Program of Study
Students usually take 3 courses per semester and conduct a laboratory rotation during each semester of the first year, and a laboratory rotation in the following summer.During the second year, they start their dissertation research in the fall semester and take one course. Preliminary qualifying exams (PQE) are held during December of the second year. Following successful completion of the PQE, students continue their dissertation research and within 6 months establish their dissertation advisory committee (DAC) in consultation with their advisor and the approval of the Program Chair.The individual components of the curriculum are discussed more fully in the sections below
Seminars, student journal clubs, and program retreats are an integral part of the scientific and educational experience of the Virology Program. Therefore, students are expected to attend and participate fully in all of these activities. Graduate study is a full-time professional endeavor. To this end, graduate students have vacation breaks only during the normal University holidays or equivalent periods of time, as per DMS policy.
Virology Required and Recommended Courses
All students are expected to be knowledgeable in the following areas: virology, molecular and cellular biology, biochemistry, and genetics. Students must take a total of 7 courses. Virology 200, Virology 201, Virology 202 are required courses for all students in the Program. Quarter-courses (Virology 330 Critical Readings in Virology and Medical Science 300 – Conduct of Science discussion forum) will also be taken by all students in the Program. These two courses do not count towards the 7-course requirement. Depending upon students’ interests and background, additional courses frequently including a course in immunology or genetics are selected to meet the 7-course requirement. Students frequently take the courses listed below.
FALL – YEAR 1
Virology 200 – Introduction to Virology
Elliott D. Kieff (Medical School), David M. Knipe (Medical School), Karl Münger (MedicalSchool), and Max L. Nibert (Medical School)
Half course (fall term). W., 12:30–3, M., 3–4:30.
Introduction to virology. The lecture component reviews the basic principles of virology and introduces the major groups of human viruses. Weekly discussion groups critically analyze selected papers from the literature.
Note: There will be a final project consisting of a proposal based on laboratory rotations (for Virology, BBS, or Immunology Program students) or a final paper based on a topic from the literature. Offered jointly with the Medical School as MG 705.0.
BCMP 200 Molecular Biology
Richard Ian Gregory (Medical School), Kami Ahmad (Medical School), Stephen Buratowski (Medical School), Joseph John Loparo, Jack Szostak (Medical School), and Johannes Walter (Medical School)Curriculum Fellow: Johanna Gulterner
Half course (fall term). M., W., F., 10:45-12:15.
An advanced treatment of molecular biology’s Central Dogma. Considers the molecular basis of information transfer from DNA to RNA to protein, using examples from eukaryotic and prokaryotic systems. Lectures, discussion groups, and research seminars.
Note: Offered jointly with the Medical School as BP 723.0.
Prerequisite: Intended primarily for graduate students familiar with basic molecular biology or with strong biology/chemistry background.
MCB 169 - Molecular and Cellular Immunology
Th – 10:30 – 12:00
Basic elements of the immune system. Molecular biology of antigen recognition structures on B and T lymphocytes. Cellular and genetic basis of immunity. Regulation and development of the immune system.
Immunology 201 – Principles of Immunology
Ulrich H. Von Andrian-Werburg (Medical School), Shannon Turley (Medical School) and members of the Department
Half course (fall term). Tu., Th., 1:30-3, with section Tu., Th., 3-4.
Comprehensive core course in immunology. Topics include a broad but intensive examination of the cells and molecules of the immune system. Special attention given to the experimental approaches that led to general principles of immunology.
Note: Intended for students who have had prior exposure to immunology on the undergraduate level. In the absence of such exposure, students must obtain the permission of the Course
Director. Offered jointly with the Medical School as IM 702.0.
Prerequisite: A background in genetics and biochemistry strongly recommended.
Genetics 201 – Principles of Genetics
Fred Winston (Medical School), Ann Hochschild (Medical School), and Mitzi I. Kuroda(Medical School)Curriculum Fellow: Leah Brault
Half course (fall term). M., W., F., 9-10:30.
An in-depth survey of genetics, beginning with basic principles and extending to modernapproaches and special topics. We will draw on examples from various systems, including yeast,Drosophila, C. elegans, mouse, human and bacteria.
Note: Intended for first-year graduate students. Offered jointly with the Medical School as GN701.0.
Virology 301qc. Advanced Topics in Virology
Catalog Number: 33563
Alan N. Engelman (Medical School) 2196
Quarter course (fall term). Tu., Th., 4:30–6:00.
Critical evaluation of virology-related papers reporting a seminal contribution, strong methodological approaches or, in some cases, due to errors in methodology or author interpretation. Requirements include written critiques and class participation.
Note: Offered in the month of January.
SPRING – YEAR 1
Virology 201. Virology
Sean P.J. Whelan (Medical School), James M. Cunningham (Medical School), David T. Evans (Medical School), and Lee Gehrke (Medical School)
Half course (spring term). Tu., Th., 2:30 - 4
Literature based reading. Proposal writing. Course covers a broad range of topics: viral genetics, structure/replication, pathogenesis, evolution ("emerging viruses"), chronic infection, latency,innate and adaptive immunity, anti-viral drugs and vaccine strategies.
Cell Biology 201 – Molecular Biology of the Cell
Sheila Thomas (Medical School), Joan V. Ruderman (Medical School), and members of theDepartment Half course (spring term). M., W., 10:30-12, and sections F., at 10:30-12.
Molecular basis of cellular dynamics: subcellular compartmentalization, protein trafficking, regulated ubiquitin-proteasome pathways, cell cycle logic, cytoskeleton dynamics, motors, signal transduction, cell-cell interactions, and programmed cell death, with emphasis on experimental design, evolving methodologies, and relevance to disease.
Note: Offered jointly with the Medical School as CB 713.0.
BCMP 201. Proteins: Structure, Function and Catalysis
Catalog Number: 5068
Stephen C. Blacklow (Medical School), Gaudenz Danuser (Medical School), Stephen Harrison (Medical School), and Peter Sorger (Medical School)
Half course (spring term). Tu., Th., 9:30 - 11
Macromolecular structure with emphasis on biochemistry , interactions and catalysis in cellular processes and pathways. Links between theory and observation will emerge from discussion of fundamental principles, computational approaches and experimental methods.
Note: The course is intended for all Division of Medical Sciences (DMS) graduate students and is open to advanced undergraduates. Offered jointly with the Medical School as BP 714.0.
FALL - YEAR 2
Virology 202. Animal Virology: Seminar
Catalog Number: 6025
Michael R. Farzan (Medical School), Michaela Gack (Medical School), Frederick C. Wang
(Medical School), and Xinzhen Yang (Medical School)
Half course (fall term). W., 1:30–4:30.
Students will write, present, and evaluate research proposals in the areas of virus replication, viral pathogenesis and treatment and prevention of viral infections.
Note: Offered jointly with the Medical School as MG 724.0.
Prerequisite: General background in biochemistry and virology.
Note: Offered jointly with the Medical School as MG 724.0.
Students are expected to rotate in three laboratories before selecting a dissertation laboratory. Students may initiate rotations as early as July 1 in the summer before they start graduate school. This provides an early start on full time research before classes begin. Rotations are often approximately one semester long, but should be at least 8-12 weeks long, the shorter period being during full time research in the summers. Frequently, the first year Fall rotation gets short changed because of the intensity of course work, and students extend this rotation through the semester break. Similarly, the Spring semester rotation can be extended into summer. If students are certain that they have found a suitable dissertation advisor in their first two rotations, a third rotation may not be mandatory. However, even students who have decided on an advisor may elect a third rotation to gain experience with different approaches. Students should normally choose a laboratory for their dissertation research by the start of the second year of graduate school.
The faculty members of the Virology Program are selected for their ability to serve as mentors for graduate student rotations and dissertation research. Students are encouraged to pursue research in laboratories of the program faculty, but rotations and dissertation research are available in any laboratory in the Harvard Integrated Life Sciences program. The Student Advisory Committee and the Program Chairperson are available to discuss rotation plans. Rotations in labs of faculty outside the Virology Program must be approved in advance by the Student Advisory Committee and Program Chair. A Rotation Registration form must be completed and returned to the Virology Program office before the start date of the rotation.
Students are encouraged to write a brief proposal within the first three weeks of their rotation and submit the proposal to their rotation mentor. The proposal can be developed with input from the mentor or the mentor’s other trainees. The proposal should be no more than two single spaced pages in length and include brief statements of the relevant background, the rationale for the proposed experiments, the specific aim of the experiments proposed, the technology that will be used, the anticipated result, and how it will advance the field, including no more than 10 references. The mentor should review and critique the proposal. Students should present their experimental results at the mentor’s laboratory meeting at the end of the rotation. The mentor will provide the student with a brief written critique of the experimental accomplishments and presentation and will forward a copy to the Program Office.
Annual Virology Retreat
The annual Virology retreat is organized by the 3rd year students and typically takes place in September prior to the commencement of classes. In 2011 the Retreat was held at the Exeter Inn in Exeter, New Hampshire. The event lasts for two days and is an opportunity for the incoming class to be exposed to current areas of research that are the focus of students and faculty in the Virology program. Students (typically in the 4th or 5th year of graduate school) and faculty present their research findings and ongoing projects in the laboratory, respectively, thereby allowing the incoming class to survey thesis lab options prior to starting the fall laboratory rotation. The retreat also includes an informal poster session in which students and faculty learn about the work of their peers. The retreat provides a great way for the incoming students to interact with the rest of the program in an informal and fun setting.
Student Advisory System
Faculty members provide advice and guidance to students throughout their graduate career. Each student is paired initially with a faculty member, who meets with the student on an as-needed basis. Faculty committees also provide advice, guidance and support to graduate students. In the pre-dissertation period, the Graduate Student Advisory Committee meets with students at the beginning and end of each semester to offer guidance on choices related to courses, laboratory rotations and potential dissertation advisors. This committee also works in conjunction with the Preliminary Examining Committee to oversee the Preliminary Qualifying Exams (PQE), in which students prepare and defend a research proposal before faculty experts in the field. Following the successful Preliminary Exam, the student and dissertation advisor select a Dissertation Advisory Committee (DAC), which meets at least every twelve months to assess progress on dissertation research and to provide advice. The Dissertation Advisory Committee and the dissertation advisor decide when the student should write and defend the dissertation. One member of the Dissertation Advisory Committee may sit on the Dissertation Defense Committee, which examines the student on the contents of the dissertation.
Virology Student Data Club
The Virology Student Data Club is organized and run by the students of the Virology Program at Harvard. In this club, which meets every other week, students in the program present their current research. In the second semester of the first year of study Virology students present a practice talk of their proposals for the current Virology course. In the first semester of the second year of study Virology students present a practice talk of their Preliminary Qualifying Exam proposals. The Virology Student Data Club is meant to allow students an opportunity to receive feedback from their peers regarding their current research or proposals for courses and the PQE. In addition the audience learns about a variety of methods and techniques, as well as the current research that takes place in different laboratories on and off campus.