Galit Alter, Ph.D.

Assistant Professor in Medicine,
Associate Director of the CFAR Immunology Core
Director of Ragon Institute Imaging Core
149 13th St, Room 6618b,
Charlestown, MA, 02114
Phone (617)724-0546
Fax (617)726-5411
galter@partners.org

Post-docs: 4
Technicians: 4

RESEARCH INTERESTS:

-The role of Natural Killer Cells in Chronic Viral Infections

-Potential vaccine induced recruitment of innate immunity through Fc-receptors

-Role of NK cell in tissues

References:

1. Alter G, Teigen N, Meier A, Lichterfeld M, Rosenberg ES, Altfeld M. Dynamic evolution of innate and adaptive immunity in acute HIV-1 infection. J. Infect Dis. 2007 May 15;195(10):1452-60.

2. Alter G, Suscovich T, Teigen N, Meier A, Streeck H, and Altfeld M. Single-Stranded RNA Derived from HIV-1 Serves as a Potent Activator of NK Cells.  J Immunol. 2007 Jun 15;178(12):7658-66.

3. Alter G, Meier A, Teigen N, Streeck H, Altfeld M. MyD88-dependent Immune Activation mediated by HIV-1-encoded TLR Ligands. J Virol. 2007 May 16.

4. Alter G, Martin M, Teigen N, Carr W, Suscovich T, Schneidewind A, Streeck H, Waring MT, Meier A, Brander B, Lifson J, Allen T, Carrington M, Altfeld M.. Differential Natural Killer cell mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes. J Exp Med. 2007 Nov 26;204(12):3027-36.

5. Alter G, Teigen N, Cohen K, Meier A, Streeck H, Altfeld M. Inhibition of HIV-specific CD8+ T cell by Killer immunoglobulin like receptors. Journal of Virology. 2008 Nov.

6. Alter G. and Altfeld M. NK cells in HIV-1 infection: evidence for their role in the control of HIV-1 infection. J intern Med. 2009 Jan; 265(1): 29-42.

7. Alter G, Suzannah Rihn, Katharine Walters, Anne Nolting, Maureen Martin, Eric S. Rosenberg, Jeffrey S. Miller, Mary Carrington, and Marcus Altfeld HLA class I subtype dependent expansion of  KIR3DS1+ and KIR3DL1+ NK cells during acute HIV-1 infection J Virol. 2009 Jul;83(13):6798-805. Epub 2009 Apr 22.

8. Liu Q , Sun Y  , Rihn S , Nolting A  , Tsoukas PN  , Jost S , Cohen K  , Walker B  , Alter G  . Matrix Metalloprotease inhibitors restore impaired NK cell mediated Antibody dependent cellular cytotoxicity in human immunodeficiency virus-1 infection. J Virol. Epub  2009 Jun 24.