Virology Faculty Member - Tun-Hou Lee

Tun-Hou Lee

Professor of Immunology and Infectious Diseases

Harvard School of Public Health
Imm.and Infectious Dis., FXB, Rm. 305
651 Huntington Avenue
Boston, MA 2115
Tel: 617-432-1332
Fax: 617-739-8348
Email: thlee@hsph.harvard.edu



Our major research interests are virus-specific antigens and their association with disease manifestations, viral replication, and host-virus interactions, with particular focus on human and related primate retroviruses. Currently, Professor Lee is focusing on the modification of the HIV vaccine development and on the study of HIV pathogenesis.



























































Last Update: 10/22/2013



Publications

Lee, TH. and Novitsky, V. HIV Vaccines: Design and Development. Pp. 594-611. In: AIDS in Africa, 2nd ed. Essex, M., Mboup S., Kanki P., Marlink R., and Tlou S. (Eds.) Kluwer Academic/Plenum Publishers, New York (2002).

Novitsky V., Gilbert P., Peter T., McLane M.F., Gaolekwe S., Rybak N., Thior I., Ndung’u T., Marlink R., Lee TH., and Essex M. Association between Virus-Specific CTL Responses and Plasma Viral Load in HIV-1 Subtype C Infection. J. Virol. 77: 882-890 (2003).

Suphaphiphat P., Thitithanyanont A., Paca-Uccaralertkun S., Essex M., and Lee TH. Effect of Amino Acid Substitution of the V3 and Bridging Sheet Residues in the HIV-1 Subtype C gp120 on CCR5 Utilization. J. Virol. 77:3832-3837 (2003)

Suptawiwat O, Sutthent R, Lee TH, Auewarakul P. Intragenic HIV-1 env sequences that enhance gag expression. Virology. 309:1-9 (2003).

Montano M, Russell M, Gilbert P, Thior I, Lockman S, Shapiro R, Chang SY, Lee TH, Essex M. Comparative Prediction of Perinatal Human Immunodeficiency Virus Type 1 Transmission, Using Multiple Virus Load Markers. J Infect Dis. 188: 406-413 (2003).

De Parseval A, Bobardt MD, Chatterji A, Chatterji U, Elder JH, David G, Zolla-Pazner S, Farzan M, Lee TH, Gallay PA. A Highly Conserved Arginine in gp120 Governs HIV-1 Binding to Both Syndecans and CCR5 Via Sulfated Motifs. J Biol Chem. 280: 39493-39504 (2005).

Paca-uccaralertkun, S., Damgaard, C.K., Auewarakul, P., Thitithanyanont, A., Suphaphiphat, P., Essex, M., Kjems, J., and Lee, T.H. The Effect of a Single Nucleotide Substitution in the Splicing Silencer in the tat/rev Intron on HIV Type 1 Envelope Expression. AIDS Res. Hum. Retroviruses. 22: 76-82 (2006).

Novitsky, V., Gilbert, P., Shea, K., McLane, M.F., Rybak, N., Klein, I., Thior, I., Ndung’u, T., Lee, T.H., and Essex, M. Interactive Association of Proviral Load and IFN-γ–Secreting T Cell Reponses in HIV-1C Infection. Virology. 349: 142-155 (2006).

Da’dara, A.A., Lautsch, N., Novitsky, V., Lee, T.H., Essex, M., and Harn, D.A. Helminth Infection Suppresses T Cell Immune Response to HIV-DNA-Based Vaccine in Mice. Vaccine. 24: 5211-5219 (2006).

Thior, I., Lockman, S., Smeaton, L.M., Shapiro, R.L., Wester, C., Heymann, S.J., Gilbert, P.B., Stevens, L., Peter, T., Kim, S., van Widenfelt, E., Moffat, C., Ndase, P., Arimi, P., Kebaabetswe, P., Mazonde, P., Makhema, J., McIntosh, K., Novitsky, V., Lee, T.H., Marlink, R., Lagakos, S., and Essex, M., for the Mashi Study Team. Breastfeeding Plus Infant Zidovudine Prophylaxis for 6 Months vs Formula Feeding Plus Infant Zidovudine for 1 Month to Reduce Mother-to-Child HIV Transmission in Botswana. A Randomized Trial: The Mashi Study. JAMA. 296: 794-805 (2006).

Suphaphiphat, P., Essex, M., and Lee, T.H. Mutations in the V3 Stem versus the V3 Crown and C4 Region Have Different Effects on the Binding and Fusion Steps of Human Immunodeficiency Virus Type 1 Gp120 Interaction with the CCR5 Coreceptor. Virology. 360:182-190 (2007).



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