Publications

2017

 

Gootenberg JS, Abudayyeh OO, Lee JW, Essletzbichler P, Dy AJ, Joung J, Verdine V, Donghia N, Daringer NM, Freije CA, Myhrvold C, Bhattacharyya RP, Livny J, Regev A, Koonin EV, Hung DT, Sabeti PC, Collins JJ, Zhang F. Nucleic acid detection with CRISPR-Cas13a/C2c2. Science. 2017 Apr 28;356(6336):438-442. doi: 10.1126/science.aam9321. Epub 2017 Apr 13. PubMed PMID: 28408723.

 

Joung J, Konermann S, Gootenberg JS, Abudayyeh OO, Platt RJ, Brigham MD, Sanjana NE, Zhang F. Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening. Nat Protoc. 2017 Apr;12(4):828-863. doi: 10.1038/nprot.2017.016. Epub 2017 Mar 23. PubMed PMID: 28333914.

 

Zetsche B, Heidenreich M, Mohanraju P, Fedorova I, Kneppers J, DeGennaro EM, Winblad N, Choudhury SR, Abudayyeh OO, Gootenberg JS, Wu WY, Scott DA, Severinov K, van der Oost J, Zhang F. Erratum: Multiplex gene editing by CRISPR-Cpf1 using  a single crRNA array. Nat Biotechnol. 2017 Feb 8;35(2):178. doi: 10.1038/nbt0217-178b. PubMed PMID: 28178246.

 

Zetsche B, Heidenreich M, Mohanraju P, Fedorova I, Kneppers J, DeGennaro EM,

Winblad N, Choudhury SR, Abudayyeh OO, Gootenberg JS, Wu WY, Scott DA, Severinov  K, van der Oost J, Zhang F. Multiplex gene editing by CRISPR-Cpf1 using a single  crRNA array. Nat Biotechnol. 2017 Jan;35(1):31-34. doi: 10.1038/nbt.3737. Epub 2016 Dec 5. PubMed PMID: 27918548; PubMed Central PMCID: PMC5225075.

 

Shmakov S, Smargon A, Scott D, Cox D, Pyzocha N, Yan W, Abudayyeh OO, Gootenberg JS, Makarova KS, Wolf YI, Severinov K, Zhang F, Koonin EV. Diversity and evolution of class 2 CRISPR-Cas systems. Nat Rev Microbiol. 2017 Mar;15(3):169-182. doi: 10.1038/nrmicro.2016.184. Epub 2017 Jan 23. PubMed PMID: 28111461.

 

Smargon AA, Cox DB, Pyzocha NK, Zheng K, Slaymaker IM, Gootenberg JS, Abudayyeh OA, Essletzbichler P, Shmakov S, Makarova KS, Koonin EV, Zhang F. Cas13b Is a Type VI-B CRISPR-Associated RNA-Guided RNase Differentially Regulated by Accessory Proteins Csx27 and Csx28. Mol Cell. 2017 Feb 16;65(4):618-630.e7. doi: 10.1016/j.molcel.2016.12.023. Epub 2017 Jan 5. PubMed PMID: 28065598; PubMed Central PMCID: PMC5432119.

 

Cox DBT, Gootenberg JS, Abudayyeh OO, Franklin B, Kellner MJ, Joung J, Zhang F. RNA editing with CRISPR-Cas13. Science. 2017 Oct 25. pii: eaaq0180. doi: 10.1126/science.aaq0180. [Epub ahead of print] PubMed PMID: 29070703.

 

Abudayyeh OO, Gootenberg JS, Essletzbichler P, Han S, Joung J, Belanto JJ, Verdine V, Cox DBT, Kellner MJ, Regev A, Lander ES, Voytas DF, Ting AY, Zhang F.  RNA targeting with CRISPR-Cas13. Nature. 2017 Oct 12;550(7675):280-284. doi: 10.1038/nature24049. Epub 2017 Oct 4. PubMed PMID: 28976959.

 

Joung J, Engreitz JM, Konermann S, Abudayyeh OO, Verdine VK, Aguet F, Gootenberg JS, Sanjana NE, Wright JB, Fulco CP, Tseng YY, Yoon CH, Boehm JS, Lander ES, Zhang F. Erratum: Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood. Nature. 2017 Sep 20;549(7672):418. doi: 10.1038/nature24009. PubMed PMID: 28933431.

 

Kim JW, Abudayyeh OO, Yeerna H, Yeang CH, Stewart M, Jenkins RW, Kitajima S, Konieczkowski DJ, Medetgul-Ernar K, Cavazos T, Mah C, Ting S, Van Allen EM, Cohen O, Mcdermott J, Damato E, Aguirre AJ, Liang J, Liberzon A, Alexe G, Doench J, Ghandi M, Vazquez F, Weir BA, Tsherniak A, Subramanian A, Meneses-Cime K, Park J, Clemons P, Garraway LA, Thomas D, Boehm JS, Barbie DA, Hahn WC, Mesirov JP,

Tamayo P. Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States. Cell Syst. 2017 Aug 23;5(2):105-118.e9. doi: 10.1016/j.cels.2017.08.002. PubMed PMID: 28837809; PubMed Central PMCID: PMC5639711.

 

Joung J, Engreitz JM, Konermann S, Abudayyeh OO, Verdine VK, Aguet F, Gootenberg JS, Sanjana NE, Wright JB, Fulco CP, Tseng YY, Yoon CH, Boehm JS, Lander ES, Zhang F. Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood. Nature. 2017 Aug 17;548(7667):343-346. doi: 10.1038/nature23451. Epub 2017 Aug 9. Erratum in: Nature. 2017 Sep 20;549(7672):418. PubMed PMID: 28792927.

 

Ferket BS, Hunink MG, Khanji M, Agarwal I, Fleischmann KE, Petersen SE. Cost-effectiveness of the polypill versus risk assessment for prevention of cardiovascular disease. Heart. 2017 Apr;103(7):483-491. doi: 10.1136/heartjnl-2016-310529. Epub 2017 Jan 11. PubMed PMID: 28077465.

 

Sanguansak T, Morley K, Morley M, Kusakul S, Lee R, Shieh E, Yospaiboon Y, Bhoomibunchoo C, Chai-Ear S, Joseph A, Agarwal I. Comparing smartphone camera adapters in imaging post-operative cataract patients. J Telemed Telecare. 2017 Jan;23(1):36-43. doi: 10.1177/1357633X15625400. Epub 2016 Jul 9. PubMed PMID: 26851243.

 

Wei D, Allsop S, Tye K, Piomelli D. Endocannabinoid Signaling in the Control of Social Behavior. Trends Neurosci. 2017 Jul;40(7):385-396. doi:

10.1016/j.tins.2017.04.005. Epub 2017 May 26. Review. PubMed PMID: 28554687.

 

Gosmann C, Anahtar MN, Handley SA, Farcasanu M, Abu-Ali G, Bowman BA, Padavattan N, Desai C, Droit L, Moodley A, Dong M, Chen Y, Ismail N, Ndung'u T, Ghebremichael MS, Wesemann DR, Mitchell C, Dong KL, Huttenhower C, Walker BD, Virgin HW, Kwon DS. Lactobacillus-Deficient Cervicovaginal Bacterial Communities Are Associated with Increased HIV Acquisition in Young South African Women. Immunity. 2017 Jan 17;46(1):29-37. doi: 10.1016/j.immuni.2016.12.013. Epub 2017 Jan 10. PubMed PMID: 28087240; PubMed Central PMCID: PMC5270628.

 

Bick AG, Wakimoto H, Kamer KJ, Sancak Y, Goldberger O, Axelsson A, DeLaughter  DM, Gorham JM, Mootha VK, Seidman JG, Seidman CE. Cardiovascular homeostasis dependence on MICU2, a regulatory subunit of the mitochondrial calcium uniporter. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E9096-E9104. doi: 10.1073/pnas.1711303114. Epub 2017 Oct 9. PubMed PMID: 29073106; PubMed Central PMCID: PMC5664535.

 

Esslinger U, Garnier S, Korniat A, Proust C, Kararigas G, Müller-Nurasyid M, Empana JP, Morley MP, Perret C, Stark K, Bick AG, Prasad SK, Kriebel J, Li J, Tiret L, Strauch K, O'Regan DP, Marguiles KB, Seidman JG, Boutouyrie P, Lacolley  P, Jouven X, Hengstenberg C, Komajda M, Hakonarson H, Isnard R, Arbustini E, Grallert H, Cook SA, Seidman CE, Regitz-Zagrosek V, Cappola TP, Charron P, Cambien F, Villard E. Exome-wide association study reveals novel susceptibility genes to sporadic dilated cardiomyopathy. PLoS One. 2017 Mar 15;12(3):e0172995. doi: 10.1371/journal.pone.0172995. eCollection 2017. PubMed PMID: 28296976; PubMed Central PMCID: PMC5351854.

 

Samad T, Billings N, Birjiniuk A, Crouzier T, Doyle PS, Ribbeck K. Swimming bacteria promote dispersal of non-motile staphylococcal species. ISME J. 2017 Apr 11. doi: 10.1038/ismej.2017.23. [Epub ahead of print] PubMed PMID: 28398350.

 

Bodnar NO, Rapoport TA. Molecular Mechanism of Substrate Processing by the Cdc48 ATPase Complex. Cell. 2017 May 4;169(4):722-735.e9. doi: 10.1016/j.cell.2017.04.020. PubMed PMID: 28475898.

 

Bodnar N, Rapoport T. Toward an understanding of the Cdc48/p97 ATPase. F1000Res. 2017 Aug 3;6:1318. doi: 10.12688/f1000research.11683.1. eCollection 2017. Review. PubMed PMID: 28815021; PubMed Central PMCID: PMC5543420.

 

Botelho, Alyssa. "Adjudicating Genetic Surgery: An Investigation of Recombinant DNA Legacies in the CRISPR Gene-Editing Era."  American Association for the History of Medicine: Report of the Eighty-Ninth Annual Meeting. Bulletin of the History of Medicine, Volume 90, Number 3, Fall 2016, pp. 491-534

 

Byrne EH, Fisher DE. Immune and molecular correlates in melanoma treated with immune checkpoint blockade. Cancer. 2017 Jun 1;123(S11):2143-2153. doi: 10.1002/cncr.30444. Review. PubMed PMID: 28543699; PubMed Central PMCID:

PMC5445935.

 

Canver MC, Bauer DE, Orkin SH. Functional interrogation of non-coding DNA through CRISPR genome editing. Methods. 2017 Mar 10. pii: S1046-2023(17)30001-4.  doi: 10.1016/j.ymeth.2017.03.008. [Epub ahead of print] Review. PubMed PMID: 28288828.

 

Canver MC, Lessard S, Pinello L, Wu Y, Ilboudo Y, Stern EN, Needleman AJ, Galactéros F, Brugnara C, Kutlar A, McKenzie C, Reid M, Chen DD, Das PP, A Cole M, Zeng J, Kurita R, Nakamura Y, Yuan GC, Lettre G, Bauer DE, Orkin SH. Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci. Nat Genet. 2017 Apr;49(4):625-634.

doi: 10.1038/ng.3793. Epub 2017 Feb 20. PubMed PMID: 28218758; PubMed Central PMCID: PMC5374001.

 

Canver MC, Bauer DE, Dass A, Yien YY, Chung J, Masuda T, Maeda T, Paw BH, Orkin SH. Characterization of genomic deletion efficiency mediated by clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 nuclease system in mammalian cells. J Biol Chem. 2017 Feb 10;292(6):2556. doi: 10.1074/jbc.A114.564625. PubMed PMID: 28188222; PubMed Central PMCID: PMC5313121.

 

Montalbano A, Canver MC, Sanjana NE. High-Throughput Approaches to Pinpoint Function within the Noncoding Genome. Mol Cell. 2017 Oct 5;68(1):44-59. doi: 10.1016/j.molcel.2017.09.017. Review. PubMed PMID: 28985510.

 

Liu Y, Pan J, Jenni S, Raymond DD, Caradonna T, Do KT, Schmidt AG, Harrison SC, Grigorieff N. CryoEM Structure of an Influenza Virus Receptor-Binding Site Antibody-Antigen Interface. J Mol Biol. 2017 May 12. pii: S0022-2836(17)30226-7.  doi: 10.1016/j.jmb.2017.05.011. [Epub ahead of print] PubMed PMID: 28506635.

 

Nakayama RT, Pulice JL, Valencia AM, McBride MJ, McKenzie ZM, Gillespie MA, Ku WL, Teng M, Cui K, Williams RT, Cassel SH, Qing H, Widmer CJ, Demetri GD, Irizarry RA, Zhao K, Ranish JA, Kadoch C. SMARCB1 is required for widespread BAF  complex-mediated activation of enhancers and bivalent promoters. Nat Genet. 2017  Nov;49(11):1613-1623. doi: 10.1038/ng.3958. Epub 2017 Sep 25. PubMed PMID:

28945250.

 

Chang K, Bai HX, Zhou H, Su C, Bi WL, Agbodza E, Kavouridis VK, Senders JT, Boaro A, Beers AL, Zhang B, Capellini A, Liao W, Shen Q, Li X, Xiao B, Cryan J, Ramkissoon S, Ramkissoon L, Ligon KL, Wen PY, Bindra RS, Woo JH, Arnaout O, Gerstner E, Zhang PJ, Rosen B, Yang L, Huang RY, Kalpathy-Cramer J. Residual Convolutional Neural Network for Determination of IDH Status in Low- and High-grade Gliomas from MR Imaging. Clin Cancer Res. 2017 Nov 22. pii: clincanres.2236.2017. doi: 10.1158/1078-0432.CCR-17-2236. [Epub ahead of print] PubMed PMID: 29167275.

 

Siless V, Chang K, Fischl B, Yendiki A. AnatomiCuts: Hierarchical clustering of tractography streamlines based on anatomical similarity. Neuroimage. 2017 Oct  31. pii: S1053-8119(17)30892-3. doi: 10.1016/j.neuroimage.2017.10.058. [Epub ahead of print] PubMed PMID: 29100937.

 

Grossmann P, Narayan V, Chang K, Rahman R, Abrey L, Reardon DA, Schwartz LH, Wen PY, Alexander BM, Huang R, Aerts HJWL. Quantitative Imaging Biomarkers for Risk Stratification of Patients with Recurrent Glioblastoma Treated with Bevacizumab. Neuro Oncol. 2017 May 11. doi: 10.1093/neuonc/nox092. [Epub ahead of print] PubMed PMID: 28499022.

 

Seker UO, Chen AY, Citorik RJ, Lu TK. Synthetic Biogenesis of Bacterial Amyloid Nanomaterials with Tunable Inorganic-Organic Interfaces and Electrical Conductivity. ACS Synth Biol. 2017 Feb 17;6(2):266-275. doi: 10.1021/acssynbio.6b00166. Epub 2016 Dec 6. PubMed PMID: 27794590.

 

Wang T, Yu H, Hughes NW, Liu B, Kendirli A, Klein K, Chen WW, Lander ES, Sabatini DM. Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras. Cell. 2017 Feb 23;168(5):890-903.e15. doi: 10.1016/j.cell.2017.01.013. Epub 2017 Feb 2. PubMed PMID: 28162770; PubMed Central PMCID: PMC5445660.

 

Wyant GA, Abu-Remaileh M, Wolfson RL, Chen WW, Freinkman E, Danai LV, Vander Heiden MG, Sabatini DM. mTORC1 Activator SLC38A9 Is Required to Efflux Essential  Amino Acids from Lysosomes and Use Protein as a Nutrient. Cell. 2017 Oct 19;171(3):642-654.e12. doi: 10.1016/j.cell.2017.09.046. PubMed PMID: 29053970.

 

Dreijerink KM, Groner AC, Vos ES, Font-Tello A, Gu L, Chi D, Reyes J, Cook J, Lim E, Lin CY, de Laat W, Rao PK, Long HW, Brown M. Enhancer-Mediated Oncogenic Function of the Menin Tumor Suppressor in Breast Cancer. Cell Rep. 2017 Mar 7;18(10):2359-2372. doi: 10.1016/j.celrep.2017.02.025. PubMed PMID: 28273452.

 

Comstock DE, Nishino M, Giardino AA. Headache in the Setting of Immunotherapy Treatment for Metastatic Melanoma. JAMA Oncol. 2017 May 1;3(5):703-704. doi: 10.1001/jamaoncol.2016.6611. PubMed PMID: 28196215.

 

Senders JT, Muskens IS, Schnoor R, Karhade AV, Cote DJ, Smith TR, Broekman ML. Agents for fluorescence-guided glioma surgery: a systematic review of preclinical and clinical results. Acta Neurochir (Wien). 2017 Jan;159(1):151-167. doi: 10.1007/s00701-016-3028-5. Epub 2016 Nov 22. Review. PubMed PMID: 27878374; PubMed Central PMCID: PMC5177668.

 

Cote DJ, Bredenoord AL, Smith TR, Ammirati M, Brennum J, Mendez I, Ammar AS, Balak N, Bolles G, Esene IN, Mathiesen T, Broekman ML. Ethical clinical translation of stem cell interventions for neurologic disease. Neurology. 2017 Jan 17;88(3):322-328. doi: 10.1212/WNL.0000000000003506. Epub 2016 Dec 7. PubMed  PMID: 27927932.

 

Zaidi HA, Cote DJ, Castlen JP, Burke WT, Liu YH, Smith TR, Laws ER Jr. Time Course of Resolution of Hyperprolactinemia After Transsphenoidal Surgery Among Patients Presenting with Pituitary Stalk Compression. World Neurosurg. 2017 Jan;97:2-7. doi: 10.1016/j.wneu.2016.09.066. Epub 2016 Sep 23. PubMed PMID: 27671881.

 

Karhade AV, Cote DJ, Larsen AM, Smith TR. Neurosurgical Infection Rates and Risk Factors: A National Surgical Quality Improvement Program Analysis of 132,000 Patients, 2006-2014. World Neurosurg. 2017 Jan;97:205-212. doi: 10.1016/j.wneu.2016.09.056. Epub 2016 Sep 23. PubMed PMID: 27671880.

 

Karhade AV, Fandino L, Gupta S, Cote DJ, Iorgulescu JB, Broekman ML, Aglio LS, Dunn IF, Smith TR. Impact of operative length on post-operative complications in meningioma surgery: a NSQIP analysis. J Neurooncol. 2017 Jan;131(1):59-67. doi: 10.1007/s11060-016-2262-2. Epub 2016 Nov 18. PubMed PMID: 27864707.

 

Din RS, Yan SC, Cote DJ, Acosta MA, Smith TR. Defensive Medicine in U.S. Spine Neurosurgery. Spine (Phila Pa 1976). 2017 Feb;42(3):177-185. doi: 10.1097/BRS.0000000000001687. PubMed PMID: 27172279.

 

Cote DJ, Laws ER Jr. The Ethics of "Choosing Wisely": The Use of Neuroimaging for Uncomplicated Headache. Neurosurgery. 2017 May 1;80(5):816-819. doi: 10.1093/neuros/nyw180. PubMed PMID: 28327977.

 

Castlen JP, Cote DJ, Moojen WA, Robe PA, Balak N, Brennum J, Ammirati M, Mathiesen T, Broekman MLD; World Federation of Neurosurgical Societies Ethics Committee and European Association of Neurosurgical Societies Ethico-Legal Committee. The Changing Health Care Landscape and Implications of Organizational  Ethics on Modern Medical Practice. World Neurosurg. 2017 Jun;102:420-424. doi: 10.1016/j.wneu.2017.03.073. Epub 2017 Mar 24. Review. PubMed PMID: 28347897.

 

Abou-Al-Shaar H, Zaidi HA, Cote DJ, Laws ER Jr. Bolstering the Nasoseptal Flap Using Sphenoid Sinus Fat Packing: A Technical Case Report. World Neurosurg. 2017  Mar;99:813.e1-813.e5. doi: 10.1016/j.wneu.2016.12.009. Epub 2016 Dec 18. PubMed PMID: 27993737

 

Cote DJ, Burke WT, Castlen JP, King CH, Zaidi HA, Smith TR, Laws ER, Aglio LS. Safety of remifentanil in transsphenoidal surgery: A single-center analysis of 540 patients. J Clin Neurosci. 2017 Apr;38:96-99. doi: 10.1016/j.jocn.2016.12.011. Epub 2017 Jan 16. PubMed PMID: 28110927.

 

Cote DJ, Balak N, Brennum J, Holsgrove DT, Kitchen N, Kolenda H, Moojen WA, Schaller K, Robe PA, Mathiesen T, Broekman ML. Ethical difficulties in the innovative surgical treatment of patients with recurrent glioblastoma multiforme. J Neurosurg. 2017 Jun;126(6):2045-2050. doi: 10.3171/2016.11.JNS162488. Epub 2017 Apr 21. PubMed PMID: 28430037.

 

Cote DJ, Dasenbrock HH, Muskens IS, Broekman MLD, Zaidi HA, Dunn IF, Smith TR,Laws ER Jr. Readmission and Other Adverse Events after Transsphenoidal Surgery: Prevalence, Timing, and Predictive Factors. J Am Coll Surg. 2017 May;224(5):971-979. doi: 10.1016/j.jamcollsurg.2017.02.015. Epub 2017 Mar 6. PubMed PMID: 28279778.

 

Cote DJ, Downer MK, Zoltick ES, Smith TR, Stampfer MJ. ABO blood group and risk of glioma. Neuro Oncol. 2017 Jun 1;19(6):871-873. doi:

10.1093/neuonc/nox013. PubMed PMID: 28339823.

 

Burke WT, Cote DJ, Iuliano SI, Zaidi HA, Laws ER. A practical method for prevention of readmission for symptomatic hyponatremia following transsphenoidal  surgery. Pituitary. 2017 Oct 26. doi: 10.1007/s11102-017-0843-5. [Epub ahead of print] PubMed PMID: 29075986.

 

Senders JT, Goldhaber NH, Cote DJ, Muskens IS, Dawood HY, De Vos FYFL, Gormley WB, Smith TR, Broekman MLD. Venous thromboembolism and intracranial hemorrhage after craniotomy for primary malignant brain tumors: a National Surgical Quality  Improvement Program analysis. J Neurooncol. 2017 Oct 16. doi: 10.1007/s11060-017-2631-5. [Epub ahead of print] PubMed PMID: 29039075.

 

Alotaibi NM, Noormohamed N, Cote DJ, Alharthi S, Doucette J, Zaidi HA, Mekary  RA, Smith TR. Physiologic Growth Hormone Replacement Therapy and Craniopharyngioma Recurrence in Pediatric Patients: A Meta-Analysis. World Neurosurg. 2017 Oct 4. pii: S1878-8750(17)31680-7. doi: 10.1016/j.wneu.2017.09.164. [Epub ahead of print] Review. PubMed PMID: 28987837.

 

Karhade AV, Larsen AMG, Cote DJ, Dubois HM, Smith TR. National Databases for Neurosurgical Outcomes Research: Options, Strengths, and Limitations. Neurosurgery. 2017 Aug 5. doi: 10.1093/neuros/nyx408. [Epub ahead of print] PubMed PMID: 28950367.

 

Castlen JP, Cote DJ, Zaidi HA, Laws ER Jr. The extended, transnasal, transsphenoidal approach for anterior skull base meningioma: considerations in patient selection. Pituitary. 2017 Jul 8. doi: 10.1007/s11102-017-0818-6. [Epub ahead of print] PubMed PMID: 28689230.

 

Gittleman H, Cote DJ, Ostrom QT, Kruchko C, Smith TR, Claus EB, Barnholtz-Sloan JS. Do race and age vary in non-malignant central nervous system  tumor incidences in the United States? J Neurooncol. 2017 Jun 30. doi: 10.1007/s11060-017-2543-4. [Epub ahead of print] PubMed PMID: 28667594.

 

Dasenbrock HH, Cote DJ, Pompeu Y, Vasudeva VS, Smith TR, Gormley WB. Validation of an International Classification of Disease, Ninth Revision coding algorithm to identify decompressive craniectomy for stroke. BMC Neurol. 2017 Jun  26;17(1):121. doi: 10.1186/s12883-017-0864-8. PubMed PMID: 28651554; PubMed Central PMCID: PMC5485549.

 

Zaidi HA, Wang AJ, Cote DJ, Smith TR, Prevedello D, Solari D, Cappabianca P, Quiroga M, Laws ER Jr. Preoperative Stratification of Transsphenoidal Pituitary Surgery Patients Based on Surgical Urgency. Neurosurgery. 2017 Oct 1;81(4):659-664. doi: 10.1093/neuros/nyx073. PubMed PMID: 28520927.

 

Evrony GD, Cordero DR, Shen J, Partlow JN, Yu TW, Rodin RE, Hill RS, Coulter ME, Lam AN, Jayaraman D, Gerrelli D, Diaz DG, Santos C, Morrison V, Galli A, Tschulena U, Wiemann S, Martel MJ, Spooner B, Ryu SC, Elhosary PC, Richardson JM, Tierney D, Robinson CA, Chibbar R, Diudea D, Folkerth R, Wiebe S, Barkovich AJ, Mochida GH, Irvine J, Lemire EG, Blakley P, Walsh CA. Integrated genome and transcriptome sequencing identifies a noncoding mutation in the genome replication factor DONSON as the cause of microcephaly-micromelia syndrome.

Genome Res. 2017 Aug;27(8):1323-1335. doi: 10.1101/gr.219899.116. Epub 2017 Jun 19. PubMed PMID: 28630177; PubMed Central PMCID: PMC5538549.

 

Gao L, Cox DBT, Yan WX, Manteiga JC, Schneider MW, Yamano T, Nishimasu H, Nureki O, Crosetto N, Zhang F. Engineered Cpf1 variants with altered PAM specificities. Nat Biotechnol. 2017 Jun 5. doi: 10.1038/nbt.3900. [Epub ahead of print] PubMed PMID: 28581492.

 

Smargon AA, Cox DB, Pyzocha NK, Zheng K, Slaymaker IM, Gootenberg JS, Abudayyeh OA, Essletzbichler P, Shmakov S, Makarova KS, Koonin EV, Zhang F. Cas13b Is a Type VI-B CRISPR-Associated RNA-Guided RNase Differentially Regulated by Accessory Proteins Csx27 and Csx28. Mol Cell. 2017 Feb 16;65(4):618-630.e7. doi: 10.1016/j.molcel.2016.12.023. Epub 2017 Jan 5. PubMed PMID: 28065598; PubMed Central PMCID: PMC5432119.

 

Cox DBT, Gootenberg JS, Abudayyeh OO, Franklin B, Kellner MJ, Joung J, Zhang F. RNA editing with CRISPR-Cas13. Science. 2017 Oct 25. pii: eaaq0180. doi: 10.1126/science.aaq0180. [Epub ahead of print] PubMed PMID: 29070703.

 

Abudayyeh OO, Gootenberg JS, Essletzbichler P, Han S, Joung J, Belanto JJ, Verdine V, Cox DBT, Kellner MJ, Regev A, Lander ES, Voytas DF, Ting AY, Zhang F.  RNA targeting with CRISPR-Cas13. Nature. 2017 Oct 12;550(7675):280-284. doi: 10.1038/nature24049. Epub 2017 Oct 4. PubMed PMID: 28976959.

 

Shmakov S, Smargon A, Scott D, Cox D, Pyzocha N, Yan W, Abudayyeh OO, Gootenberg JS, Makarova KS, Wolf YI, Severinov K, Zhang F, Koonin EV. Diversity and evolution of class 2 CRISPR-Cas systems. Nat Rev Microbiol. 2017 Mar;15(3):169-182. doi: 10.1038/nrmicro.2016.184. Epub 2017 Jan 23. PubMed PMID:  28111461.

 

Yang L, Briggs AW, Chew WL, Mali P, Guell M, Aach J, Goodman DB, Cox D, Kan Y, Lesha E, Soundararajan V, Zhang F, Church G. Corrigendum: Engineering and optimising deaminase fusions for genome editing. Nat Commun. 2017 Oct 9;8:16169.  doi: 10.1038/ncomms16169. PubMed PMID: 28991237.

 

Yang L, Briggs AW, Chew WL, Mali P, Guell M, Aach J, Goodman DB, Cox D, Kan Y, Lesha E, Soundararajan V, Zhang F, Church G. Engineering and optimising deaminase fusions for genome editing. Nat Commun. 2016 Nov 2;7:13330. doi: 10.1038/ncomms13330. Erratum in: Nat Commun. 2017 Oct 09;8:16169. PubMed PMID: 27804970; PubMed Central PMCID: PMC5097136.

 

Jamuar SS, Schmitz-Abe K, D'Gama AM, Drottar M, Chan WM, Peeva M, Servattalab  S, Lam AN, Delgado MR, Clegg NJ, Zayed ZA, Dogar MA, Alorainy IA, Jamea AA, Abu-Amero K, Griebel M, Ward W, Lein ES, Markianos K, Barkovich AJ, Robson CD, Grant PE, Bosley TM, Engle EC, Walsh CA, Yu TW. Biallelic mutations in human DCC  cause developmental split-brain syndrome. Nat Genet. 2017 Apr;49(4):606-612. doi: 10.1038/ng.3804. Epub 2017 Feb 27. PubMed PMID: 28250456; PubMed Central PMCID: PMC5374027.

 

Dy ME, Waugh JL, Sharma N, O'Leary H, Kapur K, D'Gama AM, Sahin M, Urion DK, Kaufmann WE. Defining Hand Stereotypies in Rett Syndrome: A Movement Disorders Perspective. Pediatr Neurol. 2017 Oct;75:91-95. doi: 10.1016/j.pediatrneurol.2017.05.025. Epub 2017 Jun 2. PubMed PMID: 28838622; PubMed Central PMCID: PMC5624791.

 

Lim ET, Uddin M, De Rubeis S, Chan Y, Kamumbu AS, Zhang X, D'Gama AM, Kim SN,  Hill RS, Goldberg AP, Poultney C, Minshew NJ, Kushima I, Aleksic B, Ozaki N, Parellada M, Arango C, Penzol MJ, Carracedo A, Kolevzon A, Hultman CM, Weiss LA,  Fromer M, Chiocchetti AG, Freitag CM; Autism Sequencing Consortium, Church GM, Scherer SW, Buxbaum JD, Walsh CA. Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder. Nat Neurosci. 2017 Sep;20(9):1217-1224. doi: 10.1038/nn.4598. Epub 2017 Jul 17. PubMed PMID:

28714951.

 

Manier S, Huynh D, Shen YJ, Zhou J, Yusufzai T, Salem KZ, Ebright RY, Shi J, Park J, Glavey SV, Devine WG, Liu CJ, Leleu X, Quesnel B, Roche-Lestienne C, Snyder JK, Brown LE, Gray N, Bradner J, Whitesell L, Porco JA Jr, Ghobrial IM. Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma. Sci Transl Med. 2017 May 10;9(389). pii: eaal2668. doi: 10.1126/scitranslmed.aal2668. PubMed PMID: 28490664.

 

Watabe-Uchida M, Eshel N, Uchida N. Neural Circuitry of Reward Prediction Error. Annu Rev Neurosci. 2017 Jul 25;40:373-394. doi:

10.1146/annurev-neuro-072116-031109. Epub 2017 Apr 24. PubMed PMID: 28441114.

 

Evrony GD, Cordero DR, Shen J, Partlow JN, Yu TW, Rodin RE, Hill RS, Coulter ME, Lam AN, Jayaraman D, Gerrelli D, Diaz DG, Santos C, Morrison V, Galli A, Tschulena U, Wiemann S, Martel MJ, Spooner B, Ryu SC, Elhosary PC, Richardson JM, Tierney D, Robinson CA, Chibbar R, Diudea D, Folkerth R, Wiebe S, Barkovich AJ, Mochida GH, Irvine J, Lemire EG, Blakley P, Walsh CA. Integrated genome and transcriptome sequencing identifies a noncoding mutation in the genome replication factor DONSON as the cause of microcephaly-micromelia syndrome. Genome Res. 2017 Jun 19. doi: 10.1101/gr.219899.116. [Epub ahead of print] PubMed PMID: 28630177.

 

Cho CF, Wolfe JM, Fadzen CM, Calligaris D, Hornburg K, Chiocca EA, Agar NYR, Pentelute BL, Lawler SE. Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents. Nat Commun. 2017 Jun 6;8:15623. doi: 10.1038/ncomms15623. PubMed PMID: 28585535.

 

Fadzen CM, Wolfe JM, Cho CF, Chiocca EA, Lawler SE, Pentelute BL. Perfluoroarene-Based Peptide Macrocycles To Enhance Penetration across the Blood-Brain Barrier. J Am Chem Soc. 2017 Oct 30. doi: 10.1021/jacs.7b09790. [Epub ahead of print] PubMed PMID: 28992407.

 

Tu X, Xie M, Gao J, Ma Z, Chen D, Wang Q, Finlayson SG, Ou Y, Cheng JZ. Automatic Categorization and Scoring of Solid, Part-Solid and Non-Solid Pulmonary Nodules in CT Images with Convolutional Neural Network. Sci Rep. 2017 Sep 1;7(1):8533. doi: 10.1038/s41598-017-08040-8. PubMed PMID: 28864824; PubMed Central PMCID: PMC5581338.

 

Chapel A, Garcia-Beltran WF, Hölzemer A, Ziegler M, Lunemann S, Martrus G, Altfeld M. Peptide-specific engagement of the activating NK cell receptor KIR2DS1. Sci Rep. 2017 May 25;7(1):2414. doi: 10.1038/s41598-017-02449-x. PubMed PMID: 28546555

 

Park RJ, Wang T, Koundakjian D, Hultquist JF, Lamothe-Molina P, Monel B, Schumann K, Yu H, Krupzcak KM, Garcia-Beltran W, Piechocka-Trocha A, Krogan NJ, Marson A, Sabatini DM, Lander ES, Hacohen N, Walker BD. A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors. Nat Genet. 2017 Feb;49(2):193-203. doi: 10.1038/ng.3741. Epub 2016 Dec 19. PubMed PMID: 27992415.

 

Dulberger CL, McMurtrey CP, Hölzemer A, Neu KE, Liu V, Steinbach AM, Garcia-Beltran WF, Sulak M, Jabri B, Lynch VJ, Altfeld M, Hildebrand WH, Adams EJ. Human Leukocyte Antigen F Presents Peptides and Regulates Immunity through Interactions with NK Cell Receptors. Immunity. 2017 Jun 20;46(6):1018-1029.e7. doi: 10.1016/j.immuni.2017.06.002. PubMed PMID: 28636952; PubMed Central PMCID:

PMC5523829.

 

Zhang Y, Xie L, Gunasekar SK, Tong D, Mishra A, Gibson WJ, Wang C, Fidler T, Marthaler B, Klingelhutz A, Abel ED, Samuel I, Smith JK, Cao L, Sah R. SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis. Nat Cell Biol. 2017 May;19(5):504-517. doi: 10.1038/ncb3514. Epub 2017 Apr 24. PubMed PMID: 28436964; PubMed Central PMCID: PMC5415409.

 

Zhang Y, Xie L, Gunasekar SK, Tong D, Mishra A, Gibson WJ, Wang C, Fidler T, Marthaler B, Klingelhutz A, Abel ED, Samuel I, Smith JK, Cao L, Sah R. Erratum: SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis. Nat Cell Biol. 2017 May 31;19(6):740. doi: 10.1038/ncb3536. PubMed PMID: 28561048.

 

Paolella BR, Gibson WJ, Urbanski LM, Alberta JA, Zack TI, Bandopadhayay P, Nichols CA, Agarwalla PK, Brown MS, Lamothe R, Yu Y, Choi PS, Obeng EA, Heckl D,  Wei G, Wang B, Tsherniak A, Vazquez F, Weir BA, Root DE, Cowley GS, Buhrlage SJ, Stiles CD, Ebert BL, Hahn WC, Reed R, Beroukhim R. Copy-number dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability. Elife. 2017 Feb 8;6. pii: e23268. doi: 10.7554/eLife.23268. PubMed PMID: 28177281; PubMed Central PMCID: PMC5357138.

 

Gibson WJ, Ruan DT, Paulson VA, Barletta JA, Hanna GJ, Kraft S, Calles A, Nehs MA, Moore FD Jr, Taylor-Weiner A, Wala JA, Zack TI, Lee TC, Fennessy FM, Alexander EK, Thomas T, Janne PA, Garraway LA, Carter SL, Beroukhim R, Lorch JH,  Van Allen EM. Genomic Heterogeneity and Exceptional Response to Dual Pathway Inhibition in Anaplastic Thyroid Cancer. Clin Cancer Res. 2017 May 1;23(9):2367-2373. doi: 10.1158/1078-0432.CCR-16-2154-T. Epub 2016 Oct 17. PubMed PMID: 27797976; PubMed Central PMCID: PMC5393965.

 

Bi WL, Horowitz P, Greenwald NF, Abedalthagafi M, Agarwalla PK, Gibson WJ, Mei Y, Schumacher SE, Ben-David U, Chevalier A, Carter S, Tiao G, Brastianos PK, Ligon AH, Ducar M, MacConaill L, Laws ER Jr, Santagata S, Beroukhim R, Dunn IF. Landscape of Genomic Alterations in Pituitary Adenomas. Clin Cancer Res. 2017 Apr 1;23(7):1841-1851. doi: 10.1158/1078-0432.CCR-16-0790. Epub 2016 Oct 5. PubMed PMID: 27707790; PubMed Central PMCID: PMC5380512.

 

Holst F, Hoivik EA, Gibson WJ, Taylor-Weiner A, Schumacher SE, Asmann YW, Grossmann P, Trovik J, Necela BM, Thompson EA, Meyerson M, Beroukhim R, Salvesen  HB, Cherniack AD. Corrigendum: Recurrent hormone-binding domain truncated ESR1 amplifications in primary endometrial cancers suggest their implication in hormone independent growth. Sci Rep. 2017 Jun 30;7:46873. doi: 10.1038/srep46873. PubMed PMID: 28664899; PubMed Central PMCID: PMC5492263.

 

Zhang Y, Xie L, Gunasekar SK, Tong D, Mishra A, Gibson WJ, Wang C, Fidler T, Marthaler B, Klingelhutz A, Abel ED, Samuel I, Smith JK, Cao L, Sah R. Erratum: SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis. Nat Cell Biol. 2017 Jun 29;19(7):873. doi: 10.1038/ncb3556. PubMed PMID: 28659636.

 

Gootenberg DB, Paer JM, Luevano JM, Kwon DS. HIV-associated changes in the enteric microbial community: potential role in loss of homeostasis and development of systemic inflammation. Curr Opin Infect Dis. 2017 Feb;30(1):31-43. doi: 10.1097/QCO.0000000000000341. PubMed PMID: 27922852; PubMed Central PMCID: PMC532524

 

Grossman SR, Zhang X, Wang L, Engreitz J, Melnikov A, Rogov P, Tewhey R, Isakova A, Deplancke B, Bernstein BE, Mikkelsen TS, Lander ES. Systematic dissection of genomic features determining transcription factor binding and enhancer function. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1291-E1300. doi: 10.1073/pnas.1621150114. Epub 2017 Jan 30. PubMed PMID: 28137873; PubMed Central  PMCID: PMC5321001.

 

Luengo A, Gui DY, Vander Heiden MG. Targeting Metabolism for Cancer Therapy. Cell Chem Biol. 2017 Sep 21;24(9):1161-1180. doi: 10.1016/j.chembiol.2017.08.028. Review. PubMed PMID: 28938091.

 

Muir A, Danai LV, Gui DY, Waingarten CY, Lewis CA, Vander Heiden MG. Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition. Elife. 2017 Aug 15;6. pii: e27713. doi: 10.7554/eLife.27713. PubMed PMID: 28826492; PubMed Central PMCID: PMC5589418.

 

Filippakis H, Alesi N, Ogorek B, Nijmeh J, Khabibullin D, Gutierrez C, Valvezan AJ, Cunningham J, Priolo C, Henske EP. Lysosomal regulation of

cholesterol homeostasis in tuberous sclerosis complex is mediated via NPC1 and LDL-R. Oncotarget. 2017 Apr 27. doi: 10.18632/oncotarget.17485. [Epub ahead of print] PubMed PMID: 28498820.

 

Hennessy ML, Corcoran A, Brust RD, Nattie EE, Dymecki S. Activity of Tachykinin1-expressing Pet1 raphe neurons modulates the drive to breathe. J Neurosci. 2017 Jan 10. pii: 2316-16. doi: 10.1523/JNEUROSCI.2316-16.2016. [Epub ahead of print] PubMed PMID: 28073937.

 

Johnson CP, Kim IK, Esmaeli B, Amin-Mansour A, Treacy DJ, Carter SL, Hodis EWagle N, Seepo S, Yu X, Lane AM, Gragoudas ES, Vazquez F, Nickerson E, Cibulskis  K, McKenna A, Gabriel SB, Getz G, Van Allen EM, 't Hoen PAC, Garraway LA, Woodman SE. Systematic genomic and translational efficiency studies of uveal melanoma. PLoS One. 2017 Jun 8;12(6):e0178189. doi: 10.1371/journal.pone.0178189. eCollection 2017. PubMed PMID: 28594900.

 

Gierahn TM, Wadsworth MH 2nd, Hughes TK, Bryson BD, Butler A, Satija R, Fortune S, Love JC, Shalek AK. Seq-Well: portable, low-cost RNA sequencing of single cells at high throughput. Nat Methods. 2017 Apr;14(4):395-398. doi: 10.1038/nmeth.4179. Epub 2017 Feb 13. PubMed PMID: 28192419; PubMed Central PMCID: PMC5376227.

 

Qiao Q, Wang L, Meng FL, Hwang JK, Alt FW, Wu H. AID Recognizes Structured DNA for Class Switch Recombination. Mol Cell. 2017 Aug 3;67(3):361-373.e4. doi: 10.1016/j.molcel.2017.06.034. Epub 2017 Jul 27. PubMed PMID: 28757211.

 

Hwang JK, Wang C, Du Z, Meyers RM, Kepler TB, Neuberg D, Kwong PD, Mascola JR, Joyce MG, Bonsignori M, Haynes BF, Yeap LS, Alt FW. Sequence intrinsic somatic mutation mechanisms contribute to affinity maturation of VRC01-class HIV-1 broadly neutralizing antibodies. Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):8614-8619. doi: 10.1073/pnas.1709203114. Epub 2017 Jul 26. PubMed PMID: 28747530; PubMed Central PMCID: PMC5559054.

 

Hwong AR, Sah S, Lehmann LS. The Effects of Public Disclosure of Industry Payments to Physicians on Patient Trust: A Randomized Experiment. J Gen Intern Med. 2017 Nov;32(11):1186-1192. doi: 10.1007/s11606-017-4122-y. Epub 2017 Jul 17. PubMed PMID: 28717899; PubMed Central PMCID: PMC5653550

 

Evrony GD, Cordero DR, Shen J, Partlow JN, Yu TW, Rodin RE, Hill RS, Coulter ME, Lam AN, Jayaraman D, Gerrelli D, Diaz DG, Santos C, Morrison V, Galli A, Tschulena U, Wiemann S, Martel MJ, Spooner B, Ryu SC, Elhosary PC, Richardson JM, Tierney D, Robinson CA, Chibbar R, Diudea D, Folkerth R, Wiebe S, Barkovich AJ, Mochida GH, Irvine J, Lemire EG, Blakley P, Walsh CA. Integrated genome and transcriptome sequencing identifies a noncoding mutation in the genome replication factor DONSON as the cause of microcephaly-micromelia syndrome.

Genome Res. 2017 Jun 19. doi: 10.1101/gr.219899.116. [Epub ahead of print] PubMed PMID: 28630177.

 

Kalinich M, Bhan I, Kwan TT, Miyamoto DT, Javaid S, LiCausi JA, Milner JD, Hong X, Goyal L, Sil S, Choz M, Ho U, Kapur R, Muzikansky A, Zhang H, Weitz DA, Sequist LV, Ryan DP, Chung RT, Zhu AX, Isselbacher KJ, Ting DT, Toner M, Maheswaran S, Haber DA. An RNA-based signature enables high specificity detection of circulating tumor cells in hepatocellular carcinoma. Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1123-1128. doi: 10.1073/pnas.1617032114. Epub 2017 Jan 17. PubMed PMID: 28096363; PubMed Central PMCID: PMC5293050.

 

Wolfson RL, Chantranupong L, Wyant GA, Gu X, Orozco JM, Shen K, Condon KJ, Petri S, Kedir J, Scaria SM, Abu-Remaileh M, Frankel WN, Sabatini DM. KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1. Nature. 2017 Mar 16;543(7645):438-442. doi: 10.1038/nature21423. Epub 2017 Feb 15. PubMed PMID: 28199306; PubMed Central PMCID: PMC5360989.

 

Stroud H, Su SC, Hrvatin S, Greben AW, Renthal W, Boxer LD, Nagy MA, Hochbaum  DR, Kinde B, Gabel HW, Greenberg ME. Early-Life Gene Expression in Neurons Modulates Lasting Epigenetic States. Cell. 2017 Oct 16. pii: S0092-8674(17)31141-8. doi: 10.1016/j.cell.2017.09.047. [Epub ahead of print] PubMed PMID: 29056337.

 

Santaguida S, Richardson A, Iyer DR, M'Saad O, Zasadil L, Knouse KA, Wong YL,  Rhind N, Desai A, Amon A. Chromosome Mis-segregation Generates Cell-Cycle-Arrested Cells with Complex Karyotypes that Are Eliminated by the Immune System. Dev Cell. 2017 Jun 19;41(6):638-651.e5. doi: 10.1016/j.devcel.2017.05.022. PubMed PMID: 28633018.

 

Knouse KA, Wu J, Hendricks A. Detection of Copy Number Alterations Using Single Cell Sequencing. J Vis Exp. 2017 Feb 17;(120). doi: 10.3791/55143. PubMed  PMID: 28287554; PubMed Central PMCID: PMC5409325.

 

Stevens KR, Scull MA, Ramanan V, Fortin CL, Chaturvedi RR, Knouse KA, Xiao JW, Fung C, Mirabella T, Chen AX, McCue MG, Yang MT, Fleming HE, Chung K, de Jong YP, Chen CS, Rice CM, Bhatia SN. In situ expansion of engineered human liver tissue in a mouse model of chronic liver disease. Sci Transl Med. 2017 Jul 19;9(399). pii: eaah5505. doi: 10.1126/scitranslmed.aah5505. PubMed PMID: 28724577.

 

Bruno PM, Liu Y, Park GY, Murai J, Koch CE, Eisen TJ, Pritchard JR, Pommier Y, Lippard SJ, Hemann MT. A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress. Nat Med. 2017 Apr;23(4):461-471. doi: 10.1038/nm.4291. Epub 2017 Feb 27. PubMed PMID: 28263311.

 

Wang L, Fan J, Francis JM, Georghiou G, Hergert S, Li S, Gambe R, Zhou CW, Yang C, Xiao S, Cin PD, Bowden M, Kotliar D, Shukla SA, Brown JR, Neuberg D, Alessi DR, Zhang CZ, Kharchenko PV, Livak KJ, Wu CJ. Integrated single-cell genetic and transcriptional analysis suggests novel drivers of chronic lymphocytic leukemia. Genome Res. 2017 Aug;27(8):1300-1311. doi: 10.1101/gr.217331.116. Epub 2017 Jul 5. PubMed PMID: 28679620; PubMed Central PMCID: PMC5538547.

 

Kwok SJJ, Kim M, Lin HH, Seiler TG, Beck E, Shao P, Kochevar IE, Seiler T, Yun SH. Flexible Optical Waveguides for Uniform Periscleral Cross-Linking. Invest Ophthalmol Vis Sci. 2017 May 1;58(5):2596-2602. doi: 10.1167/iovs.17-21559. PubMed PMID: 28494493; PubMed Central PMCID: PMC5433838.

 

Yun SH, Kwok SJJ. Light in diagnosis, therapy and surgery. Nat Biomed Eng. 2017;1. pii: 0008. doi: 10.1038/s41551-016-0008. Epub 2017 Jan 10. PubMed PMID: 28649464; PubMed Central PMCID: PMC5476943.

 

Lee M. Don't Give Up! A Cyber-ethnography and Discourse Analysis of an Online  Infertility Patient Forum. Cult Med Psychiatry. 2017 Jan 6. doi:

10.1007/s11013-016-9515-6. [Epub ahead of print] PubMed PMID: 28063090

 

Zaytouni T, Tsai PY, Hitchcock DS, DuBois CD, Freinkman E, Lin L, Morales-Oyarvide V, Lenehan PJ, Wolpin BM, Mino-Kenudson M, Torres EM,

Stylopoulos N, Clish CB, Kalaany NY. Critical role for arginase 2 in obesity-associated pancreatic cancer. Nat Commun. 2017 Aug 14;8(1):242. doi:

10.1038/s41467-017-00331-y. PubMed PMID: 28808255; PubMed Central PMCID: PMC5556090.

 

Li A, Jacks T. Driving Rel-iant Tregs toward an Identity Crisis. Immunity. 2017 Sep 19;47(3):391-393. doi: 10.1016/j.immuni.2017.08.014. PubMed PMID: 28930651.

 

Li EB, Truong D, Hallett SA, Mukherjee K, Schutte BC, Liao EC. Rapid functional analysis of computationally complex rare human IRF6 gene variants using a novel zebrafish model. PLoS Genet. 2017 Sep 25;13(9):e1007009. doi: 10.1371/journal.pgen.1007009. eCollection 2017 Sep. PubMed PMID: 28945736; PubMed Central PMCID: PMC5628943.

 

Oderberg IM, Li DJ, Scimone ML, Gaviño MA, Reddien PW. Landmarks in Existing Tissue at Wounds Are Utilized to Generate Pattern in Regenerating Tissue. Curr Biol. 2017 Mar 6;27(5):733-742. doi: 10.1016/j.cub.2017.01.024. Epub 2017 Feb 16. PubMed PMID: 28216315.

 

Manguso RT, Pope HW, Zimmer MD, Brown FD, Yates KB, Miller BC, Collins NB, Bi  K, LaFleur MW, Juneja VR, Weiss SA, Lo J, Fisher DE, Miao D, Van Allen E, Root DE, Sharpe AH, Doench JG, Haining WN. In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target. Nature. 2017 Jul 27;547(7664):413-418. doi: 10.1038/nature23270. Epub 2017 Jul 19. PubMed PMID: 28723893.

 

Pritz JR, Wachter F, Lee S, Luccarelli J, Wales TE, Cohen DT, Coote P, Heffron GJ, Engen JR, Massefski W, Walensky LD. Allosteric sensitization of proapoptotic  BAX. Nat Chem Biol. 2017 Sep;13(9):961-967. doi: 10.1038/nchembio.2433. Epub 2017 Jul 10. PubMed PMID: 28692068; PubMed Central PMCID: PMC5675120.

 

Mayers JR, Vander Heiden MG. Nature and Nurture: What Determines Tumor Metabolic Phenotypes? Cancer Res. 2017 Jun 15;77(12):3131-3134. doi: 10.1158/0008-5472.CAN-17-0165. Epub 2017 Jun 5. Review. PubMed PMID: 28584183.

 

Davidson SM, Jonas O, Keibler MA, Hou HW, Luengo A, Mayers JR, Wyckoff J, Del  Rosario AM, Whitman M, Chin CR, Condon KJ, Lammers A, Kellersberger KA, Stall BK, Stephanopoulos G, Bar-Sagi D, Han J, Rabinowitz JD, Cima MJ, Langer R, Vander Heiden MG. Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors. Nat Med. 2017 Feb;23(2):235-241. doi: 10.1038/nm.4256. Epub 2016 Dec 26. PubMed PMID: 28024083; PubMed Central PMCID: PMC5407288.

 

Olivares O, Mayers JR, Gouirand V, Torrence ME, Gicquel T, Borge L, Lac S, Roques J, Lavaut MN, Berthezène P, Rubis M, Secq V, Garcia S, Moutardier V, Lombardo D, Iovanna JL, Tomasini R, Guillaumond F, Vander Heiden MG, Vasseur S. Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival  under nutrient limited conditions. Nat Commun. 2017 Jul 7;8:16031. doi: 10.1038/ncomms16031. PubMed PMID: 28685754; PubMed Central PMCID: PMC5504351.

 

Wachter F, Morgan AM, Godes M, Mourtada R, Bird GH, Walensky LD. Mechanistic validation of a clinical lead stapled peptide that reactivates p53 by dual HDM2 and HDMX targeting. Oncogene. 2017 Apr;36(15):2184-2190. doi: 10.1038/onc.2016.361. Epub 2016 Oct 10. PubMed PMID: 27721413; PubMed Central PMCID: PMC5386833

 

Stroud H, Su SC, Hrvatin S, Greben AW, Renthal W, Boxer LD, Nagy MA, Hochbaum  DR, Kinde B, Gabel HW, Greenberg ME. Early-Life Gene Expression in Neurons Modulates Lasting Epigenetic States. Cell. 2017 Oct 16. pii: S0092-8674(17)31141-8. doi: 10.1016/j.cell.2017.09.047. [Epub ahead of print] PubMed PMID: 29056337

 

Nakatsuka N, Moorjani P, Rai N, Sarkar B, Tandon A, Patterson N, Bhavani GS, Girisha KM, Mustak MS, Srinivasan S, Kaushik A, Vahab SA, Jagadeesh SM, Satyamoorthy K, Singh L, Reich D, Thangaraj K. The promise of discovering population-specific disease-associated genes in South Asia. Nat Genet. 2017 Sep;49(9):1403-1407. doi: 10.1038/ng.3917. Epub 2017 Jul 17. PubMed PMID: 28714977.

 

Nguyen AT, Prado MA, Schmidt PJ, Sendamarai AK, Wilson-Grady JT, Min M, Campagna DR, Tian G, Shi Y, Dederer V, Kawan M, Kuehnle N, Paulo JA, Yao Y, Weiss MJ, Justice MJ, Gygi SP, Fleming MD, Finley D. UBE2O remodels the proteome during terminal erythroid differentiation. Science. 2017 Aug 4;357(6350). pii: eaan0218. doi: 10.1126/science.aan0218. PubMed PMID: 28774900

 

Nwanaji-Enwerem JC, Colicino E, Dai L, Cayir A, Sanchez-Guerra M, Laue HE, Nguyen VT, Di Q, Just AC, Hou L, Vokonas P, Coull BA, Weisskopf MG, Baccarelli AA, Schwartz JD. Impacts of the Mitochondrial Genome on the Relationship of Long-Term Ambient Fine Particle Exposure with Blood DNA Methylation Age. Environ  Sci Technol. 2017 Jul 7. doi: 10.1021/acs.est.7b02409. [Epub ahead of print] PubMed PMID: 28636816.

 

Nwanaji-Enwerem JC, Bind MA, Dai L, Oulhote Y, Colicino E, Di Q, Just AC, Hou  L, Vokonas P, Coull BA, Weisskopf MG, Baccarelli AA, Schwartz JD. Modifying Role  of Endothelial Function Gene Variants on the Association of Long-term PM2.5 Exposure with Blood DNA Methylation Age: the VA Normative Aging Study. Toxicol Sci. 2017 May 9. doi: 10.1093/toxsci/kfx077. [Epub ahead of print] PubMed PMID: 28486674

 

Nwanaji-Enwerem JC, Dai L, Colicino E, Oulhote Y, Di Q, Kloog I, Just AC, Hou  L, Vokonas P, Baccarelli AA, Weisskopf MG, Schwartz JD. Associations between long-term exposure to PM(2.5) component species and blood DNA methylation age in  the elderly: The VA normative aging study. Environ Int. 2017 May;102:57-65. doi:  10.1016/j.envint.2016.12.024. Epub 2017 Mar 9. PubMed PMID: 28284819; PubMed Central PMCID: PMC5396466.

 

Wolfson RL, Chantranupong L, Wyant GA, Gu X, Orozco JM, Shen K, Condon KJ, Petri S, Kedir J, Scaria SM, Abu-Remaileh M, Frankel WN, Sabatini DM. KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1. Nature. 2017 Mar 16;543(7645):438-442. doi: 10.1038/nature21423. Epub 2017 Feb 15. PubMed PMID: 28199306; PubMed Central PMCID: PMC5360989.

 

Chang BP, Pany MJ, Obermeyer Z. Early death after emergency department discharge in patients with psychiatric illness. Am J Emerg Med. 2017

May;35(5):784-786. doi: 10.1016/j.ajem.2016.11.040. Epub 2016 Nov 17. PubMed PMID: 27884584; PubMed Central PMCID: PMC5435542.

 

Patel SH, Camargo FD, Yimlamai D. Hippo Signaling in the Liver Regulates Organ Size, Cell Fate, and Carcinogenesis. Gastroenterology. 2017 Feb;152(3):533-545. doi: 10.1053/j.gastro.2016.10.047. Epub 2016 Dec 19. Review. PubMed PMID: 28003097; PubMed Central PMCID: PMC5285449.

 

Tsanov KM, Pearson DS, Wu Z, Han A, Triboulet R, Seligson MT, Powers JT, Osborne JK, Kane S, Gygi SP, Gregory RI, Daley GQ. LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of pluripotency.  Nat Cell Biol. 2017 Jan;19(1):60-67. doi: 10.1038/ncb3453. Epub 2016 Dec 19. PubMed PMID: 27992407; PubMed Central PMCID: PMC5182091.

 

Fung V, Liang CY, Donelan K, Peitzman CG, Dow WH, Zaslavsky AM, Fireman B, Derose SF, Chernew ME, Newhouse JP, Hsu J. Nearly One-Third Of Enrollees In California's Individual Market Missed Opportunities To Receive Financial Assistance. Health Aff (Millwood). 2017 Jan 1;36(1):21-31. doi: 10.1377/hlthaff.2016.0472. PubMed PMID: 28069843.

 

Pashos EE, Park Y, Wang X, Raghavan A, Yang W, Abbey D, Peters DT, Arbelaez J, Hernandez M, Kuperwasser N, Li W, Lian Z, Liu Y, Lv W, Lytle-Gabbin SL, Marchadier DH, Rogov P, Shi J, Slovik KJ, Stylianou IM, Wang L, Yan R, Zhang X, Kathiresan S, Duncan SA, Mikkelsen TS, Morrisey EE, Rader DJ, Brown CD, Musunuru  K. Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells  Reveal Functional Genetic Variation at Blood Lipid-Associated Loci. Cell Stem Cell. 2017 Apr 6;20(4):558-570.e10. doi: 10.1016/j.stem.2017.03.017. PubMed PMID: 28388432; PubMed Central PMCID: PMC5476422.

 

Warren CR, O'Sullivan JF, Friesen M, Becker CE, Zhang X, Liu P, Wakabayashi Y, Morningstar JE, Shi X, Choi J, Xia F, Peters DT, Florido MH, Tsankov AM, Duberow  E, Comisar L, Shay J, Jiang X, Meissner A, Musunuru K, Kathiresan S, Daheron L, Zhu J, Gerszten RE, Deo RC, Vasan RS, O'Donnell CJ, Cowan CA. Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease. Cell Stem Cell. 2017 Apr 6;20(4):547-557.e7. doi: 10.1016/j.stem.2017.01.010. PubMed PMID: 28388431.

 

Guerriero JL, Sotayo A, Ponichtera HE, Castrillon JA, Pourzia AL, Schad S, Johnson SF, Carrasco RD, Lazo S, Bronson RT, Davis SP, Lobera M, Nolan MA, Letai  A. Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages. Nature. 2017 Mar 16;543(7645):428-432. doi: 10.1038/nature21409. Epub 2017 Mar 8. PubMed PMID: 28273064.

 

Li H, Mar BG, Zhang H, Puram RV, Vazquez F, Weir BA, Hahn WC, Ebert B, Pellman D. The EMT regulator ZEB2 is a novel dependency of human and murine acute myeloid leukemia. Blood. 2017 Jan 26;129(4):497-508. doi: 10.1182/blood-2016-05-714493. Epub 2016 Oct 18. PubMed PMID: 27756750; PubMed Central PMCID: PMC5270388.

 

Ramos A, Hemann MT. Drugs, Bugs, and Cancer: Fusobacterium nucleatum Promotes  Chemoresistance in Colorectal Cancer. Cell. 2017 Jul 27;170(3):411 10.1016/j.cell.2017.07.018. PubMed PMID: 28753421.

 

Fenouille N, Bassil CF, Ben-Sahra I, Benajiba L, Alexe G, Ramos A, Pikman Y, Conway AS, Burgess MR, Li Q, Luciano F, Auberger P, Galinsky I, DeAngelo DJ, Stone RM, Zhang Y, Perkins AS, Shannon K, Hemann MT, Puissant A, Stegmaier K. The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia. Nat Med. 2017 Mar;23(3):301-313. doi: 10.1038/nm.4283. Epub 2017 Feb 13. PubMed PMID: 28191887; PubMed Central PMCID: PMC5540325.

 

Jonas Mueller, David Reshef, George Du, Tommi Jaakkola ; Learning Optimal Interventions. Proceedings of the 20th International Conference on Artificial Intelligence and Statistics, PMLR 54:1039-1047, 2017.

 

Evrony GD, Cordero DR, Shen J, Partlow JN, Yu TW, Rodin RE, Hill RS, Coulter ME, Lam AN, Jayaraman D, Gerrelli D, Diaz DG, Santos C, Morrison V, Galli A, Tschulena U, Wiemann S, Martel MJ, Spooner B, Ryu SC, Elhosary PC, Richardson JM, Tierney D, Robinson CA, Chibbar R, Diudea D, Folkerth R, Wiebe S, Barkovich AJ, Mochida GH, Irvine J, Lemire EG, Blakley P, Walsh CA. Integrated genome and transcriptome sequencing identifies a noncoding mutation in the genome replication factor DONSON as the cause of microcephaly-micromelia syndrome.

Genome Res. 2017 Jun 19. doi: 10.1101/gr.219899.116. [Epub ahead of print] PubMed PMID: 28630177.

 

McConnell MJ, Moran JV, Abyzov A, Akbarian S, Bae T, Cortes-Ciriano I, Erwin JA, Fasching L, Flasch DA, Freed D, Ganz J, Jaffe AE, Kwan KY, Kwon M, Lodato MA, Mills RE, Paquola ACM, Rodin RE, Rosenbluh C, Sestan N, Sherman MA, Shin JH, Song S, Straub RE, Thorpe J, Weinberger DR, Urban AE, Zhou B, Gage FH, Lehner T, Senthil G, Walsh CA, Chess A, Courchesne E, Gleeson JG, Kidd JM, Park PJ, Pevsner J, Vaccarino FM; Brain Somatic Mosaicism Network. Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network. Science. 2017 Apr 28;356(6336). pii: eaal1641. doi: 10.1126/science.aal1641. Epub 2017 Apr 27. Review. PubMed PMID: 28450582; PubMed  Central PMCID: PMC5558435.

 

Ritter-Makinson SL, Paquet M, Bogenpohl JW, Rodin RE, Chris Yun C, Weinman EJ, Smith Y, Hall RA. Group II metabotropic glutamate receptor interactions with NHERF scaffold proteins: Implications for receptor localization in brain. Neuroscience. 2017 Jun 14;353:58-75. doi: 10.1016/j.neuroscience.2017.03.060. Epub 2017 Apr 7. PubMed PMID: 28392297; PubMed Central PMCID: PMC5503475.

 

Corleis B, Lisanti AC, Körner C, Schiff AE, Rosenberg ES, Allen TM, Altfeld M, Kwon DS. Early type I Interferon response induces upregulation of human β-defensin 1 during acute HIV-1 infection. PLoS One. 2017 Mar 2;12(3):e0173161. doi: 10.1371/journal.pone.0173161. eCollection 2017. PubMed PMID: 28253319; PubMed Central PMCID: PMC5333889.

 

Schwartz AL, Friedman AB. Geographic Variations in Controlled Trials. N Engl J Med. 2017 Mar 23;376(12):1196. doi: 10.1056/NEJMc1700529. PubMed PMID: 28332387.

 

McWilliams JM, Schwartz AL. Focusing on High-Cost Patients - The Key to Addressing High Costs? N Engl J Med. 2017 Mar 2;376(9):807-809. doi: 10.1056/NEJMp1612779. PubMed PMID: 28249127; PubMed Central PMCID: PMC5503135.

 

Chua KP, Schwartz AL, Volerman A, Conti RM, Huang ES. Use of Low-Value Pediatric Services Among the Commercially Insured. Pediatrics. 2016 Dec;138(6). pii: e20161809. Erratum in: Pediatrics. 2017 Mar;139(3):null. PubMed PMID: 27940698; PubMed Central PMCID: PMC5127068.

 

Tothova Z, Krill-Burger JM, Popova KD, Landers CC, Sievers QL, Yudovich D, Belizaire R, Aster JC, Morgan EA, Tsherniak A, Ebert BL. Multiplex CRISPR/Cas9-Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal  Hematopoiesis and Myeloid Neoplasia. Cell Stem Cell. 2017 Oct 5;21(4):547-555.e8. doi: 10.1016/j.stem.2017.07.015. PubMed PMID: 28985529.

 

Starkweather CK, Babayan BM, Uchida N, Gershman SJ. Dopamine reward prediction errors reflect hidden-state inference across time. Nat Neurosci. 2017 Apr;20(4):581-589. doi: 10.1038/nn.4520. Epub 2017 Mar 6. PubMed PMID: 28263301;  PubMed Central PMCID: PMC5374025.

 

Steinhorn B, Sartoretto JL, Sorrentino A, Romero N, Kalwa H, Abel ED, Michel T. Insulin-dependent metabolic and inotropic responses in the heart are modulated by hydrogen peroxide from NADPH-oxidase isoforms NOX2 and NOX4. Free Radic BiolnMed. 2017 Sep 14;113:16-25. doi: 10.1016/j.freeradbiomed.2017.09.006. [Epub ahead of print] PubMed PMID: 28917508.

 

Su MY, Fisher DE. Immunotherapy in the Precision Medicine Era: Melanoma and Beyond. PLoS Med. 2016 Dec 13;13(12):e1002196. doi: 10.1371/journal.pmed.1002196. eCollection 2016 Dec. PubMed PMID: 27959922; PubMed Central PMCID: PMC5154509.

 

Rissland OS, Subtelny AO, Wang M, Lugowski A, Nicholson B, Laver JD, Sidhu SS, Smibert CA, Lipshitz HD, Bartel DP. The influence of microRNAs and poly(A) tail length on endogenous mRNA-protein complexes. Genome Biol. 2017 Oct 31;18(1):211. doi: 10.1186/s13059-017-1330-z. PubMed PMID: 29089021; PubMed Central PMCID: PMC5664449.

 

Chen W, Bichara DA, Suhardi J, Sheng P, Muratoglu OK. Effects of vitamin E-diffused highly cross-linked UHMWPE particles on inflammation, apoptosis and immune response against S. aureus. Biomaterials. 2017 Oct;143:46-56. doi: 10.1016/j.biomaterials.2017.07.028. Epub 2017 Jul 24. PubMed PMID: 28759874

 

Susman MW, Karuna EP, Kunz RC, Gujral TS, Cantú AV, Choi SS, Jong BY, Okada K, Scales MK, Hum J, Hu LS, Kirschner MW, Nishinakamura R, Yamada S, Laird DJ, Jao LE, Gygi SP, Greenberg ME, Ho HH. Kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of cell and tissue behaviors in vertebrates. Elife. 2017 Sep 8;6. pii: e26509. doi: 10.7554/eLife.26509. PubMed PMID: 28885975; PubMed Central PMCID: PMC5590807.

 

Unger ES, Kawachi I, Milliren CE, Sonneville KR, Thurston IB, Gooding HC, Richmond TK. Protective Misperception? Prospective Study of Weight

Self-Perception and Blood Pressure in Adolescents With Overweight and Obesity. J  Adolesc Health. 2017 Jun;60(6):680-687. doi: 10.1016/j.jadohealth.2016.12.017. Epub 2017 Feb 14. PubMed PMID: 28214169; PubMed Central PMCID: PMC5441931.

 

van Schaik, K. 2017. "The 'medical market place' in the High Roman Empire." Review of Patients and Healers in the High Roman Empire, by Ido Israelowich. The Classical Review 67: 194-195.

 

Zilionis R, Nainys J, Veres A, Savova V, Zemmour D, Klein AM, Mazutis L. Single-cell barcoding and sequencing using droplet microfluidics. Nat Protoc. 2017 Jan;12(1):44-73. doi: 10.1038/nprot.2016.154. Epub 2016 Dec 8. PubMed PMID:  27929523.

 

Bi WL, Greenwald NF, Abedalthagafi M, Wala J, Gibson WJ, Agarwalla PK, Horowitz P, Schumacher SE, Esaulova E, Mei Y, Chevalier A, Ducar M, Thorner AR, van Hummelen P, Stemmer-Rachamimov A, Artyomov M, Al-Mefty O, Dunn GP, Santagata  S, Dunn IF, Beroukhim R. Genomic landscape of high-grade meningiomas. NPJ Genom Med. 2017;2. pii: 15. doi: 10.1038/s41525-017-0014-7. Epub 2017 Apr 26. PubMed PMID: 28713588; PubMed Central PMCID: PMC5506858.

 

Wala J, Beroukhim R. SeqLib: a C ++ API for rapid BAM manipulation, sequence alignment and sequence assembly. Bioinformatics. 2017 Mar 1;33(5):751-753. doi: 10.1093/bioinformatics/btw741. PubMed PMID: 28011768.

 

Wang B, Krall EB, Aguirre AJ, Kim M, Widlund HR, Doshi MB, Sicinska E, Sulahian R, Goodale A, Cowley GS, Piccioni F, Doench JG, Root DE, Hahn WC. ATXN1L, CIC, and ETS Transcription Factors Modulate Sensitivity to MAPK Pathway Inhibition. Cell Rep. 2017 Feb 7;18(6):1543-1557. doi: 10.1016/j.celrep.2017.01.031. PubMed PMID: 28178529; PubMed Central PMCID: PMC5313047.

 

Krall EB, Wang B, Munoz DM, Ilic N, Raghavan S, Niederst MJ, Yu K, Ruddy DA, Aguirre AJ, Kim JW, Redig AJ, Gainor JF, Williams JA, Asara JM, Doench JG, Janne PA, Shaw AT, McDonald Iii RE, Engelman JA, Stegmeier F, Schlabach MR, Hahn WC. KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer. Elife. 2017 Feb 1;6. pii: e18970. doi: 10.7554/eLife.18970. PubMed PMID: 28145866; PubMed Central PMCID: PMC5305212.

 

Warren KE, Tay S, Wen LS. The role of public health in combatting synthetic cannabinoid use in adolescents. J of Adolescent Health. 2017 May;60(5):483-6. doi: 10.1016/j.jadohealth.2017.02.015. PubMed PMID: 28433118.

 

Manguso RT, Pope HW, Zimmer MD, Brown FD, Yates KB, Miller BC, Collins NB, Bi  K, LaFleur MW, Juneja VR, Weiss SA, Lo J, Fisher DE, Miao D, Van Allen E, Root DE, Sharpe AH, Doench JG, Haining WN. In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target. Nature. 2017 Jul 27;547(7664):413-418. doi: 10.1038/nature23270. Epub 2017 Jul 19. PubMed PMID: 28723893.

 

Wolfson RL, Chantranupong L, Wyant GA, Gu X, Orozco JM, Shen K, Condon KJ, Petri S, Kedir J, Scaria SM, Abu-Remaileh M, Frankel WN, Sabatini DM. KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1. Nature. 2017 Mar 16;543(7645):438-442. doi: 10.1038/nature21423. Epub 2017 Feb 15. PubMed PMID: 28199306; PubMed Central PMCID: PMC5360989.

 

Wolfson RL, Sabatini DM. The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway. Cell Metab. 2017 Aug 1;26(2):301-309. doi:

10.1016/j.cmet.2017.07.001. Review. PubMed PMID: 28768171; PubMed Central PMCID: PMC5560103.

 

Engblom C, Pfirschke C, Zilionis R, Da Silva Martins J, Bos SA, Courties G, Rickelt S, Severe N, Baryawno N, Faget J, Savova V, Zemmour D, Kline J, Siwicki M, Garris C, Pucci F, Liao HW, Lin YJ, Newton A, Yaghi OK, Iwamoto Y, Tricot B, Wojtkiewicz GR, Nahrendorf M, Cortez-Retamozo V, Meylan E, Hynes RO, Demay M, Klein A, Bredella MA, Scadden DT, Weissleder R, Pittet MJ. Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF(high) neutrophils. Science. 2017 Dec 1;358(6367). pii: eaal5081. doi: 10.1126/science.aal5081. PubMed PMID: 29191879.

 

Shmakov S, Smargon A, Scott D, Cox D, Pyzocha N, Yan W, Abudayyeh OO, Gootenberg JS, Makarova KS, Wolf YI, Severinov K, Zhang F, Koonin EV. Diversity and evolution of class 2 CRISPR-Cas systems. Nat Rev Microbiol. 2017 Mar;15(3):169-182. doi: 10.1038/nrmicro.2016.184. Epub 2017 Jan 23. PubMed PMID:  28111461.

 

Gao L, Cox DBT, Yan WX, Manteiga JC, Schneider MW, Yamano T, Nishimasu H, Nureki O, Crosetto N, Zhang F. Engineered Cpf1 variants with altered PAM specificities. Nat Biotechnol. 2017 Aug;35(8):789-792. doi: 10.1038/nbt.3900. Epub 2017 Jun 5. PubMed PMID: 28581492; PubMed Central PMCID: PMC5548640

 

Yan WX, Mirzazadeh R, Garnerone S, Scott D, Schneider MW, Kallas T, Custodio J, Wernersson E, Li Y, Gao L, Federova Y, Zetsche B, Zhang F, Bienko M, Crosetto  N. BLISS is a versatile and quantitative method for genome-wide profiling of DNA  double-strand breaks. Nat Commun. 2017 May 12;8:15058. doi: 10.1038/ncomms15058.  PubMed PMID: 28497783; PubMed Central PMCID: PMC5437291.