC4767554.

 

Evrony GD. A PIECE OF MY MIND. A Wild Rotation. JAMA. 2016 Aug 16;316(7):713-4. doi: 10.1001/jama.2016.4994. PubMed PMID: 27533153.

 

Evrony GD. One brain, many genomes. Science. 2016 Nov 4;354(6312):557-558. PubMed PMID: 27811258.

 

Finlayson SG, Levy M, Reddy S, Rubin DL. Toward rapid learning in cancer treatment selection: An analytical engine for practice-based clinical data. J Biomed Inform. 2016 Apr;60:104-13. doi: 10.1016/j.jbi.2016.01.005. Epub 2016 Feb  2. PubMed PMID: 26836975; PubMed Central PMCID: PMC4836997.

 

Garcia-Beltran WF, Hölzemer A, Martrus G, Chung AW, Pacheco Y, Simoneau CR, Rucevic M, Lamothe-Molina PA, Pertel T, Kim TE, Dugan H, Alter G, Dechanet-Merville J, Jost S, Carrington M, Altfeld M. Open conformers of HLA-F

are high-affinity ligands of the activating NK-cell receptor KIR3DS1. Nat Immunol. 2016 Jul 25. doi: 10.1038/ni.3513. [Epub ahead of print] PubMed PMID:

27455421.

 

Lunemann S, Martrus G, Hölzemer A, Chapel A, Ziegler M, Körner C, Garcia Beltran W, Carrington M, Wedemeyer H, Altfeld M. Sequence variations in HCV core-derived epitopes alter binding of KIR2DL3 to HLA-C∗03:04 and modulate NK cell function. J Hepatol. 2016 Aug;65(2):252-8. doi: 10.1016/j.jhep.2016.03.016.  Epub 2016 Apr 4. PubMed PMID: 27057987; PubMed Central PMCID: PMC4955726.

 

Scully EP, Lockhart A, Garcia-Beltran W, Palmer CD, Musante C, Rosenberg E, Allen TM, Chang JJ, Bosch RJ, Altfeld M. Innate immune reconstitution with suppression of HIV-1. JCI Insight. 2016 Mar 17;1(3):e85433. PubMed PMID: 27158667; PubMed Central PMCID: PMC4855526.

 

Garza-Mayers AC, McClurkin M, Smith GP. Review of treatment for discoid lupus  erythematosus. Dermatol Ther. 2016 Jul;29(4):274-83. doi: 10.1111/dth.12358. Epub 2016 Apr 12. Review. PubMed PMID: 27073142.

 

Tang M, Zhao R, van de Velde H, Tross (Ge) JG, Mitsiades C, Viselli S, Neuwirth R,  Esseltine DL, Anderson K, Ghobrial IM, San Miguel JF, Richardson PG, Tomasson MH, Michor F. Myeloma Cell Dynamics in Response to Treatment Supports a Model of Hierarchical Differentiation and Clonal Evolution. Clin Cancer Res. 2016 Aug 15;22(16):4206-14. doi: 10.1158/1078-0432.CCR-15-2793. PubMed PMID: 27006493; PubMed Central PMCID: PMC4987182.

 

Gibson WJ, Hoivik EA, Halle MK, Taylor-Weiner A, Cherniack AD, Berg A, Holst F, Zack TI, Werner HM, Staby KM, Rosenberg M, Stefansson IM, Kusonmano K, Chevalier A, Mauland KK, Trovik J, Krakstad C, Giannakis M, Hodis E, Woie K, Bjorge L, Vintermyr OK, Wala JA, Lawrence MS, Getz G, Carter SL, Beroukhim R, Salvesen HB. The genomic landscape and evolution of endometrial carcinoma

progression and abdominopelvic metastasis. Nat Genet. 2016 Aug;48(8):848-55. doi: 10.1038/ng.3602. Epub 2016 Jun 27. PubMed PMID: 27348297; PubMed Central PMCID: PMC4963271.

 

Holst F, Hoivik EA, Gibson WJ, Taylor-Weiner A, Schumacher SE, Asmann YW, Grossmann P, Trovik J, Necela BM, Thompson EA, Meyerson M, Beroukhim R, Salvesen  HB, Cherniack AD. Corrigendum: Recurrent hormone-binding domain truncated ESR1 amplifications in primary endometrial cancers suggest their implication in hormone independent growth. Sci Rep. 2016 Jun 24;6:27960. doi: 10.1038/srep27960. PubMed PMID: 27338572; PubMed Central PMCID: PMC4919648.

 

Holst F, Hoivik EA, Gibson WJ, Taylor-Weiner A, Schumacher SE, Asmann YW, Grossmann P, Trovik J, Necela BM, Thompson EA, Meyerson M, Beroukhim R, Salvesen  HB, Cherniack AD. Recurrent hormone-binding domain truncated ESR1 amplifications  in primary endometrial cancers suggest their implication in hormone independent growth. Sci Rep. 2016 May 10;6:25521. doi: 10.1038/srep25521. PubMed PMID: 27160768; PubMed Central PMCID: PMC4861919.

 

Bandopadhayay P, Ramkissoon LA, Jain P, Bergthold G, Wala J, Zeid R, Schumacher SE, Urbanski L, O'Rourke R, Gibson WJ, Pelton K, Ramkissoon SH, Han HJ, Zhu Y, Choudhari N, Silva A, Boucher K, Henn RE, Kang YJ, Knoff D, Paolella BR, Gladden-Young A, Varlet P, Pages M, Horowitz PM, Federation A, Malkin H, Tracy AA, Seepo S, Ducar M, Van Hummelen P, Santi M, Buccoliero AM, Scagnet M, Bowers DC, Giannini C, Puget S, Hawkins C, Tabori U, Klekner A, Bognar L, Burger  PC, Eberhart C, Rodriguez FJ, Hill DA, Mueller S, Haas-Kogan DA, Phillips JJ, Santagata S, Stiles CD, Bradner JE, Jabado N, Goren A, Grill J, Ligon AH, Goumnerova L, Waanders AJ, Storm PB, Kieran MW, Ligon KL, Beroukhim R, Resnick AC. MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a  tripartite mechanism. Nat Genet. 2016 Mar;48(3):273-82. doi: 10.1038/ng.3500. Epub 2016 Feb 1. PubMed PMID: 26829751; PubMed Central PMCID: PMC4767685.

 

Olenchock BA, Moslehi J, Baik AH, Davidson SM, Williams J, Gibson WJ, Chakraborty AA, Pierce KA, Miller CM, Hanse EA, Kelekar A, Sullivan LB, Wagers AJ, Clish CB, Vander Heiden MG, Kaelin WG Jr. EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection. Cell. 2016 Feb 25;164(5):884-95. doi: 10.1016/j.cell.2016.02.006. Erratum in: Cell. 2016 Apr 7;165(2):497. PMID: 26919427

 

Ceccarelli M, Barthel FP, Malta TM, Sabedot TS, Salama SR, Murray BA, Morozova O, Newton Y, Radenbaugh A, Pagnotta SM, Anjum S, Wang J, Manyam G, Zoppoli P, Ling S, Rao AA, Grifford M, Cherniack AD, Zhang H, Poisson L, Carlotti CG Jr, Tirapelli DP, Rao A, Mikkelsen T, Lau CC, Yung WK, Rabadan R, Huse J, Brat DJ, Lehman NL, Barnholtz-Sloan JS, Zheng S, Hess K, Rao G, Meyerson M, Beroukhim R, Cooper L, Akbani R, Wrensch M, Haussler D, Aldape KD, Laird PW, Gutmann DH; TCGA Research Network (Gibson, WJ), Noushmehr H, Iavarone A, Verhaak RG. Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma. Cell. 2016 Jan 28;164(3):550-63. doi: 10.1016/j.cell.2015.12.028. PMID: 26824661

 

Monaco CL, Gootenberg DB, Zhao G, Handley SA, Ghebremichael MS, Lim ES, Lankowski A, Baldridge MT, Wilen CB, Flagg M, Norman JM, Keller BC, Luévano JM, Wang D, Boum Y, Martin JN, Hunt PW, Bangsberg DR, Siedner MJ, Kwon DS, Virgin HW. Altered Virome and Bacterial Microbiome in Human Immunodeficiency Virus-Associated Acquired Immunodeficiency Syndrome. Cell Host Microbe. 2016 Mar  9;19(3):311-22. doi: 10.1016/j.chom.2016.02.011. PubMed PMID: 26962942; PubMed Central PMCID: PMC4821831.

 

Woodworth MB, Greig LC, Liu KX, Ippolito GC, Tucker HO, Macklis JD. Ctip1 Regulates the Balance between Specification of Distinct Projection Neuron Subtypes in Deep Cortical Layers. Cell Rep. 2016 May 3;15(5):999-1012. doi:

10.1016/j.celrep.2016.03.064. Epub 2016 Apr 21. PubMed PMID: 27117402; PubMed Central PMCID: PMC4873759.

 

Greig LC, Woodworth MB, Greppi C, Macklis JD. Ctip1 Controls Acquisition of Sensory Area Identity and Establishment of Sensory Input Fields in the Developing Neocortex. Neuron. 2016 Apr 20;90(2):261-77. doi: 10.1016/j.neuron.2016.03.008. PubMed PMID: 27100196; PubMed Central PMCID: PMC4873772.

 

Fulco CP, Munschauer M, Anyoha R, Munson G, Grossman SR, Perez EM, Kane M, Cleary B, Lander ES, Engreitz JM. Systematic mapping of functional enhancer-promoter connections with CRISPR interference. Science. 2016 Sep 29. pii: aag2445. [Epub ahead of print] PubMed PMID: 27708057.

 

Davidson SM, Papagiannakopoulos T, Olenchock BA, Heyman JE, Keibler MA, Luengo A, Bauer MR, Jha AK, O'Brien JP, Pierce KA, Gui DY, Sullivan LB, Wasylenko TM, Subbaraj L, Chin CR, Stephanopolous G, Mott BT, Jacks T, Clish CB, Vander Heiden  MG. Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer. Cell Metab. 2016 Mar 8;23(3):517-28. doi: 10.1016/j.cmet.2016.01.007. Epub 2016 Feb 4. PubMed PMID: 26853747; PubMed Central PMCID: PMC4785096.

 

Gutierrez C, Lindor RA, Baker O, Cutler D, Schuur JD. State Regulation Of Freestanding Emergency Departments Varies Widely, Affecting Location, Growth, And Services Provided. Health Aff (Millwood). 2016 Oct 1;35(10):1857-1866. PubMed PMID: 27702960.

 

Akeju O, Hamilos AE, Song AH, Pavone KJ, Purdon PL, Brown EN. GABAA circuit mechanisms are associated with ether anesthesia-induced unconsciousness. Clin Neurophysiol. 2016 Jun;127(6):2472-81. doi: 10.1016/j.clinph.2016.02.012. Epub 2016 Feb 27. PubMed PMID: 27178867; PubMed Central PMCID: PMC4869993.

 

Akeju O, Song AH, Hamilos AE, Pavone KJ, Flores FJ, Brown EN, Purdon PL. Electroencephalogram signatures of ketamine anesthesia-induced unconsciousness. Clin Neurophysiol. 2016 Jun;127(6):2414-22. doi: 10.1016/j.clinph.2016.03.005. Epub 2016 Mar 16. PubMed PMID: 27178861; PubMed Central PMCID: PMC4871620.

 

Gibson WJ, Hoivik EA, Halle MK, Taylor-Weiner A, Cherniack AD, Berg A, Holst F, Zack TI, Werner HM, Staby KM, Rosenberg M, Stefansson IM, Kusonmano K, Chevalier A, Mauland KK, Trovik J, Krakstad C, Giannakis M, Hodis E, Woie K, Bjorge L, Vintermyr OK, Wala JA, Lawrence MS, Getz G, Carter SL, Beroukhim R, Salvesen HB. The genomic landscape and evolution of endometrial carcinoma

progression and abdominopelvic metastasis. Nat Genet. 2016 Aug;48(8):848-55. doi: 10.1038/ng.3602. Epub 2016 Jun 27. PubMed PMID: 27348297; PubMed Central PMCID: PMC4963271.

 

Han B, Pouget JG, Slowikowski K, Stahl E, Lee CH, Diogo D, Hu X, Park YR, Kim  E, Gregersen PK, Dahlqvist SR, Worthington J, Martin J, Eyre S, Klareskog L, Huizinga T, Chen WM, Onengut-Gumuscu S, Rich SS; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Wray NR, Raychaudhuri S. A  method to decipher pleiotropy by detecting underlying heterogeneity driven by

hidden subgroups applied to autoimmune and neuropsychiatric diseases. Nat Genet.  2016 Jul;48(7):803-10. doi: 10.1038/ng.3572. Epub 2016 May 16. PubMed PMID: 27182969; PubMed Central PMCID: PMC4925284.

 

Tirosh I, Izar B, Prakadan SM, Wadsworth MH 2nd, Treacy D, Trombetta JJ, Rotem A, Rodman C, Lian C, Murphy G, Fallahi-Sichani M, Dutton-Regester K, Lin JR, Cohen O, Shah P, Lu D, Genshaft AS, Hughes TK, Ziegler CG, Kazer SW, Gaillard A, Kolb KE, Villani AC, Johannessen CM, Andreev AY, Van Allen EM, Bertagnolli M, Sorger PK, Sullivan RJ, Flaherty KT, Frederick DT, Jané-Valbuena J, Yoon CH, Rozenblatt-Rosen O, Shalek AK, Regev A, Garraway LA. Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq. Science. 2016 Apr 8;352(6282):189-96. doi: 10.1126/science.aad0501. PubMed PMID: 27124452; PubMed Central PMCID: PMC4944528.

 

Wadsworth MH 2nd, Hughes TK, Shalek AK. Marrying microfluidics and microwells  for parallel, high-throughput single-cell genomics. Genome Biol. 2015 Jun 20;16:129. doi: 10.1186/s13059-015-0695-0. PubMed PMID: 26087845; PubMed Central  PMCID: PMC4474330.

 

Cox AG, Hwang KL, Brown KK, Evason KJ, Beltz S, Tsomides A, O'Connor K, Galli  GG, Yimlamai D, Chhangawala S, Yuan M, Lien EC, Wucherpfennig J, Nissim S, Minami A, Cohen DE, Camargo FD, Asara JM, Houvras Y, Stainier DY, Goessling W. Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth. Nat Cell Biol. 2016 Aug;18(8):886-96. doi: 10.1038/ncb3389. Epub 2016 Jul 18. PubMed PMID: 27428308; PubMed Central PMCID: PMC4990146.

 

Hwang KL, Goessling W. Baiting for Cancer: Using the Zebrafish as a Model in Liver and Pancreatic Cancer. Adv Exp Med Biol. 2016;916:391-410. doi: 10.1007/978-3-319-30654-4_17. PubMed PMID: 27165363.

 

Cox AG, Tsomides A, Kim AJ, Saunders D, Hwang KL, Evason KJ, Heidel J, Brown KK, Yuan M, Lien EC, Lee BC, Nissim S, Dickinson B, Chhangawala S, Chang CJ, Asara JM, Houvras Y, Gladyshev VN, Goessling W. Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis. Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):E5562-71. doi: 10.1073/pnas.1600204113. PubMed PMID: 27588899; PubMed Central PMCID: PMC5035897

 

Hwang WL, Marciscano AE, Niemierko A, Kim DW, Stemmer-Rachamimov AO, Curry WT, Barker FG  2nd, Martuza RL, Loeffler JS, Oh KS, Shih HA, Larvie M. Imaging and extent of surgical resection predict risk of meningioma recurrence better than WHO histopathological grade. Neuro Oncol. 2016 Jun;18(6):863-72. doi: 10.1093/neuonc/nov285. Epub 2015 Nov 22. PubMed PMID: 26597949; PubMed Central PMCID: PMC4864259.

 

Harada BT, Hwang WL, Deindl S, Chatterjee N, Bartholomew B, Zhuang X. Stepwise nucleosome translocation by RSC remodeling complexes. Elife. 2016 Feb 19;5. pii:  e10051. doi: 10.7554/eLife.10051. PubMed PMID: 26895087; PubMed Central PMCID: PMC4769157.

 

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