Publications

2017

 

Gootenberg JS, Abudayyeh OO, Lee JW, Essletzbichler P, Dy AJ, Joung J, Verdine V, Donghia N, Daringer NM, Freije CA, Myhrvold C, Bhattacharyya RP, Livny J, Regev A, Koonin EV, Hung DT, Sabeti PC, Collins JJ, Zhang F. Nucleic acid detection with CRISPR-Cas13a/C2c2. Science. 2017 Apr 28;356(6336):438-442. doi: 10.1126/science.aam9321. Epub 2017 Apr 13. PubMed PMID: 28408723.

 

Joung J, Konermann S, Gootenberg JS, Abudayyeh OO, Platt RJ, Brigham MD, Sanjana NE, Zhang F. Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening. Nat Protoc. 2017 Apr;12(4):828-863. doi: 10.1038/nprot.2017.016. Epub 2017 Mar 23. PubMed PMID: 28333914.

 

Zetsche B, Heidenreich M, Mohanraju P, Fedorova I, Kneppers J, DeGennaro EM, Winblad N, Choudhury SR, Abudayyeh OO, Gootenberg JS, Wu WY, Scott DA, Severinov K, van der Oost J, Zhang F. Erratum: Multiplex gene editing by CRISPR-Cpf1 using  a single crRNA array. Nat Biotechnol. 2017 Feb 8;35(2):178. doi: 10.1038/nbt0217-178b. PubMed PMID: 28178246.

 

Zetsche B, Heidenreich M, Mohanraju P, Fedorova I, Kneppers J, DeGennaro EM,

Winblad N, Choudhury SR, Abudayyeh OO, Gootenberg JS, Wu WY, Scott DA, Severinov  K, van der Oost J, Zhang F. Multiplex gene editing by CRISPR-Cpf1 using a single  crRNA array. Nat Biotechnol. 2017 Jan;35(1):31-34. doi: 10.1038/nbt.3737. Epub 2016 Dec 5. PubMed PMID: 27918548; PubMed Central PMCID: PMC5225075.

 

Shmakov S, Smargon A, Scott D, Cox D, Pyzocha N, Yan W, Abudayyeh OO, Gootenberg JS, Makarova KS, Wolf YI, Severinov K, Zhang F, Koonin EV. Diversity and evolution of class 2 CRISPR-Cas systems. Nat Rev Microbiol. 2017 Mar;15(3):169-182. doi: 10.1038/nrmicro.2016.184. Epub 2017 Jan 23. PubMed PMID: 28111461.

 

Hogan NC, Anahtar MN, Taberner AJ, Hunter IW. Delivery of immunoreactive antigen using a controllable needle-free jet injector. J Control Release. 2017 May 4;258:73-80. doi: 10.1016/j.jconrel.2017.05.003. [Epub ahead of print] PubMed PMID: 28479095.

 

Gosmann C, Anahtar MN, Handley SA, Farcasanu M, Abu-Ali G, Bowman BA, Padavattan N, Desai C, Droit L, Moodley A, Dong M, Chen Y, Ismail N, Ndung'u T, Ghebremichael MS, Wesemann DR, Mitchell C, Dong KL, Huttenhower C, Walker BD, Virgin HW, Kwon DS. Lactobacillus-Deficient Cervicovaginal Bacterial Communities Are Associated with Increased HIV Acquisition in Young South African Women. Immunity. 2017 Jan 17;46(1):29-37. doi: 10.1016/j.immuni.2016.12.013. Epub 2017 Jan 10. PubMed PMID: 28087240; PubMed Central PMCID: PMC5270628.

 

Samad T, Billings N, Birjiniuk A, Crouzier T, Doyle PS, Ribbeck K. Swimming bacteria promote dispersal of non-motile staphylococcal species. ISME J. 2017 Apr 11. doi: 10.1038/ismej.2017.23. [Epub ahead of print] PubMed PMID: 28398350.

 

Bodnar NO, Rapoport TA. Molecular Mechanism of Substrate Processing by the Cdc48 ATPase Complex. Cell. 2017 May 4;169(4):722-735.e9. doi: 10.1016/j.cell.2017.04.020. PubMed PMID: 28475898.

 

Byrne EH, Fisher DE. Immune and molecular correlates in melanoma treated with immune checkpoint blockade. Cancer. 2017 Jun 1;123(S11):2143-2153. doi: 10.1002/cncr.30444. Review. PubMed PMID: 28543699; PubMed Central PMCID:

PMC5445935.

 

Canver MC, Bauer DE, Orkin SH. Functional interrogation of non-coding DNA through CRISPR genome editing. Methods. 2017 Mar 10. pii: S1046-2023(17)30001-4.  doi: 10.1016/j.ymeth.2017.03.008. [Epub ahead of print] Review. PubMed PMID: 28288828.

 

Canver MC, Lessard S, Pinello L, Wu Y, Ilboudo Y, Stern EN, Needleman AJ, Galactéros F, Brugnara C, Kutlar A, McKenzie C, Reid M, Chen DD, Das PP, A Cole M, Zeng J, Kurita R, Nakamura Y, Yuan GC, Lettre G, Bauer DE, Orkin SH. Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci. Nat Genet. 2017 Apr;49(4):625-634.

doi: 10.1038/ng.3793. Epub 2017 Feb 20. PubMed PMID: 28218758; PubMed Central PMCID: PMC5374001.

 

Canver MC, Bauer DE, Dass A, Yien YY, Chung J, Masuda T, Maeda T, Paw BH, Orkin SH. Characterization of genomic deletion efficiency mediated by clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 nuclease system in mammalian cells. J Biol Chem. 2017 Feb 10;292(6):2556. doi: 10.1074/jbc.A114.564625. PubMed PMID: 28188222; PubMed Central PMCID: PMC5313121.

 

Liu Y, Pan J, Jenni S, Raymond DD, Caradonna T, Do KT, Schmidt AG, Harrison SC, Grigorieff N. CryoEM Structure of an Influenza Virus Receptor-Binding Site Antibody-Antigen Interface. J Mol Biol. 2017 May 12. pii: S0022-2836(17)30226-7.  doi: 10.1016/j.jmb.2017.05.011. [Epub ahead of print] PubMed PMID: 28506635

 

Wang T, Yu H, Hughes NW, Liu B, Kendirli A, Klein K, Chen WW, Lander ES, Sabatini DM. Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras. Cell. 2017 Feb 23;168(5):890-903.e15. doi: 10.1016/j.cell.2017.01.013. Epub 2017 Feb 2. PubMed PMID: 28162770; PubMed Central PMCID: PMC5445660.

 

Seker UO, Chen AY, Citorik RJ, Lu TK. Synthetic Biogenesis of Bacterial Amyloid Nanomaterials with Tunable Inorganic-Organic Interfaces and Electrical Conductivity. ACS Synth Biol. 2017 Feb 17;6(2):266-275. doi: 10.1021/acssynbio.6b00166. Epub 2016 Dec 6. PubMed PMID: 27794590.

 

Dreijerink KM, Groner AC, Vos ES, Font-Tello A, Gu L, Chi D, Reyes J, Cook J, Lim E, Lin CY, de Laat W, Rao PK, Long HW, Brown M. Enhancer-Mediated Oncogenic Function of the Menin Tumor Suppressor in Breast Cancer. Cell Rep. 2017 Mar 7;18(10):2359-2372. doi: 10.1016/j.celrep.2017.02.025. PubMed PMID: 28273452.

 

Comstock DE, Nishino M, Giardino AA. Headache in the Setting of Immunotherapy Treatment for Metastatic Melanoma. JAMA Oncol. 2017 May 1;3(5):703-704. doi: 10.1001/jamaoncol.2016.6611. PubMed PMID: 28196215.

 

Senders JT, Muskens IS, Schnoor R, Karhade AV, Cote DJ, Smith TR, Broekman ML. Agents for fluorescence-guided glioma surgery: a systematic review of preclinical and clinical results. Acta Neurochir (Wien). 2017 Jan;159(1):151-167. doi: 10.1007/s00701-016-3028-5. Epub 2016 Nov 22. Review. PubMed PMID: 27878374; PubMed Central PMCID: PMC5177668.

 

Cote DJ, Bredenoord AL, Smith TR, Ammirati M, Brennum J, Mendez I, Ammar AS, Balak N, Bolles G, Esene IN, Mathiesen T, Broekman ML. Ethical clinical translation of stem cell interventions for neurologic disease. Neurology. 2017 Jan 17;88(3):322-328. doi: 10.1212/WNL.0000000000003506. Epub 2016 Dec 7. PubMed  PMID: 27927932.

 

Zaidi HA, Cote DJ, Castlen JP, Burke WT, Liu YH, Smith TR, Laws ER Jr. Time Course of Resolution of Hyperprolactinemia After Transsphenoidal Surgery Among Patients Presenting with Pituitary Stalk Compression. World Neurosurg. 2017 Jan;97:2-7. doi: 10.1016/j.wneu.2016.09.066. Epub 2016 Sep 23. PubMed PMID: 27671881.

 

Karhade AV, Cote DJ, Larsen AM, Smith TR. Neurosurgical Infection Rates and Risk Factors: A National Surgical Quality Improvement Program Analysis of 132,000 Patients, 2006-2014. World Neurosurg. 2017 Jan;97:205-212. doi: 10.1016/j.wneu.2016.09.056. Epub 2016 Sep 23. PubMed PMID: 27671880.

 

Karhade AV, Fandino L, Gupta S, Cote DJ, Iorgulescu JB, Broekman ML, Aglio LS, Dunn IF, Smith TR. Impact of operative length on post-operative complications in meningioma surgery: a NSQIP analysis. J Neurooncol. 2017 Jan;131(1):59-67. doi: 10.1007/s11060-016-2262-2. Epub 2016 Nov 18. PubMed PMID: 27864707.

 

Din RS, Yan SC, Cote DJ, Acosta MA, Smith TR. Defensive Medicine in U.S. Spine Neurosurgery. Spine (Phila Pa 1976). 2017 Feb;42(3):177-185. doi: 10.1097/BRS.0000000000001687. PubMed PMID: 27172279.

 

Cote DJ, Laws ER Jr. The Ethics of "Choosing Wisely": The Use of Neuroimaging for Uncomplicated Headache. Neurosurgery. 2017 May 1;80(5):816-819. doi: 10.1093/neuros/nyw180. PubMed PMID: 28327977.

 

Castlen JP, Cote DJ, Moojen WA, Robe PA, Balak N, Brennum J, Ammirati M, Mathiesen T, Broekman MLD; World Federation of Neurosurgical Societies Ethics Committee and European Association of Neurosurgical Societies Ethico-Legal Committee. The Changing Health Care Landscape and Implications of Organizational  Ethics on Modern Medical Practice. World Neurosurg. 2017 Jun;102:420-424. doi: 10.1016/j.wneu.2017.03.073. Epub 2017 Mar 24. Review. PubMed PMID: 28347897.

 

Abou-Al-Shaar H, Zaidi HA, Cote DJ, Laws ER Jr. Bolstering the Nasoseptal Flap Using Sphenoid Sinus Fat Packing: A Technical Case Report. World Neurosurg. 2017  Mar;99:813.e1-813.e5. doi: 10.1016/j.wneu.2016.12.009. Epub 2016 Dec 18. PubMed PMID: 27993737

 

Cote DJ, Burke WT, Castlen JP, King CH, Zaidi HA, Smith TR, Laws ER, Aglio LS. Safety of remifentanil in transsphenoidal surgery: A single-center analysis of 540 patients. J Clin Neurosci. 2017 Apr;38:96-99. doi: 10.1016/j.jocn.2016.12.011. Epub 2017 Jan 16. PubMed PMID: 28110927.

 

Cote DJ, Balak N, Brennum J, Holsgrove DT, Kitchen N, Kolenda H, Moojen WA, Schaller K, Robe PA, Mathiesen T, Broekman ML. Ethical difficulties in the innovative surgical treatment of patients with recurrent glioblastoma multiforme. J Neurosurg. 2017 Jun;126(6):2045-2050. doi: 10.3171/2016.11.JNS162488. Epub 2017 Apr 21. PubMed PMID: 28430037.

 

Cote DJ, Dasenbrock HH, Muskens IS, Broekman MLD, Zaidi HA, Dunn IF, Smith TR,Laws ER Jr. Readmission and Other Adverse Events after Transsphenoidal Surgery: Prevalence, Timing, and Predictive Factors. J Am Coll Surg. 2017 May;224(5):971-979. doi: 10.1016/j.jamcollsurg.2017.02.015. Epub 2017 Mar 6. PubMed PMID: 28279778.

 

Cote DJ, Downer MK, Zoltick ES, Smith TR, Stampfer MJ. ABO blood group and risk of glioma. Neuro Oncol. 2017 Jun 1;19(6):871-873. doi:

10.1093/neuonc/nox013. PubMed PMID: 28339823.

 

 

Gao L, Cox DBT, Yan WX, Manteiga JC, Schneider MW, Yamano T, Nishimasu H, Nureki O, Crosetto N, Zhang F. Engineered Cpf1 variants with altered PAM specificities. Nat Biotechnol. 2017 Jun 5. doi: 10.1038/nbt.3900. [Epub ahead of print] PubMed PMID: 28581492.

 

Smargon AA, Cox DB, Pyzocha NK, Zheng K, Slaymaker IM, Gootenberg JS, Abudayyeh OA, Essletzbichler P, Shmakov S, Makarova KS, Koonin EV, Zhang F. Cas13b Is a Type VI-B CRISPR-Associated RNA-Guided RNase Differentially Regulated by Accessory Proteins Csx27 and Csx28. Mol Cell. 2017 Feb 16;65(4):618-630.e7. doi: 10.1016/j.molcel.2016.12.023. Epub 2017 Jan 5. PubMed PMID: 28065598; PubMed Central PMCID: PMC5432119.

 

Jamuar SS, Schmitz-Abe K, D'Gama AM, Drottar M, Chan WM, Peeva M, Servattalab  S, Lam AN, Delgado MR, Clegg NJ, Zayed ZA, Dogar MA, Alorainy IA, Jamea AA, Abu-Amero K, Griebel M, Ward W, Lein ES, Markianos K, Barkovich AJ, Robson CD, Grant PE, Bosley TM, Engle EC, Walsh CA, Yu TW. Biallelic mutations in human DCC  cause developmental split-brain syndrome. Nat Genet. 2017 Apr;49(4):606-612. doi: 10.1038/ng.3804. Epub 2017 Feb 27. PubMed PMID: 28250456; PubMed Central PMCID: PMC5374027.

 

Manier S, Huynh D, Shen YJ, Zhou J, Yusufzai T, Salem KZ, Ebright RY, Shi J, Park J, Glavey SV, Devine WG, Liu CJ, Leleu X, Quesnel B, Roche-Lestienne C, Snyder JK, Brown LE, Gray N, Bradner J, Whitesell L, Porco JA Jr, Ghobrial IM. Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma. Sci Transl Med. 2017 May 10;9(389). pii: eaal2668. doi: 10.1126/scitranslmed.aal2668. PubMed PMID: 28490664.

 

Evrony GD, Cordero DR, Shen J, Partlow JN, Yu TW, Rodin RE, Hill RS, Coulter ME, Lam AN, Jayaraman D, Gerrelli D, Diaz DG, Santos C, Morrison V, Galli A, Tschulena U, Wiemann S, Martel MJ, Spooner B, Ryu SC, Elhosary PC, Richardson JM, Tierney D, Robinson CA, Chibbar R, Diudea D, Folkerth R, Wiebe S, Barkovich AJ, Mochida GH, Irvine J, Lemire EG, Blakley P, Walsh CA. Integrated genome and transcriptome sequencing identifies a noncoding mutation in the genome replication factor DONSON as the cause of microcephaly-micromelia syndrome. Genome Res. 2017 Jun 19. doi: 10.1101/gr.219899.116. [Epub ahead of print] PubMed PMID: 28630177.

 

Cho CF, Wolfe JM, Fadzen CM, Calligaris D, Hornburg K, Chiocca EA, Agar NYR, Pentelute BL, Lawler SE. Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents. Nat Commun. 2017 Jun 6;8:15623. doi: 10.1038/ncomms15623. PubMed PMID: 28585535.

 

Chapel A, Garcia-Beltran WF, Hölzemer A, Ziegler M, Lunemann S, Martrus G, Altfeld M. Peptide-specific engagement of the activating NK cell receptor KIR2DS1. Sci Rep. 2017 May 25;7(1):2414. doi: 10.1038/s41598-017-02449-x. PubMed PMID: 28546555

 

Park RJ, Wang T, Koundakjian D, Hultquist JF, Lamothe-Molina P, Monel B, Schumann K, Yu H, Krupzcak KM, Garcia-Beltran W, Piechocka-Trocha A, Krogan NJ, Marson A, Sabatini DM, Lander ES, Hacohen N, Walker BD. A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors. Nat Genet. 2017 Feb;49(2):193-203. doi: 10.1038/ng.3741. Epub 2016 Dec 19. PubMed PMID: 27992415.

 

Gootenberg DB, Paer JM, Luevano JM, Kwon DS. HIV-associated changes in the enteric microbial community: potential role in loss of homeostasis and development of systemic inflammation. Curr Opin Infect Dis. 2017 Feb;30(1):31-43. doi: 10.1097/QCO.0000000000000341. PubMed PMID: 27922852; PubMed Central PMCID: PMC532524

 

Zhang Y, Xie L, Gunasekar SK, Tong D, Mishra A, Gibson WJ, Wang C, Fidler T, Marthaler B, Klingelhutz A, Abel ED, Samuel I, Smith JK, Cao L, Sah R. SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis. Nat Cell Biol. 2017 May;19(5):504-517. doi: 10.1038/ncb3514. Epub 2017 Apr 24. PubMed PMID: 28436964; PubMed Central PMCID: PMC5415409.

 

Zhang Y, Xie L, Gunasekar SK, Tong D, Mishra A, Gibson WJ, Wang C, Fidler T, Marthaler B, Klingelhutz A, Abel ED, Samuel I, Smith JK, Cao L, Sah R. Erratum: SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis. Nat Cell Biol. 2017 May 31;19(6):740. doi: 10.1038/ncb3536. PubMed PMID: 28561048.

 

Paolella BR, Gibson WJ, Urbanski LM, Alberta JA, Zack TI, Bandopadhayay P, Nichols CA, Agarwalla PK, Brown MS, Lamothe R, Yu Y, Choi PS, Obeng EA, Heckl D,  Wei G, Wang B, Tsherniak A, Vazquez F, Weir BA, Root DE, Cowley GS, Buhrlage SJ, Stiles CD, Ebert BL, Hahn WC, Reed R, Beroukhim R. Copy-number dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability. Elife. 2017 Feb 8;6. pii: e23268. doi: 10.7554/eLife.23268. PubMed PMID: 28177281; PubMed Central PMCID: PMC5357138.

 

Gibson WJ, Ruan DT, Paulson VA, Barletta JA, Hanna GJ, Kraft S, Calles A, Nehs MA, Moore FD Jr, Taylor-Weiner A, Wala JA, Zack TI, Lee TC, Fennessy FM, Alexander EK, Thomas T, Janne PA, Garraway LA, Carter SL, Beroukhim R, Lorch JH,  Van Allen EM. Genomic Heterogeneity and Exceptional Response to Dual Pathway Inhibition in Anaplastic Thyroid Cancer. Clin Cancer Res. 2017 May 1;23(9):2367-2373. doi: 10.1158/1078-0432.CCR-16-2154-T. Epub 2016 Oct 17. PubMed PMID: 27797976; PubMed Central PMCID: PMC5393965.

 

Bi WL, Horowitz P, Greenwald NF, Abedalthagafi M, Agarwalla PK, Gibson WJ, Mei Y, Schumacher SE, Ben-David U, Chevalier A, Carter S, Tiao G, Brastianos PK, Ligon AH, Ducar M, MacConaill L, Laws ER Jr, Santagata S, Beroukhim R, Dunn IF. Landscape of Genomic Alterations in Pituitary Adenomas. Clin Cancer Res. 2017 Apr 1;23(7):1841-1851. doi: 10.1158/1078-0432.CCR-16-0790. Epub 2016 Oct 5. PubMed PMID: 27707790; PubMed Central PMCID: PMC5380512.

 

Grossman SR, Zhang X, Wang L, Engreitz J, Melnikov A, Rogov P, Tewhey R, Isakova A, Deplancke B, Bernstein BE, Mikkelsen TS, Lander ES. Systematic dissection of genomic features determining transcription factor binding and enhancer function. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1291-E1300. doi: 10.1073/pnas.1621150114. Epub 2017 Jan 30. PubMed PMID: 28137873; PubMed Central  PMCID: PMC5321001.

 

Filippakis H, Alesi N, Ogorek B, Nijmeh J, Khabibullin D, Gutierrez C, Valvezan AJ, Cunningham J, Priolo C, Henske EP. Lysosomal regulation of

cholesterol homeostasis in tuberous sclerosis complex is mediated via NPC1 and LDL-R. Oncotarget. 2017 Apr 27. doi: 10.18632/oncotarget.17485. [Epub ahead of print] PubMed PMID: 28498820.

 

Hennessy ML, Corcoran A, Brust RD, Nattie EE, Dymecki S. Activity of Tachykinin1-expressing Pet1 raphe neurons modulates the drive to breathe. J Neurosci. 2017 Jan 10. pii: 2316-16. doi: 10.1523/JNEUROSCI.2316-16.2016. [Epub ahead of print] PubMed PMID: 28073937.

 

Johnson CP, Kim IK, Esmaeli B, Amin-Mansour A, Treacy DJ, Carter SL, Hodis EWagle N, Seepo S, Yu X, Lane AM, Gragoudas ES, Vazquez F, Nickerson E, Cibulskis  K, McKenna A, Gabriel SB, Getz G, Van Allen EM, 't Hoen PAC, Garraway LA, Woodman SE. Systematic genomic and translational efficiency studies of uveal melanoma. PLoS One. 2017 Jun 8;12(6):e0178189. doi: 10.1371/journal.pone.0178189. eCollection 2017. PubMed PMID: 28594900.

 

Gierahn TM, Wadsworth MH 2nd, Hughes TK, Bryson BD, Butler A, Satija R, Fortune S, Love JC, Shalek AK. Seq-Well: portable, low-cost RNA sequencing of single cells at high throughput. Nat Methods. 2017 Apr;14(4):395-398. doi: 10.1038/nmeth.4179. Epub 2017 Feb 13. PubMed PMID: 28192419; PubMed Central PMCID: PMC5376227.

 

Evrony GD, Cordero DR, Shen J, Partlow JN, Yu TW, Rodin RE, Hill RS, Coulter ME, Lam AN, Jayaraman D, Gerrelli D, Diaz DG, Santos C, Morrison V, Galli A, Tschulena U, Wiemann S, Martel MJ, Spooner B, Ryu SC, Elhosary PC, Richardson JM, Tierney D, Robinson CA, Chibbar R, Diudea D, Folkerth R, Wiebe S, Barkovich AJ, Mochida GH, Irvine J, Lemire EG, Blakley P, Walsh CA. Integrated genome and transcriptome sequencing identifies a noncoding mutation in the genome replication factor DONSON as the cause of microcephaly-micromelia syndrome.

Genome Res. 2017 Jun 19. doi: 10.1101/gr.219899.116. [Epub ahead of print] PubMed PMID: 28630177.

 

Kalinich M, Bhan I, Kwan TT, Miyamoto DT, Javaid S, LiCausi JA, Milner JD, Hong X, Goyal L, Sil S, Choz M, Ho U, Kapur R, Muzikansky A, Zhang H, Weitz DA, Sequist LV, Ryan DP, Chung RT, Zhu AX, Isselbacher KJ, Ting DT, Toner M, Maheswaran S, Haber DA. An RNA-based signature enables high specificity detection of circulating tumor cells in hepatocellular carcinoma. Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1123-1128. doi: 10.1073/pnas.1617032114. Epub 2017 Jan 17. PubMed PMID: 28096363; PubMed Central PMCID: PMC5293050.

 

Wolfson RL, Chantranupong L, Wyant GA, Gu X, Orozco JM, Shen K, Condon KJ, Petri S, Kedir J, Scaria SM, Abu-Remaileh M, Frankel WN, Sabatini DM. KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1. Nature. 2017 Mar 16;543(7645):438-442. doi: 10.1038/nature21423. Epub 2017 Feb 15. PubMed PMID: 28199306; PubMed Central PMCID: PMC5360989.

 

Santaguida S, Richardson A, Iyer DR, M'Saad O, Zasadil L, Knouse KA, Wong YL,  Rhind N, Desai A, Amon A. Chromosome Mis-segregation Generates Cell-Cycle-Arrested Cells with Complex Karyotypes that Are Eliminated by the Immune System. Dev Cell. 2017 Jun 19;41(6):638-651.e5. doi: 10.1016/j.devcel.2017.05.022. PubMed PMID: 28633018.

 

Knouse KA, Wu J, Hendricks A. Detection of Copy Number Alterations Using Single Cell Sequencing. J Vis Exp. 2017 Feb 17;(120). doi: 10.3791/55143. PubMed  PMID: 28287554; PubMed Central PMCID: PMC5409325.

 

Bruno PM, Liu Y, Park GY, Murai J, Koch CE, Eisen TJ, Pritchard JR, Pommier Y, Lippard SJ, Hemann MT. A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress. Nat Med. 2017 Apr;23(4):461-471. doi: 10.1038/nm.4291. Epub 2017 Feb 27. PubMed PMID: 28263311.

 

Kwok SJJ, Kim M, Lin HH, Seiler TG, Beck E, Shao P, Kochevar IE, Seiler T, Yun SH. Flexible Optical Waveguides for Uniform Periscleral Cross-Linking. Invest Ophthalmol Vis Sci. 2017 May 1;58(5):2596-2602. doi: 10.1167/iovs.17-21559. PubMed PMID: 28494493; PubMed Central PMCID: PMC5433838.

 

Lee M. Don't Give Up! A Cyber-ethnography and Discourse Analysis of an Online  Infertility Patient Forum. Cult Med Psychiatry. 2017 Jan 6. doi:

10.1007/s11013-016-9515-6. [Epub ahead of print] PubMed PMID: 28063090

 

Oderberg IM, Li DJ, Scimone ML, Gaviño MA, Reddien PW. Landmarks in Existing Tissue at Wounds Are Utilized to Generate Pattern in Regenerating Tissue. Curr Biol. 2017 Mar 6;27(5):733-742. doi: 10.1016/j.cub.2017.01.024. Epub 2017 Feb 16. PubMed PMID: 28216315.

 

Mayers JR, Vander Heiden MG. Nature and Nurture: What Determines Tumor Metabolic Phenotypes? Cancer Res. 2017 Jun 15;77(12):3131-3134. doi: 10.1158/0008-5472.CAN-17-0165. Epub 2017 Jun 5. Review. PubMed PMID: 28584183.

 

Davidson SM, Jonas O, Keibler MA, Hou HW, Luengo A, Mayers JR, Wyckoff J, Del  Rosario AM, Whitman M, Chin CR, Condon KJ, Lammers A, Kellersberger KA, Stall BK, Stephanopoulos G, Bar-Sagi D, Han J, Rabinowitz JD, Cima MJ, Langer R, Vander Heiden MG. Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors. Nat Med. 2017 Feb;23(2):235-241. doi: 10.1038/nm.4256. Epub 2016 Dec 26. PubMed PMID: 28024083; PubMed Central PMCID: PMC5407288.

 

Wachter F, Morgan AM, Godes M, Mourtada R, Bird GH, Walensky LD. Mechanistic validation of a clinical lead stapled peptide that reactivates p53 by dual HDM2 and HDMX targeting. Oncogene. 2017 Apr;36(15):2184-2190. doi: 10.1038/onc.2016.361. Epub 2016 Oct 10. PubMed PMID: 27721413; PubMed Central PMCID: PMC5386833

 

Nwanaji-Enwerem JC, Colicino E, Dai L, Cayir A, Sanchez-Guerra M, Laue HE, Nguyen VT, Di Q, Just AC, Hou L, Vokonas P, Coull BA, Weisskopf MG, Baccarelli AA, Schwartz JD. Impacts of the Mitochondrial Genome on the Relationship of Long-Term Ambient Fine Particle Exposure with Blood DNA Methylation Age. Environ  Sci Technol. 2017 Jul 7. doi: 10.1021/acs.est.7b02409. [Epub ahead of print] PubMed PMID: 28636816.

 

Nwanaji-Enwerem JC, Bind MA, Dai L, Oulhote Y, Colicino E, Di Q, Just AC, Hou  L, Vokonas P, Coull BA, Weisskopf MG, Baccarelli AA, Schwartz JD. Modifying Role  of Endothelial Function Gene Variants on the Association of Long-term PM2.5 Exposure with Blood DNA Methylation Age: the VA Normative Aging Study. Toxicol Sci. 2017 May 9. doi: 10.1093/toxsci/kfx077. [Epub ahead of print] PubMed PMID: 28486674

 

Nwanaji-Enwerem JC, Dai L, Colicino E, Oulhote Y, Di Q, Kloog I, Just AC, Hou  L, Vokonas P, Baccarelli AA, Weisskopf MG, Schwartz JD. Associations between long-term exposure to PM(2.5) component species and blood DNA methylation age in  the elderly: The VA normative aging study. Environ Int. 2017 May;102:57-65. doi:  10.1016/j.envint.2016.12.024. Epub 2017 Mar 9. PubMed PMID: 28284819; PubMed Central PMCID: PMC5396466.

 

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