Virology
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Martin S. Hirsch, M.D.

Professor of Medicine

Mass General Hospital
Gray Building, Room E, 441
Fruit Street
Boston, MA 02114
Tel:(617) 726-3815
Fax: (617) 726-7416
e-mail:hirsch.martin@mgh.harvard.edu
2 postdoctoral fellows, 1 graduate students

  

Our group is interested in the pathogenesis and therapy of infections with human retroviruses . Studies range from the molecular to the clinical. We are interested in host cell-mediated immune responses to HIV and their role in both protection and immunopathology.

Therapeutic studies target HIV. We study mechanisms of resistance to current antivirals and combination therapy strategies to overcome resistance. Viral reservoirs during HIV infection, and in attempts to diminish them by therapeutic manipulations.

 

References:

  1. Oh, M.D., Merrill, D.P., Sutton, L., Hirsch, M.S. 1997. Sequential versus simultaneous combination antiretroviral regimens for the treatment of HIV-1 infection in vitro. J. Infect. Dis. 176:510-514.
  2. Merrill, D.P., Martinez-Picado, J., Tremblay, C., Sax, P.E., Boswell, S.L., Wong, J.T., D'Aquila, R.T., Walker, B.D., Hirsch, M.S. 1999. Improved CD4 lymphocyte outgrowth in response to effective antiretroviral therapy. J. Infect Dis. 179:345-351.
  3. Tremblay, C.L., Giquel, F., Merrill, D.P., Wong, J.T., Rosenberg, E.S., Kalams, S., Walker, B.D., D'Aquila, R.T., Hirsch, M.S. Marked differences in quantity of infectious human immunodeficiency virus type 1 detected in persons with controlled plasma viremia by a simple enhanced culture method. J Clin Microbiol. 2000, 38:4246-48.
  4. Tremblay, C.L., Kollmann, C., Giguel, F., Chou, T.C., Hirsch, M.S. Strong in vitro synergy between the fusion inhibitor T-20 and CXCR4 blocker AMD-3100. JAIDS. 2000; 25:99-102.