Student Publications

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2017


Gootenberg DB, Paer JM, Luévano JM, Kwon DS: HIV-associated changes in the enteric microbial community: potential role in loss of homeostasis and development of systemic inflammation. Review. Current Opinion in Infectious Diseases. 2017 Feb;30(1):31-43. doi: 10.1097/QCO.0000000000000341 PMID: 27922852


Harden ME, Prasad N, Griffiths A, Munger K. Modulation of microRNA-mRNA Target Pairs by Human Papillomavirus 16 Oncoproteins. MBio. 2017 Jan 3;8(1). pii: e02170-16. doi: 10.1128/mBio.02170-16. PMID: 28049151 PMCID: PMC5210503 read article


Geva-Zatorsky, N., E. Sefik, L. Kua, L. Pasman, T. G. Tan, A. Ortiz-Lopez, T. B. Yanortsang, L. Yang, R. Jupp, D. Mathis, C. Benoist, and D. L. Kasper. 2017. Mining the human gut microbiota for immunomodulatory organisms. Cell, in press.


Rooks MG, Veiga P, Reeves AZ, Lavoie S, Yasuda K, Asano Y, Yoshihara K, Michaud M, Wardwell-Scott L, Gallini CA, Glickman JN, Sudo N, Huttenhower C, Lesser CF, Garrett WS. QseC inhibition as an antivirulence approach for colitis-associated bacteria. Proc Natl Acad Sci U S A. 2017 Jan 3;114(1):142-147. doi: 10.1073/pnas.1612836114. PMID: 27980034  read article


Madani N, Princiotto AM, Zhao C, Jahanbakhshsefidi F, Mertens M, Herschhorn A, Melillo B, Smith AB 3rd, Sodroski J. Activation and Inactivation of Primary Human Immunodeficiency Virus Envelope Glycoprotein Trimers by CD4-Mimetic Compounds.J Virol. 2017 Jan 18;91(3). pii: e01880-16. doi: 10.1128/JVI.01880-16. Print 2017 Feb 1. PMID:27881646


Pyle, J. D., Keeling, P. J., and Nibert, M. L. 2017. Amalga-like virus infecting Antonospora locustae, a microsporidian pathogen of grasshoppers, plus related viruses associated with other arthropods. Virus Research. In Press.


Wang MK, Lim SY, Lee SM, Cunningham JM. Biochemical Basis for Increased Activity of Ebola Glycoprotein in the 2013-16 Epidemic. Cell Host Microbe. 2017 Mar 8;21(3):367-375. doi: 10.1016/j.chom.2017.02.002. Epub 2017 Feb 23. PMID: 28238624


Wang X, Moazed D. DNA sequence-dependent epigenetic inheritance of gene silencing and histone H3K9 methylation. Science. 2017 Mar 16. pii: eaaj2114. doi: 10.1126/science.aaj2114. PMID: 28302794 read article


Zilionis R, Nainys J, Veres A, Savova V, Zemmour D, Klein AM, Mazutis L. Single-cell barcoding and sequencing using droplet microfluidics. Nat Protoc. 2017 Jan;12(1):44-73. doi: 10.1038/nprot.2016.154. Epub 2016 Dec 8.


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2016


Amamoto R, Huerta VG, Takahashi E, Dai G, Grant AK, Fu Z, Arlotta P. Adult axolotls can regenerate original neuronal diversity in response to brain injury. Elife. 2016 May 9;5. pii: e13998. doi: 10.7554/eLife.13998. PMID: 27156560


Beyaz S, Mana MD, Roper J, Kedrin D, Saadatpour S, Hong SJ, Bauer-Rowe KE, Xifaras ME, Akkad A, Pinello L, Katz Y, Shinagare Y, Abu-Remaileh M, Lamming D, Guo G, Selig M, Nielsen GP, Gupta N, Ferrone C, Deshpande V, Yuan GC, Orkin SH, Sabatini DM, Yilmaz OH. High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature 2016, Mar 3; 531(7592):53-8.


Beyaz S, Kim JH, Pinello L, Xifaras ME, Hu Y, Huang J, Kerenyi MA, Das PP, Barnitz RA, Herault A, Dogum R, Haining WN, Yilmaz ÖH, Passegue E, Yuan GC, Orkin SH, Winau F. The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells. Nat Immunol. 2016 Dec 19. doi: 10.1038/ni.3644. [Epub ahead of print] PMID: 27992400


Beyaz S, Yilmaz ÖH. Molecular Pathways: Dietary Regulation of Stemness and Tumor Initiation by the PPAR-δ Pathway. Clin Cancer Res. 2016 Dec 1;22(23):5636-5641. PMID: 27702819


Larocca RA, Provine NM, Aid M, Iampietro MJ, Borducchi EN, Badamchi-Zadeh A, Abbink P, Ng'ang'a D, Bricault CA, Blass E, Penaloza-MacMaster P, Stephenson KE, Barouch DH. Adenovirus serotype 5 vaccine vectors trigger IL-27-dependent inhibitory CD4+ T cell responses that impair CD8+ T cell function. Sci Immunol. 2016 Nov;1(5). pii: eaaf7643. doi: 10.1126/sciimmunol.aaf7643. Epub 2016 Nov 4. read article


Graham DB, Lefkovith A, Deelen P, de Klein N, Varma M, Boroughs A, Desch AN, Ng AC, Guzman G, Schenone M, Petersen CP, Bhan AK, Rivas MA, Daly MJ, Carr SA, Wijmenga C, Xavier RJ. TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation. Cell Rep. 2016 Dec 13;17(11):2955-2965. doi: 10.1016/j.celrep.2016.11.042. PMID: 27974209  read article


Choudhury R, Bonacci T, Arceci A, Lahiri D, Mills CA, Kernan JL, Branigan TB, DeCaprio JA, Burke DJ, Emanuele MJ. APC/C and SCF(cyclin F) Constitute a Reciprocal Feedback Circuit Controlling S-Phase Entry. Cell Rep. 2016 Sep 20;16(12):3359-72. doi: 10.1016/j.celrep.2016.08.058. PMID: 27653696  read article


Schwer B, Wei PC, Chang AN, Kao J, Du Z, Meyers RM, Alt FW. Transcription-associated processes cause DNA double-strand breaks and translocations in neural stem/progenitor cells. Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2258-63. doi: 10.1073/pnas.1525564113. Epub 2016 Feb 12. PMID: 26873106 PMCID:26873106 read article


Wei PC, Chang AN, Kao J, Du Z, Meyers RM, Alt FW, Schwer B. Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells. Cell. 2016 Feb 11;164(4):644-55. doi: 10.1016/j.cell.2015.12.039. PMID:26871630


Dev J, Park D, Fu Q, Chen J, Ha HJ, Ghantous F, Herrmann T, Chang W, Liu Z, Frey G, Seaman MS, Chen B, Chou JJ. Structural basis for membrane anchoring of HIV-1 envelope spike. Science. 2016 Jul 8;353(6295):172-5. doi: 10.1126/science.aaf7066. Epub 2016 Jun 23. PMID: 27338706


Zhao L, Wang S, Du L, Dev J, Zhou L, Liu Z, Chou JJ, OuYang B. Structural basis of interaction between the hepatitis C virus p7 channel and its blocker hexamethylene amiloride. Protein Cell. 2016 Apr;7(4):300-4. doi: 10.1007/s13238-016-0256-7. No abstract available. PMID: 26951497 PMCID: 26951497 read article


Piai A, Fu Q, Dev J, Chou JJ. Optimal Bicelle Size q for Solution NMR Studies of the Protein Transmembrane Partition. Chemistry. 2017 Jan 26;23(6):1361-1367. doi: 10.1002/chem.201604206. Epub 2016 Dec 22. PMID: 27747952 PMCID: PMC5272838


Zanoni I, Tan Y, Di Gioia M, Broggi A, Ruan J, Shi J, Donado CA, Shao F, Wu H, Springstead JR, Kagan JC. An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells. Science. 2016 Apr 21. pii: aaf3036


Kohlgruber AC, Donado CA, LaMarche NM, Brenner MB, Brennan PJ. Activation strategies for invariant natural killer T cells. Immunogenetics. 2016 Aug 1;68(8):649-63.


Pucci F, Garris C, Lai CP, Newton A, Pfirschke C, Engblom C, Alvarez D, Sprachman M, Evavold C, Magnuson A, von Andrian UH, Glatz K, Breakefield XO, Mempel TR, Weissleder R, Pittet MJ. SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions. Science. 2016 Apr 8;352(6282):242-6. doi: 10.1126/science.aaf1328. Epub 2016 Mar 17.


Pfirschke C*, Engblom C*, Rickelt S, Cortez-Retamozo V, Garris C, Pucci F, Yamazaki T, Poirier-Colame V, Newton A, Redouane Y, Lin YJ, Wojtkiewicz G, Iwamoto Y, Mino-Kenudson M, Huynh TG, Hynes RO, Freeman GJ, Kroemer G, Zitvogel L, Weissleder R, Pittet MJ. Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy. Immunity. 2016 Feb 16;44(2):343-54. doi: 10.1016/j.immuni.2015.11.024. Epub 2016 Feb 9.
*Co-first author


Engblom C, Pfirschke C, Pittet MJ. The role of myeloid cells in cancer therapies. Nat Rev Cancer. 2016 Jul;16(7):447-62. doi: 10.1038/nrc.2016.54. PMID: 27339708


Pucci F, Rickelt S, Newton AP, Garris C, Nunes E, Evavold C, Pfirschke C, Engblom C, Mino-Kenudson M, Hynes RO, Weissleder R, Pittet MJ. PF4 Promotes Platelet Production and Lung Cancer Growth. Cell Rep. 2016 Nov 8;17(7):1764-1772. doi: 10.1016/j.celrep.2016.10.031. PMID: 27829148


Siwicki M, Engblom C, Pittet MJ. Gal3 Links Inflammation and Insulin Resistance. Cell Metab. 2016 Nov 8;24(5):655-656. doi: 10.1016/j.cmet.2016.10.014. PMID: 27829136


Pucci F, Garris C, Lai CP, Newton A, Pfirschke C, Engblom C, Alvarez D, Sprachman M, Evavold C, Magnuson A, von Andrian UH, Glatz K, Breakefield XO, Mempel TR, Weissleder R, Pittet MJ. macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions. Science. 2016 Apr 8;352(6282):242-6. doi: 10.1126/science.aaf1328. Epub 2016 Mar 17.
SCS


Pucci F, Rickelt S, Newton AP, Garris C, Nunes E, Evavold C, Pfirschke C, Engblom C, Mino-Kenudson M, Hynes RO, Weissleder R, Pittet MJ. PF4 Promotes Platelet Production and Lung Cancer Growth. Cell Rep. 2016 Nov 8;17(7):1764-1772. doi: 10.1016/j.celrep.2016.10.031. PMID: 27829148  read article


NA Zwang, R Zhang, S Germana, M Fan, WD Hastings, A Cao, and LA Turka. Selective sparing of human Tregs by pharmacologic inhibitors of the Phosphatidylinositol 3-Kinase and MEK pathways. American Journal of Transplantation, 16, 2624-2638. 2016. PMCID: PMC5007157


Pucci F, Garris C, Lai CP, Newton A, Pfirschke C, Engblom C, Alvarez D, Sprachman M, Evavold C, Magnuson A, von Andrian UH, Glatz K, Breakefield XO, Mempel TR, Weissleder R, Pittet MJ SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions Science. 2016;352(6282):242-246 - PMID: 26989197


Pfirschke C, Engblom C, Rickelt S, Cortez-Retamozo V, Garris C, Pucci F, Yamasaki T, Poirier-Colame V, Newton A, Redouane Y, Lin YJ, Wojtkiewicz G, Iwamoto Y, Mino-Kenudson M, Huynh TG, Hynes RO, Freeman GJ Kroemer G, Zitvogel L, Weissleder R, Pittet MJ Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy Immunity. 2016;44:1-12 - PMID: 26872698 - PMCID: PMC4758865


Jernej Godec, Yan Tan, Arthur Liberzon, Pablo Tamayo, Atul J. Butte, Jill P. Mesirov, W. Nicholas Haining. A novel compendium of immune signatures identifies both conserved and species-specific biology in the mouse and human response to inflammation. Immunity. 2016 Jan 19;44(1):194-206. (PMID: 26795250)


Yan Tan*, Jernej Godec*, Pablo Tamayo, W. Nicholas Haining, Jill P. Mesirov. A method for downstream analysis of gene set enrichment results facilitates the biological interpretation of vaccine efficacy studies. 2016 bioRxiv doi: 10.1101/043158. *Co-first author.


Larocca RA, Abbink P, Peron JP, Zanotto PM, Iampietro MJ, Badamchi-Zadeh A, Boyd M, Ng'ang'a D, Kirilova M, Nityanandam R, Mercado NB, Li Z, Moseley ET, Bricault CA, Borducchi EN, Giglio PB, Jetton D, Neubauer G, Nkolola JP, Maxfield LF, De La Barrera RA, Jarman RG, Eckels KH, Michael NL, Thomas SJ, Barouch DH. Vaccine protection against Zika virus from Brazil. Nature. 2016 Aug 25;536(7617):474-8. read article


Penaloza MacMaster P, Shields JL, Alayo QA, Cabral C, Jimenez J, Mondesir J, Chandrashekar A, Cabral JM, Lim M, Iampietro MJ, Provine NM, Bricault CA, Seaman M, Orlinger K, Aspoeck A, Fuhrmann G, Lilja AE, Monath T, Mangeat B, Pinschewer DD, Barouch DH. Development of novel replication-defective lymphocytic choriomeningitis virus vectors expressing SIV antigens. Vaccine. 2017 Jan 3;35(1):1-9. doi: 10.1016/j.vaccine.2016.11.063. Epub 2016 Nov 26. read article


Larocca RA, Provine NM, Aid M, Iampietro MJ, Borducchi EN, Badamchi-Zadeh A, Abbink P, Ng'ang'a D, Bricault CA, Blass E, Penaloza-MacMaster P, Stephenson KE, Barouch DH. Adenovirus serotype 5 vaccine vectors trigger IL-27-dependent inhibitory CD4+ T cell responses that impair CD8+ T cell function. Sci Immunol. 2016 Nov;1(5). pii: eaaf7643. doi: 10.1126/sciimmunol.aaf7643. Epub 2016 Nov 4. read article


Mahan AE, Jennewein MF, Suscovich T, Dionne K, Tedesco J, Chung AW, Streeck H, Pau M, Schuitemaker H, Francis D, Fast P, Laufer D, Walker BD, Baden L, Barouch DH, Alter G .Antigen-Specific Antibody Glycosylation Is Regulated via Vaccination. PLoS Pathog. 2016 Mar 16;12(3):e1005456. doi: 10.1371/journal.ppat.1005456. eCollection 2016 Mar 16. Erratum in: PLoS Pathog. 2016 Jun;12(6):e1005694.  read article


Shouval DS, Biswas A, Kang YH, Griffith AE, Konnikova L, Mascanfroni ID, Redhu NS, Frei SM, Field M, Doty AL, Goldsmith JD, Bhan AK, Loizides A, Weiss B, Yerushalmi B, Yanagi T, Lui X, Quintana FJ, Muise AM, Klein C, Horwitz BH, Glover SC, Bousvaros A2, Snapper SB. Interleukin 1β Mediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor Deficiency. Gastroenterology. 2016 Dec;151(6):1100-1104. doi: 10.1053/j.gastro.2016.08.055. Epub 2016 Sep 28. PMID: 27693323


Kim JH, Hu Y, Yongqing T, Kim J, Hughes VA, Le Nours J, Marquez EA, Purcell AW, Wan Q, Sugita M, Rossjohn J, Winau F. CD1a on Langerhans cells controls inflammatory skin disease. Nat Immunol. 2016 Oct;17(10):1159-66. doi: 10.1038/ni.3523. PMID: 27548435


Hu Y, Kim JH, He K, Wan Q, Kim J, Flach M, Kirchhausen T, Vortkamp A, Winau F. Scramblase TMEM16F terminates T cell receptor signaling to restrict T cell exhaustion. J Exp Med. 2016 Nov 14;213(12):2759-2772.PMID: 27810927


Kohlgruber, A.C., LaMarche, N.M., Lynch, L. (2016) Adipose tissue at the nexus of systemic and cellular metabolism. Seminars in Immunology 28(5):431-440. DOI: 10.1016/j.smim.2016.09.005


Kohlgruber, A.C., Donado, C.A., LaMarche, N.M., Brenner, M.B., Brennan, P.J. (2016). Activation strategies for invariant natural killer T cells. Immunogenetics 68(8):649-63. DOI: 10.1007/s00251-016- 0944-8


Tan, T. G., E. Sefik, N. Geva-Zatorsky, L. Kua, D. Naskar, F. Teng, L. Pasman, A. Ortiz-Lopez, R. Jupp, H.-J. J. Wu, D. L. Kasper, C. Benoist, and D. Mathis. 2016. Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice. Proceedings of the National Academy of Sciences 113: E8141-E8150.


Sen, D.R., Kaminski, J., Barnitz, R.A., Kurachi, M., Gerdemann, U., Yates, K.B., Tsao, H., Godec, J., LaFleur, M.W., Brown, F.D., Tonnerre, P., Chung, R.T., Allen, T.M., Frahm, N., Lauer, G.M., Wherry, E.J., Yosef, N., and Haining, W.N. The Epigenetic Landscape of T Cell Exhaustion. Science 2016;354(6316):1165-1169. PMID: 27789799


Howitt MR, Lavoie S, Michaud M, Blum AM, Tran SV, Weinstock JV, Gallini CA, Redding K, Margolskee RF, Osborne LC, Artis D, Garrett WS. Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut. Science. 2016 Mar 18;351(6279):1329-33. doi: 10.1126/science.aaf1648. PMID: 26847546


Berrios C, Padi M, Keibler MA, Park DE, Molla V, Cheng J, Lee SM, Stephanopoulos G, Quackenbush J, DeCaprio JA. Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation. PLoS Pathog. 2016 Nov 23;12(11):e1006020. doi: 10.1371/journal.ppat.1006020. eCollection 2016 Nov 23. PMID: 27880818  read article


Penaloza MacMaster P, Shields JL, Alayo QA, Cabral C, Jimenez J, Mondesir J, Chandrashekar A, Cabral JM, Lim M, Iampietro MJ, Provine NM, Bricault CA, Seaman M, Orlinger K, Aspoeck A, Fuhrmann G, Lilja AE, Monath T, Mangeat B, Pinschewer DD, Barouch DH. Development of novel replication-defective lymphocytic choriomeningitis virus vectors expressing SIV antigens. Vaccine. 2017 Jan 3;35(1):1-9. doi: 10.1016/j.vaccine.2016.11.063. Epub 2016 Nov 26. read article


Rahbari NN, Kedrin D, Incio J, Liu H, Ho WW, Nia HT, Edrich CM, Jung K, Daubriac J, Chen I, Heishi T, Martin JD, Huang Y, Maimon N, Reissfelder C, Weitz J, Boucher Y, Clark JW, Grodzinsky AJ, Duda DG, Jain RK, Fukumura D. Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases. Sci Transl Med. 2016 Oct 12;8(360):360ra135. PMID: 27733559


Panduro M, Benoist C, Mathis D.Tissue Tregs. Annu Rev Immunol. 2016 May 20;34:609-33. doi: 10.1146/annurev-immunol-032712-095948. PMID: 27168246


Kuswanto W, Burzyn D, Panduro M, Wang KK, Jang YC, Wagers AJ, Benoist C, Mathis D. Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells. Immunity. 2016 Feb 16;44(2):355-67. doi: 10.1016/j.immuni.2016.01.009. Epub 2016 Feb 9. PMID: 26872699


Berrios C, Padi M, Keibler MA, Park DE, Molla V, Cheng J, Lee SM, Stephanopoulos G, Quackenbush J, DeCaprio JA. Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation. PLoS Pathog. 2016 Nov 23;12(11):e1006020. doi: 10.1371/journal.ppat. 1006020.


Nibert, M. L., Pyle, J. D., and Firth, A. E. 2016. A +1 ribosomal frameshifting motif prevalent among plant amalgaviruses. Virology. 498:201-208.


Sharaf R, Mempel TR, Murooka TT. Visualizing the Behavior of HIV-Infected T Cells In Vivo Using Multiphoton Intravital Microscopy. Methods Mol Biol. 2016;1354:189-201. doi: 10.1007/978-1-4939-3046-3_13. PMID: 26714713


Siwicki M, Engblom C, Pittet MJ. Gal3 Links Inflammation and Insulin Resistance. Cell Metab. 2016 Nov 8;24(5):655-656. doi: 10.1016/j.cmet.2016.10.014. PMID: 27829136


Gene control of tyrosine kinase TIE2 and vascular manifestations of infections. Ghosh CC, David S, Zhang R, Berghelli A, Milam K, Higgins SJ, Hunter J, Mukherjee A, Wei Y, Tran M, Suber F, Kobzik L, Kain KC, Lu S, Santel A, Yano K, Guha P, Dumont DJ, Christiani DC, Parikh SM. Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):2472-7. doi: 10.1073/pnas.1519467113. Epub 2016 Feb 16.


Singhal G, Fisher M, Tan TG, Fattah A, Adams A, Najaria R, Kulkarni R, Benoist C, Flier J, Maratos-Flier E. Fibroblast growth factor 21 (FGF21) protects against high fat diet induced inflammation and islet hyperplasia in pancreas. PLoS One 11(2): e0148252 (2016).


Lye MF, Wilkie AR, Filman DJ, Hogle JM, Coen DM. Getting to and through the inner nuclear membrane during herpesvirus nuclear egress. Curr Opin Cell Biol. 2017 Jan 10;46:9-16. doi: 10.1016/j.ceb.2016.12.007. [Epub ahead of print] Review. PMID: 28086162.


Wilkie AR, Lawler JL, Coen DM. A Role for Nuclear F-Actin Induction in Human Cytomegalovirus Nuclear Egress. MBio. 2016 Aug 23;7(4). pii: e01254-16. doi: 10.1128/mBio.01254-16. PMID: 27555312


Singer M, Wang C, Cong L, Marjanovic ND, Kowalczyk MS, Zhang H, Nyman J, Sakuishi K, Kurtulus S, Gennert D, Xia J, Kwon JY, Nevin J, Herbst RH, Yanai I, Rozenblatt-Rosen O, Kuchroo VK, Regev A, Anderson AC. A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells. Cell. 2016 Sep 8;166(6):1500-1511.e9. doi: 10.1016/j.cell.2016.08.052. PMID: 27610572


Liu C, Colón BC, Ziesack M, Silver PA, Nocera DG. Water splitting-biosynthetic system with CO₂ reduction efficiencies exceeding photosynthesis. Science. 2016 Jun 3;352(6290):1210-3. doi: 10.1126/science.aaf5039. PMID: 27257255


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2015


Kwon M, Bagonis M, Danuser G, Pellman D. Direct Microtubule-Binding by Myosin-10 Orients Centrosomes toward Retraction Fibers and Subcortical Actin Clouds. Dev Cell. 2015 Aug 10;34(3):323-37. doi: 10.1016/j.devcel.2015.06.013. PMID: 26235048  read article


Paulo JA, McAllister FE, Everley RA, Beausoleil SA, Banks AS, Gygi SP. Effects
of MEK inhibitors GSK1120212 and PD0325901 in vivo using 10-plex quantitative
proteomics and phosphoproteomics. Proteomics. 2015 Jan;15(2-3):462-73. doi:
10.1002/pmic.201400154. Epub 2014 Oct 18. PubMed PMID: 25195567; PubMed Central PMCID: PMC4515953.


Das PP, Hendrix DA, Apostolou E, Buchner AH, Canver MC, Beyaz S, Ljuboja D, Kuintzle R, Kim W, Karnik R, Shao Z, Xie H, Xu J, De Los Angeles A, Zhang Y, Choe J, Jun DL, Shen X, Gregory RI, Daley GQ, Meissner A, Kellis M, Hochedlinger K, Kim J, Orkin SH (2015) PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells. Cell Reports. 2015 Sep 1; 12;1-12.


Black JC, Atabakhsh E, Kim J, Biette KM, Van Rechem C, Ladd B, Burrowes PD, Donado C, Mattoo H, Kleinstiver BP, Song B, Andriani G, Joung JK, Iliopoulos O, Montagna C, Pillai S, Getz G, Whetstine JR. Hypoxia drives transient site-specific copy gain and drug-resistant gene expression. Genes Dev. 2015 May 15;29(10):1018-31. doi: 10.1101/gad.259796.115.


Vincent BJ, Scholes C, Staller MV, Wunderlich Z, Estrada J, Park J, Bragdon MD, Lopez Rivera F, Biette KM, DePace AH. Yearly planning meetings: individualized development plans aren't just more paperwork. Mol Cell. 2015 Jun 4;58(5):718-21. doi: 10.1016/j.molcel.2015.04.025.


Penaloza-MacMaster P, Provine NM, Blass E, Barouch DH. CD4 T Cell Depletion Substantially Augments the Rescue Potential of PD-L1 Blockade for Deeply Exhausted CD8 T Cells. J Immunol. 2015 Aug 1;195(3):1054-63. doi: 10.4049/jimmunol.1403237. Epub 2015 Jun 26. PMID: 26116499 PMCID: PMC4505958
 read article


Reeves RK, Li H, Jost S, Blass E, Li H, Schafer JL, Varner V, Manickam C, Eslamizar L, Altfeld M, von Andrian UH, Barouch DH. Antigen-specific NK cell memory in rhesus macaques. Nat Immunol. 2015 Sep;16(9):927-32. doi: 10.1038/ni.3227. Epub 2015 Jul 20. PMID: 26193080


Stable inhibitory activity of regulatory T cells requires the transcription factor Helios.
Kim HJ, Barnitz RA, Kreslavsky T, Brown FD, Moffett H, Lemieux ME, Kaygusuz Y, Meissner T, Holderried TA, Chan S, Kastner P, Haining WN, Cantor H.
Science. 2015 Oct 16;350(6258):334-9. doi: 10.1126/science.aad0616.
PMID:26472910


Fibroblastic reticular cells: organization and regulation of the T lymphocyte life cycle.
Brown FD, Turley SJ.J Immunol. 2015 Feb 15;194(4):1389-94. doi: 10.4049/jimmunol.1402520. Review.
PMID:25663676


Chow, j., Franz, K.M., Kagan, J.C. PRRs are watching you: Localization of innate sensing and signaling regulators.Virology. 2015 May;479-480:104-9. doi: 10.1016/j.virol.2015.02.051.


Conwell, SE, White, AE, Harper, JW, Knipe, DM. Identification of TRIM27 as a Novel Degradation Target of Herpes Simplex Virus 1 ICP0. J Virol. 2015 Jan;89(1):220-9. doi: 10.1128/JVI.02635-14. Epub 2014 Oct 15.PMID: 25320289 PMCID: PMC4301158  read article


Davis CP, West JA. Purification of Specific Chromatin Regions Using Oligonucleotides: Capture Hybridization Analysis of RNA Targets (CHART). Methods Mol Biol. 2015;1262:167-82. doi: 10.1007/978-1-4939-2253-6_10. PMID: 25555581


Dev J, Brüschweiler S, Ouyang B, Chou JJ. Transverse relaxation dispersion of the p7 membrane channel from hepatitis C virus reveals conformational breathing. J Biomol NMR. 2015 Apr;61(3-4):369-78. doi: 10.1007/s10858-015-9912-0. Epub 2015 Feb 28. PMID: 25724842 PMCID: 25724842 read article


Ziller MJ, Edri R, Yaffe Y, Donaghey J, Pop R, Mallard W, Issner R, Gifford CA, Goren A, Xing J, Gu H, Cacchiarelli D, Tsankov AM, Epstein C, Rinn JL, Mikkelsen TS, Kohlbacher O, Gnirke A, Bernstein BE, Elkabetz Y, Meissner A. Dissecting neural differentiation regulatory networks through epigenetic footprinting. Nature. 2015 Feb 19;518(7539):355-9. doi: 10.1038/nature13990. Epub 2014 Dec 24. PMID: 25533951 PMCID: PMC4336237


Eisner A, Pazyra-Murphy MF, Durresi E, Zhou P, Zhao X, Chadwick EC, Xu PX, Hillman RT, Scott MP, Greenberg ME, Segal RA. The Eya1 Phosphatase Promotes Shh Signaling during Hindbrain Development and Oncogenesis. Dev Cell. 2015 Apr 6;33(1):22-35. doi: 10.1016/j.devcel.2015.01.033. Epub 2015 Mar 26. PMID: 25816987 PMCID: PMC4418443


Emanuel AJ, Do MT. Melanopsin tristability for sustained and broadband phototransduction. Neuron. 2015 Mar 4;85(5):1043-55. doi: 10.1016/j.neuron.2015.02.011. PMID: 25741728 PMCID: PMC4351474


Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle. Miller MA, Gadde S, Pfirschke C, Engblom C, Sprachman MM, Kohler RH, Yang KS, Laughney AM, Wojtkiewicz G, Kamaly N, Bhonagiri S, Pittet MJ, Farokhzad OC, Weissleder R. Sci Transl Med. 2015 Nov 18;7(314):314ra183. doi: 10.1126/scitranslmed.aac6522.


Tumour-associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug. Miller MA, Zheng YR, Gadde S, Pfirschke C, Zope H, Engblom C, Kohler RH, Iwamoto Y, Yang KS, Askevold B, Kolishetti N, Pittet M, Lippard SJ, Farokhzad OC, Weissleder R. Nat Commun. 2015 Oct 27;6:8692. doi: 10.1038/ncomms9692.


Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy. Sistigu A, Yamazaki T, Vacchelli E, Chaba K, Enot DP, Adam J, Vitale I, Goubar A, Baracco EE, Remédios C, Fend L, Hannani D, Aymeric L, Ma Y, Niso-Santano M, Kepp O, Schultze JL, Tüting T, Belardelli F, Bracci L, La Sorsa V, Ziccheddu G, Sestili P, Urbani F, Delorenzi M, Lacroix-Triki M, Quidville V, Conforti R, Spano JP, Pusztai L, Poirier-Colame V, Delaloge S, Penault-Llorca F, Ladoire S, Arnould L, Cyrta J, Dessoliers MC, Eggermont A, Bianchi ME, Pittet M, Engblom C, Pfirschke C, Préville X, Uzè G, Schreiber RD, Chow MT, Smyth MJ, Proietti E, André F, Kroemer G, Zitvogel L. Nat Med. 2014 Nov;20(11):1301-9. doi: 10.1038/nm.3708. Epub 2014 Oct 26


Zhang, R., Borges, CM., Fan, M., Harris, JE., Turka, LA. (2015). Requirement for CD28 in effector regulatory T cell differentiation, CCR6 induction, and skin homing. The Journal of Immunology. 195: 4154-4161.


R Zhang, CM Borges, MY Fan, JE Harris, and LA Turka. Requirement for CD28 in effector regulatory T cell differentiation, CCR6 induction, and skin homing. The Journal of Immunology, 195(9). 2015. PMCID: PMC4610862


Garris CS, Pittet MJ ER Stress in Dendritic Cells Promotes Cancer.Cell. 2015;161(7):1492-3 - PMID: 26091029


Pfirschke C, Garris C, Pittet MJ Common TLR5 Mutations Control Cancer Progression. Cancer Cell. 2015;27(1):1-3 - PMID: 25584886


Prakash K. Gupta*, Jernej Godec*, David Wolski*, Emily Adland, Kathleen Yates, Cormac Cosgrove, Carola Ledderose, Wolfgang G. Junger, Simon C. Robson, E. John Wherry, Galit Alter, Philip J. R. Goulder, Paul Klenerman, Arlene H. Sharpe, Georg M. Lauer, W. Nicholas Haining. CD39 expression identifies terminally exhausted CD8+ T cells. PLOS Pathogens. 2015 Oct 20;11(10):e1005177. (PMID: 26485519).


Neil Ruparelia, Jernej Godec, Regent Lee, Joshua T. Chai, Erica Dall'Armellina, Debra McAndrew, Janet E. Digby, J. Colin Forfar, Bernard D. Prendergast, Rajesh K Kharbanda, Adrian P. Banning, Stefan Neubauer, Craig A. Lygate, Keith M. Channon, W. Nicholas Haining, Robin P. Choudhury. Acute myocardial infarction activates distinct inflammatory and proliferation pathways in circulating monocytes, prior to recruitment, identified through conserved transcriptional responses in mice and humans. European Heart Journal. 2015 Aug 1;36(29):1923-34. (PMID: 25982896).


Jernej Godec, Glenn S. Cowley, R. Anthony Barnitz, David E. Root, Arlene H. Sharpe, W. Nicholas Haining. Inducible RNAi in vivo reveals that BATF is required to initiate but not to maintain CD8+ T cell effector differentiation. Proceedings of the National Academy of Sciences USA. 2015 Jan 13;112(2):512-7. (PMID: 25548173)


Holoch D, Moazed D. RNA-mediated epigenetic regulation of gene expression. Nat Rev Genet. 2015 Feb;16(2):71-84. doi: 10.1038/nrg3863. Epub 2015 Jan 2. PMID: 25554358


Hwang JK*, Alt FW, Yeap LS*. Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination. Microbiology Spectrum. 2015 Feb;3(1). doi: 10.1128/microbiolspec.MDNA3-0037-2014. *Equal contribution.


Yeap, LS*, Hwang JK*, Du Z, Meyers RM, Meng FL, Jakubauskaite, A, Liu M, Mani V, Neuberg D, Kepler TB, Wang, JH and Alt FW Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody Genes. Cell, 2015, 163 (5): 1124-37. *Equal contribution.


Schmidt SC, Jiang S, Zhou H, Willox B, Holthaus AM, Kharchenko PV, Johannsen
EC, Kieff E, Zhao B. Epstein-Barr virus nuclear antigen 3A partially coincides
with EBNA3C genome-wide and is tethered to DNA through BATF complexes. Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):554-9. doi: 10.1073/pnas.1422580112. Epub 2014 Dec 24. PubMed PMID: 25540416; PubMed Central PMCID: PMC4299249.
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Zhou H, Schmidt SC, Jiang S, Willox B, Bernhardt K, Liang J, Johannsen EC,
Kharchenko P, Gewurz BE, Kieff E, Zhao B. Epstein-Barr virus oncoprotein
super-enhancers control B cell growth. Cell Host Microbe. 2015 Feb
11;17(2):205-16. doi: 10.1016/j.chom.2014.12.013. Epub 2015 Jan 29. PubMed PMID:
25639793.
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Luo LY, Kim E, Cheung HW, Weir BA, Dunn GP, Shen RR, Hahn WC. The Tyrosine Kinase Adaptor Protein FRS2 Is Oncogenic and Amplified in High-Grade Serous Ovarian Cancer. Mol Cancer Res. 2015 Mar;13(3):502-9. doi: 10.1158/1541-7786.MCR-14-0407. Epub 2014 Nov 3. PMID: 25368431 PMCID: PMC4369154


Chun E, Lavoie S, Michaud M, Gallini CA, Kim J, Soucy G, Odze R, Glickman JN, Garrett WS. CCL2 Promotes Colorectal Carcinogenesis by Enhancing Polymorphonuclear Myeloid-Derived Suppressor Cell Population and Function. Cell Rep. 2015 Jul 14;12(2):244-57. doi: 10.1016/j.celrep.2015.06.024. PMID: 26146082  read article


Lian J, Luster AD. Chemokine-guided cell positioning in the lymph node orchestrates the generation of adaptive immune responses. Curr Opin Cell Biol. 2015 Oct;36:1-6. doi: 10.1016/j.ceb.2015.05.003. Review. PMID: 26067148  read article


Kugelman JR, Sanchez-Lockhart M, Andersen KG, Gire S, Park DJ, Sealfon R, Lin AE, Wohl S, Sabeti PC, Kuhn JH, Palacios GF. Evaluation of the potential impact of Ebola virus genomic drift on the efficacy of sequence-based candidate therapeutics. MBio. 2015 Jan 20;6(1). pii: e02227-14. doi: 10.1128/mBio.02227-14. PMID: 25604787
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Park DJ, Dudas G, Wohl S, Goba A, Whitmer SL, Andersen KG, Sealfon RS, Ladner JT, Kugelman JR, Matranga CB, Winnicki SM, Qu J, Gire SK, Gladden-Young A, Jalloh S, Nosamiefan D, Yozwiak NL, Moses LM, Jiang PP, Lin AE, Schaffner SF, Bird B, Towner J, Mamoh M, Gbakie M, Kanneh L, Kargbo D, Massally JL, Kamara FK, Konuwa E, Sellu J, Jalloh AA, Mustapha I, Foday M, Yillah M, Erickson BR, Sealy T, Blau D, Paddock C, Brault A, Amman B, Basile J, Bearden S, Belser J, Bergeron E, Campbell S, Chakrabarti A, Dodd K, Flint M, Gibbons A, Goodman C, Klena J, McMullan L, Morgan L, Russell B, Salzer J, Sanchez A, Wang D, Jungreis I, Tomkins-Tinch C, Kislyuk A, Lin MF, Chapman S, MacInnis B, Matthews A, Bochicchio J, Hensley LE, Kuhn JH, Nusbaum C, Schieffelin JS, Birren BW, Forget M, Nichol ST, Palacios GF, Ndiaye D, Happi C, Gevao SM, Vandi MA, Kargbo B, Holmes EC, Bedford T, Gnirke A, Ströher U, Rambaut A, Garry RF, Sabeti PC Ebola Virus Epidemiology, Transmission, and Evolution during Seven Months in Sierra Leone. Cell. 2015 Jun 18;161(7):1516-26. doi: 10.1016/j.cell.2015.06.007. PMID: 26091036 read article


Andersen KG, Shapiro BJ, Matranga CB, Sealfon R, Lin AE, Moses LM, Folarin OA, Goba A, Odia I, Ehiane PE, Momoh M, England EM, Winnicki S, Branco LM, Gire SK, Phelan E, Tariyal R, Tewhey R, Omoniwa O, Fullah M, Fonnie R, Fonnie M, Kanneh L, Jalloh S, Gbakie M, Saffa S, Karbo K, Gladden AD, Qu J, Stremlau M, Nekoui M, Finucane HK, Tabrizi S, Vitti JJ, Birren B, Fitzgerald M, McCowan C, Ireland A, Berlin AM, Bochicchio J, Tazon-Vega B, Lennon NJ, Ryan EM, Bjornson Z, Milner DA Jr, Lukens AK, Broodie N, Rowland M, Heinrich M, Akdag M, Schieffelin JS, Levy D, Akpan H, Bausch DG, Rubins K, McCormick JB, Lander ES, Günther S, Hensley L, Okogbenin S; Viral Hemorrhagic Fever Consortium., Schaffner SF, Okokhere PO, Khan SH, Grant DS, Akpede GO, Asogun DA, Gnirke A, Levin JZ, Happi CT, Garry RF, Sabeti PC. Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus. Cell. 2015 Aug 13;162(4):738-50. doi: 10.1016/j.cell.2015.07.020. PMID: 26276630 read article


Gierut JJ, Wood LB, Lau KS, Lin YJ, Genetti C, Samatar AA, Lauffenburger DA, Haigis KM. Network-level effects of kinase inhibitors modulate TNF-α-induced apoptosis in the intestinal epithelium. Sci Signal. 2015 Dec 15;8(407):ra129. doi: 10.1126/scisignal.aac7235. PMID: 26671150 PMCID: PMC4812576 read article


Mandel-Brehm C, Salogiannis J, Dhamne SC, Rotenberg A, Greenberg ME. Seizure-like activity in a juvenile Angelman syndrome mouse model is attenuated by reducing Arc expression. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5129-34. doi: 10.1073/pnas.1504809112. Epub 2015 Apr 6. PMID: 25848016 PMCID: PMC4413330


K.T.C. Shade, B. Platzer, N. Washburn, V. Mani, Y. Bartsch, M. Conroy, J.D. Pagan, C. Bosques, T.R. Mempel, E. Fiebiger, R. M. Anthony. A Single Glycan on IgE is Indispensable for Initiation of Anaphylaxis. Journal of Experimental Medicine, 2015; DOI: 10.1064/jem.20142182


L.S. Yeap*, J. Hwang*, R.M. Meyers, A. Jakubauskaite, M. Liu, V. Mani, T.B. Kepler, J. Wang, F.W.Alt. Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody Genes. Cell, 2015;163(5):1124- 37. doi: 10.1016/j.cell.2015.10.042.


Madhavan R, Millman D, Tang H, Crone N, Lenz F, Tierney T, Madsen J, Kreiman G, Anderson W. Decrease in gamma-band activity tracks sequence learning. Front Syst Neurosci. 2015 Jan 21;8:222. doi: 10.3389/fnsys.2014.00222. eCollection 2014. PMID: 25653598 PMCID: PMC4300908 read article


Platzer B, Baker K, Vera MP, Singer K, Panduro M, Lexmond WS, Turner D, Vargas SO, Kinet JP, Maurer D, Baron RM, Blumberg RS, Fiebiger E. Dendritic cell-bound IgE functions to restrain allergic inflammation at mucosal sites. Mucosal Immunol. 2015 May;8(3):516-32. doi: 10.1038/mi.2014.85.


Chau KF, Springel MW, Broadbelt KG, Park HY, Topal S, Lun MP, Mullan H, Maynard T, Steen H, LaMantia AS, Lehtinen MK. Progressive Differentiation and Instructive Capacities of Amniotic Fluid and Cerebrospinal Fluid Proteomes following Neural Tube Closure. Dev Cell. 2015 Dec 21;35(6):789-802. doi: 10.1016/j.devcel.2015.11.015. PMID: 26702835


Muona M, Berkovic SF, Dibbens LM, Oliver KL, Maljevic S, Bayly MA, Joensuu T, Canafoglia L, Franceschetti S, Michelucci R, Markkinen S, Heron SE, Hildebrand MS, Andermann E, Andermann F, Gambardella A, Tinuper P, Licchetta L, Scheffer IE, Criscuolo C, Filla A, Ferlazzo E, Ahmad J, Ahmad A, Baykan B, Said E, Topcu M, Riguzzi P, King MD, Ozkara C, Andrade DM, Engelsen BA, Crespel A, Lindenau M, Lohmann E, Saletti V, Massano J, Privitera M, Espay AJ, Kauffmann B, Duchowny M, Møller RS, Straussberg R, Afawi Z, Ben-Zeev B, Samocha KE, Daly MJ, Petrou S, Lerche H, Palotie A, Lehesjoki AE. A recurrent de novo mutation in KCNC1 causes progressive myoclonus epilepsy. Nat Genet. 2015 Jan;47(1):39-46. doi: 10.1038/ng.3144. Epub 2014 Nov 17. PMID: 25401298 PMCID: PMC4281260


San Roman, A.K., Aaronson, B.E., Krasinski, S.D., Shivdasani, R.A., and Verzi, M.P. Transcription factors GATA4 and HNF4A control distinct aspects of intestinal homeostasis in conjunction with transcription factor CDX2. J Biol Chem. 2015 Jan 16;290(3):1850-60. doi: 10.1074/jbc.M114.620211. Epub 2014 Dec 8. PMID: 25488664 PMCID: PMC4340426


Murooka TT, Sharaf RR, Mempel TR. Large Syncytia in Lymph Nodes Induced by CCR5-Tropic HIV-1. AIDS Res Hum Retroviruses. 2015 May;31(5):471-2. doi: 10.1089/aid.2014.0378. Epub 2015 Apr 2. No abstract available. PMID: 25835064  read article


Chang RB, Strochlic DE, Williams EK, Umans BD, Liberles SD. Vagal Sensory Neuron Subtypes that Differentially Control Breathing. Cell. 2015 Apr 23;161(3):622-33. doi: 10.1016/j.cell.2015.03.022. Epub 2015 Apr 16. PMID: 2589222


Chiu IM, Barrett LB, Williams EK, Strochlic DE, Lee S, Weyer AD, Lou S, Bryman G, Roberson DP, Ghasemlou N, Piccoli C, Ahat E, Wang V, Cobos EJ, Stucky CL, Ma Q, Liberles SD, Woolf C. Correction: Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity. Elife. 2015 Feb 6;4:e06720. doi: 10.7554/eLife.06720. PMID: 25658835 PMCID: PMC4337598 read article


Vicuña L, Strochlic DE, Latremoliere A, Bali KK, Simonetti M, Husainie D, Prokosch S, Riva P, Griffin RS, Njoo C, Gehrig S, Mall MA, Arnold B, Devor M, Woolf CJ, Liberles SD, Costigan M, Kuner R. The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase. Nat Med. 2015 May;21(5):518-23. doi: 10.1038/nm.3852. Epub 2015 Apr 27. PMID: 25915831


Yazawa EM, Geddes-Sweeney JE, Cedeno-Laurent F, Walley KC, Barthel SR, Opperman MJ, Liang J, Lin JY, Schatton T, Laga AC, Mihm MC, Qureshi AA, Widlund HR, Murphy GF, Dimitroff CJ. Melanoma Cell Galectin-1 Ligands Functionally Correlate with Malignant Potential. J Invest Dermatol. 2015 Jul;135(7):1849-62. PMID: 25756799


Trott AR, Born RT. Input-gain control produces feature-specific surround suppression. J Neurosci. 2015 Mar 25;35(12):4973-82. doi: 10.1523/JNEUROSCI.4000-14.2015. PMID: 25810527 PMCID: PMC4389596


Staller MV, Vincent BJ, Bragdon MD, Lydiard-Martin T, Wunderlich Z, Estrada J, DePace AH. Shadow enhancers enable Hunchback bifunctionality in the Drosophila embryo. Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):785-90. doi: 10.1073/pnas.1413877112. Epub 2015 Jan 6. PMID: 25564665 PMCID: PMC4311800 read article


MUCOSAL IMMUNOLOGY. Individual intestinal symbionts induce a distinct population of RORγ⁺ regulatory T cells. Sefik E, Geva-Zatorsky N, Oh S, Konnikova L, Zemmour D, McGuire AM, Burzyn D, Ortiz-Lopez A, Lobera M, Yang J, Ghosh S, Earl A, Snapper SB, Jupp R, Kasper D, Mathis D, Benoist C. Science. 2015 Aug 28;349(6251):993-7. doi: 10.1126/science.aaa9420. Epub 2015 Aug 13.


Meredith M, Zemmour D, Mathis D, Benoist C. Aire controls gene expression in the thymic epithelium with ordered stochasticity. Nat Immunol. 2015 Sep;16(9):942-9. doi: 10.1038/ni.3247. Epub 2015 Aug 3.


Hays SG, Patrick WG, Ziesack M, Oxman N, Silver PA. Better together: engineering and application of microbial symbioses. Curr Opin Biotechnol. 2015 Dec;36:40-9. doi: 10.1016/j.copbio.2015.08.008. Epub 2015 Aug 28. Review. PMID: 26319893


top

2014


Lee DH, Acharya SS, Kwon M, Drane P, Guan Y, Adelmant G, Kalev P, Shah J, Pellman D, Marto JA, Chowdhury D. Dephosphorylation Enables the Recruitment of 53BP1 to Double-Strand DNA Breaks. Mol Cell. 2014 May 8;54(3):512-25. doi: 10.1016/j.molcel.2014.03.020. Epub 2014 Apr 3. PMID: 24703952 PMCID: PMC4030556


Amamoto, R, Arlotta, P. Development-Inspired Reprogramming of the Central Nervous System. Science. Science. 2014 Jan 31;343(6170):1239882. doi: 10.1126/science.1239882. PMID: 24482482 PMCID: PMC4122114 read article


Lee JH, Daugharthy ER, Scheiman J, Kalhor R, Yang JL, Ferrante TC, Terry R, Jeanty SS, Li C, Amamoto R, Peters DT, Turczyk BM, Marblestone AH, Inverso SA, Bernard A, Mali P, Rios X, Aach J, Church GM. (2014). Highly multiplexed subcellular RNA sequencing in situ. Science. 2014 Mar 21;343(6177):1360-3. doi: 10.1126/science.1250212. Epub 2014 Feb 27. PMID: 24578530 PMCID:PMC4140943 read article


Ben-Zvi A, Lacoste B, Kur E, Andreone BJ, Mayshar Y, Yan H, Gu C. Mfsd2a is critical for the formation and function of the blood-brain barrier. Nature. 2014 May 22;509(7501):507-11. doi: 10.1038/nature13324. Epub 2014 May 14. PMID: 24828040


Tschopp P, Sherratt E, Sanger TJ, Groner AC, Aspiras AC, Hu JK, Pourquié O, Gros J, Tabin CJ. A relative shift in cloacal location repositions external genitalia in amniote evolution. Nature. 2014 Dec 18;516(7531):391-4. doi: 10.1038/nature13819. Epub 2014 Nov 5. PMID: 25383527


Bauer BW, Shemesh T, Chen Y, Rapoport TA. A "push and slide" mechanism allows sequence-insensitive translocation of secretory proteins by the SecA ATPase. Cell. 2014 Jun 5;157(6):1416-29. doi: 10.1016/j.cell.2014.03.063. PMID: 24906156 PMCID: PMC4104599


Knyazev DG, Winter L, Bauer BW, Siligan C, Pohl P. Ion conductivity of the bacterial translocation channel SecYEG engaged in translocation. J Biol Chem. 2014 Aug 29;289(35):24611-6. doi: 10.1074/jbc.M114.588491. Epub 2014 Jul 11. PMID: 25016015 PMCID: PMC4148884 read article


Ordureau A, Sarraf SA, Duda DM, Heo JM, Jedrychowski MP, Sviderskiy VO,
Olszewski JL, Koerber JT, Xie T,
Beausoleil SA, Wells JA, Gygi SP, Schulman BA, Harper JW. Quantitative proteomics reveal a feedforward mechanism for
mitochondrial PARKIN translocation and ubiquitin chain synthesis. Mol Cell. 2014 Nov 6;56(3):360-75. doi: 10.1016/j.molcel.2014.09.007. Epub 2014 Oct 2. Erratum in: Mol Cell. 2014 Nov 6;56(3):462. PubMed PMID: 25284222; PubMed Central PMCID:
PMC4254048.


Beliveau BJ, Apostolopoulos N, Wu CT. Visualizing genomes with Oligopaint FISH probes. Curr Protoc Mol Biol. 2014 Jan 6;105:Unit 14.23.. doi: 10.1002/0471142727.mb1423s105. PMID: 24510436 PMCID: PMC3928790


Das PP, Shao Z, Beyaz S, Apostolou E, Pinello Angeles Ade L, O'Brien K, Atsma JM, Fujiwara Y, Nguyen M, Ljuboja D, Guo G, Woo A, Yuan GC, Onder T, Daley G, Hochedlinger K, Kim J, Orkin SH. Distinct and combinatorial functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in mouse embryonic stem cell identity. Mol Cell. 2014 Jan 9;53(1):32-48. doi: 10.1016/j.molcel.2013.11.011. Epub 2013 Dec 19. PMID: 24361252 PMCID: PMC3919500


Haspot F, Li HW, Lucas CL, Fehr T, Beyaz S, Sykes M. Allospecific rejection of MHC class I-deficient bone marrow by CD8 T cells. Am J Transplant. 2014 Jan;14(1):49-58. doi: 10.1111/ajt.12525. Epub 2013 Dec 4. PMID: 24304495 PMCID: PMC4045013


Bonham KS, Kagan JC. Endosomes as Platforms for NOD-like Receptor Signaling. Cell Host Microbe. 2014 May 14;15(5):523-5. doi: 10.1016/j.chom.2014.05.001. PMID: 24832447


Bonham KS, Orzalli MH, Hayashi K, Wolf AI, Glanemann C, Weninger W, Iwasaki A, Knipe DM, Kagan JC. A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction. Cell. 2014 Feb 13;156(4):705-16. doi: 10.1016/j.cell.2014.01.019. PMID: 24529375 PMCID: PMC3951743


Nunes-Alves C, Booty MG, Carpenter SM, Jayaraman P, Rothchild AC, Behar SM. In search of a new paradigm for protective immunity to TB. Nat Rev Microbiol. 2014 Apr;12(4):289-99. doi: 10.1038/nrmicro3230. Epub 2014 Mar 3. PMID: 24590243


Lymph node fibroblastic reticular cell transplants show robust therapeutic efficacy in high-mortality murine sepsis. Fletcher AL, Elman JS, Astarita J, Murray R, Saeidi N, D'Rozario J, Knoblich K, Brown FD, Schildberg FA, Nieves JM, Heng TS, Boyd RL, Turley SJ, Parekkadan B.
Sci Transl Med. 2014 Aug 13;6(249):249ra109. doi: 10.1126/scitranslmed.3009377.
PMID:25122637


Bryant DM, O'Meara CC, Ho NN, Gannon J, Cai L, Lee RT. A systematic analysis of neonatal mouse heart regeneration after apical resection. J Mol Cell Cardiol. 2014 Dec 19;79C:315-318. doi: 10.1016/j.yjmcc.2014.12.011. [Epub ahead of print] PMID: 25533939


Pauli EK, Chan YK, Davis ME, Gableske S, Wang MK, Feister KF, Gack MU. The ubiquitin-specific protease USP15 promotes RIG-I-mediated antiviral signaling by deubiquitylating TRIM25. Sci Signal. 2014 Jan 7;7(307):ra3. doi: 10.1126/scisignal.2004577. PMID: 24399297 PMCID: PMC4008495
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Gostissa M, Schwer B, Chang A, Dong J, Meyers RM, Marecki GT, Choi VW, Chiarle R, Zarrin AA, Alt FW. IgH class switching exploits a general property of two DNA breaks to be joined in cis over long chromosomal distances. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2644-9. doi: 10.1073/pnas.1324176111. Epub 2014 Feb 3. PMID: 24550291 PMCID: 24550291 read article


Chang, Jonathan E; Turley, Shannon J. Stromal infrastructure of the lymph node and coordination of immunity. Trends in immunology, 2014, ISSN: 1471-4906


Chen JW, Galloway JL. The development of zebrafish tendon and ligament progenitors. Development. 2014 May;141(10):2035-45. doi: 10.1242/dev.104067. PMID: 24803652 PMCID: PMC4011085


Choi JE, Mostoslavsky R. Sirtuins, metabolism, and DNA repair. Curr Opin Genet Dev. 2014 Jun;26C:24-32. doi: 10.1016/j.gde.2014.05.005. Epub 2014 Jul 5. PMID: 25005742 PMCID: PMC4254145


Choi Y, Mango SE. Hunting for Darwin's gemmules and Lamarck's fluid: Transgenerational signaling and histone methylation. Biochim Biophys Acta. 2014 May 21. pii: S1874-9399(14)00117-5. doi: 10.1016/j.bbagrm.2014.05.011. [Epub ahead of print] PMID: 24859459


Jamuar SS, Lam AT, Kircher M, D'Gama AM, Wang J, Barry BJ, Zhang X, Hill RS, Partlow JN, Rozzo A, Servattalab S, Mehta BK, Topcu M, Amrom D, Andermann E, Dan B, Parrini E, Guerrini R, Scheffer IE, Berkovic SF, Leventer RJ, Shen Y, Wu BL, Barkovich AJ, Sahin M, Chang BS, Bamshad M, Nickerson DA, Shendure J, Poduri A, Yu TW, Walsh CA. Somatic mutations in cerebral cortical malformations. N Engl J Med. 2014 Aug 21;371(8):733-43. doi: 10.1056/NEJMoa1314432. PMID: 25140959 PMCID: PMC4274952


Davila SJ, Olive AJ, Starnbach MN. Integrin α4β1 is necessary for CD4+ T cell-mediated protection against genital Chlamydia trachomatis infection. J Immunol. 2014 May 1;192(9):4284-93. doi: 10.4049/jimmunol.1303238. Epub 2014 Mar 21. PMID: 24659687 PMCID: PMC3995848


West JA, Davis CP, Sunwoo H, Simon MD, Sadreyev RI, Wang PI, Tolstorukov MY, Kingston RE. The long noncoding RNAs NEAT1 and MALAT1 bind active chromatin sites. Mol Cell. 2014 Sep 4;55(5):791-802. doi: 10.1016/j.molcel.2014.07.012. Epub 2014 Aug 21. PMID: 25155612


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Davis ME, Wang MK, Rennick LJ, Full F, Gableske S, Mesman AW, Gringhuis SI, Geijtenbeek TB, Duprex WP, Gack MU. Antagonism of the phosphatase PP1 by the measles virus V protein is required for innate immune escape of MDA5. Cell Host Microbe. 2014 Jul 9;16(1):19-30. doi: 10.1016/j.chom.2014.06.007 PMID: 25011105 PMCID: PMC4120867


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Donahue RJ, Muschamp JW, Russo SJ, Nestler EJ, Carlezon WA Jr. Effects of Striatal ΔFosB Overexpression and Ketamine on Social Defeat Stress-Induced Anhedonia in Mice. Biol Psychiatry. 2014 Jan 8. pii: S0006-3223(14)00004-3. doi: 10.1016/j.biopsych.2013.12.014. [Epub ahead of print] PMID: 24495460


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Janzer A, German NJ, Gonzalez-Herrera KN, Asara JM, Haigis MC, Struhl K. Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10574-9. doi: 10.1073/pnas.1409844111. Epub 2014 Jul 7. PMID: 25002509 PMCID: PMC4115496 read article


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Guth CA, Sodroski J. Contribution of PDZD8 to stabilization of the human immunodeficiency virus type 1 capsid. J Virol. 2014 May;88(9):4612-23. doi: 10.1128/JVI.02945-13. Epub 2014 Feb 19. PMID: 24554657 PMCID: PMC3993830


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Rohlfing AE, Dove SL. Coordinate control of virulence gene expression in Francisella tularensis involves direct interaction between key regulators. J Bacteriol. 2014 Oct;196(19):3516-26. doi: 10.1128/JB.01700-14. Epub 2014 Jul 28. PMID: 25070738 PMCID: PMC4187675


Batal I, Azzi J, Mounayar M, Abdoli R, Moore R, Lee JY, Rosetti F, Wang C, Fiorina P, Sackstein R, Ichimura T, Abdi R. The mechanisms of up-regulation of dendritic cell activity by oxidative stress. J Leukoc Biol. 2014 Mar 27. [Epub ahead of print] PMID: 24676276


Rothchild AC, Jayaraman P, Nunes-Alves C, Behar SM. iNKT cell production of GM-CSF controls Mycobacterium tuberculosis. PLoS Pathog. 2014 Jan;10(1):e1003805. doi: 10.1371/journal.ppat.1003805. Epub 2014 Jan 2. PMID: 24391492 PMCID: PMC3879349 read article


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Slowikowski K, Hu X, Raychaudhuri S. SNPsea: an algorithm to identify cell types, tissues and pathways affected by risk loci. Bioinformatics. 2014 Sep 1;30(17):2496-7. doi: 10.1093/bioinformatics/btu326. Epub 2014 May 10. PMID: 24813542 PMCID: PMC4147889 read article


Lee MN, Ye C, Villani AC, Raj T, Li W, Eisenhaure TM, Imboywa SH, Chipendo PI, Ran FA, Slowikowski K, Ward LD, Raddassi K, McCabe C, Lee MH, Frohlich IY, Hafler DA, Kellis M, Raychaudhuri S, Zhang F, Stranger BE, Benoist CO, De Jager PL, Regev A, Hacohen N. Common genetic variants modulate pathogen-sensing responses in human dendritic cells. Science. 2014 Mar 7;343(6175):1246980. doi: 10.1126/science.1246980. PMID: 24604203 PMCID: PMC4124741 read article


Patel N, Smith LL, Faqeih E, Mohamed J, Gupta VA, Alkuraya FS. ZBTB42 mutation defines a novel lethal congenital contracture syndrome (LCCS6). Hum Mol Genet. 2014 Dec 15;23(24):6584-93. doi: 10.1093/hmg/ddu384. Epub 2014 Jul 23. PMID: 25055871
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Smith LL, Gupta VA, Beggs AH. Bridging integrator 1 (Bin1) deficiency in zebrafish results in centronuclear myopathy. Hum Mol Genet. 2014 Jul 1;23(13):3566-78. doi: 10.1093/hmg/ddu067. Epub 2014 Feb 18. PMID: 24549043 PMCID: PMC4049309


Srikanth P, Young-Pearse TL. Stem Cells on the Brain: Modeling Neurodevelopmental and Neurodegenerative Diseases Using Human Induced Pluripotent Stem Cells. J Neurogenet. 2014 Mar-Jun;28(1-2):5-29. doi: 10.3109/01677063.2014.881358. Epub 2014 Mar 17. PMID: 24628482 PMCID: PMC4285381 read article


Tata A, Stoppel DC, Hong S, Ben-Zvi A, Xie T, Gu C. An image-based RNAi screen identifies SH3BP1 as a key effector of Semaphorin 3E-PlexinD1 signaling. J Cell Biol. 2014 May 26;205(4):573-590. Epub 2014 May 19. PMID: 24841563


Krashes MJ, Shah BP, Madara JC, Olson DP, Strochlic DE, Garfield AS, Vong L, Pei H, Watabe-Uchida M, Uchida N, Liberles SD, Lowell BB. An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger. Nature. 2014 Mar 13;507(7491):238-42. doi: 10.1038/nature12956. Epub 2014 Feb 2. PMID: 24487620 PMCID: PMC3955843


Marusyk A, Tabassum DP, Altrock PM, Almendro V, Michor F, Polyak K. Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity. Nature. 2014 Oct 2;514(7520):54-8. doi: 10.1038/nature13556. Epub 2014 Jul 30. PMID: 25079331
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Joller N, Lozano E, Burkett PR, Patel B, Xiao S, Zhu C, Xia J, Tan TG, Sefik E, Yajnik V, Sharpe AH, Quintana FJ, Mathis D, Benoist C, Hafler DA, Kuchroo VK. Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses. Immunity. 2014 Apr 17;40(4):569-81. doi: 10.1016/j.immuni.2014.02.012. PMID: 24745333


Tang Q, Abdelfattah NS, Blackburn JS, Moore JC, Martinez SA, Moore FE, Lobbardi R, Tenente IM, Ignatius MS, Berman JN, Liwski RS, Houvras Y, Langenau DM. Optimized cell transplantation using adult rag2 mutant zebrafish. Nat Methods. 2014 Aug;11(8):821-4. doi: 10.1038/nmeth.3031. Epub 2014 Jul 20. PMID: 25042784 PMCID: PMC4294527 read article


Tenente IM, Tang Q, Moore JC, Langenau DM. Normal and malignant muscle cell transplantation into immune compromised adult zebrafish. J Vis Exp. 2014 Dec 26;(94). doi: 10.3791/52597. PMID: 25591079 PMCID: PMC4354485 read article


Eshel N, Tian J. Dopamine gates sensory representations in cortex. J Neurophysiol. 2014 Jun 1;111(11):2161-3. doi: 10.1152/jn.00795.2013. Epub 2014 Jan 8. PMID: 24401705


Born RT, Trott AR, Hartmann TS. Cortical magnification plus cortical plasticity equals vision? Vision Res. 2014 Oct 16. pii: S0042-6989(14)00235-1. doi: 10.1016/j.visres.2014.10.002. [Epub ahead of print] PMID: 25449335 PMCID: PMC4400204


Spiegel I, Mardinly AR, Gabel HW, Bazinet JE, Couch CH, Tzeng CP, Harmin DA, Greenberg ME. Npas4 Regulates Excitatory-Inhibitory Balance within Neural Circuits through Cell-Type-Specific Gene Programs. Cell. 2014 May 22;157(5):1216-29. doi: 10.1016/j.cell.2014.03.058. PMID: 24855953


Teo AK, Valdez IA, Dirice E, Kulkarni RN. Comparable generation of activin-induced definitive endoderm via additive Wnt or BMP signaling in absence of serum. Stem Cell Reports. 2014 Jun 12;3(1):5-14. doi: 10.1016/j.stemcr.2014.05.007. eCollection 2014. PMID: 25068117 PMCID: PMC4110751 read article


Berger AH, Imielinski M, Duke F, Wala J, Kaplan N, Shi GX, Andres DA, Meyerson M. Oncogenic RIT1 mutations in lung adenocarcinoma. Oncogene. 2014 Jan 27. doi: 10.1038/onc.2013.581. [Epub ahead of print] PMID: 24469055


Helming KC, Wang X, Wilson BG, Vazquez F, Haswell JR, Manchester HE, Kim Y, Kryukov GV, Ghandi M, Aguirre AJ, Jagani Z, Wang Z, Garraway LA, Hahn WC, Roberts CW. ARID1B is a specific vulnerability in ARID1A-mutant cancers. Nat Med. 2014 Mar;20(3):251-4. doi: 10.1038/nm.3480. Epub 2014 Feb 23. PMID: 24562383 PMCID: PMC3954704 read article


Wilson BG, Helming KC, Wang X, Kim Y, Vazquez F, Jagani Z, Hahn WC, Roberts CW. Residual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutation. Mol Cell Biol. 2014 Mar;34(6):1136-44. doi: 10.1128/MCB.01372-13. Epub 2014 Jan 13. PMID: 24421395 PMCID: PMC3958034 read article


Helming KC, Wang X, Roberts CW. Vulnerabilities of mutant SWI/SNF complexes in cancer. Cancer Cell. 2014 Sep 8;26(3):309-17. doi: 10.1016/j.ccr.2014.07.018. PMID: 25203320 PMCID: PMC4159614


Bae BI, Tietjen I, Atabay KD, Evrony GD, Johnson MB, Asare E, Wang PP, Murayama AY, Im K, Lisgo SN, Overman L, Sestan N, Chang BS, Barkovich AJ, Grant PE, Topçu M, Politsky J, Okano H, Piao X, Walsh CA. Evolutionarily dynamic alternative splicing of GPR56 regulates regional cerebral cortical patterning. Science. 2014 Feb 14;343(6172):764-8. doi: 10.1126/science.1244392. PMID: 24531968


Rooks MG, Veiga P, Wardwell-Scott LH, Tickle T, Segata N, Michaud M, Gallini CA, Beal C, van Hylckama-Vlieg JE, Ballal SA, Morgan XC, Glickman JN, Gevers D, Huttenhower C, Garrett WS. Gut microbiome composition and function in experimental colitis during active disease and treatment-induced remission. ISME J. 2014 Jul;8(7):1403-17. doi: 10.1038/ismej.2014.3. Epub 2014 Feb 6. PMID: 24500617 PMCID: PMC4069400 read article


Kye MJ, Niederst ED, Wertz MH, Gonçalves Ido C, Akten B, Dover KZ, Peters M, Riessland M, Neveu P, Wirth B, Kosik KS, Sardi SP, Monani UR, Passini MA, Sahin M. SMN regulates axonal local translation via miR-183/mTOR pathway. Hum Mol Genet. 2014 Dec 1;23(23):6318-31. doi: 10.1093/hmg/ddu350. Epub 2014 Jul 4. PMID: 25055867 PMCID: PMC4271102


Di Nardo A, Wertz MH, Kwiatkowski E, Tsai PT, Leech JD, Greene-Colozzi E, Goto J, Dilsiz P, Talos DM, Clish CB, Kwiatkowski DJ, Sahin M. Neuronal Tsc1/2 complex controls autophagy through AMPK-dependent regulation of ULK1. Hum Mol Genet. 2014 Jul 15;23(14):3865-74. doi: 10.1093/hmg/ddu101. Epub 2014 Mar 5. PMID: 24599401 PMCID: PMC4065158


Kong SW, Sahin M, Collins CD, Wertz MH, Campbell MG, Leech JD, Krueger D, Bear MF, Kunkel LM, Kohane IS. Divergent dysregulation of gene expression in murine models of fragile X syndrome and tuberous sclerosis. Mol Autism. 2014 Feb 24;5(1):16. doi: 10.1186/2040-2392-5-16. PMID: 24564913 PMCID: PMC3940253 read article


Kim DY, Wertz MH, Gautam V, D'Avanzo C, Bhattacharyya R, Kovacs DM. The E280A presenilin mutation reduces voltage-gated sodium channel levels in neuronal cells. Neurodegener Dis. 2014;13(2-3):64-8. doi: 10.1159/000354669. Epub 2013 Nov 5. PMID: 24217025 PMCID: PMC3940070 read article


Wainger BJ, Kiskinis E, Mellin C, Wiskow O, Han SS, Sandoe J, Perez NP, Williams LA, Lee S, Boulting G, Berry JD, Brown RH Jr, Cudkowicz ME, Bean BP, Eggan K, Woolf CJ. Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons. Cell Rep. 2014 Apr 10;7(1):1-11. doi: 10.1016/j.celrep.2014.03.019. Epub 2014 Apr 3. PMID: 24703839 PMCID: PMC4023477 read article


Davis-Dusenbery BN, Williams LA, Klim JR, Eggan K. How to make spinal motor neurons. Development. 2014 Feb;141(3):491-501. doi: 10.1242/dev.097410. PMID: 24449832


Ringgaard S, Zepeda-Rivera M, Wu X, Schirner K, Davis BM, Waldor MK. ParP prevents dissociation of CheA from chemotactic signaling arrays and tethers them to a polar anchor. Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):E255-64. doi: 10.1073/pnas.1315722111. Epub 2013 Dec 30. PMID: 24379357 PMCID: PMC3896188 read article


Wu H, Wu X, Shen L, Zhang Y. Single-base resolution analysis of active DNA demethylation using methylase-assisted bisulfite sequencing. Nat Biotechnol. 2014 Dec;32(12):1231-40. doi: 10.1038/nbt.3073. Epub 2014 Nov 2. PMID: 25362244 PMCID: PMC4269366


Chu Y, Fioravante D, Leitges M, Regehr WG. Calcium-Dependent PKC Isoforms Have Specialized Roles in Short-Term Synaptic Plasticity. Neuron. 2014 May 21;82(4):859-71. doi: 10.1016/j.neuron.2014.04.003. Epub 2014 May 1. PMID: 24794094


Wu Z, Autry AE, Bergan JF, Watabe-Uchida M, Dulac CG. Galanin neurons in the medial preoptic area govern parental behaviour. Nature. 2014 May 15;509(7500):325-30. doi: 10.1038/nature13307. PMID: 24828191


Xia X, Owen MS, Lee RE, Gaudet S. Cell-to-cell variability in cell death: can systems biology help us make sense of it all? Cell Death Dis. 2014 May 29;5:e1261. doi: 10.1038/cddis.2014.199. PMID: 24874733 PMCID: PMC4047886 read article


Hill SJ, Rolland T, Adelmant G, Xia X, Owen MS, Dricot A, Zack TI, Sahni N, Jacob Y, Hao T, McKinney KM, Clark AP, Reyon D, Tsai SQ, Joung JK, Beroukhim R, Marto JA, Vidal M, Gaudet S, Hill DE, Livingston DM. Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage. Genes Dev. 2014 Sep 1;28(17):1957-75. doi: 10.1101/gad.241620.114. PMID: 25184681 PMCID: PMC4197947 read article


Yang L, Yang JL, Byrne S, Pan J, Church GM. CRISPR/Cas9-Directed Genome Editing of Cultured Cells. Curr Protoc Mol Biol. 2014 Jul 1;107:31.1.1-31.1.17. doi: 10.1002/0471142727.mb3101s107. PMID: 24984853


Lee JH, Daugharthy ER, Scheiman J, Kalhor R, Yang JL, Ferrante TC, Terry R, Jeanty SS, Li C, Amamoto R, Peters DT, Turczyk BM, Marblestone AH, Inverso SA, Bernard A, Mali P, Rios X, Aach J, Church GM. Highly multiplexed subcellular RNA sequencing in situ. Science. 2014 Mar 21;343(6177):1360-3. doi: 10.1126/science.1250212. Epub 2014 Feb 27. PMID: 24578530 PMCID: PMC4140943 read article


Xiang M, Birkbak NJ, Vafaizadeh V, Walker SR, Yeh JE, Liu S, Kroll Y, Boldin M, Taganov K, Groner B, Richardson AL, Frank DA. STAT3 induction of miR-146b forms a feedback loop to inhibit the NF-κB to IL-6 signaling axis and STAT3-driven cancer phenotypes. Sci Signal. 2014 Jan 28;7(310):ra11. doi: 10.1126/scisignal.2004497. PMID: 24473196 PMCID: PMC4233120 read article


Yen PJ, Herschhorn A, Haim H, Salas I, Gu C, Sodroski J, Gabuzda D. Loss of a conserved N-linked glycosylation site in the simian immunodeficiency virus envelope glycoprotein V2 region enhances macrophage tropism by increasing CD4-independent cell-to-cell transmission. J Virol. 2014 May;88(9):5014-28. doi: 10.1128/JVI.02785-13. Epub 2014 Feb 19. PMID: 24554659 PMCID: PMC3993815


Yu R, Jih G, Iglesias N, Moazed D. Determinants of heterochromatic siRNA biogenesis and function. Mol Cell. 2014 Jan 23;53(2):262-76. doi: 10.1016/j.molcel.2013.11.014. Epub 2013 Dec 26. PMID: 24374313 PMCID: PMC4357591 read article


Yuen GJ, Ausubel FM. Enterococcus infection biology: lessons from invertebrate host models. J Microbiol. 2014 Mar;52(3):200-10. doi: 10.1007/s12275-014-4011-6. Epub 2014 Mar 1. PMID: 24585051


Tan X, Fuchs BB, Wang Y, Chen W, J Yuen G, Chen RB, Jayamani E, Anastassopoulou C, Pukkila-Worley R, Coleman JJ, Mylonakis E. The Role of Candida albicans SPT20 in Filamentation, Biofilm Formation and Pathogenesis. PLoS One. 2014 Apr 14;9(4):e94468. doi: 10.1371/journal.pone.0094468. eCollection 2014. PMID: 24732310 PMCID: PMC3986095 read article


Bandopadhayay P, Bergthold G, Nguyen B, Schubert S, Gholamin S, Tang Y, Bolin S, Schumacher SE, Zeid R, Masoud S, Yu F, Vue N, Gibson WJ, Paolella BR, Mitra SS, Cheshier SH, Qi J, Liu KW, Wechsler-Reya R, Weiss WA, Swartling FJ, Kieran MW, Bradner JE, Beroukhim R, Cho YJ. BET bromodomain inhibition of MYC-amplified medulloblastoma. Clin Cancer Res. 2014 Feb 15;20(4):912-25. doi: 10.1158/1078-0432.CCR-13-2281. Epub 2013 Dec 2. PMID 24297863 PMCID: PMC4198154 read article


top

2013


Chatterjee P, Agyemang AF, Alimzhanov MB, Degn S, Tsiftsoglou SA, Alicot E, Jones SA, Ma M, Carroll MC. Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner. Eur J Immunol. 2013 Jun 10. doi: 10.1002/eji.201343412. [Epub ahead of print] PMID: 23749435


Albacker LA, Chaudhary V, Chang YJ, Kim HY, Chuang YT, Pichavant M, DeKruyff RH, Savage PB, Umetsu DT. Invariant natural killer T cells recognize a fungal glycosphingolipid that can induce airway hyperreactivity. Nat Med. 2013 Oct;19(10):1297-304. doi: 10.1038/nm.3321. Epub 2013 Sep 1. PMID: 23995283


Albacker LA, Yu S, Bedoret D, Lee WL, Umetsu SE, Monahan S, Freeman GJ, Umetsu DT, DeKruyff RH. TIM-4, expressed by medullary macrophages, regulates respiratory tolerance by mediating phagocytosis of antigen-specific T cells. Mucosal Immunol. 2013 May;6(3):580-90. doi: 10.1038/mi.2012.100. Epub 2012 Nov 14. PMID: 23149665


Chaudhary V, Albacker LA, Deng S, Chuang YT, Li Y, Umetsu DT, Savage PB. Synthesis of fungal glycolipid asperamide B and investigation of its ability to stimulate natural killer T cells. Org Lett. 2013 Oct 18;15(20):5242-5. doi: 10.1021/ol4024375. Epub 2013 Oct 10. PMID: 24111801


Amamoto, R., Arlotta, P. Reshaping the Brain: Direct Lineage Conversion in the Nervous System. F1000Prime Rep. 2013 Sep 2;5:33. eCollection 2013. PMID: 24049637 PMCID: PMC3768326 read article


Su X, Arellano-Santoyo H, Portran D, Gaillard J, Vantard M, Thery M, Pellman D. Microtubule-sliding activity of a kinesin-8 promotes spindle assembly and spindle-length control. Nat Cell Biol. 2013 Aug;15(8):948-57. doi: 10.1038/ncb2801. Epub 2013 Jul 14. PMID:23851487 PMCID: PMC3767134 read article


Atkins BD, Yoshida S, Saito K, Wu CF, Lew DJ, Pellman D. Inhibition of Cdc42 during mitotic exit is required for cytokinesis. J Cell Biol. 2013 Jul 22;202(2):231-40. doi: 10.1083/jcb.201301090. PMID: 23878274 PMCID: PMC3718968 read article


Long JB, Bagonis M, Lowery LA, Lee H, Danuser G, Van Vactor D. Multiparametric analysis of CLASP-interacting protein functions during interphase microtubule dynamics. Mol Cell Biol. 2013 Apr;33(8):1528-45. doi: 10.1128/MCB.01442-12. PMID: 23382075  read article


Lehnert BP, Baker AE, Gaudry Q, Chiang AS, Wilson RI. Distinct roles of TRP channels in auditory transduction and amplification in Drosophila. Neuron. 2013 Jan 9;77(1):115-28. doi: 10.1016/j.neuron.2012.11.030. PMID: 23312520 PMCID: PMC3811118 read article


Veeramah KR, Johnstone L, Karafet TM, Wolf D, Sprissler R, Salogiannis J, Barth-Maron A, Greenberg ME, Stuhlmann T, Weinert S, Jentsch TJ, Pazzi M, Restifo LL, Talwar D, Erickson RP, Hammer MF. Exome sequencing reveals new causal mutations in children with epileptic encephalopathies. Epilepsia. 2013 Jul;54(7):1270-81. doi: 10.1111/epi.12201. Epub 2013 May 3.PMID:23647072 PMCID: PMC3700577 read article


Joyce EF, Apostolopoulos N, Beliveau BJ, Wu CT. Germline progenitors escape the widespread phenomenon of homolog pairing during Drosophila development. PLoS Genet. 2013;9(12):e1004013. doi: 10.1371/journal.pgen.1004013. Epub 2013 Dec 19.PMID: 24385920 PMCID: PMC3868550 read article


Guo G, Luc S, Marco E, Lin TW, Peng C, Kerenyi MA, Beyaz S, Kim W, Xu J, Das PP, Neff T, Zou K, Yuan GC, Orkin SH. Mapping cellular hierarchy by single-cell analysis of the cell surface repertoire. Cell Stem Cell. 2013 Oct 3;13(4):492-505. doi: 10.1016/j.stem.2013.07.017. Epub 2013 Sep 12. PMID: 24035353 PMCID: PMC3845089 read article


Chang J, Burkett PR, Borges CM, Kuchroo VK, Turka LA, Chang CH. MyD88 is essential to sustain mTOR activation necessary to promote Th17 cell proliferation by linking IL-1 and IL-23 signaling. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2270-5. doi: 10.1073/pnas.1206048110. Epub 2013 Jan 22. PMID: 23341605 PMCID: PMC3568327 read article


Duncan MB, Yang C, Tanjore H, Boyle PM, Keskin D, Sugimoto H, Zeisberg M, Olsen BR, Kalluri R. Type XVIII collagen is essential for survival during acute liver injury in mice. Dis Model Mech. 2013 Jul;6(4):942-51. doi: 10.1242/dmm.011577. Epub 2013 Apr 4. PMID: 23580202 PMCID: PMC3701214 read article


Kim SG, Buel GR, and Blenis J. 2013. Nutrient regulation of the mTOR Complex 1 signaling pathway. Mol Cells. 2013 Jun;35(6):463-73. doi: 10.1007/s10059-013-0138-2. Epub 2013 May 20. PMID: 23694989 PMCID: PMC3887879


Buel GR, Kim SG, and Blenis J. 2013. mTORC1 Signaling Aids in CADalyzing Pyrimidine Biosynthesis. Cell Metab. 2013 May 7;17(5):633-5. doi: 10.1016/j.cmet.2013.04.018. PMID: 23663734


Kim SG, Hoffman GR, Poulogiannis G, Buel GR, Jang YJ, Lee KW, Kim BY, Erikson RL, Cantley LC, Choo AY, and Blenis J. 2013. Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex. Mol Cell. 2013 Jan 10;49(1):172-85. doi: 10.1016/j.molcel.2012.10.003. Epub 2012 Nov 8. PMID: 23142078 PMCID: PMC3545014 read article


Rajasagi M, Shukla SA, Fritsch EF, Keskin DB, DeLuca D, Carmona E, Zhang W, Sougnez C, Cibulskis K, Sidney J, Stevenson K, Ritz J, Neuberg D, Brusic V, Gabriel S, Lander ES, Getz G, Hacohen N, Wu CJ. Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia. Blood. 2014 Jul 17;124(3):453-62. doi: 10.1182/blood-2014-04-567933. Epub 2014 Jun 2. PMID: 24891321 PMCID: PMC4102716


Harris JM; Esain V; Frechette GM; Harris LJ; Cox AG; Cortes M; Garnaas MK; Carroll KJ; Cutting CC; Khan T; Elks PM; Renshaw SA; Dickinson BC; Chang CJ; Murphy MP; Paw BH; Vander Heiden MG; Goessling W; North TE. Glucose metabolism impacts the spatiotemporal onset and magnitude of HSC induction in vivo. Blood. 2013 Mar 28;121(13):2483-93. doi: 10.1182/blood-2012-12-471201. Epub 2013 Jan 22. PMID: 23341543 PMCID: PMC3612858 read article


Jemielity S, Wang JJ, Chan YK, Ahmed AA, Li W, Monahan S, Bu X, Farzan M, Freeman GJ, Umetsu DT, Dekruyff RH, Choe H. TIM-family proteins promote infection of multiple enveloped viruses through virion-associated phosphatidylserine. PLoS Pathog. 2013 Mar;9(3):e1003232. doi: 10.1371/journal.ppat.1003232. Epub 2013 Mar 28. PMID:23555248. PMCID:PMC3610696. read article


Gat-Viks I, Chevrier N, Wilentzik R, Eisenhaure T, Raychowdhury R, Steuerman Y, Shalek AK, Hacohen N, Amit I, Regev A. Deciphering molecular circuits from genetic variation underlying transcriptional responsiveness to stimuli. Nat Biotechnol. 2013 Apr;31(4):342-9. doi: 10.1038/nbt.2519. Epub 2013 Mar 17. PMID: 23503680 PMCID: PMC3622156 read article


Tonti E, Jiménez de Oya N, Galliverti G, Moseman EA, Di Lucia P, Amabile A, Sammicheli S, De Giovanni M, Sironi L, Chevrier N, Sitia G, Gennari L, Guidotti LG, von Andrian UH, Iannacone M. Bisphosphonates target B cells to enhance humoral immune responses. Cell Rep. 2013 Oct 31;5(2):323-30. doi: 10.1016/j.celrep.2013.09.004. Epub 2013 Oct 10. PMID: 24120862 PMCID: PMC3838640 read article


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Beier KT, Saunders AB, Oldenburg IA, Sabatini BL, Cepko CL. Vesicular stomatitis virus with the rabies virus glycoprotein directs retrograde transsynaptic transport among neurons in vivo. Front Neural Circuits. 2013 Feb 7;7:11. doi: 10.3389/fncir.2013.00011. eCollection 2013. PMID: 23403489 PMCID: PMC3566411 read article


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Traag BA, Ramirez-Peralta A, Wang Erickson AF, Setlow P, Losick R. A novel RNA polymerase-binding protein controlling genes involved in spore germination in Bacillus subtilis. Mol Microbiol. 2013 Jul;89(1):113-22. doi: 10.1111/mmi.12262. Epub 2013 Jun 5. PMID: 23678950 PMCID: PMC3694343 read article


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Munger K, Gwin TK, McLaughlin-Drubin ME. p16 in HPV-associated cancers. Oncotarget. 2013 Nov;4(11):1864-5. PMID:24192550 PMCID: PMC3875753 read article


Woodruff MC, Herndon CN, Heesters BA, Carroll MC. Contextual analysis of immunological response through whole-organ fluorescent imaging. Lymphat Res Biol. 2013 Sep;11(3):121-7. doi: 10.1089/lrb.2013.0011. PMID: 24044754 PMCID: PMC3780310


Hull CA, Chu Y, Thanawala M, Regehr WG. Hyperpolarization induces a long-term increase in the spontaneous firing rate of cerebellar Golgi cells. J Neurosci. 2013 Apr 3;33(14):5895-902. doi: 10.1523/JNEUROSCI.4052-12.2013. PMID: 23554471 PMCID: PMC3641191 read article


Yamada-Hanff J, Bean BP. Persistent sodium current drives conditional pacemaking in CA1 pyramidal neurons under muscarinic stimulation. J Neurosci. 2013 Sep 18;33(38):15011-21. doi: 10.1523/JNEUROSCI.0577-13.2013. PMID: 24048831 PMCID: PMC3776055 read article


Yang L, Guell M, Byrne S, Yang JL, De Los Angeles A, Mali P, Aach J, Kim-Kiselak C, Briggs AW, Rios X, Huang PY, Daley G, Church G. Optimization of scarless human stem cell genome editing. Nucleic Acids Res. 2013 Oct;41(19):9049-61. doi: 10.1093/nar/gkt555. Epub 2013 Jul 31. PMID: 23907390 PMCID: PMC3799423 read article


Froberg JE, Yang L, Lee JT. Guided by RNAs: X-inactivation as a model for lncRNA function. J Mol Biol. 2013 Oct 9;425(19):3698-706. doi: 10.1016/j.jmb.2013.06.031. Epub 2013 Jun 28. PMID: 23816838 PMCID: PMC3771680 read article


Walker SR, Nelson EA, Yeh JE, Pinello L, Yuan GC, Frank DA. STAT5 outcompetes STAT3 to regulate the expression of the oncogenic transcriptional modulator BCL6. Mol Cell Biol. 2013 Aug;33(15):2879-90. doi: 10.1128/MCB.01620-12. Epub 2013 May 28. PMID: 23716595 PMCID: PMC3719667 read article


Yeh JE, Toniolo P2, Frank DA. JAK2-STAT5 signaling: A novel mechanism of resistance to targeted PI3K/mTOR inhibition. JAKSTAT. 2013 Oct 1;2(4):e24635. doi: 10.4161/jkst.24635. Epub 2013 Apr 15. PMID: 24470973 PMCID: PMC3891630 read article


Yeh JE, Toniolo PA, Frank DA. Targeting transcription factors: promising new strategies for cancer therapy. Curr Opin Oncol. 2013 Nov;25(6):652-8. doi: 10.1097/01.cco.0000432528.88101.1a. PMID: 24048019


Yu Y, Munger K. Human papillomavirus type 16 E7 oncoprotein inhibits the anaphase promoting complex/cyclosome activity by dysregulating EMI1 expression in mitosis. Virology. 2013 Nov;446(1-2):251-9. doi: 10.1016/j.virol.2013.08.013. Epub 2013 Sep 5. PMID: 24074588 PMCID: PMC3799973


Cezairliyan B, Vinayavekhin N, Grenfell-Lee D, Yuen GJ, Saghatelian A, Ausubel FM. Identification of Pseudomonas aeruginosa phenazines that kill Caenorhabditis elegans. PLoS Pathog. 2013 Jan;9(1):e1003101. doi: 10.1371/journal.ppat.1003101. Epub 2013 Jan 3. PMID: 23300454 PMCID: PMC3536714


Yung A, Goodrich LV. How to survive a nerve-wracking journey. Elife. 2013 Dec 17;2:e01845. doi: 10.7554/eLife.01845. PMID: 24347551 PMCID: PMC3865645 read article


Puissant A, Frumm SM, Alexe G, Bassil CF, Qi J, Chanthery YH, Nekritz EA, Zeid R, Gustafson WC, Greninger P, Garnett MJ, McDermott U, Benes CH, Kung AL, Weiss WA, Bradner JE, Stegmaier K. Targeting MYCN in neuroblastoma by BET bromodomain inhibition. Cancer Discov. 2013 Mar;3(3):308-23. doi: 10.1158/2159-8290.CD-12-0418. Epub 2013 Feb 21. PMID: 23430699 PMCID: PMC3672953 read article


Shay T, Jojic V, Zuk O, Rothamel K, Puyraimond-Zemmour D, Feng T, Wakamatsu E, Benoist C, Koller D, Regev A; ImmGen Consortium. Conservation and divergence in the transcriptional programs of the human and mouse immune systems. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2946-51. doi: 10.1073/pnas.1222738110. Epub 2013 Feb 4. PMID: 23382184 PMCID: PMC3581886 read article


top

2012


Roberts KA, Abraira VE, Tucker AF, Goodrich LV, Andrews NC. Mutation of rubie, a novel long non-coding RNA located upstream of bmp4, causes vestibular malformation in mice. PLoS One. 2012;7(1):e29495. Epub 2012 Jan 12. PubMed PMID: 22253730; PubMed Central PMCID: PMC3257225.


Adamson B, Smogorzewska A, Sigoillot FD, King RW, Elledge SJ. A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. Nat Cell Biol. 2012 Feb 19;14(3):318-28. doi: 10.1038/ncb2426. PMID: 22344029 PMCID: PMC3290715 read article


Sigoillot FD, Lyman S, Huckins JF, Adamson B, Chung E, Quattrochi B, King RW. A bioinformatics method identifies prominent off-targeted transcripts in RNAi screens. Nat Methods. 2012 Feb 19;9(4):363-6. doi: 10.1038/nmeth.1898. PMID: 22343343 PMCID: PMC3482495 read article


Ciccia A, Nimonkar AV, Hu Y, Hajdu I, Achar YJ, Izhar L, Petit SA, Adamson B, Yoon JC, Kowalczykowski SC, Livingston DM, Haracska L, Elledge SJ. Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress. Mol Cell. 2012 Aug 10;47(3):396-409. doi: 10.1016/j.molcel.2012.05.024. Epub 2012 Jun 14. PMID: 22704558 PMCID: PMC3613862 read article


Boyle PM, Burrill DR, Inniss MC, Agapakis CM, Deardon A, Dewerd JG, Gedeon MA, Quinn JY, Paull ML, Raman AM, Theilmann MR, Wang L, Winn JC, Medvedik O, Schellenberg K, Haynes KA, Viel A, Brenner TJ, Church GM, Shah JV, Silver PA. A BioBrick compatible strategy for genetic modification of plants. J Biol Eng. 2012 Jun 20;6(1):8. doi: 10.1186/1754-1611-6-8. PMID: 22716313 PMCID: PMC3537565 read article


Detre C, Keszei M, Garrido-Mesa N, Kis-Toth K, Castro W, Agyemang AF, Veerapen N, Besra GS, Carroll MC, Tsokos GC, Wang N, Leadbetter EA, Terhorst C. SAP expression in invariant NKT cells is requisite for cognate help and dispensable for non-cognate support to B cells. Blood. 2012 May 21. [Epub ahead of print] PMID: 22613797


Kim HY, Chang YJ, Subramanian S, Lee HH, Albacker LA, Matangkasombut P, Savage PB, McKenzie AN, Smith DE, Rottman JB, DeKruyff RH, Umetsu DT. Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity. J Allergy Clin Immunol. 2012 Jan;129(1):216-27.e1-6. doi: 10.1016/j.jaci.2011.10.036. Epub 2011 Nov 25. PMID: 22119406 PMCID: PMC3246069 read article


Varadarajan N, Kwon DS, Law KM, Ogunniyi AO, Anahtar MN, Richter JM, Walker BD, Love JC. Rapid, efficient functional characterization and recovery of HIV-specific human CD8+ T cells using microengraving. Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3885-90. Epub 2012 Feb 21. PMID:22355106 PMCID: PMC3309713 read article


Astarita JL, Acton SE, Turley SJ. 2012. Podoplanin: emerging functions in development, the immune system, and cancer. Front Immunol. 2012 Sep 12;3:283. doi: 10.3389/fimmu.2012.00283. eCollection 2012. PMID: 22988448 PMCID: PMC3439854 read article


Acton SE*, Astarita JL*, Malhotra D, Lukacs-Kornek V, Franz B, Hess PR, Jakus Z, Kuligowski M, Fletcher AL, Elpek KG, Bellemare-Pelletier A, Sceats L, Reynoso ED, Gonzalez SF, Graham DB, Chang J, Peters A, Woodruff M, Kim YA, Swat W, Morita T, Kuchroo V, Carroll MC, Kahn ML, Wucherpfennig KW, Turley SJ. 2012. Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2. Immunity. Immunity. 2012 Aug 24;37(2):276-89. doi: 10.1016/j.immuni.2012.05.022. Epub 2012 Aug 9. PMID 22884313 PMCID: PMC3556784 *co-first authors read article


Malhotra D, Fletcher AL, Astarita J, Lukacs-Kornek V, Tayalia P, Gonzalez SF, Elpek KG, Chang SK, Knoblich K, Hemler ME, Brenner MB, Carroll MC, Mooney DJ, Turley SJ; Immunological Genome Project Consortium. 2012. Nat Immunol. 2012. Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks. Nat Immunol. 2012 Apr 1;13(5):499-510. doi: 10.1038/ni.2262. PMID:22466668 PMCID: PMC3366863 read article


Dulak AM, Schumacher SE, van Lieshout J, Imamura Y, Fox C, Shim B, Ramos AH, Saksena G, Baca SC, Baselga J, Tabernero J, Barretina J, Enzinger PC, Corso G, Roviello F, Lin L, Bandla S, Luketich JD, Pennathur A, Meyerson M, Ogino S, Shivdasani RA, Beer DG, Godfrey TE, Beroukhim R, Bass AJ. Gastrointestinal adenocarcinomas of the esophagus, stomach, and colon exhibit distinct patterns of genome instability and oncogenesis. Cancer Res. 2012 Sep 1;72(17):4383-93. Epub 2012 Jul 2. PMID: 22751462 PMCID: PMC3432726 read article


Baca SC, Garraway LA. The genomic landscape of prostate cancer. Front Endocrinol (Lausanne). 2012 May 16;3:69. doi: 10.3389/fendo.2012.00069. eCollection 2012. PMID: 22649426 PMCID: PMC3355898 read article


Hafler BP, Surzenko N, Beier KT, Punzo C, Trimarchi JM, Kong JH, Cepko CL. Transcription factor Olig2 defines subpopulations of retinal progenitor cells biased toward specific cell fates. Proc Natl Acad Sci U S A. 2012 May 15;109(20):7882-7. Epub 2012 Apr 27. PubMed PMID: 22543161; PubMed Central PMCID: PMC3356608.


Beliveau BJ, Joyce EF, Apostolopoulos N, Yilmaz F, Fonseka CY, McCole RB, Chang Y, Li JB, Senaratne TN, Williams BR, Rouillard JM, Wu CT. Versatile design and synthesis platform for visualizing genomes with Oligopaint FISH probes. Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21301-6. doi: 10.1073/pnas.1213818110. Epub 2012 Dec 11. PMID: 23236188 PMCID: PMC3535588 read article


Fine DA, Rozenblatt-Rosen O, Padi M, Korkhin A, James RL, Adelmant G, Yoon R, Guo L, Berrios C, Zhang Y, Calderwood MA, Velmurgan S, Cheng J, Marto JA, Hill DE, Cusick ME, Vidal M, Florens L, Washburn MP, Litovchick L, DeCaprio JA. Identification of FAM111A as an SV40 host range restriction and adenovirus helper factor. PLoS Pathog. 2012;8(10):e1002949. doi: 10.1371/journal.ppat.1002949. Epub 2012 Oct 18. PMID:23093934 PMCID:PMC3475652 read article


Boboila C, Alt FW, Schwer B. Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks. Adv Immunol. 2012;116:1-49. doi: 10.1016/B978-0-12-394300-2.00001-6. PMID: 23063072


Boboila C, Oksenych V, Gostissa M, Wang JH, Zha S, Zhang Y, Chai H, Lee CS, Jankovic M, Saez LM, Nussenzweig MC, McKinnon PJ, Alt FW, Schwer B. Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1). Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2473-8. doi: 10.1073/pnas.1121470109. Epub 2012 Jan 30. PMID: 22308491 PMCID: PMC3289296 read article


Boettger LM, Handsaker RE, Zody MC, McCarroll SA. Structural haplotypes and recent evolution of the human 17q21.31 region. Nat Genet. 2012 Jul 1;44(8):881-5. doi: 10.1038/ng.2334. PMID: 22751096 PMCID: PMC4020351 read article


Martin CJ, Booty MG, Rosebrock TR, Nunes-Alves C, Desjardins DM, Keren I, Fortune SM, Remold HG, Behar SM. Efferocytosis is an innate antibacterial mechanism. Cell Host Microbe. 2012 Sep 13;12(3):289-300. doi: 10.1016/j.chom.2012.06.010. PMID: 22980326; PMCID: PMC3517204 read article


Bowen ME, Henke K, Siegfried KR, Warman ML, Harris MP. (2012) Efficient mapping and cloning of mutations in zebrafish by low-coverage whole-genome sequencing. Genetics 190(3):1017-24. PMCID:PMC3296239.


Kurek KC, Luks VL, Ayturk UM, Alomari AI, Fishman SJ, Spencer SA, Mulliken JB, Bowen ME, Yamamoto GL, Kozakewich HP, Warman ML. (2012) Somatic mosaic activating mutations in PIK3CA cause CLOVES syndrome. Am J Hum Genet 90(6):1108-15. PMCID:PMC3370283.


Boyle PM, Silver PA. Parts plus pipes: synthetic biology approaches to metabolic engineering. Metab Eng. 2012 May;14(3):223-32. doi: 10.1016/j.ymben.2011.10.003. Epub 2011 Oct 25. PMID: 22037345 PMCID: PMC3293987 read article


Agapakis CM, Boyle PM, Silver PA. Natural strategies for the spatial optimization of metabolism in synthetic biology. Nat Chem Biol. 2012 May 17;8(6):527-35. doi: 10.1038/nchembio.975. PMID: 22596204


Ray, R.S., Corcoran, A.E., Brust, R.B., Nattie, E., Dymecki, S.M. Egr2-neurons control the adult respiratory response to hypercapnia. Brain Res. 2013 May 20;1511:115-25. doi: 10.1016/j.brainres.2012.12.017. Epub 2012 Dec 19. PMID: 23261662 PMCID: PMC3947592


Engleka, K., Manderfield, L., Brust, R.B., Lu, M.M., Dymecki, S.M., and Epstein J.A. Islet1 Derivatives in the Heart are of Both Neural Crest and Second Heard Field Origin. Circ Res. 2012 Mar 30;110(7):922-6. doi: 10.1161/CIRCRESAHA.112.266510. Epub 2012 Mar 6. PMID: 22394517 PMCID: PMC3355870 read article


Burrill DR, Inniss MC, Boyle PM, Silver PA. Synthetic memory circuits for tracking human cell fate. Genes Dev. 2012 Jul 1;26(13):1486-97. doi: 10.1101/gad.189035.112. PMID: 22751502 PMCID: PMC3403016 read article


Boyle PM, Burrill DR, Inniss MC, Agapakis CM, Deardon A, Dewerd JG, Gedeon MA, Quinn JY, Paull ML, Raman AM, Theilmann MR, Wang L, Winn JC, Medvedik O, Schellenberg K, Haynes KA, Viel A, Brenner TJ, Church GM, Shah JV, Silver PA. A BioBrick compatible strategy for genetic modification of plants. J Biol Eng. 2012 Jun 20;6(1):8. doi: 10.1186/1754-1611-6-8. PMID: 22716313 PMCID: PMC3537565 read article


Cooney JD; Hildick-Smith GJ; Shafizadeh E; McBride PF; Carroll KJ; Anderson H; Shaw GC; Tamplin OK; Branco DS; Dalton AJ; Shah DI; Wong C; Gallagher PG; Zon LI; North TE; Paw, BH. Teleost growth factor idendependence (gfi) genes differentially regulate successive waves of hematopoiesis. Dev Biol. 2013 Jan 15;373(2):431-41. doi: 10.1016/j.ydbio.2012.08.015. Epub 2012 Aug 29. PMID: 22960038 PMCID: PMC3532562 read article


Cedeno-Laurent F, Dimitroff CJ. Galectin-1 research in T cell immunity: past, present and future. Clin Immunol. 2012 Feb;142(2):107-16. doi: 10.1016/j.clim.2011.09.011. Epub 2011 Oct 6. PMID: 22019770 PMCID: PMC3266984 read article


Cedeno-Laurent F, Opperman MJ, Barthel SR, Hays D, Schatton T, Zhan Q, He X, Matta KL, Supko JG, Frank MH, Murphy GF, Dimitroff CJ. Metabolic inhibition of galectin-1-binding carbohydrates accentuates antitumor immunity. J Invest Dermatol. 2012 Feb;132(2):410-20. doi: 10.1038/jid.2011.335. Epub 2011 Dec 8. PMID: 22158550 PMCID: PMC3258338  read article


Cedeno-Laurent F, Dimitroff CJ. Galectins and their ligands: negative regulators of anti-tumor immunity. Glycoconj J. 2012 Dec;29(8-9):619-25. doi: 10.1007/s10719-012-9379-0. Epub 2012 Apr 29. PMID: 22544342 PMCID: PMC3410977 read article


Cedeno-Laurent F, Opperman M, Barthel SR, Kuchroo VK, Dimitroff CJ. Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression. J Immunol. 2012 Apr 1;188(7):3127-37. doi: 10.4049/jimmunol.1103433. Epub 2012 Feb 17. PMID: 22345665 PMCID: PMC3311782 read article


Cedeno-Laurent F, Watanabe R, Teague JE, Kupper TS, Clark RA, Dimitroff CJ. Galectin-1 inhibits the viability, proliferation, and Th1 cytokine production of nonmalignant T cells in patients with leukemic cutaneous T-cell lymphoma. Blood. 2012 Apr 12;119(15):3534-8. doi: 10.1182/blood-2011-12-396457. Epub 2012 Mar 1. PMID: 22383798 PMCID: PMC3325040 read article


Cedeno-Laurent F, Dimitroff CJ. Evidence of a novel galectin-9-binding membrane glycoprotein ligand on T helper cells. Clin Immunol. 2012 Apr;143(1):6-7. doi: 10.1016/j.clim.2012.01.010. Epub 2012 Jan 24. PMID: 22321867


Chambers AR, Hancock KE, Maison SF, Liberman MC, Polley DB. Sound-Evoked Olivocochlear Activation in Unanesthetized Mice. J Assoc Res Otolaryngol. 2012 Apr;13(2):209-17. doi: 10.1007/s10162-011-0306-z. Epub 2011 Dec 13. PMID: 22160753 PMCID: PMC3298614 read article


Chan YK, Huang IC, Farzan M. IFITM proteins restrict antibody-dependent enhancement of dengue virus infection. PLoS One. 2012;7(3):e34508. doi: 10.1371/journal.pone.0034508. Epub 2012 Mar 30. PMID: 22479637; PMCID: PMC3316688.  read article


Lui JC, Nilsson O, Chan Y, Palmer CD, Andrade AC, Hirschhorn JN, Baron J. Synthesizing genome-wide association studies and expression microarray reveals novel genes that act in the human growth plate to modulate height. Hum Mol Genet. 2012 Dec 1;21(23):5193-201. doi: 10.1093/hmg/dds347. Epub 2012 Aug 21. PMID: 22914739 PMCID: PMC3490510 read article


Acton SE, Astarita JL, Malhotra D, Lukacs-Kornek V, Franz B, Hess PR, Jakus Z, Kuligowski M, Fletcher AL, Elpek KG, Bellemare-Pelletier A, Sceats L,Reynoso ED, Gonzalez SF, Graham DB, Chang J, Peters A, Woodruff M, Kim YA, Swat W, Morita T, Kuchroo V, Carroll MC, Kahn ML, Wucherpfennig KW,Turley SJ. Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2. Immunity. 2012 Aug 24;37(2):276-89. doi: 10.1016/j.immuni.2012.05.022. Epub 2012 Aug 9. PMID: 22884313 PMCID: PMC3556784 read article


Cherry AB, Daley GQ. Reprogramming cellular identity for regenerative medicine. Cell. 2012 Mar 16;148(6):1110-22. doi: 10.1016/j.cell.2012.02.031. PMID: 22424223; PMCID: PMC3354575.  read article


Garber M, Yosef N, Goren A, Raychowdhury R, Thielke A, Guttman M, Robinson J, Minie B, Chevrier N, Itzhaki Z, Blecher-Gonen R, Bornstein C, Amann-Zalcenstein D, Weiner A, Friedrich D, Meldrim J, Ram O, Cheng C, Gnirke A, Fisher S, Friedman N, Wong B, Bernstein BE, Nusbaum C, Hacohen N, Regev A, Amit I. A high-throughput chromatin immunoprecipitation approach reveals principles of dynamic gene regulation in mammals. Mol Cell. 2012 Sep 14;47(5):810-22. doi: 10.1016/j.molcel.2012.07.030. Epub 2012 Aug 30. PMID: 22940246 PMCID: PMC3873101 read article


Moseman EA, Iannacone M, Bosurgi L, Tonti E, Chevrier N, Tumanov A, Fu YX, Hacohen N, von Andrian UH. B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity. Immunity. 2012 Mar 23;36(3):415-26. doi: 10.1016/j.immuni.2012.01.013. Epub 2012 Mar 1. PMID: 22386268 PMCID: PMC3359130 read article


Shalek AK, Gaublomme JT, Wang L, Yosef N, Chevrier N, Andersen MS, Robinson JT, Pochet N, Neuberg D, Gertner RS, Amit I, Brown JR, Hacohen N, Regev A, Wu CJ, Park H. Nanowire-mediated delivery enables functional interrogation of primary immune cells: application to the analysis of chronic lymphocytic leukemia. Nano Lett. 2012 Dec 12;12(12):6498-504. doi: 10.1021/nl3042917. Epub 2012 Dec 3. PMID: 23190424 PMCID: PMC3573729 read article


Chiang CW, Liu CT, Lettre G, Lange LA, Jorgensen NW, Keating BJ, Vedantam S, Nock NL, Franceschini N, Reiner AP, Demerath EW, Boerwinkle E, Rotter JI, Wilson JG, North KE, Papanicolaou GJ, Cupples LA, Murabito JM, Consortium G, Hirschhorn JN. Ultraconserved Elements in the Human Genome: Association and Transmission Analyses of Highly Constrained SNPs. Genetics. 2012 Jun 19. [Epub ahead of print] PubMed PMID: 22714408.


Choi EY, Yeo BT, Buckner RL. The organization of the human striatum estimated by intrinsic functional connectivity. J Neurophysiol. 2012 Oct;108(8):2242-63. doi: 10.1152/jn.00270.2012. Epub 2012 Jul 25. PMID: 22832566. PMCID:PMC3545026.


Stadtfeld, M., Apostolou, E., Ferrari, F., Choi, J., Walsh, R.M., Chen, T., Oi, S., Kim, S.Y., Bestor, T., Shioda, T., et al. (2012). Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells. Nat Genet. 2012 Mar 4;44(4):398-405, S1-2. doi: 10.1038/ng.1110. PMID: 22387999 PMCID: PMC3538378 read article


He A, Ma Q, Cao J, von Gise A, Zhou P, Xie H, Zhang B, Hsing M, Christodoulou DC, Cahan P, Daley GQ, Kong SW, Orkin SH, Seidman CE, Seidman JG, Pu WT. Polycomb repressive complex 2 regulates normal development of the mouse heart. Circ Res. 2012 Feb 3;110(3):406-15. Epub 2011 Dec 8. PubMed PMID: 22158708; PubMed Central PMCID: PMC3282145.


Xu Y, Xu C, Kato A, Tempel W, Abreu JG, Bian C, Hu Y, Hu D, Zhao B, Cerovina T, Diao J, Wu F, He HH, Cui Q, Clark E, Ma C, Barbara A, Veenstra GJ, Xu G, Kaiser UB, Liu XS, Sugrue SP, He X, Min J, Kato Y, Shi YG. Tet3 CXXC domain and dioxygenase activity cooperatively regulate key genes for Xenopus eye and neural development. Cell. 2012 Dec 7;151(6):1200-13. doi: 10.1016/j.cell.2012.11.014. PMID: 23217707 PMCID: PMC3705565 read article


Narayan K, Sylvia KE, Malhotra N, Yin CC, Martens G, Vallerskog T, Kornfeld H, Xiong N, Cohen NR, Brenner MB, Berg LJ, Kang J; Immunological Genome Project Consortium. Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes. Nat Immunol. 2012 Apr 1;13(5):511-8. doi: 10.1038/ni.2247. PMID: 22473038 PMCID: PMC3427768


Cohen NA, Stewart ML, Gavathiotis E, Tepper JL, Bruekner SR, Koss B, Opferman JT, Walensky LD. A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival. Chem Biol. 2012 Sep 21;19(9):1175-86. doi: 10.1016/j.chembiol.2012.07.018. PMID: 22999885 PMCID: PMC3582387 read article


Wang HH, Kim H, Cong L, Jeong J, Bang D, Church GM. Genome-scale promoter engineering by coselection MAGE. Nat Methods. 2012 Jun;9(6):591-3. doi: 10.1038/nmeth.1971. Epub 2012 Apr 8. PubMed PMID: 22484848 PMCID: PMC3428217 read article


Folco EG, Lee CS, Dufu K, Yamazaki T, Reed R. The proteins PDIP3 and ZC11A associate with the human TREX complex in an ATP-dependent manner and function in mRNA export. PLoS One. 2012;7(8):e43804. doi: 10.1371/journal.pone.0043804. Epub 2012 Aug 23. PMID: 22928037 PMCID: PMC3426524 read article


Silveira-Neto AP, Leal LF, Emerman AB, Henderson KD, Piskounova E, Henderson BE, Gregory RI, Silveira LF, Hirschhorn JN, Nguyen TT, Beneduzzi D, Tusset C, Reis AC, Brito VN, Mendonca BB, Palmert MR, Antonini SR, Latronico AC. Absence of functional LIN28B mutations in a large cohort of patients with idiopathic central precocious puberty. Horm Res Paediatr. 2012;78(3):144-50. doi: 10.1159/000342212. Epub 2012 Sep 6. PMID: 22964795. PMCID: PMC3526815. read article


Fu W, Ergun A, Lu T, Hill JA, Haxhinasto S, Fassett MS, Gazit R, Adoro S, Glimcher L, Chan S, Kastner P, Rossi D, Collins JJ, Mathis D, Benoist C. A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells.Nat Immunol. 2012 Oct;13(10):972-80. doi: 10.1038/ni.2420. Epub 2012 Sep 9.PMID: 22961053. PMCID: PMC3698954


Fassett MS, Jiang W, D'Alise AM, Mathis D, Benoist C Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion. Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3891-6. Epub 2012 Feb 15. PMID: 22345564. PMCID: PMC3309794


Finley LW, Lee J, Souza A, Rowe G, Clish CB, Arany Z, Haigis MC. Skeletal muscle transcriptional coactivator PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restriction. Proc Natl Acad Sci USA 2012 Feb 3. PMCID: PMC3286952


Ford KM, D'Amore PA. Molecular regulation of vascular endothelial growth factor expression in the retinal pigment epithelium. Mol Vis. 2012;18:519-27. Epub 2012 Mar 1. PMID: 22419845 PMCID: PMC3298425 read article


Ford KM, Saint-Geniez M, Walshe TE, D'Amore PA. Expression and role of VEGF--a in the ciliary body. Invest Ophthalmol Vis Sci. 2012 Nov 7;53(12):7520-7. doi: 10.1167/iovs.12-10098. PMID: 23081980 PMCID: PMC3493183 read article


Clapham KR, Yu TW, Ganesh VS, Barry B, Chan Y, Mei D, Parrini E, Funalot B, Dupuis L, Nezarati MM, du Souich C, van Karnebeek C, Guerrini R, Walsh CA. FLNA genomic rearrangements cause periventricular nodular heterotopia. Neurology. 2012 Jan 24;78(4):269-78. PMID: 22238415. PMCID - PMC Journal in Process


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Akopian V, Chan MM, Clement K, Galonska C, Gifford CA, Lehtola E, Liao J, Samavarchi-Tehrani P, Sindhu C, Smith ZD, Tsankov AM, Webster J, Zhang Y, Ziller MJ, Meissner A. Epigenomics and chromatin dynamics. Genome Biol. 2012 Feb 24;13(2):313. doi: 10.1186/gb-2012-13-2-313. PMID: 22364154 PMCID: PMC3334565 read article


Sindhu C, Samavarchi-Tehrani P, Meissner A. Transcription factor-mediated epigenetic reprogramming. J Biol Chem. 2012 Sep 7;287(37):30922-31. doi: 10.1074/jbc.R111.319046. Epub 2012 Sep 5. PMID: 22952239 PMCID: PMC3438925 read article


Soghoian DZ, Jessen H, Flanders M, Sierra-Davidson K, Cutler S, Pertel T, Ranasinghe S, Lindqvist M, Davis I, Lane K, Rychert J, Rosenberg ES, Piechocka-Trocha A, Brass AL, Brenchley JM, Walker BD, Streeck H. HIV-specific cytolytic CD4 T cell responses during acute HIV infection predict disease outcome. Sci Transl Med. 2012 Feb 29;4(123):123ra25. doi: 10.1126/scitranslmed.3003165. PMID: 22378925 PMCID: PMC3918726 read article


Lindqvist M, van Lunzen J, Soghoian DZ, Kuhl BD, Ranasinghe S, Kranias G, Flanders MD, Cutler S, Yudanin N, Muller MI, Davis I, Farber D, Hartjen P, Haag F, Alter G, Schulze zur Wiesch J, Streeck H. Expansion of HIV-specific T follicular helper cells in chronic HIV infection. J Clin Invest. 2012 Sep 4;122(9):3271-80. doi: 10.1172/JCI64314. Epub 2012 Aug 27. PMID: 22922259 PMCID: PMC3428098 read article


Ranasinghe S, Flanders M, Cutler S, Soghoian DZ, Ghebremichael M, Davis I, Lindqvist M, Pereyra F, Walker BD, Heckerman D, Streeck H. HIV-specific CD4 T cell responses to different viral proteins have discordant associations with viral load and clinical outcome. J Virol. 2012 Jan;86(1):277-83. doi: 10.1128/JVI.05577-11. Epub 2011 Oct 26. PMID: 22031937 PMCID: PMC3255877 read article


Ho HY, Susman MW, Bikoff JB, Ryu YK, Jonas AM, Hu L, Kuruvilla R, Greenberg ME. Wnt5a-Ror-Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4044-51. doi: 10.1073/pnas.1200421109. Epub 2012 Feb 17. PMID: 22343533 PMCID: PMC3306699 read article


Harper JW, Tan MK. Understanding cullin-RING E3 biology through proteomics-based substrate identification. Mol Cell Proteomics. 2012 Dec;11(12):1541-50. doi: 10.1074/mcp.R112.021154. Epub 2012 Sep 7. PMID: 22962057 PMCID: PMC3518111 read article


White EA, Kramer RE, Tan MJ, Hayes SD, Harper JW, Howley PM. Comprehensive analysis of host cellular interactions with human papillomavirus E6 proteins identifies new E6 binding partners and reflects viral diversity. J Virol. 2012 Dec;86(24):13174-86. doi: 10.1128/JVI.02172-12. Epub 2012 Sep 26. PMID: 23015706 PMCID: PMC3503137 read article


White EA, Sowa ME, Tan MJ, Jeudy S, Hayes SD, Santha S, Münger K, Harper JW, Howley PM. Systematic identification of interactions between host cell proteins and E7 oncoproteins from diverse human papillomaviruses. Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):E260-7. doi: 10.1073/pnas.1116776109. Epub 2012 Jan 9. PMID: 22232672 PMCID: PMC3277141 read article


Tan MJ, White EA, Sowa ME, Harper JW, Aster JC, Howley PM. Cutaneous β-human papillomavirus E6 proteins bind Mastermind-like coactivators and repress Notch signaling. Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):E1473-80. doi: 10.1073/pnas.1205991109. Epub 2012 Apr 30. PMID: 22547818 PMCID: PMC3384212 read article


Taylor AM, Humphries JM, White RM, Murphey RD, Burns CE, Zon LI. Hematopoietic defects in rps29 mutant zebrafish depend upon p53 activation. Exp Hematol. 2012 Mar;40(3):228-237.e5. doi: 10.1016/j.exphem.2011.11.007.. Epub 2011 Nov 25. PMID: 22120640 PMCID: PMC3310385 read article


Tamplin OJ, White RM, Jing L, Kaufman CK, Lacadie SA, Li P, Taylor AM, Zon LI. Small molecule screening in zebrafish: swimming in potential drug therapies. Wiley Interdiscip Rev Dev Biol. 2012 May-Jun;1(3):459-68. doi: 10.1002/wdev.37. Epub 2012 Feb 28. PMID: 23801494


Chu Y, Fioravante D, Thanawala M, Leitges M, Regehr WG. Calcium-dependent isoforms of protein kinase C mediate glycine-induced synaptic enhancement at the calyx of Held. J Neurosci. 2012 Oct 3;32(40):13796-804. doi: 10.1523/JNEUROSCI.2158-12.2012. PMID: 23035091 PMCID: PMC3626456 read article


Rajani DK, Walch M, Martinvalet D, Thomas MP, Lieberman J. Alterations in RNA processing during immune-mediated programmed cell death. Proc Natl Acad Sci U S A. 2012 May 29;109(22):8688-93. doi: 10.1073/pnas.1201327109. Epub 2012 May 15. PMID: 22589304 PMCID: PMC3365155 read article


Thompson DB, Cronican JJ, Liu DR. Engineering and identifying supercharged proteins for macromolecule delivery into mammalian cells. Methods Enzymol. 2012;503:293-319. doi: 10.1016/B978-0-12-396962-0.00012-4. PMID: 22230574 PMCID: PMC3505079 read article


Thompson DB, Villaseñor R, Dorr BM, Zerial M, Liu DR. Cellular uptake mechanisms and endosomal trafficking of supercharged proteins. Chem Biol. 2012 Jul 27;19(7):831-43. doi: 10.1016/j.chembiol.2012.06.014. PMID: 22840771 PMCID: PMC3408882 read article


Ching S, Purdon PL, Vijayan S, Kopell NJ, Brown EN. A neurophysiological-metabolic model for burst suppression. Proc Natl Acad Sci U S A. 2012 Feb 7. [Epub ahead of print] PubMed PMID: 22323592. PMCID: PMC Journal in Process


Vo TT, Ryan J, Carrasco R, Neuberg D, Rossi DJ, Stone RM, Deangelo DJ, Frattini MG, Letai A. Relative mitochondrial priming of myeloblasts and normal HSCs determines chemotherapeutic success in AML. Cell. 2012 Oct 12;151(2):344-55. doi: 10.1016/j.cell.2012.08.038. PMID: 23063124 PMCID: PMC3534747 read article


Williams LA, Davis-Dusenbery BN, Eggan KC. SnapShot: directed differentiation of pluripotent stem cells. Cell. 2012 May 25;149(5):1174-1174.e1. doi: 10.1016/j.cell.2012.05.015. PMID: 22632979


Wivagg CN, Hung DT. Resuscitation-promoting factors are required for β-lactam tolerance and the permeability barrier in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2012 Mar;56(3):1591-4. doi: 10.1128/AAC.06027-11. Epub 2011 Dec 12. PMID: 22155826 PMCID: PMC3294900 read article


Stanley SA, Grant SS, Kawate T, Iwase N, Shimizu M, Wivagg C, Silvis M, Kazyanskaya E, Aquadro J, Golas A, Fitzgerald M, Dai H, Zhang L, Hung DT. Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening. ACS Chem Biol. 2012 Aug 17;7(8):1377-84. doi: 10.1021/cb300151m. Epub 2012 May 21. PMID: 22577943 PMCID: PMC3560293 read article


Acton S, Astarita J, Malhotra D, Lukacs-Kornek V, Franz B, Hess P, Jakus Z, Kuligowski M, Fletcher A, Elpek K, Bellemare-Pelletier A, Sceats L, Reynoso E, Gonzalez S, Graham D, Chang J, Peters A, Woodruff M, Kim Y, Swat W, Morita T, Kuchroo V, Carroll M, Kahn M, Wucherpfennig K, Turley S Podoplanin-Rich Stromal Networks Induce Dendritic Cell Motility via Activation of the C-type Lectin Receptor CLEC-2 Immunity. 2012 Aug 24;37(2):276-89. doi: 10.1016/j.immuni.2012.05.022. Epub 2012 Aug 9. PMID: 22884313 PMCID: PMC3556784 read article


Chu Y, Fioravante D, Thanawala M, Leitges M, Regehr WG. Calcium-dependent isoforms of protein kinase C mediate glycine-induced synaptic enhancement at the calyx of Held. J Neurosci. 2012 Oct 3;32(40):13796-804. doi: 10.1523/JNEUROSCI.2158-12.2012. PMID: 23035091 PMCID: PMC3626456 read article


Tsai PT, Hull C, Chu Y, Greene-Colozzi E, Sadowski AR, Leech JM, Steinberg J, Crawley JN, Regehr WG, Sahin M. Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice. Nature. 2012 Aug 30;488(7413):647-51. doi: 10.1038/nature11310. PMID: 22763451 PMCID: PMC3615424 read article


Ball MP, Thakuria JV, Zaranek AW, Clegg T, Rosenbaum AM, Wu X, Angrist M, Bhak J, Bobe J, Callow MJ, Cano C, Chou MF, Chung WK, Douglas SM, Estep PW, Gore A, Hulick P, Labarga A, Lee JH, Lunshof JE, Kim BC, Kim JI, Li Z, Murray MF, Nilsen GB, Peters BA, Raman AM, Rienhoff HY, Robasky K, Wheeler MT, Vandewege W, Vorhaus DB, Yang JL, Yang L, Aach J, Ashley EA, Drmanac R, Kim SJ, Li JB, Peshkin L, Seidman CE, Seo JS, Zhang K, Rehm HL, Church GM. A public resource facilitating clinical use of genomes. Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):11920-7. doi: 10.1073/pnas.1201904109. Epub 2012 Jul 13. PMID: 22797899 PMCID: PMC3409785 read article


Kim H, Yang K, Dejsuphong D, D'Andrea AD. Regulation of Rev1 by the Fanconi anemia core complex. Nat Struct Mol Biol. 2012 Jan 22;19(2):164-70. doi: 10.1038/nsmb.2222. PubMed PMID: 22266823; PubMed Central PMCID: PMC3280818.


Ball MP, Thakuria JV, Zaranek AW, Clegg T, Rosenbaum AM, Wu X, Angrist M, Bhak J, Bobe J, Callow MJ, Cano C, Chou MF, Chung WK, Douglas SM, Estep PW, Gore A, Hulick P, Labarga A, Lee JH, Lunshof JE, Kim BC, Kim JI, Li Z, Murray MF, Nilsen GB, Peters BA, Raman AM, Rienhoff HY, Robasky K, Wheeler MT, Vandewege W, Vorhaus DB, Yang JL, Yang L, Aach J, Ashley EA, Drmanac R, Kim SJ, Li JB, Peshkin L, Seidman CE, Seo JS, Zhang K, Rehm HL, Church GM. A public resource facilitating clinical use of genomes. Proc Natl Acad Sci U S A. 2012 Jul 13. [Epub ahead of print] PubMed PMID: 22797899.


Briggs AW, Rios X, Chari R, Yang L, Zhang F, Mali P, Church GM. Iterative capped assembly: rapid and scalable synthesis of repeat-module DNA such as TAL effectors from individual monomers. Nucleic Acids Res. 2012 Jun 26. [Epub ahead of print] PubMed PMID: 22740649.


Fine DA, Rozenblatt-Rosen O, Padi M, Korkhin A, James RL, Adelmant G, Yoon R, Guo L, Berrios C, Zhang Y, Calderwood MA, Velmurgan S, Cheng J, Marto JA, Hill DE, Cusick ME, Vidal M, Florens L, Washburn MP, Litovchick L, DeCaprio JA. Identification of FAM111A as an SV40 host range restriction and adenovirus helper factor. PLoS Pathog. 2012;8(10):e1002949. doi: 10.1371/journal.ppat.1002949. Epub 2012 Oct 18. PMID: 23093934 PMCID: PMC3475652 read article


Yu Y, Munger K. Human papillomavirus type 16 E7 oncoprotein engages but does not abrogate the mitotic spindle assembly checkpoint. Virology. 2012 Oct 10;432(1):120-6. doi: 10.1016/j.virol.2012.06.006. Epub 2012 Jun 28. PMID: 22748180 PMCID: PMC3402702 read article


Zeng X, King RW. An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination. Nat Chem Biol. 2012 Feb 26;8(4):383-92. doi: 10.1038/nchembio.801. PubMed PMID: 22366722; PubMed Central PMCID: PMC3307893.


Christofferson DE, Li Y, Hitomi J, Zhou W, Upperman C, Zhu H, Gerber SA, Gygi S, Yuan J .A novel role for RIP1 kinase in mediating TNFα production. Cell Death Dis. 2012 Jun 14;3:e320. doi: 10.1038/cddis.2012.64. PMID: 22695613 PMCID: PMC3388236 read article


Zhou W, Yuan J. Cell biology: Death by deacetylation. Nature. 2012 Dec 13;492(7428):194-5. doi: 10.1038/nature11761. Epub 2012 Nov 28. PMID:23201692


top

2011


Li L, Rutlin M, Abraira VE, Cassidy C, Kus L, Gong S, Jankowski MP, Luo W,Heintz N, Koerber HR, Woodbury CJ, Ginty DD. The functional organization of cutaneous low-threshold mechanosensory neurons. Cell. 2011 Dec 23;147(7):1615-27. PubMed PMID: 22196735; PubMed Central PMCID: PMC3262167.


Sykes SM, Lane SW, Bullinger L, Kalaitzidis D, Yusuf R, Saez B, Ferraro F, Mercier F, Singh H, Brumme KM, Acharya SS, Scholl C, Tothova Z, Attar E, Frohling S, DePinho RA, Gilliland DG, Armstrong SA, Scadden DT. AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias. Cell. 2011 Sep 2;146(5):697-708. doi: 10.1016/j.cell.2011.07.032. PMID: 21884932 PMCID: PMC3826540 read article


Barstow B, Agapakis CM, Boyle PM, Grandl G, Silver PA, Wintermute EH. A synthetic system links FeFe-hydrogenases to essential E. coli sulfur metabolism. J Biol Eng. 2011 May 26;5:7. doi: 10.1186/1754-1611-5-7. PMID: 21615937 PMCID: PMC3130634 read article


Agapakis CM, Niederholtmeyer H, Noche RR, Lieberman TD, Megason SG, Way JC, Silver PA. Towards a synthetic chloroplast. PLoS One. 2011 Apr 20;6(4):e18877. doi: 10.1371/journal.pone.0018877. PMID: 21533097 PMCID: PMC3080389 read article


Henrickson SE, Agyemang AF, Garg S, Hafler JP. Integrating clinical perspectives into graduate education. Clin Immunol. 2011 Nov;141(2):228-30PMID: 21944668


Chang YJ, Kim HY, Albacker LA, Baumgarth N, McKenzie ANJ, Smith DE, DeKruyff RH, Umetsu DT (2011) Innate lymphoid cells mediate influenza-induced asthma independent of adaptive immunity. Nat. Immunol. 12(7):631-8. PMID: 21623379 PMCID: PMC3417123


Moldt B, Schultz N, Dunlop DC, Alpert MD, Harvey JD, Evans DT, Poignard P, Hessell AJ, Burton DR. A panel of IgG1 b12 variants with selectively diminished or enhanced affinity for Fcγ receptors to define the role of effector functions in protection against HIV. J Virol. 2011 Oct;85(20):10572-81. Epub 2011 Aug 17. PMID: 21849450 PMCID: PMC3187489 read article


Aoki ST, Trask SD, Coulson BS, Greenberg HB, Dormitzer PR, Harrison SC. Cross-linking of rotavirus outer capsid protein VP7 by antibodies or disulfides inhibits viral entry. J Virol. 2011 Oct;85(20):10509-17. Epub 2011 Aug 17. PMID: 21849465 PMCID: PMC3187514 read article


Appler JM, Goodrich LV. Connecting the ear to the brain: Molecular mechanisms of auditory circuit assembly. Prog Neurobiol. 2011 Apr;93(4):488-508. Epub 2011 Jan 11. Review. PubMed PMID: 21232575; PubMed Central PMCID: PMC3078955.


Lu CC, Appler JM, Houseman EA, Goodrich LV. Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly. J Neurosci. 2011 Jul 27;31(30):10903-18. PubMed PMID: 21795542; PubMed Central PMCID: PMC3167573.


Pathak N, Austin CA, Drummond IA. Tubulin tyrosine ligase-like genes ttll3 and ttll6 maintain zebrafish cilia structure and motility. J Biol Chem. 2011 Apr 1;286(13):11685-95. doi: 10.1074/jbc.M110.209817. Epub 2011 Jan 24. PMID: 21262966 PMCID: PMC3064220 read article


Applegate KT, Besson S, Matov A, Bagonis MH, Jaqaman K, Danuser G. plusTipTracker: Quantitative image analysis software for the measurement of microtubule dynamics. J Struct Biol. 2011 Nov;176(2):168-84. doi: 10.1016/j.jsb.2011.07.009. PMID: 21821130  read article


Baughman JM, Perocchi F, Girgis HS, Plovanich M, Belcher-Timme CA, Sancak Y, Bao XR, Strittmatter L, Goldberger O, Bogorad RL, Koteliansky V, Mootha VK*. Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter. Nature. 2011 Jun 19;476(7360):341-5. doi: 10.1038/nature10234. PubMed PMID: 21685886. PMCID: PMC3486726.  read article


Beier KT, Saunders A, Oldenburg IA, Miyamichi K, Akhtar N, Luo L, Whelan SP, Sabatini B, Cepko CL. Anterograde or retrograde transsynaptic labeling of CNS neurons with vesicular stomatitis virus vectors. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15414-9. Epub 2011 Aug 8. PubMed PMID: 21825165; PubMed Central PMCID: PMC3174680.


Cronican JJ, Beier KT, Davis TN, Tseng JC, Li W, Thompson DB, Shih AF, May EM, Cepko CL, Kung AL, Zhou Q, Liu DR. A class of human proteins that deliver functional proteins into mammalian cells in vitro and in vivo. Chem Biol. 2011 Jul 29;18(7):833-8. PubMed PMID: 21802004; PubMed Central PMCID: PMC3154086.


Beier KT, Samson ME, Matsuda T, Cepko CL. Conditional expression of the TVA receptor allows clonal analysis of descendents from Cre-expressing progenitor cells. Dev Biol. 2011 May 15;353(2):309-20. Epub 2011 Mar 21. PubMed PMID: 21397594; PubMed Central PMCID: PMC3100772.


Lucas CL, Workman CJ, Beyaz S, LoCascio S, Zhao G, Vignali DA, Sykes M. LAG-3, TGF-β, and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T-cell tolerance induced by allogeneic BMT with anti-CD40L. Blood. 2011 May 19;117(20):5532-40. Epub 2011 Mar 21. PubMed PMID: 21422469; PubMed Central PMCID: PMC3109721. read article


Bilimoria PM, Bonni A. Molecular Regulation of Axon Branching. Neuroscientist. 2011 Dec 15. [Epub ahead of print] PubMed PMID: 22179123. PMCID: PMC Journal in Process


Zha S, Guo C, Boboila C, Oksenych V, Cheng HL, Zhang Y, Wesemann DR, Yuen G, Patel H, Goff PH, Dubois RL, Alt FW. ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks. Nature. 2011 Jan 13;469(7329):250-4. Epub 2010 Dec 15. PubMed PMID: 21160472; PubMed Central PMCID: PMC3058373.


Wesemann DR, Magee JM, Boboila C, Calado DP, Gallagher MP, Portuguese AJ, Manis JP, Zhou X, Recher M, Rajewsky K, Notarangelo LD, Alt FW. Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination. J Exp Med. 2011 Dec 19;208(13):2733-46. doi: 10.1084/jem.20111155. Epub 2011 Dec 5. PMID: 22143888 PMCID: PMC3244039 read article


Akselrod-Ballin A, Bock D, Reid RC, Warfield SK. Accelerating image registration with the Johnson-Lindenstrauss lemma: application to imaging 3-D neural ultrastructure with electron microscopy. IEEE Trans Med Imaging. 2011 Jul;30(7):1427-38. Epub 2011 Mar 10. PubMed PMID: 21402511; PubMed Central PMCID: PMC3183508.


Bock DD, Lee WC, Kerlin AM, Andermann ML, Hood G, Wetzel AW, Yurgenson S, Soucy ER, Kim HS, Reid RC. Network anatomy and in vivo physiology of visual cortical neurons. Nature. 2011 Mar 10;471(7337):177-82. PubMed PMID: 21390124; PubMed Central PMCID: PMC3095821.


Behar SM, Martin CJ, Booty MG, Nishimura T, Zhao X, Gan HX, Divangahi M, Remold HG. Apoptosis is an innate defense function of macrophages against Mycobacterium tuberculosis. Mucosal Immunol. 2011 May;4(3):279-87. doi: 10.1038/mi.2011.3. Epub 2011 Feb 9. PMID: 21307848; PubMed Central PMCID: PMC3155700.  read article


Bowen ME, Boyden ED, Holm IA, Campos-Xavier B, Bonafé L, et al. (2011) Loss-of-function mutations in PTPN11 cause Metachondromatosis, but not Ollier disease or Maffucci syndrome. PLoS Genetics 7(4):e1002050. PMCID:PMC3077396.


Burrill DR, Boyle PM, Silver PA. A new approach to an old problem: synthetic biology tools for human disease and metabolism. Cold Spring Harb Symp Quant Biol. 2011;76:145-54. doi: 10.1101/sqb.2011.76.010686. Epub 2011 Dec 14. PMID: 22169233


Senapedis WT, Kennedy CJ, Boyle PM, Silver PA. Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chain. Mol Biol Cell. 2011 May 15;22(10):1791-805. doi: 10.1091/mbc.E10-10-0854. Epub 2011 Apr 1. PMID: 21460183 PMCID: PMC3093329 read article


Barstow B, Agapakis CM, Boyle PM, Grandl G, Silver PA, Wintermute EH. A synthetic system links FeFe-hydrogenases to essential E. coli sulfur metabolism. J Biol Eng. 2011 May 26;5:7. doi: 10.1186/1754-1611-5-7. PMID: 21615937 PMCID: PMC3130634 read article


Paterson AM, Brown KE, Keir ME, Vanguri VK, Riella LV, Chandraker A, Sayegh MH, Blazar BR, Freeman GJ, Sharpe AH. The programmed death-1 ligand 1:b7-1 pathway restrains diabetogenic effector T cells in vivo. J Immunol. 2011 Aug 1;187(3):1097-105. Epub 2011 Jun 22. PubMed PMID: 21697456; PubMed Central PMCID: PMC3148082.


Ray, R.S.*, Corcoran, A.E.*, Brust, R.D.*, Kim, J.C., Richerson, G.B., Nattie, E., Dymecki, S.M. Impaired Respiratory and Body Temperature Control Upon Acute Serotonergic Neuron Inhibition. Science. 2011 Jul 29;333(6042):637-42. doi: 10.1126/science.1205295. PMID: 21798952 PMCID: PMC3729433 *- These authors contributed equally to this work. read article


Buchman JJ, Durak O, Tsai LH. ASPM regulates Wnt signaling pathway activity in the developing brain. Genes Dev. 2011 Sep 15;25(18):1909-14. doi:10.1101/gad.16830211. PubMed PMID: 21937711; PubMed Central PMCID: PMC3185963.


Burrill DR, Silver PA. Synthetic circuit identifies subpopulations with sustained memory of DNA damage. Genes Dev. 2011 Mar 1;25(5):434-9. doi: 10.1101/gad.1994911. PMID: 21363961 PMCID: PMC3049284 read article


Burrill DR, Silver PA. Recording cellular experiences of DNA damage. Cell Cycle. 2011 Aug 1;10(15):2410-1. Epub 2011 Aug 1. PMID: 21670599


Meerbrey KL, Hu G, Kessler JD, Roarty K, Li MZ, Fang JE, Herschkowitz JI, Burrows AE, Ciccia A, Sun T, Schmitt EM, Bernardi RJ, Fu X, Bland CS, Cooper TA, Schiff R, Rosen JM, Westbrook TF, Elledge SJ. The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo. Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3665-70. doi: 10.1073/pnas.1019736108. Epub 2011 Feb 9. PMID: 21307310 PMCID: PMC3048138 read article


Alkuraya FS, Cai X, Emery C, Mochida GH, Al-Dosari MS, Felie JM, Hill RS, Barry BJ, Partlow JN, Gascon GG, Kentab A, Jan M, Shaheen R, Feng Y, Walsh CA. Human mutations in NDE1 cause extreme microcephaly with lissencephaly [corrected]. Am J Hum Genet. 2011 May 13;88(5):536-47. doi: 10.1016/j.ajhg.2011.04.003. Epub 2011 Apr 28. PMID: 21529751 PMCID: PMC3146728 read article


Cale EM, Hraber P, Giorgi EE, Fischer W, Bhattacharya T, Leitner T, Yeh WW, Gleasner C, Green LD, Han CS, Korber B, Letvin NL. Epitope-specific CD8+ T lymphocytes cross-recognize mutant simian immunodeficiency virus (SIV) sequences but fail to contain very early evolution and eventual fixation of epitope escape mutations during SIV infection. J Virol. 2011 Apr;85(8):3746-57. Epub 2011 Feb 9. PMID: 21307185 PMCID: PMC3126128


Hulot SL, Cale EM, Korber BT, Letvin NL. Vaccine-induced CD8+ T lymphocytes of rhesus monkeys recognize variant forms of an HIV epitope but do not mediate optimal functional activity. J Immunol. 2011 May 15;186(10):5663-74. Epub 2011 Apr 13. PubMed PMID: 21490161


Cale EM, Bazick HS, Rianprakaisang TA, Alam SM, Letvin NL. Mutations in a Dominant Nef Epitope of SIVmac Diminish TCR:Epitope Peptide Affinity but not Epitope Peptide:MHC Class I Binding. J Immunol. 2011 Sep 15;187(6):3300-13. doi: 10.4049/jimmunol.1101080. Epub 2011 Aug 12. PMID: 21841125 PMCID: PMC3175636


Carter BC, Bean BP. Incomplete inactivation and rapid recovery ofvoltage-dependent sodium channels during high-frequency firing in cerebellar Purkinje neurons. J Neurophysiol. 2011 Feb;105(2):860-71. Epub 2010 Dec 15. PubMed PMID: 21160003; PubMed Central PMCID: PMC3059179.


Barthel SR, Antonopoulos A, Cedeno-Laurent F, Schaffer L, Hernandez G, Patil SA, North SJ, Dell A, Matta KL, Neelamegham S, Haslam SM, Dimitroff CJ. Peracetylated 4-Fluoro-glucosamine Reduces the Content and Repertoire of N- and O-Glycans without Direct Incorporation. J Biol Chem. 2011 Jun 17;286(24):21717-31. Epub 2011 Apr 14. PubMed PMID: 21493714; PubMed Central PMCID: PMC3122228.


Cedeno-Laurent F, Penalva de Oliveira AC, Vidal JE, Trujillo JR. Human Polyomavirus-Associated Cerebral Disorders in the Post-HAART Era. Patholog Res Int. 2011 Feb 22;2011:562427. PubMed PMID: 21437187; PubMed Central PMCID: PMC3062102.


Cedeno-Laurent F, Gómez-Flores M, Mendez N, Ancer-Rodríguez J, Bryant JL,Gaspari AA, Trujillo JR. New insights into HIV-1-primary skin disorders. J Int AIDS Soc. 2011 Jan 24;14:5. Review. PubMed PMID: 21261982; PubMed Central PMCID: PMC3037296.


Chan Y, Holmen OL, Dauber A, Vatten L, Havulinna AS, Skorpen F, Kvaløy K, Silander K, Nguyen TT, Willer C, Boehnke M, Perola M, Palotie A, Salomaa V, Hveem K, Frayling TM, Hirschhorn JN, Weedon MN. Common variants show predicted polygenic effects on height in the tails of the distribution, except in extremely short individuals. PLoS Genet. 2011 Dec;7(12):e1002439. doi: 10.1371/journal.pgen.1002439. Epub 2011 Dec 29. PMID: 22242009 PMCID: PMC3248463 read article


Chevrier N, Mertins P, Artyomov MN, Shalek AK, Iannacone M, Ciaccio MF, Gat-Viks I, Tonti E, Degrace MM, Clauser KR, Garber M, Eisenhaure TM, Yosef N, Robinson J, Sutton A, Andersen MS, Root DE, von Andrian U, Jones RB, Park H, Carr SA, Regev A, Amit I, Hacohen N. Systematic Discovery of TLR Signaling Components Delineates Viral-Sensing Circuits. Cell. 2011 Nov 11;147(4):853-67. PubMed PMID: 22078882


Dauber A, Yu Y, Turchin MC, Chiang CW, Meng YA, Demerath EW, Patel SR, Rich SS, Rotter JI, Schreiner PJ, Wilson JG, Shen Y, Wu BL, Hirschhorn JN. Genome-wide association of copy-number variation reveals an association between short stature and the presence of low-frequency genomic deletions. Am J Hum Genet. 2011 Dec 9;89(6):751-9. Epub 2011 Nov 23. PubMed PMID: 22118881; PubMed Central PMCID: PMC3234379.


Chiang CW, Gajdos ZK, Korn JM, Butler JL, Hackett R, Guiducci C, Nguyen TT, Wilks R, Forrester T, Henderson KD, Le Marchand L, Henderson BE, Haiman CA, Cooper RS, Lyon HN, Zhu X, McKenzie CA, Palmert MR, Hirschhorn JN. The efficacy of detecting variants with small effects on the Affymetrix 6.0 platform using pooled DNA. Hum Genet. 2011 Nov;130(5):607-21. Epub 2011 Mar 22. PubMed PMID: 21424828.


Zhu X, Young JH, Fox E, Keating BJ, Franceschini N, Kang S, Tayo B, Adeyemo A, Sun YV, Li Y, Morrison A, Newton-Cheh C, Liu K, Ganesh SK, Kutlar A, Vasan RS, Dreisbach A, Wyatt S, Polak J, Palmas W, Musani S, Taylor H, Fabsitz R, Townsend RR, Dries D, Glessner J, Chiang CW, Mosley T, Kardia S, Curb D, Hirschhorn JN, Rotimi C, Reiner A, Eaton C, Rotter JI, Cooper RS, Redline S, Chakravarti A, Levy D. Combined admixture mapping and association analysis identifies a novel blood pressure genetic locus on 5p13: contributions from the CARe consortium. Hum Mol Genet. 2011 Jun 1;20(11):2285-95. Epub 2011 Mar 21. PubMed PMID: 21422096; PubMed Central PMCID: PMC3090198.


Christodoulou DC, Gorham JM, Herman DS, Seidman JG. Construction of normalized RNA-seq libraries for next-generation sequencing using the crab duplex-specific nuclease. Curr Protoc Mol Biol. 2011 Apr;Chapter 4:Unit4.12. PubMed PMID: 21472699; PubMed Central PMCID: PMC3152986.


Alon S, Vigneault F, Eminaga S, Christodoulou DC, Seidman JG, Church GM, Eisenberg E. Barcoding bias in high-throughput multiplex sequencing of miRNA. Genome Res. 2011 Sep;21(9):1506-11. Epub 2011 Jul 12. PubMed PMID: 21750102; PubMed Central PMCID: PMC3166835.


Brigl M, Tatituri RV, Watts GF, Bhowruth V, Leadbetter EA, Barton N, Cohen NR, Hsu FF, Besra GS, Brenner MB. Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection. J Exp Med. 2011 Jun 6;208(6):1163-77. Epub 2011 May 9. PMID: 21555485 PMCID:PMC3173255


Cohen NR, Tatituri RV, Rivera A, Watts GF, Kim EY, Chiba A, Fuchs BB, Mylonakis E, Besra GS, Levitz SM, Brigl M, Brenner MB. Innate recognition of cell wall β-glucans drives invariant natural killer T cell responses against fungi. Cell Host Microbe. 2011 Nov 17;10(5):437-50. doi: 10.1016/j.chom.2011.09.011. PMID: 22100160


Wang L, Colodner KJ, Feany MB. Protein misfolding and oxidative stress promote glial-mediated neurodegeneration in an Alexander disease model. J Neurosci. 2011 Feb 23;31(8):2868-77. PubMed PMID: 21414908; PubMed Central PMCID: PMC3082397.


Zhang F, Cong L, Lodato S, Kosuri S, Church GM, Arlotta P. Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription. Nat Biotechnol. 2011 Feb;29(2):149-53. Epub 2011 Jan 19. PubMed PMID: 21248753; PubMed Central PMCID: PMC3084533.  read article


Cornejo MG, Mabialah V, Sykes SM, Khandan T, Lo Celso C, Lopez C, Rivera-Muñoz P, Rameau P, Tothova Z, Aster JC, Depinho RA, Scadden DT, Gilliland DG, Mercher T. Crosstalk between Notch and AKT signaling during murine megakaryocyte lineage specification. Blood. 2011 Jun 7. [Epub ahead of print] PMID: 21653327 PMCID: PMC3152494


Baecher-Allan CM, Costantino CM, Cvetanovich GL, Ashley CW, Beriou G, Dominguez-Villar M, Hafler DA. CD2 costimulation reveals defective activity by human CD4+CD25(hi) regulatory cells in patients with multiple sclerosis. J Immunol. 2011 Mar 15;186(6):3317-26. Epub 2011 Feb 7. PubMed PMID: 21300823.


Courchesne SL, Karch C, Pazyra-Murphy MF, Segal RA. Sensory neuropathy attributable to loss of Bcl-w. J Neurosci. 2011 Feb 2;31(5):1624-34. PubMed PMID: 21289171; PubMed Central PMCID: PMC3074348.


Courchesne SL, Pazyra-Murphy MF, Lee DJ, Segal RA. Neuromuscular junction defects in mice with mutation of dynein heavy chain 1. PLoS One. 2011 Feb 4;6(2):e16753. PubMed PMID: 21346813; PubMed Central PMCID: PMC3035627.


Park KS, Liang MC, Raiser DM, Zamponi R, Roach RR, Curtis SJ, Walton Z, Schaffer BE, Roake CM, Zmoos AF, Kriegel C, Wong KK, Sage J, Kim CF. Characterization of the cell of origin for small cell lung cancer. Cell Cycle. 2011 Aug 15;10(16):2806-15. Epub 2011 Aug 15. PubMed PMID: 21822053; PubMed Central PMCID: PMC3219544.


Kasprowicz VO, Mitchell JE, Chetty S, Govender P, Huang KH, Fletcher HA, Webster DP, Brown S, Kasmar A, Millington K, Day CL, Mkhwanazi N, McClurg C, Chonco F, Lalvani A, Walker BD, Ndung'u T, Klenerman P. A molecular assay for sensitive detection of pathogen-specific T-cells. PLoS One. 2011;6(8):e20606. doi: 10.1371/journal.pone.0020606. Epub 2011 Aug 11. PMID: 21853018 PMCID: PMC3154901 read article


Kay JN, De la Huerta I, Kim IJ, Zhang Y, Yamagata M, Chu MW, Meister M, Sanes JR. Retinal ganglion cells with distinct directional preferences differ in molecular identity, structure, and central projections. J Neurosci. 2011 May 25;31(21):7753-62. PubMed PMID: 21613488; PubMed Central PMCID: PMC3108146.


Christensen R, de la Torre-Ubieta L, Bonni A, Colón-Ramos DA. A conserved PTEN/FOXO pathway regulates neuronal morphology during C. elegans development. Development. 2011 Dec;138(23):5257-67. PubMed PMID: 22069193; PubMed Central PMCID: PMC3210501.


Huynh MA, Ikeuchi Y, Netherton S, de la Torre-Ubieta L, Kanadia R, Stegmüller J, Cepko C, Bonni S, Bonni A. An isoform-specific SnoN1-FOXO1 repressor complex controls neuronal morphogenesis and positioning in the mammalian brain. Neuron. 2011 Mar 10;69(5):930-44. PubMed PMID: 21382553; PubMed Central PMCID: PMC3073069.


de Vries SE, Baccus SA, Meister M. The projective field of a retinal amacrine cell. J Neurosci. 2011 Jun 8;31(23):8595-604. PubMed PMID: 21653863; PubMed Central PMCID: PMC3130123.


Deans MR, Krol A, Abraira VE, Copley CO, Tucker AF, Goodrich LV. Control of
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Chevrier N, Mertins P, Artyomov MN, Shalek AK, Iannacone M, Ciaccio MF,Gat-Viks I, Tonti E, DeGrace MM, Clauser KR, Garber M, Eisenhaure TM, Yosef N, Robinson J, Sutton A, Andersen MS, Root DE, von Andrian U, Jones RB, Park H, Carr SA, Regev A, Amit I, Hacohen N. Systematic discovery of TLR signaling components delineates viral-sensing circuits. Cell. 2011 Nov 11;147(4):853-67. PubMed PMID: 22078882.


Dietz SB, Markopoulos F, Murthy VN. Postnatal development of dendrodendritic inhibition in the Mammalian olfactory bulb. Front Cell Neurosci. 2011;5:10. Epub 2011 Jun 27. PubMed PMID: 21738497; PubMed Central PMCID: PMC3125518.


Dong CK, Urgaonkar S, Cortese JF, Gamo FJ, Garcia-Bustos JF, Lafuente MJ,
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Dougan M, Li D, Neuberg D, Mihm M, Googe P, Wong KK, Dranoff G. A dual rolefor the immune response in a mouse model of inflammation-associated lung cancer. J Clin Invest. 2011 May 2. pii: 44796. doi: 10.1172/JCI44796. [Epub ahead of print] PMID: 21537082


Goessling W, Allen RS, Guan X, Jin P, Uchida N, Dovey M, Harris JM, Metzger ME, Bonifacino AC, Stroncek D, Stegner J, Armant M, Schlaeger T, Tisdale JF, Zon LI, Donahue RE, North TE. Prostaglandin E2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models. Cell Stem Cell. 2011 Apr 8;8(4):445-58. doi: 10.1016/j.stem.2011.02.003. PMID: 21474107 PMCID: PMC3148081 read article


Kokel D, Dunn TW, Ahrens MB, Alshut R, Cheung CY, Saint-Amant L, Bruni G, Mateus R, van Ham TJ, Shiraki T, Fukada Y, Kojima D, Yeh JR, Mikut R, von Lintig J, Engert F, Peterson RT. Identification of nonvisual photomotor response cells in the vertebrate hindbrain. J Neurosci. 2013 Feb 27;33(9):3834-43. doi: 10.1523/JNEUROSCI.3689-12.2013. PMID: 23447595 PMCID: PMC3600642 read article


Trompouki E, Bowman TV, Lawton LN, Fan ZP, Wu DC, DiBiase A, Martin CS, Cech JN, Sessa AK, Leblanc JL, Li P, Durand EM, Mosimann C, Heffner GC, Daley GQ, Paulson RF, Young RA, Zon LI. Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration. Cell. 2011 Oct 28;147(3):577-89. PubMed PMID: 22036566; PubMed Central PMCID: PMC3219441.


Li X, Yeung DF, Fiegen AM, Sodroski J. Determinants of the higher order association of the restriction factor TRIM5alpha and other tripartite motif (TRIM) proteins. J Biol Chem. 2011 Aug 12;286(32):27959-70. Epub 2011 Jun 16. PMID: 21680743 PMCID: PMC3151041 read article


Anderl S, Freeland M, Kwiatkowski DJ, Goto J. (2011)Therapeutic value of prenatal rapamycin treatment in a mouse brain model of tuberous sclerosis complex. Hum Mol Genet. 2011 Dec 1;20(23):4597-604. doi: 10.1093/hmg/ddr393. Epub 2011 Sep 1. PMID: 21890496 PMCID: PMC3209830 read article


Kim T, Escudero S, and Shivdasani RA. Intact function of Lgr5-expressing intestinal stem cells in the absence of paneth cells. Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3932-7. doi: 10.1073/pnas.1113890109. Epub 2012 Feb 21. PMID: 22355124 PMCID: PMC3309789 read article


Sukumaran B, Mastronunzio JE, Narasimhan S, Fankhauser S, Uchil PD, Levy R, Graham M, Colpitts TM, Lesser CF, Fikrig E. Anaplasma phagocytophilum AptA modulates Erk1/2 signalling. Cell Microbiol. 2011 Jan;13(1):47-61. doi: 10.1111/j.1462-5822.2010.01516.x. Epub 2010 Aug 27. PMID: 20716207 PMCID: PMC3005019 read article


Ferrero DM, Lemon JK, Fluegge D, Pashkovski SL, Korzan WJ, Datta SR, Spehr M, Fendt M, Liberles SD. Detection and avoidance of a carnivore odor by prey. Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11235-40. Epub 2011 Jun 20. PubMed PMID: 21690383; PubMed Central PMCID: PMC3131382.


Finley LW, Haas W, Desquiret-Dumas V, Wallace DC, Procaccio V, Gygi SP, Haigis MC. Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity. PLoS One 2011;6(8):e23295. Epub 2011 Aug 17. PMID: 21858060. PMCID: PMC3157345.


Fitzgerald JK, Freedman DJ, Assad JA. Generalized associative representations in parietal cortex. Nat Neurosci. 2011 Jul 17;14(8):1075-9. doi: 10.1038/nn.2878. PubMed PMID: 21765425; PubMed Central PMCID: PMC3145031.


Ford KM, Saint-Geniez M, Walshe T, Zahr A, D'Amore PA. Expression and role of VEGF in the adult retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2011 Dec 9;52(13):9478-87. doi: 10.1167/iovs.11-8353. PMID: 22058334 PMCID: PMC3250352 read article


Garg S, Sharma M, Ung C, Tuli A, Barral DC, Hava DL, Veerapen N, Besra GS, Hacohen N, Brenner MB. Lysosomal trafficking, antigen presentation, and microbial killing are controlled by the Arf-like GTPase Arl8b. Immunity. 2011 Aug 26;35(2):182-93. Epub 2011 Jul 28. PMID: 21802320. PMCID: PMC3584282


Liu CT, Garnaas MK, Tin A, Kottgen A, Franceschini N, Peralta CA, de Boer IH, Lu X, Atkinson E, Ding J, Nalls M, Shriner D, Coresh J, Kutlar A, Bibbins-Domingo K, Siscovick D, Akylbekova E, Wyatt S, Astor B, Mychaleckjy J, Li M, Reilly MP, Townsend RR, Adeyemo A, Zonderman AB, de Andrade M, Turner ST, Mosley TH, Harris TB; CKDGen Consortium, Rotimi CN, Liu Y, Kardia SL, Evans MK, Shlipak MG, Kramer H, Flessner MF, Dreisbach AW, Goessling W, Cupples LA, Kao WL, Fox CS. Genetic association for renal traits among participants of African ancestry reveals new loci for renal function. PLoS Genet. 2011 Sep;7(9):e1002264. Epub 2011 Sep 8. PubMed PMID: 21931561; PubMed Central PMCID: PMC3169523. read article


Giessel AJ, Sabatini BL. Boosting of synaptic potentials and spine Ca transients by the peptide toxin SNX-482 requires alpha-1E-encoded voltage-gated Ca channels. PLoS One. 2011;6(6):e20939. Epub 2011 Jun 9. PubMed PMID: 21695265; PubMed Central PMCID: PMC3111456.


Gomila RC, Martin GW, Gehrke L. NF90 binds the dengue virus RNA 3' terminus and is a positive regulator of dengue virus replication. PLoS One. 2011 Feb 28;6(2):e16687. doi: 10.1371/journal.pone.0016687. PMID: 21386893 PMCID: PMC3046124 read article


Puram SV, Kim AH, Ikeuchi Y, Wilson-Grady JT, Merdes A, Gygi SP, Bonni A. A CaMKIIβ signaling pathway at the centrosome regulates dendrite patterning in the brain. Nat Neurosci. 2011 Jul 3;14(8):973-83. doi: 10.1038/nn.2857. PMID: 21725312 PMCID: PMC3391735 read article


Grassian AR, Coloff JL, Brugge JS. Extracellular matrix regulation of metabolism and implications for tumorigenesis. Cold Spring Harb Symp Quant Biol. 2011;76:313-24. Epub 2011 Nov 21. PubMed PMID: 22105806.


Grassian AR, Metallo CM, Coloff JL, Stephanopoulos G, Brugge JS. Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation. Genes Dev. 2011 Aug 15;25(16):1716-33. PubMed PMID: 21852536; PubMed Central PMCID: PMC3165936.


Locasale JW, Grassian AR, Melman T, Lyssiotis CA, Mattaini KR, Bass AJ, Heffron G, Metallo CM, Muranen T, Sharfi H, Sasaki AT, Anastasiou D, Mullarky E, Vokes NI, Sasaki M, Beroukhim R, Stephanopoulos G, Ligon AH, Meyerson M, Richardson AL, Chin L, Wagner G, Asara JM, Brugge JS, Cantley LC, Vander Heiden MG. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat Genet. 2011 Jul 31;43(9):869-74. doi: 10.1038/ng.890. PubMed PMID: 21804546.


Shim JH, Greenblatt MB, Singh A, Brady N, Hu D, Drapp R, Ogawa W, Kasuga M, Noda T, Yang SH, Lee SK, Rebel VI, Glimcher LH. Administration of recombinant BMP2/7 in utero partially reverses Rubinstein Taybi Syndrome-like skeletal defects induced by Pdk1 or Cbp mutations. J Clin Invest. 2012 Jan 3;122(1):91-106. doi: 10.1172/JCI59466. Epub 2011 Dec 1. PMID: 22133875 PMCID: PMC3248303 read article


Dougan SK, Hu CC, Paquet ME, Greenblatt MB, Kim J, Lilley BN, Watson N, Ploegh HL. Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes. Mol Cell Biol. 2011 Mar;31(6):1145-59. Epub 2011 Jan 10. PMID: 21220515. PMCID: PMC3067910


Zou W, Greenblatt MB, Shim JH, Kant S, Zhai B, Lotinun S, Brady N, Hu DZ, Gygi SP, Baron R, Davis RJ, Jones D, Glimcher LH. MLK3 regulates bone development downstream of the Faciogenital Dysplasia protein FGD1 in mice. J Clin Invest. 2011 Nov;121(11):4383-92. doi: 10.1172/JCI59041. Epub 2011 Oct 3. PMID: 21965325 PMCID: PMC3204846 read article


Castillo M, Hall JA, Correa-Medina M, Ueta C, Kang HW, Cohen DE, Bianco AC. Disruption of thyroid hormone activation in type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality. Diabetes. 2011 Apr;60(4):1082-9. doi: 10.2337/db10-0758. Epub 2011 Feb 18. PMID: 21335378 PMCID: PMC3064082 read article


Han JM, Sahin M. TSC1/TSC2 signaling in the CNS. FEBS Lett. 2011 Apr 6;585(7):973-80. Epub 2011 Feb 15. Review. PubMed PMID: 21329690; PubMed Central PMCID: PMC3070766.


Hartlerode A, Odate S, Shim I, Brown J, Scully R. Cell cycle-dependent induction of homologous recombination by a tightly regulated I-SceI fusion protein. PLoS One. 2011 Mar 9;6(3):e16501. PubMed PMID: 21408059; PubMed Central PMCID: PMC3052302.


Hayes GD, Riedel CG, Ruvkun G. The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA. Genes Dev. 2011 Oct 1;25(19):2079-92. doi: 10.1101/gad.17153811. PMID: 21979920 PMCID: PMC3197206 read article


Henrickson SE, Agyemang AF, Garg S, Hafler JP. Integrating clinical perspectives into graduate education.Clin Immunol. 2011 Nov;141(2):228-30. Epub 2011 Sep 5. No abstract available. PMID:21944668


Pathania S, Nguyen J, Hill SJ, Scully R, Adelmant GO, Marto JA, Feunteun J, Livingston DM. BRCA1 is required for postreplication repair after UV-induced DNA damage. Mol Cell. 2011 Oct 21;44(2):235-51. Epub 2011 Sep 29. PMID: 21963239. PMCID: PMC3200447. NIHMSID: NIHMS326474


Zheng J, Ho B, Mekalanos JJ. Genetic analysis of anti-amoebae and anti-bacterial activities of the type VI secretion system in Vibrio cholerae. PLoS One. 2011;6(8):e23876. doi: 10.1371/journal.pone.0023876. Epub 2011 Aug 31. PMID: 21909372 PMCID: PMC3166118 read article


Hong S, Quintero-Monzon O, Ostaszewski BL, Podlisny DR, Cavanaugh WT, Yang T, Holtzman DM, Cirrito JR, Selkoe DJ. Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aβ during age-related plaque formation. J Neurosci. 2011 Nov 2;31(44):15861-9. PubMed PMID: 22049429; PubMed Central PMCID: PMC3227224.


Hong YK, Kim IJ, Sanes JR. Stereotyped axonal arbors of retinal ganglion cell subsets in the mouse superior colliculus. J Comp Neurol. 2011 Jun15;519(9):1691-711. doi: 10.1002/cne.22595. PubMed PMID: 21452242. PMCID - PMC Journal in Process


Houser BL, Tilburgs T, Hill J, Nicotra ML, Strominger JL. (2011). Two unique human decidual macrophage populations. J Immunol. 2011 Feb 15;186(4):2633-42. doi: 10.4049/jimmunol.1003153. Epub 2011 Jan 21. PMID: 21257965 PMCID: PMC3712354 read article


Hu CK, Coughlin M, Field CM, Mitchison TJ. KIF4 regulates midzone length during cytokinesis. Curr Biol. 2011 May 24;21(10):815-24. doi: 10.1016/j.cub.2011.04.019. Epub 2011 May 12. PMID: 21565503  read article


Ponce CR, Hunter JN, Pack CC, Lomber SG, Born RT. Contributions of indirect pathways to visual response properties in macaque middle temporal area MT. J Neurosci. 2011 Mar 9;31(10):3894-903. PubMed PMID: 21389244; PubMed Central PMCID: PMC3117290.


Hunter JN, Born RT. Stimulus-dependent modulation of suppressive influences in MT. J Neurosci. 2011 Jan 12;31(2):678-86. PubMed PMID: 21228177. NIHMSID: 356969.


Huynh MA, Ikeuchi Y, Netherton S, de la Torre-Ubieta L, Kanadia R, Stegmüller J, Cepko C, Bonni S, Bonni A. An isoform-specific SnoN1-FOXO1 repressor complex controls neuronal morphogenesis and positioning in the mammalian brain. Neuron. 2011 Mar 10;69(5):930-44. doi: 10.1016/j.neuron.2011.02.008. PMID: 21382553 PMCID: PMC3073069 read article


Hyde R, Corkins ME, Somers GA, Hart AC. PKC-1 acts with the ERK MAPK signaling pathway to regulate Caenorhabditis elegans mechanosensory response. Genes Brain Behav. 2011 Apr;10(3):286-98. doi: 10.1111/j.1601-183X.2010.00667.x. Epub 2011 Jan 10. PubMed PMID: 21143768. PMCID: PMC Journal in Process


Janas MM, Khaled M, Schubert S, Bernstein JG, Golan D, Veguilla RA, Fisher DE, Shomron N, Levy C, Novina CD. Feed-forward microprocessing and splicing activities at a microRNA-containing intron. PLoS Genet. 2011 Oct;7(10):e1002330. doi: 10.1371/journal.pgen.1002330. Epub 2011 Oct 20. PMID: 22028668 PMCID: PMC3197686 read article


Lal A, Thomas MP, Altschuler G, Navarro F, O'Day E, Li XL, Concepcion C, Han YC, Thiery J, Rajani DK, Deutsch A, Hofmann O, Ventura A, Hide W, Lieberman J. Capture of microRNA-bound mRNAs identifies the tumor suppressor miR-34a as a regulator of growth factor signaling. PLoS Genet. 2011 Nov;7(11):e1002363. doi: 10.1371/journal.pgen.1002363. Epub 2011 Nov 10. PMID: 22102825 PMCID: PMC3213160 read article


Zimmermann K, Lennerz JK, Hein A, Link AS, Kaczmarek JS, Delling M, Uysal S, Pfeifer JD, Riccio A, Clapham DE. Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system. Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):18114-9. Epub 2011 Oct 24. PubMed PMID: 22025699; PubMed Central PMCID: PMC3207667.


Lahiri S, Shen K, Klein M, Tang A, Kane E, Gershow M, Garrity P, Samuel AD. Two alternating motor programs drive navigation in Drosophila larva. PLoS One. 2011;6(8):e23180. doi: 10.1371/journal.pone.0023180. Epub 2011 Aug 15. PMID: 21858019 PMCID: PMC3156121 read article


Bock DD, Lee WC, Kerlin AM, Andermann ML, Hood G, Wetzel AW, Yurgenson S, Soucy ER, Kim HS, Reid RC. Network anatomy and in vivo physiology of visual cortical neurons. Nature. 2011 Mar 10;471(7337):177-82. PubMed PMID: 21390124; PubMed Central PMCID: PMC3095821.


Kiely CM, Marguerat S, Garcia JF, Madhani HD, Bähler J, Winston F. Spt6 is required for heterochromatic silencing in the fission yeast Schizosaccharomyces pombe. Mol Cell Biol. 2011 Oct;31(20):4193-204. doi: 10.1128/MCB.05568-11. Epub 2011 Aug 15. PMID: 21844224 PMCID: PMC3187285 read article


Kingston D, Chang H, Ensser A, Lee HR, Lee J, Lee SH, Jung JU, Cho NH. Inhibition of retromer activity by herpesvirus saimiri tip leads to CD4 downregulation and efficient T cell transformation. J Virol. 2011 Oct;85(20):10627-38. Epub 2011 Aug 17. PMID: 21849449 PMCID: PMC3187508 read article


Knoll AT, Muschamp JW, Sillivan SE, Ferguson D, Dietz DM, Meloni EG, Carroll FI, Nestler EJ, Konradi C, Carlezon WA Jr. Kappa opioid receptor signaling in the basolateral amygdala regulates conditioned fear and anxiety in rats. Biol Psychiatry. 2011 Sep 1;70(5):425-33. Epub 2011 Apr 30. PubMed PMID: 21531393; PubMed Central PMCID: PMC3150294.


Cipolletta D, Kolodin D, Benoist C, and Mathis D. Tissular Tregs: A unique population of adipose-tissue-resident Foxp3+CD4+ T cells that impacts organismal metabolism. Semin Immunol. 2011 Dec;23(6):431-7. doi: 10.1016/j.smim.2011.06.002. Epub 2011 Jul 2. PMID: 21724410


Kim EJ, Hori K, Wyckoff A, Dickel LK, Koundakjian EJ, Goodrich LV, Johnson JE. Spatiotemporal fate map of neurogenin1 (Neurog1) lineages in the mouse central nervous system. J Comp Neurol. 2011 May 1;519(7):1355-70. doi: 10.1002/cne.22574. PubMed PMID: 21452201. PMCID: PMC Journal in Process


Kranzusch PJ, Whelan SP. Arenavirus Z protein controls viral RNA synthesis by locking a polymerase-promoter complex. Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19743-8. Epub 2011 Nov 21. PMID: 22106304 PMCID: PMC3241799 read article


Carette JE, Raaben M, Wong AC, Herbert AS, Obernosterer G, Mulherkar N, Kuehne AI, Kranzusch PJ, Griffin AM, Ruthel G, Dal Cin P, Dye JM, Whelan SP, Chandran K, Brummelkamp TR. Ebola virus entry requires the cholesterol transporter Niemann-Pick C1. Nature. 2011 Aug 24;477(7364):340-3. doi: 10.1038/nature10348. PMID: 21866103 PMCID: PMC3175325 read article


Radoshitzky SR, Warfield KL, Chi X, Dong L, Kota K, Bradfute SB, Gearhart JD, Retterer C, Kranzusch PJ, Misasi JN, Hogenbirk MA, Wahl-Jensen V, Volchkov VE, Cunningham JM, Jahrling PB, Aman MJ, Bavari S, Farzan M, Kuhn JH. Ebolavirus delta-peptide immunoadhesins inhibit marburgvirus and ebolavirus cell entry. J Virol. 2011 Sep;85(17):8502-13. Epub 2011 Jun 22. PMID: 21697477 PMCID: PMC3165852 read article


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Deng X, Yang Q, Kwiatkowski N, Sim T, McDermott U, Settleman JE, Lee JD, Gray NS. ACS Med Chem Lett. 2011 Mar 10;2(3):195-200. Epub 2011 Jan 12. PMID: 21412406 PMCID: PMC3055678 read article


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Zacharek SJ, Fillmore CM, Lau AN, Gludish DW, Chou A, Ho JW, Zamponi R, Gazit R, Bock C, Jäger N, Smith ZD, Kim TM, Saunders AH, Wong J, Lee JH, Roach RR, Rossi DJ, Meissner A, Gimelbrant AA, Park PJ, Kim CF. Lung stem cell self-renewal relies on BMI1-dependent control of expression at imprinted loci. Cell Stem Cell. 2011 Sep 2;9(3):272-81. doi: 10.1016/j.stem.2011.07.007. PMID: 21885022 PMCID: PMC3167236 read article


Marotta LL, Almendro V, Marusyk A, Shipitsin M, Schemme J, Walker SR, Bloushtain-Qimron N, Kim JJ, Choudhury SA, Maruyama R, Wu Z, Gönen M, Mulvey LA, Bessarabova MO, Huh SJ, Silver SJ, Kim SY, Park SY, Lee HE, Anderson KS, Richardson AL, Nikolskaya T, Nikolsky Y, Liu XS, Root DE, Hahn WC, Frank DA, Polyak K. The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors. J Clin Invest. 2011 Jul;121(7):2723-35. doi: 10.1172/JCI44745. PMID: 21633165 PMCID: PMC3223826 read article


LeBlanc JJ, Fagiolini M. Autism: a "critical period" disorder? Neural Plast. 2011;2011:921680. Epub 2011 Aug 3. Review. PubMed PMID: 21826280; PubMed Central PMCID: PMC3150222.


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Lin Y, Zhang L, Cai AX, Lee M, Zhang W, Neuberg D, Canning CM, Soiffer RJ, Alyea EP, Ritz J, Hacohen N, Means TK, Wu CJ. Effective posttransplant antitumor immunity is associated with TLR-stimulating nucleic acid-immunoglobulin complexes in humans. J Clin Invest. 2011. 121(4):1574-84. PMCID: PMC3069775.


Chang SK, Noss EH, Chen M, Gu Z, Townsend K, Grenha R, Leon L, Lee SY, Lee DM, Brenner MB. Cadherin-11 regulates fibroblast inflammation. Proc Natl Acad Sci U S A. 2011 May 17;108(20):8402-7. doi: 10.1073/pnas.1019437108. Epub 2011 May 2. PMID: 21536877 PMCID: PMC3100978 read article


Peters A, Lee Y, Kuchroo VK. The many faces of Th17 cells. Curr Opin Immunol. 2011 Dec;23(6):702-6. doi: 10.1016/j.coi.2011.08.007. Epub 2011 Sep 6. PMID: 21899997; PMCID: PMC3232281 read article


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Libedinsky C, Livingstone M. Role of prefrontal cortex in conscious visual perception. J Neurosci. 2011 Jan 5;31(1):64-9. PubMed PMID: 21209190; PubMed Central PMCID: PMC3079255.


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Bian X, Klemm RW, Liu TY, Zhang M, Sun S, Sui X, Liu X, Rapoport TA, Hu J. Structures of the atlastin GTPase provide insight into homotypic fusion of endoplasmic reticulum membranes. Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):3976-81. doi: 10.1073/pnas.1101643108. Epub 2011 Feb 22. PMID: 21368113 PMCID: PMC3054032 read article


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Yang DC, Peters NT, Parzych KR, Uehara T, Markovski M, Bernhardt TG. An ATP-binding cassette transporter-like complex governs cell-wall hydrolysis at the bacterial cytokinetic ring. Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):E1052-60. Epub 2011 Oct 17. PubMed PMID: 22006326; PubMed Central PMCID: PMC3215046.


Koh Y, Matreyek KA, Engelman A. Differential sensitivities of retroviruses to integrase strand transfer inhibitors. J Virol. 2011 Apr;85(7):3677-82. doi: 10.1128/JVI.02541-10. Epub 2011 Jan 26. PMID: 21270168 PMCID: PMC3067883 read article


Matreyek KA, Engelman A. The requirement for nucleoporin NUP153 during human immunodeficiency virus type 1 infection is determined by the viral capsid. J Virol. 2011 Aug;85(15):7818-27. doi: 10.1128/JVI.00325-11. Epub 2011 May 18. PMID: 21593146 PMCID: PMC3147902 read article


Brown DR, Calpe S, Keszei M, Wang N, McArdel S, Terhorst C, Sharpe AH. Cutting edge: an NK cell-independent role for slamf4 in controlling humoral autoimmunity. J Immunol. 2011 Jul 1;187(1):21-5. doi: 10.4049/jimmunol.1100510. Epub 2011 May 27.PMID 21622868 PMCID: PMC3119727 read article


Cho H, McManus HR, Dove SL, Bernhardt TG. Nucleoid occlusion factor SlmA is a DNA-activated FtsZ polymerization antagonist. Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3773-8. doi: 10.1073/pnas.1018674108. Epub 2011 Feb 14. PMID: 21321206 PMCID: PMC3048121 read article


McManus HR, Dove SL. The CgrA and CgrC proteins form a complex that positively regulates cupA fimbrial gene expression in Pseudomonas aeruginosa. J Bacteriol. 2011 Nov;193(22):6152-61. doi: 10.1128/JB.05904-11. Epub 2011 Sep 16. PMID: 21926232 PMCID: PMC3209204 read article


Li S, Moffett HF, Lu J, Werner L, Zhang H, Ritz J, Neuberg D, Wucherpfennig KW, Brown JR, Novina CD. MicroRNA expression profiling identifies activated B cell status in chronic lymphocytic leukemia cells. PLoS One. 2011 Mar 8;6(3):e16956. PubMed PMID: 21408091; PubMed Central PMCID: PMC3050979.


Mullarky E, Mattaini KR, Vander Heiden MG, Cantley LC, Locasale JW. PHGDH amplification and altered glucose metabolism in human melanoma. Pigment Cell Melanoma Res. 2011 Dec;24(6):1112-5. doi: 10.1111/j.1755-148X.2011.00919.x. Epub 2011 Oct 28. PMID: 21981974


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Fioravante D, Chu Y, Myoga MH, Leitges M, Regehr WG. Calcium-dependentisoforms of protein kinase C mediate posttetanic potentiation at the calyx ofHeld. Neuron. 2011 Jun 9;70(5):1005-19. PubMed PMID: 21658591; PubMed Central PMCID: PMC3113702.


Myoga MH, Regehr WG. Calcium microdomains near R-type calcium channels control the induction of presynaptic long-term potentiation at parallel fiber to purkinje cell synapses. J Neurosci. 2011 Apr 6;31(14):5235-43. PubMed PMID: 21471358; PubMed Central PMCID: PMC3089026.


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Helman E, Naxerova K, Kohane IS. DNA hypermethylation in lung cancer is targeted at differentiation-associated genes. Oncogene. 2012 Mar 1;31(9):1181-8. doi: 10.1038/onc.2011.307. Epub 2011 Aug 1. PubMed PMID: 21804601.


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Gallegos L, Ng MR, Brugge JS. The myosin-II-responsive focal adhesion proteome: a tour de force? Nat Cell Biol. 2011 Apr;13(4):344-6. doi: 10.1038/ncb0411-344. Epub 2011 Mar 20. PMID: 21460805


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Olive AJ, Gondek DC, Starnbach MN. CXCR3 and CCR5 are both required for T cell-mediated protection against C. trachomatis infection in the murine genital mucosa. Mucosal Immunol. 2011 Mar;4(2):208-16. doi: 10.1038/mi.2010.58. Epub 2010 Sep 15. PMID: 20844481 PMCID: PMC3010299 read article


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Moskwa P, Buffa FM, Pan Y, Panchakshari R, Gottipati P, Muschel RJ, Beech J, Kulshrestha R, Abdelmohsen K, Weinstock DM, Gorospe M, Harris AL, Helleday T, Chowdhury D. miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors. Mol Cell. 2011 Jan 21;41(2):210-20. Epub 2010 Dec 30. PMID: 21195000 PMCID: PMC3249932 read article


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Roberson DP, Binshtok AM, Blasl F, Bean BP, Woolf CJ. Targeting of sodium channel blockers into nociceptors to produce long-duration analgesia: a systematic study and review. Br J Pharmacol. 2011 Sep;164(1):48-58. doi:10.1111/j.1476-5381.2011.01391.x. PubMed PMID: 21457220; PubMed Central PMCID: PMC3171859. read article


Mitra D, Robinson KC, Fisher DE. Melanoma and viagra: an unexpected connection. Pigment Cell Melanoma Res. 2011 Feb;24(1):16-8.


Coers J, Gondek DC, Olive AJ, Rohlfing A, Taylor GA, Starnbach MN. Compensatory T cell responses in IRG-deficient mice prevent sustained Chlamydia trachomatis infections. PLoS Pathog. 2011 Jun;7(6):e1001346. doi: 10.1371/journal.ppat.1001346. Epub 2011 Jun 23. PMID: 21731484 PMCID: PMC3121881 read article


Dong CK, Urgaonkar S, Cortese JF, Gamo FJ, Garcia-Bustos JF, Lafuente MJ, Patel V, Ross L, Coleman BI, Derbyshire ER, Clish CB, Serrano AE, Cromwell M, Barker RH Jr, Dvorin JD, Duraisingh MT, Wirth DF, Clardy J, Mazitschek R. Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors. Chem Biol. 2011 Dec 23;18(12):1602-10. doi: 10.1016/j.chembiol.2011.09.016. PMID: 22195562 PMCID: PMC3474356 read article


Sillé FC, Martin C, Jayaraman P, Rothchild A, Fortune S , Besra GS, Behar SM, Boes M. Requirement for Invariant chain in macrophages for Mycobacterium tuberculosis replication and CD1d antigen presentation. Infect Immun. 2011 Aug;79(8):3053-63. doi: 10.1128/IAI.01108-10. Epub 2011 May 16. PMID: 21576321 PMCID: PMC3147586 read article


Sillé FC, Martin C, Jayaraman P, Rothchild A, Besra GS, Behar SM, Boes M. Critical role for invariant chain in CD1d-mediated selection and maturation of Vα14-invariant NKT cells. Immunol Lett. 2011 Sep 30;139(1-2):33-41. doi: 10.1016/j.imlet.2011.04.012. Epub 2011 May 5. PMID: 21565221 PMCID: PMC3146573 read article


Cohen S, Gabel HW, Hemberg M, Hutchinson AN, Sadacca LA, Ebert DH, Harmin DA, Greenberg RS, Verdine VK, Zhou Z, Wetsel WC, West AE, Greenberg ME. Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function. Neuron. 2011 Oct 6;72(1):72-85. PubMed PMID: 21982370; PubMed Central PMCID: PMC3226708.


Jin Y, Chauhan SK, Annan JE, Sage PT, Sharpe AH, Dana R. A novel function for programmed death ligand-1 regulation of angiogenesis. Am J Pathol. 2011 Apr;178(4):1922-9. PMCID: PMC3078456.


Riella LV, Watanabe T, Sage PT, Yang J, Yeung M, Azzi J, Vanguri V, Chandraker A, Sharpe AH, Sayegh MH, Najafian N. Essential role of PDL1 expression on nonhematopoietic donor cells in acquired tolerance to vascularized cardiac allografts. Am J Transplant. 2011 Apr;11(4):832-40.


Soskis M, Salogiannis J, Greenberg M. EphrinBs send mixed messages. NatNeurosci. 2011 Oct 26;14(11):1356-8. doi: 10.1038/nn.2968. PubMed PMID: 22030542. PMC3269007.


San Roman AK, Shivdasani RA. Boundaries, junctions and transitions in the gastrointestinal tract. Exp Cell Res. 2011 Nov 15;317(19):2711-8. doi: 10.1016/j.yexcr.2011.07.011. Epub 2011 Jul 23. PMID: 21802415 PMCID: PMC3210370 read article


Sarkar A, Hochedlinger K. A gutsy way to grow: intestinal stem cells as nutrient sensors. Cell. 2011 Oct 28;147(3):487-9. doi: 10.1016/j.cell.2011.10.006. PMID: 22036555


Arnold K, Sarkar A, Yram MA, Polo JM, Bronson R, Sengupta S, Seandel M, Geijsen N, Hochedlinger K. Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice. Cell Stem Cell. 2011 Oct 4;9(4):317-29. doi: 10.1016/j.stem.2011.09.001. PMID: 21982232 PMCID: PMC3538360 read article


Beier KT, Saunders A, Oldenburg IA, Miyamichi K, Akhtar N, Luo L, Whelan SP, Sabatini B, Cepko CL. Anterograde or retrograde transsynaptic labeling of CNS neurons with vesicular stomatitis virus vectors. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15414-9. doi: 10.1073/pnas.1110854108. Epub 2011 Aug 8. PMID: 21825165 PMCID: PMC3174680 read article


Sequist LV, Waltman BA, Dias-Santagata D, Digumarthy S, Turke AB, Fidias P, Bergethon K, Shaw AT, Gettinger S, Cosper AK, Akhavanfard S, Heist RS, Temel J, Christensen JG, Wain JC, Lynch TJ, Vernovsky K, Mark EJ, Lanuti M, Iafrate AJ, Mino-Kenudson M, Engelman JA. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci Transl Med. 2011 Mar 23;3(75):75ra26. doi: 10.1126/scitranslmed.3002003. PMID: 21430269 PMCID: PMC3132801 read article


Yang X, Turke AB, Qi J, Song Y, Rexer BN, Miller TW, Jänne PA, Arteaga CL, Cantley LC, Engelman JA, Asara JM. Using tandem mass spectrometry in targeted mode to identify activators of class IA PI3K in cancer. Cancer Res. 2011 Sep 15;71(18):5965-75. doi: 10.1158/0008-5472.CAN-11-0445. Epub 2011 Jul 20. PMID: 21775521 PMCID: PMC3209668 read article


Chen X, Tukachinsky H, Huang CH, Jao C, Chu YR, Tang HY, Mueller B, Schulman S, Rapoport TA, Salic A. Processing and turnover of the Hedgehog protein in the endoplasmic reticulum. J Cell Biol. 2011 Mar 7;192(5):825-38. doi: 10.1083/jcb.201008090. Epub 2011 Feb 28. PMID: 21357747 PMCID: PMC3051819 read article


Kriegel MA, Sefik E, Hill JA, Wu HJ, Benoist C, Mathis D. Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11548-53. doi: 10.1073/pnas.1108924108. Epub 2011 Jun 27. PMID: 21709219 PMCID: PMC3136249 read article


Senapedis WT, Kennedy CJ, Boyle PM, Silver PA*. Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chain. Mol Biol Cell. 2011 May 15;22(10):1791-805. Epub 2011 Apr 1. PubMed PMID: 21460183; PubMed Central PMCID: PMC3093329.


Shepardson NE, Shankar GM, Selkoe DJ. Cholesterol level and statin use in Alzheimer disease: II. Review of human trials and recommendations. Arch Neurol. 2011 Nov;68(11):1385-92. Review. PubMed PMID: 22084122; PubMed Central PMCID: PMC3248784.


Shepardson NE, Shankar GM, Selkoe DJ. Cholesterol level and statin use in Alzheimer disease: I. Review of epidemiological and preclinical studies. Arch Neurol. 2011 Oct;68(10):1239-44. Review. PubMed PMID: 21987540; PubMed Central PMCID: PMC3211071.


Li S, Jin M, Koeglsperger T, Shepardson NE, Shankar GM, Selkoe DJ. Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors. J Neurosci. 2011 May 4;31(18):6627-38. PubMed PMID: 21543591; PubMed Central PMCID: PMC3100898.


Dutt A, Ramos AH, Hammerman PS, Mermel C, Cho J, Sharifnia T, Chande A, Tanaka KE, Stransky N, Greulich H, Gray NS, Meyerson M. Inhibitor-sensitive FGFR1 amplification in human non-small cell lung cancer. PLoS One. 2011;6(6):e20351. doi: 10.1371/journal.pone.0020351. Epub 2011 Jun 7. PMID: 21666749 PMCID: PMC3110189 read article


Savin T, Kurpios NA, Shyer AE, Florescu P, Liang H, Mahadevan L, Tabin CJ. On the growth and form of the gut. Nature. 2011 Aug 3;476(7358):57-62. doi: 10.1038/nature10277. PMID: 21814276 PMCID: PMC3335276 read article


Zhou F, Sikorski TW, Ficarro SB, Webber JT, Marto JA. Online nanoflow reversed phase-strong anion exchange-reversed phase liquid chromatography-tandem mass spectrometry platform for efficient and in-depth proteome sequence analysis of complex organisms. Anal Chem. 2011 Sep 15;83(18):6996-7005. doi: 10.1021/ac200639v. Epub 2011 Aug 18. PMID: 21851055 PMCID: PMC3196608 read article


Sikorski TW, Ficarro SB, Holik J, Kim T, Rando OJ, Marto JA, Buratowski S. Sub1 and RPA associate with RNA polymerase II at different stages of transcription. Mol Cell. 2011 Nov 4;44(3):397-409. doi: 10.1016/j.molcel.2011.09.013. PMID: 22055186 PMCID: PMC3227220 read article


Broadbent KM, Park D, Wolf AR, Van Tyne D, Sims JS, Ribacke U, Volkman S, Duraisingh M, Wirth D, Sabeti PC, Rinn JL. A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs. Genome Biol. 2011 Jun 20;12(6):R56. doi: 10.1186/gb-2011-12-6-r56.PMID: 21689454PMCID: PMC3218844 read article


Chevalier MF, Jülg B, Pyo A, Flanders M, Ranasinghe S, Soghoian DZ, Kwon DS, Rychert J, Lian J, Muller MI, Cutler S, McAndrew E, Jessen H, Pereyra F, Rosenberg ES, Altfeld M, Walker BD, Streeck H. HIV-1-specific interleukin-21+ CD4+ T cell responses contribute to durable viral control through the modulation of HIV-specific CD8+ T cell function. J Virol. 2011 Jan;85(2):733-41. doi: 10.1128/JVI.02030-10. Epub 2010 Nov 3. PMID: 21047960 PMCID: PMC3020027 read article


Smith SE, Zhou YD, Zhang G, Jin Z, Stoppel DC, Anderson MP. Increased gene dosage of Ube3a results in autism traits and decreased glutamate synaptic transmission in mice. Sci Transl Med. 2011 Oct 5;3(103):103ra97. doi: 10.1126/scitranslmed.3002627. PMID: 21974935 PMCID: PMC3356696 read article


Koh KP, Yabuuchi A, Rao S, Huang Y, Cunniff K, Nardone J, Laiho A, Tahiliani M, Sommer CA, Mostoslavsky G, Lahesmaa R, Orkin SH, Rodig SJ, Daley GQ, Rao A. Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell. 2011 Feb 4;8(2):200-13. PMID: 21295276. PMCID: PMC313431.


Pastor WA, Pape UJ, Huang Y, Henderson HR, Lister R, Ko M, McLoughlin EM, Brudno Y, Mahapatra S, Kapranov P, Tahiliani M, Daley GQ, Liu XS, Ecker JR, Milos PM, Agarwal S, Rao A. Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells. Nature. 2011 May 19;473(7347):394-7. Epub 2011 May 8. PMID: 21552279. PMCID: PMC3124347.


Gao D, Inuzuka H, Tan MK, Fukushima H, Locasale JW, Liu P, Wan L, Zhai B, Chin YR, Shaik S, Lyssiotis CA, Gygi SP, Toker A, Cantley LC, Asara JM, Harper JW, Wei W. mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR. Mol Cell. 2011 Oct 21;44(2):290-303. doi: 10.1016/j.molcel.2011.08.030. PMID: 22017875 PMCID: PMC3229299 read article


Tan MK, Lim HJ, Harper JW. SCF(FBXO22) regulates histone H3 lysine 9 and 36 methylation levels by targeting histone demethylase KDM4A for ubiquitin-mediated proteasomal degradation. Mol Cell Biol. 2011 Sep;31(18):3687-99. doi: 10.1128/MCB.05746-11. Epub 2011 Jul 18. PMID: 21768309 PMCID: PMC3165736 read article


Isogai Y, Si S, Pont-Lezica L, Tan T, Kapoor V, Murthy VN, Dulac C. Molecular organization of vomeronasal chemoreception. Nature. 2011 Sep 21;478(7368):241-5. doi: 10.1038/nature10437. PMID: 21937988 PMCID: PMC3192931 read article


Tanner GR, Lutas A, Martínez-François JR, Yellen G. Single K ATP channelopening in response to action potential firing in mouse dentate granule neurons. J Neurosci. 2011 Jun 8;31(23):8689-96. PubMed PMID: 21653873; PubMed Central PMCID: PMC3133530.


Tanner NA, Tolun G, Loparo JJ, Jergic S, Griffith JD, Dixon NE, van Oijen AM. E. coli DNA replication in the absence of free β clamps. EMBO J. 2011 May 4;30(9):1830-40. doi: 10.1038/emboj.2011.84. Epub 2011 Mar 25. PMID: 21441898 PMCID: PMC3101994 read article


Taylor AM, Zon LI. Modeling Diamond Blackfan anemia in the zebrafish. Semin Hematol. 2011 Apr;48(2):81-8. doi: 10.1053/j.seminhematol.2011.02.002. PMID: 21435504


Lal A, Thomas MP, Altschuler G, Navarro F, O'Day E, Li XL, Concepcion C, Han YC, Thiery J, Rajani DK, Deutsch A, Hofmann O, Ventura A, Hide W, Lieberman J. Capture of microRNA-bound mRNAs identifies the tumor suppressor miR-34a as a regulator of growth factor signaling. PLoS Genet. 2011 Nov;7(11):e1002363. doi: 10.1371/journal.pgen.1002363. Epub 2011 Nov 10. PMID: 22102825 PMCID: PMC3213160 read article


Cronican JJ, Beier KT, Davis TN, Tseng JC, Li W, Thompson DB, Shih AF, May EM, Cepko CL, Kung AL, Zhou Q, Liu DR. A class of human proteins that deliver functional proteins into mammalian cells in vitro and in vivo. Chem Biol. 2011 Jul 29;18(7):833-8. doi: 10.1016/j.chembiol.2011.07.003. PMID: 21802004 PMCID: PMC3154086 read article


Tischfield MA, Cederquist GY, Gupta ML Jr, Engle EC. Phenotypic spectrum of the tubulin-related disorders and functional implications of disease-causing mutations. Curr Opin Genet Dev. 2011 Jun;21(3):286-94. Epub 2011 Feb 1. Review. PubMed PMID: 21292473; PubMed Central PMCID: PMC3100401.


Tse JC, Kalluri R. Waking up dormant tumors. Breast Cancer Res. 2011 Jun 10;13(3):310. doi: 10.1186/bcr2872. PMID: 21672272 PMCID: PMC3218930 read article


Chen X, Tukachinsky H, Huang CH, Jao C, Chu YR, Tang HY, Mueller B, Schulman S, Rapoport TA, Salic A. Processing and turnover of the Hedgehog protein in the endoplasmic reticulum. J Cell Biol. 2011 Mar 7;192(5):825-38. doi: 10.1083/jcb.201008090. Epub 2011 Feb 28. PMID: 21357747 PMCID: PMC3051819 read article


Smith KS, Meloni EG, Myers KMM, Van't Veer A, Carlezon WA Jr., and Rudolph U. Reduction of fear-potentiated startle by chlordiazepoxide in C57BL/6J mice. Psychopharmocology. 2011 Feb;213(4):697-706. PMCID: PMC3056161.


Muschamp JW, Van't Veer A, Parsegian A, Gallo MS, Chen M, Neve RL, Meloni EG, and Carlezon WA Jr. Activation of CREB in the nucleus accumbens shell produces anhedonia and resistance to extinction of fear in rats. J Neurosci. 2011 Feb 23;31(8):3095-103. PMCID: PMC3096840.


Muschamp JW, Van't Veer A, Carlezon WA Jr. Tracking down the molecular substrates of stress: New roles for p38a MAPK and kappa-opioid receptors. Neuron. 2011 Aug 11;71(3):383-5. PMCID: PMC3155977.


Vander Lugt B, Beck ZT, Fuhlbrigge RC, Hacohen N, Campbell JJ, Boes M. TGF-β Suppresses β-Catenin-Dependent Tolerogenic Activation Program in Dendritic Cells. PLoS One. 2011;6(5):e20099. Epub 2011 May 20. PMID: 21625453. PMCID: PMC3098869


Ni Chonghaile T, Sarosiek KA, Vo TT, Ryan JA, Tammareddi A, Moore Vdel G, Deng J, Anderson KC, Richardson P, Tai YT, Mitsiades CS, Matulonis UA, Drapkin R, Stone R, Deangelo DJ, McConkey DJ, Sallan SE, Silverman L, Hirsch MS, Carrasco DR, Letai A. Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy. Science. 2011 Nov 25;334(6059):1129-33. doi: 10.1126/science.1206727. Epub 2011 Oct 27. PMID: 22033517 PMCID: PMC3280949 read article


Vong S, Kalluri R. The role of stromal myofibroblast and extracellular matrix in tumor angiogenesis. Genes Cancer. 2011 Dec;2(12):1139-45. doi: 10.1177/1947601911423940. PMID: 22866205 PMCID: PMC3411128 read article


Gao JT, Guimerà R, Li H, Pinto IM, Sales-Pardo M, Wai SC, Rubinstein B, Li R. Modular coherence of protein dynamics in yeast cell polarity system. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7647-52. Epub 2011 Apr 18. PubMed PMID: 21502521; PubMed Central PMCID: PMC3088571.


Nelson EA, Walker SR, Weisberg E, Bar-Natan M, Barrett R, Gashin LB, Terrell S, Klitgaard JL, Santo L, Addorio MR, Ebert BL, Griffin JD, Frank DA*. The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors. Blood. 2011 Jan 13. [Epub ahead of print] PMID: 21233313. PMCID: PMC3069678.


Camp AH, Wang AF, Losick R. A small protein required for the switch from {sigma}F to {sigma}G during sporulation in Bacillus subtilis.J Bacteriol. 2011 Jan;193(1):116-24. doi: 10.1128/JB.00949-10. Epub 2010 Oct 29. PMID: 21037003 PMCID: PMC3019954 read article


Wang AY, Cohen JY. EMBO Conference Series on the Assembly and Function of Neuronal Circuits. Neural Syst Circuits. 2011 Oct 27;1(1):15. PubMed PMID: 22329922; PubMed Central PMCID: PMC3278469.


Wardwell LH, Huttenhower C, Garrett WS. Current concepts of the intestinal microbiota and the pathogenesis of infection. Curr Infect Dis Rep. 2011 Feb;13(1):28-34. doi: 10.1007/s11908-010-0147-7. PMID: 21308452 PMCID: PMC3077078 read article


Akten B, Kye MJ, Hao le T, Wertz MH, Singh S, Nie D, Huang J, Merianda TT, Twiss JL, Beattie CE, Steen JA, Sahin M. Interaction of survival of motor neuron (SMN) and HuD proteins with mRNA cpg15 rescues motor neuron axonal deficits. Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10337-42. doi: 10.1073/pnas.1104928108. Epub 2011 Jun 7. PMID: 21652774 PMCID: PMC3121858 read article


Wheeler LA, Trifonova R, Vrbanac V, Basar E, McKernan S, Xu Z, Seung E, Deruaz M, Dudek T, Einarsson JI, Yang L, Allen TM, Luster AD, Tager AM, Dykxhoorn DM, Lieberman J. Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras. J Clin Invest. 2011 Jun 1;121(6):2401-12. doi: 10.1172/JCI45876. Epub 2011 May 16. PubMed PMID: 21576818; PubMed Central PMCID: PMC3104760.


Yan N, O'Day E, Wheeler LA, Engelman A, Lieberman J. HIV DNA is heavily uracilated, which protects it from autointegration. Proc Natl Acad Sci U S A. 2011 May 31;108(22):9244-9. Epub 2011 May 16. PubMed PMID: 21576478; PubMed Central PMCID: PMC3107311.


Gonzalez SF, Degn SE, Pitcher LA, Woodruff M, Heesters BA, Carroll MC. Trafficking of B cell antigen in lymph nodes. Annu Rev Immunol. 2011;29:215-33. doi: 10.1146/annurev-immunol-031210-101255. PMID: 21219172


Woodworth JS, Shin D, Volman M, Nunes-Alves C, Fortune SM, Behar SM. Mycobacterium tuberculosis directs immunofocusing of CD8+ T cell responses despite vaccination. J Immunol. 2011 Feb 1;186(3):1627-37. Epub 2010 Dec 22. PubMed PMID: 21178003; PubMed Central PMCID: PMC3133636.


Wu MP, Gussoni E. Carbamylated erythropoietin does not alleviate signs of dystrophy in mdx mice. Muscle Nerve. 2011 Jan;43(1):88-93. doi: 10.1002/mus.21785. PMID: 21171099 PMCID: PMC3057654 read article


Fioravante D, Chu Y, Myoga MH, Leitges M, Regehr WG. Calcium-dependent isoforms of protein kinase C mediate posttetanic potentiation at the calyx of Held. Neuron. 2011 Jun 9;70(5):1005-19. doi: 10.1016/j.neuron.2011.04.019. PMID: 21658591 PMCID: PMC3113702 read article


Yang K, Moldovan GL, Vinciguerra P, Murai J, Takeda S, D'Andrea AD. Regulation of the Fanconi anemia pathway by a SUMO-like delivery network. Genes Dev. 2011 Sep 1;25(17):1847-58. PubMed PMID: 21896657; PubMed Central PMCID: PMC3175720.


Murai J, Yang K, Dejsuphong D, Hirota K, Takeda S, D'Andrea AD. The USP1/UAF1 complex promotes double-strand break repair through homologous recombination. Mol Cell Biol. 2011 Jun;31(12):2462-9. Epub 2011 Apr 11. PubMed PMID: 21482670; PubMed Central PMCID: PMC3133424.


Loh YH, Yang L, Yang JC, Li H, Collins JJ, Daley GQ. Genomic approaches to deconstruct pluripotency. Annu Rev Genomics Hum Genet. 2011;12:165-85. doi: 10.1146/annurev-genom-082410-101506. PMID: 21801025 PMCID: PMC3652340  read article


Lehtinen MK, Zappaterra MW, Chen X, Yang YJ, Hill AD, Lun M, Maynard T, Gonzalez D, Kim S, Ye P, D'Ercole AJ, Wong ET, LaMantia AS, Walsh CA. The cerebrospinal fluid provides a proliferative niche for neural progenitor cells. Neuron. 2011 Mar 10;69(5):893-905. doi: 10.1016/j.neuron.2011.01.023. PMID: 21382550 PMCID: PMC3085909 read article


Yuan TL, Wulf G, Burga L, Cantley LC. Cell-to-cell variability in PI3K protein level regulates PI3K-AKT pathway activity in cell populations. Curr Biol. 2011 Feb 8;21(3):173-83. Epub 2011 Jan 20. PubMed PMID: 21256021.


Basu U, Meng FL, Keim C, Grinstein V, Pefanis E, Eccleston J, Zhang T, Myers D, Wasserman CR, Wesemann DR, Januszyk K, Gregory RI, Deng H, Lima CD, Alt FW. The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Cell. 2011 Feb 4;144(3):353-63. PMCID: PMC3065114.


Ise W, Kohyama M, Schraml BU, Zhang T, Schwer B, Basu U, Alt FW, Tang J, Oltz EM, Murphy TL, Murphy KM. The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nature Immunology. 2011 May 15. PMCID: PMC3117275.


top

2010


Abraira VE, Satoh T, Fekete DM, Goodrich LV. Vertebrate Lrig3-ErbBinteractions occur in vitro but are unlikely to play a role in Lrig3-dependentinner ear morphogenesis. PLoS One. 2010 Feb 1;5(2):e8981. PubMed PMID: 20126551; PubMed Central PMCID: PMC2813878.


Chou DM, Adamson B, Dephoure NE, Tan X, Nottke AC, Hurov KE, Gygi SP, Colaiácovo MP, Elledge SJ. A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage. Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18475-80. doi: 10.1073/pnas.1012946107. Epub 2010 Oct 11. PMID: 20937877 PMCID: PMC2972950 read article


O'Connell BC, Adamson B, Lydeard JR, Sowa ME, Ciccia A, Bredemeyer AL, Schlabach M, Gygi SP, Elledge SJ, Harper JW. A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability. Mol Cell. 2010 Nov 24;40(4):645-57. doi: 10.1016/j.molcel.2010.10.022. Epub 2010 Nov 4. PMID: 21055985 PMCID: PMC3006237 read article


Agapakis CM, Silver PA. Modular electron transfer circuits for synthetic biology: insulation of an engineered biohydrogen pathway. Bioeng Bugs. 2010 Nov-Dec;1(6):413-8. doi: 10.4161/bbug.1.6.12462. PMID: 21468209 PMCID: PMC3056092 read article


Agapakis CM, Ducat DC, Boyle PM, Wintermute EH, Way JC, Silver PA. Insulation of a synthetic hydrogen metabolism circuit in bacteria. J Biol Eng. 2010 Feb 25;4:3. doi: 10.1186/1754-1611-4-3. PMID: 20184755 PMCID: PMC2847965 read article


Albacker LA, Karisola P, Chang YJ, Umetsu SE, Zhou M, Akbari O, Kobayashi N, Baumgarth N, Freeman GJ, Umetsu DT, DeKruyff RH. (2010) TIM-4, a Receptor for Phosphatidylserine, Controls Adaptive Immunity by Regulating the Removal of Antigen-Specific T Cells. Journal of Immunology. 185(11):6839-49. PMID: 21037090 PMCID: PMC3153437


Chang YJ, Kim HY, Albacker LA, Lee HH, Baumgarth N, Akira S, Savage PB, Endo S, Yamamura T, Maaskant J, Kitano N, Singh A, Bhatt A, Besra GS, van den Elzen P, Appelmelk B, Franck RW, Chen G, DeKruyff RH, Shimamura M, Illarionov P, Umetsu DT. Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity. J Clin Invest. 2011 Jan 4;121(1):57-69. doi: 10.1172/JCI44845. Epub 2010 Dec 13. PMID: 21157038 PMCID: PMC3007162


Dhawale AK, Hagiwara A, Bhalla US, Murthy VN, Albeanu DF. Non-redundant odor coding by sister mitral cells revealed by light addressable glomeruli in the mouse. Nat Neurosci. 2010 Nov;13(11):1404-12. Epub 2010 Oct 17. PubMed PMID: 20953197; PubMed Central PMCID: PMC3208311.


Alpert MD, Rahmberg AR, Neidermyer W, Ng SK, Carville A, Camp JV, Wilson RL, Piatak M Jr, Mansfield KG, Li W, Miller CJ, Lifson JD, Kozlowski PA, Evans DT. Envelope-modified single-cycle simian immunodeficiency virus selectively enhances antibody responses and partially protects against repeated, low-dose vaginal challenge. J Virol. 2010 Oct;84(20):10748-64. Epub 2010 Aug 11. PMID: 20702641 PMCID: PMC2950576 read article


Giallourakis CC, Franklin A, Guo C, Cheng HL, Yoon HS, Gallagher M, Perlot T, Andzelm M, Murphy AJ, Macdonald LE, Yancopoulos GD, Alt FW. Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination. Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22207-12. Epub 2010 Dec 1. PubMed PMID: 21123744; PubMed Central PMCID: PMC3009784. read article


Liu H, Chi AW, Arnett KL, Chiang MY, Xu L, Shestova O, Wang H, Li YM, Bhandoola A, Aster JC, Blacklow SC, Pear WS. Notch dimerization is required for leukemogenesis and T-cell development. Genes Dev. 2010 Nov 1;24(21):2395-407. Epub 2010 Oct 8. PubMed PMID: 20935071; PubMed Central PMCID: PMC2964750.


Arnett KL, Hass M, McArthur DG, Ilagan MX, Aster JC, Kopan R, Blacklow SC. Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes. Nat Struct Mol Biol. 2010 Nov;17(11):1312-7. Epub 2010 Oct 24. PubMed PMID: 20972443; PubMed Central PMCID: PMC3024583.


Miller CL, Arnold MM, Broering TJ, Hastings CE, Nibert ML. Localization of mammalian orthoreovirus proteins to cytoplasmic factory-like structures via nonoverlapping regions of microNS. J Virol. 2010 Jan;84(2):867-82. Epub 2009 Nov 4. PMID: 19889754 PMCID: PMC2798337 read article


Whited JL, Lehoczky JA, Austin CA, Tabin CJ. Dynamic expression of two thrombospondins during axolotl limb regeneration. Dev Dyn. 2011 May;240(5):1249-58. doi: 10.1002/dvdy.22548. Epub 2011 Feb 1. PMID: 21360624 PMCID: PMC3081376 read article


Hellman NE, Liu Y, Merkel E, Austin C, Le Corre S, Beier DR, Sun Z, Sharma N, Yoder BK, Drummond IA. The zebrafish foxj1a transcription factor regulates cilia function in response to injury and epithelial stretch. Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18499-504. doi: 10.1073/pnas.1005998107. Epub 2010 Oct 11. PMID: 20937855 PMCID: PMC2972951 read article


Ching MS, Shen Y, Tan WH, Jeste SS, Morrow EM, Chen X, Mukaddes NM, Yoo SY, Hanson E, Hundley R, Austin C, Becker RE, Berry GT, Driscoll K, Engle EC, Friedman S, Gusella JF, Hisama FM, Irons MB, Lafiosca T, LeClair E, Miller DT, Neessen M, Picker JD, Rappaport L, Rooney CM, Sarco DP, Stoler JM, Walsh CA, Wolff RR, Zhang T, Nasir RH, Wu BL; Children's Hospital Boston Genotype Phenotype Study Group. Deletions of NRXN1 (neurexin-1) predispose to a wide spectrum of developmental disorders. Am J Med Genet B Neuropsychiatr Genet. 2010 Jun 5;153B(4):937-47. doi: 10.1002/ajmg.b.31063. PMID: 20468056 PMCID: PMC3001124 read article


Kim S, Lehtinen MK, Sessa A, Zappaterra MW, Cho SH, Gonzalez D, Boggan B, Austin CA, Wijnholds J, Gambello MJ, Malicki J, LaMantia AS, Broccoli V, Walsh CA. The apical complex couples cell fate and cell survival to cerebral cortical development. Neuron. 2010 Apr 15;66(1):69-84. doi: 10.1016/j.neuron.2010.03.019. PMID: 20399730 PMCID: PMC2872122 read article


Barker BR, Gladstone MN, Gillard GO, Panas MW, Letvin NL. Critical role for IL-21 in both primary and memory anti-viral CD8+ T cell responses. European Journal of Immunology, 2010; 40(11):3085-96. PMCID: PMC3119210.


Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villén J, Haas W, Sowa ME, Gygi SP. A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001. PMID: 21183079 PMCID: PMC3035969 read article


Aguiar M, Haas W, Beausoleil SA, Rush J, Gygi SP. Gas-phase rearrangements do not affect site localization reliability in phosphoproteomics data sets. J Proteome Res. 2010 Jun 4;9(6):3103-7. doi: 10.1021/pr1000225. PMID: 20377248 PMCID: PMC2912977 read article


Cronican JJ, Thompson DB, Beier KT, McNaughton BR, Cepko CL, Liu DR. Potent delivery of functional proteins into Mammalian cells in vitro and in vivo using a supercharged protein. ACS Chem Biol. 2010 Aug 20;5(8):747-52. PubMed PMID: 20545362; PubMed Central PMCID: PMC2924640.


Rosen AM, Stevens B. The role of the classical complement cascade in synapse loss during development and glaucoma. Adv Exp Med Biol. 2010;703:75-93. Review. PubMed PMID: 20711708.


Bilimoria PM, de la Torre-Ubieta L, Ikeuchi Y, Becker EB, Reiner O, Bonni A. AJIP3-regulated GSK3β/DCX signaling pathway restricts axon branching. J Neurosci. 2010 Dec 15;30(50):16766-76. PubMed PMID: 21159948.


Greer PL, Hanayama R, Bloodgood BL, Mardinly AR, Lipton DM, Flavell SW, Kim TK, Griffith EC, Waldon Z, Maehr R, Ploegh HL, Chowdhury S, Worley PF, Steen J, Greenberg ME. The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc. Cell. 2010 Mar 5;140(5):704-16. PubMed PMID: 20211139; PubMed Central PMCID: PMC2843143.


Zhang T, Franklin A, Boboila C, McQuay A, Gallagher MP, Manis JP, Khamlichi AA, Alt FW. Downstream class switching leads to IgE antibody production by B lymphocytes lacking IgM switch regions. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3040-5. Epub 2010 Feb 1. PubMed PMID: 20133637; PubMed Central PMCID: PMC2840363.


Boboila C, Jankovic M, Yan CT, Wang JH, Wesemann DR, Zhang T, Fazeli A, Feldman L, Nussenzweig A, Nussenzweig M, Alt FW. Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3034-9. Epub 2010 Jan 25. PubMed PMID: 20133803; PubMed Central PMCID: PMC2840344.


Zhang Y, Gostissa M, Hildebrand DG, Becker MS, Boboila C, Chiarle R, Lewis S, Alt FW. The role of mechanistic factors in promoting chromosomal translocations found in lymphoid and other cancers. Adv Immunol. 2010;106:93-133. Review. PubMed PMID: 20728025; PubMed Central PMCID: PMC3073861.


Boboila C, Yan C, Wesemann DR, Jankovic M, Wang JH, Manis J, Nussenzweig A, Nussenzweig M, Alt FW. Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4. J Exp Med. 2010 Feb 15;207(2):417-27. doi: 10.1084/jem.20092449. Epub 2010 Feb 8. PMID: 20142431 PMCID: PMC2822597 read article


Zhang T, Franklin A, Boboila C, McQuay A, Gallagher MP, Manis JP, Khamlichi AA, Alt FW. Downstream class switching leads to IgE antibody production by B lymphocytes lacking IgM switch regions. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3040-5. doi: 10.1073/pnas.0915072107. Epub 2010 Feb 1. PMID: 20133637 PMCID: PMC2840363 read article


Rowley CF, Boutwell CL, Lee EJ, MacLeod IJ, Ribaudo HJ, Essex M, Lockman S. Ultrasensitive detection of minor drug-resistant variants for HIV after nevirapine exposure using allele-specific PCR: clinical significance. AIDS Res Hum Retroviruses. 2010 Mar;26(3):293-300. doi: 10.1089/aid.2009.0082. PMID: 20334564 PMCID: PMC2864062 read article


Agapakis CM, Ducat DC, Boyle PM, Wintermute EH, Way JC, Silver PA. Insulation of a synthetic hydrogen metabolism circuit in bacteria. J Biol Eng. 2010 Feb 25;4:3. doi: 10.1186/1754-1611-4-3. PMID: 20184755 PMCID: PMC2847965 read article


Tcherkezian J, Brittis PA, Thomas F, Roux PP, Flanagan JG. Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. Cell. 2010 May 14;141(4):632-44. Epub 2010 Apr 29. PubMed PMID: 20434207; PubMed Central PMCID: PMC2881594.


Brown KE, Freeman GJ, Wherry EJ, Sharpe AH. Role of PD-1 in regulating acute infections. Curr Opin Immunol. 2010 Jun;22(3):397-401. Epub 2010 Apr 27. Review. PubMed PMID: 20427170; PubMed Central PMCID: PMC2905659.


Burrill DR, Silver PA. Making cellular memories. Cell. 2010 Jan 8;140(1):13-8. doi: 10.1016/j.cell.2009.12.034. PMID: 20085698 PMCID: PMC2882105 read article


Burrows AE, Smogorzewska A, Elledge SJ. Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence. Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14280-5. doi: 10.1073/pnas.1009559107. Epub 2010 Jul 26. PMID: 20660729 PMCID: PMC2922604 read article


Cedeno-Laurent F, Barthel SR, Opperman MJ, Lee DM, Clark RA, Dimitroff CJ. Development of a nascent galectin-1 chimeric molecule for studying the role of leukocyte galectin-1 ligands and immune disease modulation. J Immunol. 2010 Oct 15;185(8):4659-72. Epub 2010 Sep 15. PubMed PMID: 20844192; PubMed Central PMCID:PMC2953643.


Derti A, Cenik C, Kraft P, Roth FP. Absence of evidence for MHC-dependent mate selection within HapMap populations. PLoS Genet. 2010 Apr 29;6(4):e1000925. PubMed PMID: 20442868; PubMed Central PMCID: PMC2861700.


Cenik C, Derti A, Mellor JC, Berriz GF, Roth FP. Genome-wide functional analysis of human 5' untranslated region introns. Genome Biol. 2010;11(3):R29. Epub 2010 Mar 11. PubMed PMID: 20222956; PubMed Central PMCID: PMC2864569.


Ch'ng YH, Reid RC. Cellular imaging of visual cortex reveals the spatial and functional organization of spontaneous activity. Front Integr Neurosci. 2010 Aug 19;4. pii: 20. PubMed PMID: 20941381; PubMed Central PMCID: PMC2952458.


Chao MC, Rubin EJ. Letting sleeping dos lie: does dormancy play a role in tuberculosis? Annu Rev Microbiol. 2010;64:293-311. Review. PubMed PMID: 20825351.


Hett EC, Chao MC, Rubin EJ. Interaction and modulation of two antagonistic cell wall enzymes of mycobacteria. PLoS Pathog. 2010 Jul 29;6(7):e1001020. PubMed PMID: 20686708; PubMed Central PMCID: PMC2912383.


Chen AC, Guo LY, Ostaszewski BL, Selkoe DJ, LaVoie MJ. Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates. J Biol Chem. 2010 Apr 9;285(15):11378-91. Epub 2010 Feb 9. PubMed PMID: 20145246; PubMed Central PMCID: PMC2857016.


Chiang CW, Gajdos ZK, Korn JM, Kuruvilla FG, Butler JL, Hackett R, Guiducci C, Nguyen TT, Wilks R, Forrester T, Haiman CA, Henderson KD, Le Marchand L, Henderson BE, Palmert MR, McKenzie CA, Lyon HN, Cooper RS, Zhu X, Hirschhorn JN. Rapid assessment of genetic ancestry in populations of unknown origin by genome-wide genotyping of pooled samples. PLoS Genet. 2010 Mar 5;6(3):e1000866. PubMed PMID: 20221249; PubMed Central PMCID: PMC2832667.


Kang SJ, Chiang CW, Palmer CD, Tayo BO, Lettre G, Butler JL, Hackett R, Adeyemo AA, Guiducci C, Berzins I, Nguyen TT, Feng T, Luke A, Shriner D, Ardlie K, Rotimi C, Wilks R, Forrester T, McKenzie CA, Lyon HN, Cooper RS, Zhu X, Hirschhorn JN. Genome-wide association of anthropometric traits in African- and African-derived populations. Hum Mol Genet. 2010 Jul 1;19(13):2725-38. Epub 2010 Apr 16. PubMed PMID: 20400458; PubMed Central PMCID: PMC2883343.


Haas MS, Alicot EM, Schuerpf F, Chiu I, Li J, Moore FD, Carroll MC. Blockade of self-reactive IgM significantly reduces injury in a murine model of acute myocardial infarction. Cardiovasc Res. 2010 Sep 1;87(4):618-27. Epub 2010 May 11. PMID: 20462867. PMCID: PMC2920809.


Nowak RJ, Cuny GD, Choi S, Lansbury PT, Ray SS. Improving binding specificity of pharmacological chaperones that target mutant superoxide dismutase-1 linked to familial amyotrophic lateral sclerosis using computational methods. J Med Chem. 2010 Apr 8;53(7):2709-18. PubMed PMID: 20232802.


Kim SG, Choo AY, Blenis J*. ATM: Promoter of metabolic "cost" reduction and "savings" usage during hypoxia through mTORC1 regulation. Mol Cell. 2010 Nov 24;40(4):501-2. PubMed PMID: 21095578.


Choo AY, Kim SG, Vander Heiden MG, Mahoney SJ, Vu H, Yoon SO, Cantley LC, Blenis J*. Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply. Mol Cell. 2010 May 28;38(4):487-99. PubMed PMID: 20513425; PubMed Central PMCID: PMC2896794.


Prisic S, Dankwa S, Schwartz D, Chou MF, Locasale JW, Kang CM, Bemis G, Church GM, Steen H, Husson RN. Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinases. Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7521-6. Epub 2010 Apr 5. PubMed PMID: 20368441.


Christofferson DE, Yuan J. Necroptosis as an alternative form of programmed cell death. Curr Opin Cell Biol. 2010 Apr;22(2):263-8. doi: 10.1016/j.ceb.2009.12.003. Epub 2010 Jan 4. PMID: 20045303 PMCID: PMC2854308 read article


Christofferson DE, Yuan J. Cyclophilin A release as a biomarker of necrotic cell death. Cell Death Differ. 2010 Dec;17(12):1942-3. doi: 10.1038/cdd.2010.123. Epub 2010 Oct 8. PMID: 20930851 PMCID: PMC2981659 read article


Zhang H, Zhang X, Clark E, Mulcahey M, Huang S, Shi YG. TET1 is a DNA-binding protein that modulates DNA methylation and gene transcription via hydroxylation of 5-methylcytosine. Cell Res. 2010 Dec;20(12):1390-3. doi: 10.1038/cr.2010.156. Epub 2010 Nov 16. PMID: 21079648


Colodner KJ, Feany MB. Glial fibrillary tangles and JAK/STAT-mediated glial and neuronal cell death in a Drosophila model of glial tauopathy. J Neurosci. 2010 Dec 1;30(48):16102-13. PubMed PMID: 21123557. PubMed Central PMCID: PMC3073608.


Beriou G, Bradshaw EM, Lozano E, Costantino CM, Hastings WD, Orban T, Elyaman W, Khoury SJ, Kuchroo VK, Baecher-Allan C, Hafler DA. TGF-beta induces IL-9 production from human Th17 cells. J Immunol. 2010 Jul 1;185(1):46-54. Epub 2010 May 24. PubMed PMID: 20498357; PubMed Central PMCID: PMC2936106.


Sakaguchi S, Miyara M, Costantino CM, Hafler DA. FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol. 2010 Jul;10(7):490-500. Epub 2010 Jun 18. Review. PubMed PMID: 20559327.


Curtis SJ, Sinkevicius KW, Li D, Lau AN, Roach RR, Zamponi R, Woolfenden AE, Kirsch DG, Wong KK, Kim CF. Primary tumor genotype is an important determinant in identification of lung cancer propagating cells. Cell Stem Cell. 2010 Jul 2;7(1):127-33. PubMed PMID: 20621056; PubMed Central PMCID: PMC2908996.


Cury KM, Uchida N. Robust odor coding via inhalation-coupled transient activity in the mammalian olfactory bulb. Neuron. 2010 Nov 4;68(3):570-85. PubMed PMID: 21040855.


de la Torre-Ubieta L, Gaudillière B, Yang Y, Ikeuchi Y, Yamada T, DiBacco S, Stegmüller J, Schüller U, Salih DA, Rowitch D, Brunet A, Bonni A. A FOXO-Pak1 transcriptional pathway controls neuronal polarity. Genes Dev. 2010 Apr 15;24(8):799-813. PubMed PMID: 20395366; PubMed Central PMCID: PMC2854394.


Tu C, Ortega-Cava CF, Winograd P, Stanton MJ, Reddi AL, Dodge I, Arya R, Dimri M, Clubb RJ, Naramura M, Wagner KU, Band V, Band H. Endosomal-sorting complexes required for transport (ESCRT) pathway-dependent endosomal traffic regulates the localization of active Src at focal adhesions. Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16107-12. Epub 2010 Aug 30. PubMed PMID: 20805499; PubMed Central PMCID: PMC2941294.


Dougan ML, Dougan S, Slisz J, Firestone B, Vanneman M, Draganov D, Goyal G, Li W, Neuberg D, Blumberg R, Hacohen N, Porter D, Zawel L, Dranoff G. IAP inhibitors enhance co-stimulation to promote tumor immunity. J Exp Med. 2010 Sep 27;207(10):2195-206. Epub 2010 Sep 13. PMID: 20837698


Zeissig S, Dougan SK, Barral DC, Junker Y, Chen Z, Kaser A, Ho M, Mandel H, McIntyre A, Kennedy SM, Painter GF, Veerapen N, Besra GS, Cerundolo V, Yue S, Beladi S, Behar SM, Chen X, Gumperz JE, Breckpot K, Raper A, Baer A, Exley MA, Hegele RA, Cuchel M, Rader DJ, Davidson NO, Blumberg RS. Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function. J Clin Invest. 2010 Aug 2;120(8):2889-99. doi: 10.1172/JCI42703. Epub 2010 Jul 1. PubMed PMID: 20592474; PubMed Central PMCID: PMC2912200.


Dougan M, Dougan S, Slisz J, Firestone B, Vanneman M, Draganov D, Goyal G, Li W, Neuberg D, Blumberg R, Hacohen N, Porter D, Zawel L, Dranoff G. IAP inhibitors enhance co-stimulation to promote tumor immunity. J Exp Med. 2010 Sep 27;207(10):2195-206. Epub 2010 Sep 13. PubMed PMID: 20837698; PubMed Central PMCID: PMC2947073.


Dougan M, Dougan S, Slisz J, Firestone B, Vanneman M, Draganov D, Goyal G, Li W, Neuberg D, Blumberg R, Hacohen N, Porter D, Zawel L, Dranoff G. IAP inhibitors enhance co-stimulation to promote tumor immunity. J Exp Med. 2010 Sep 27;207(10):2195-206. Epub 2010 Sep 13. PubMed PMID: 20837698; PubMed Central PMCID: PMC2947073.


Dufu K Livingstone MJ, Seebacher J, Gygi SP, Wilson SA, Reed R. ATP is required for interactions between UAP56 and two conserved mRNA export proteins, Aly and CIP29, to assemble the TREX complex. Genes Dev. 2010 Sep 15;24(18):2043-53. doi: 10.1101/gad.1898610. PMID: 20844015 PMCID: PMC2939366 read article


Li W, Schulman S, Dutton RJ, Boyd D, Beckwith J, Rapoport TA. Structure of a bacterial homologue of vitamin K epoxide reductase. Nature. 2010 Jan 28;463(7280):507-12. PubMed PMID: 20110994.


Warren L, Manos PD, Ahfeldt T, Loh YH, Li H, Lau F, Ebina W, Mandal PK, Smith ZD, Meissner A, Daley GQ, Brack AS, Collins JJ, Cowan C, Schlaeger TM, Rossi DJ. Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA. Cell Stem Cell. 2010 Sep 29. [Epub ahead of print] PMID: 20888316


Tan CS, Ellis LC, Wüthrich C, Ngo L, Broge TA Jr, Saint-Aubyn J, Miller JS, Koralnik IJ. JC virus latency in the brain and extraneural organs of patients with and without progressive multifocal leukoencephalopathy. J Virol. 2010 Sep;84(18):9200-9. Epub 2010 Jul 7. PubMed PMID: 20610709; PubMed Central PMCID: PMC2937633. read article


Erwin JA, Lee JT. Characterization of X-chromosome inactivation status in human pluripotent stem cells. Curr Protoc Stem Cell Biol. 2010 Feb;Chapter 1:Unit 1B.6. PubMed PMID: 20127856.


Yang W, Cai Q, Lui VW, Everley PA, Kim J, Bhola N, Quesnelle KM, Zetter BR, Steen H, Freeman MR, Grandis JR. Quantitative proteomics analysis reveals molecular networks regulated by epidermal growth factor receptor level in head and neck cancer. J Proteome Res. 2010 Jun 4;9(6):3073-82. doi: 10.1021/pr901211j. PMID: 20426488 PMCID: PMC3149825 read article


Greer PL, Hanayama R, Bloodgood BL, Mardinly AR, Lipton DM, Flavell SW, Kim TK, Griffith EC, Waldon Z, Maehr R, Ploegh HL, Chowdhury S, Worley PF, Steen J, Greenberg ME. The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc. Cell. 2010 Mar 5;140(5):704-16. PubMed PMID: 20211139; PubMed Central PMCID: PMC2843143.


Frank CL, Ge X, Xie Z, Zhou Y, Tsai LH*. Control of activating transcription factor 4 (ATF4) persistence by multisite phosphorylation impacts cell cycle progression and neurogenesis. J Biol Chem. 2010 Oct 22;285(43):33324-37. PMC2963346.


Buchman JJ, Tseng HC, Zhou Y, Frank CL, Xie Z, Tsai LH*. Cdk5rap2 interacts with pericentrin to maintain the neural progenitor pool in the developing neocortex. Neuron. 2010 May 13;66(3):386-402. PMID: 20471352


Ge X, Frank CL, Calderon F, Tsai LH*. Hook3 interacts with PCM1 to regulate pericentriolar material assembly and the timing of neurogenesis. Neuron. 2010 Jan 28; 65(2):191-203. PMC2902371.


Fry JL, Toker A. Secreted and membrane-bound isoforms of protease ADAM9 have opposing effects on breast cancer cell migration. Cancer Res. 2010 Oct 15;70(20):8187-98. Epub 2010 Aug 24. PMC2955804


Chiang CW, Gajdos ZK, Korn JM, Kuruvilla FG, Butler JL, Hackett R, Guiducci C, Nguyen TT, Wilks R, Forrester T, Haiman CA, Henderson KD, Le Marchand L, Henderson BE, Palmert MR, McKenzie CA, Lyon HN, Cooper RS, Zhu X, Hirschhorn JN. Rapid assessment of genetic ancestry in populations of unknown origin by genome-wide genotyping of pooled samples. PLoS Genet. 2010 Mar 5;6(3):e1000866. PubMed PMID: 20221249; PubMed Central PMCID: PMC2832667.


Gajdos ZK, Henderson KD, Hirschhorn JN, Palmert MR. Genetic determinants of pubertal timing in the general population. Mol Cell Endocrinol. 2010 Feb 6. [Epub ahead of print] PubMed PMID: 20144687.


Shen J, Gilmore EC, Marshall CA, Haddadin M, Reynolds JJ, Eyaid W, Bodell A, Barry B, Gleason D, Allen K, Ganesh VS, Chang BS, Grix A, Hill RS, Topcu M, Caldecott KW, Barkovich AJ, Walsh CA. Mutations in PNKP cause microcephaly, seizures and defects in DNA repair. Nat Genet. 2010 Mar;42(3):245-9. Epub 2010 Jan 31. PubMed PMID: 20118933; PubMed Central PMCID: PMC2835984.


Mochida GH, Ganesh VS, Felie JM, Gleason D, Hill RS, Clapham KR, Rakiec D, Tan WH, Akawi N, Al-Saffar M, Partlow JN, Tinschert S, Barkovich AJ, Ali B, Al-Gazali L, Walsh CA. A homozygous mutation in the tight-junction protein JAM3 causes hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Am J Hum Genet. 2010 Dec 10;87(6):882-9. PMID: 21109224. PMCID: PMC2997371


Kharas MG, Okabe R, Ganis JJ, Gozo M, Khandan T, Paktinat M, Gilliland DG,Gritsman K. Constitutively active AKT depletes hematopoietic stem cells andinduces leukemia in mice. Blood. 2010 Feb 18;115(7):1406-15. Epub 2009 Dec 14. PubMed PMID: 20008787; PubMed Central PMCID: PMC2826762. read article


Odyniec AN, Barral DC, Garg S, Tatituri RV, Besra GS, Brenner MB. Regulation of CD1 antigen-presenting complex stability. J Biol Chem. 2010 Apr 16;285(16):11937-47. Epub 2010 Feb 4. PMID: 20133943 PMCID: PMC2852931


Gao D, Wan L, Inuzuka H, Berg AH, Tseng A, Zhai B, Shaik S, Bennett E, Tron AE, Gasser JA, Lau A, Gygi SP, Harper JW, DeCaprio JA, Toker A, Wei W. Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction. Mol Cell. 2010 Sep 10;39(5):797-808. doi: 10.1016/j.molcel.2010.08.016. PMID: 20832730 PMCID: PMC2939073 read article


Ge X, Frank CL, Calderon de Anda F, Tsai LH. Hook3 interacts with PCM1 to regulate pericentriolar material assembly and the timing of neurogenesis. Neuron. 2010 Jan 28;65(2):191-203. PubMed PMID: 20152126; PubMed Central PMCID: PMC2902371.


Marín O, Valiente M, Ge X, Tsai LH. Guiding neuronal cell migrations. Cold Spring Harb Perspect Biol. 2010 Feb;2(2):a001834. Review. PubMed PMID: 20182622; PubMed Central PMCID: PMC2828271.


Singh KK, Ge X, Mao Y, Drane L, Meletis K, Samuels BA, Tsai LH. Dixdc1 is a critical regulator of DISC1 and embryonic cortical development. Neuron. 2010 Jul 15;67(1):33-48. PubMed PMID: 20624590; PubMed Central PMCID: PMC2938013.


de Anda FC, Meletis K, Ge X, Rei D, Tsai LH. Centrosome motility is essential for initial axon formation in the neocortex. J Neurosci. 2010 Aug 4;30(31):10391-406. PubMed PMID: 20685982.


Frank CL, Ge X, Xie Z, Zhou Y, Tsai LH. Control of activating transcription factor 4 (ATF4) persistence by multisite phosphorylation impacts cell cycle progression and neurogenesis. J Biol Chem. 2010 Oct 22;285(43):33324-37. Epub 2010 Aug 19. PubMed PMID: 20724472; PubMed Central PMCID: PMC2963346.


Laurent G, German N, Haigis M. SIRT4 enzymatic activity and biological functions. Review. Experimental Medicine. December 2010. (Invited Review Article - Not a peer reviewed article.)


Giessel AJ, Sabatini BL. M1 muscarinic receptors boost synaptic potentials and calcium influx in dendritic spines by inhibiting postsynaptic SK channels.Neuron. 2010 Dec 9;68(5):936-47. PubMed PMID: 21145006; PubMed Central PMCID: PMC3052967.


Noseda R, Kainz V, Jakubowski M, Gooley JJ, Saper CB, Digre K, Burstein R. A neural mechanism for exacerbation of headache by light. Nat Neurosci. 2010 Feb;13(2):239-45. Epub 2010 Jan 10. PubMed PMID: 20062053; PubMed Central PMCID: PMC2818758.


Gouwens NW, Zeberg H, Tsumoto K, Tateno T, Aihara K, Robinson HP. Synchronization of firing in cortical fast-spiking interneurons at gamma frequencies: a phase-resetting analysis. PLoS Comput Biol. 2010 Sep 30;6(9). pii: e1000951. PubMed PMID: 20941393; PubMed Central PMCID: PMC2947988.


Dougan M, Dougan S, Slisz J, Firestone B, Vanneman M, Draganov D, Goyal G, Li W, Neuberg D, Blumberg R, Hacohen N, Porter D, Zawel L, Dranoff G. IAP inhibitors enhance co-stimulation to promote tumor immunity. J Exp Med. 2010 Sep 27;207(10):2195-206. Epub 2010 Sep 13. PubMed PMID: 20837698; PubMed Central PMCID: PMC2947073. read article


Grassian AR, Schafer ZT, Brugge JS. ErbB2 stabilizes epidermal growth factor receptor (EGFR) expression via Erk and Sprouty2 in extracellular matrix-detached cells. J Biol Chem. 2011 Jan 7;286(1):79-90. Epub 2010 Oct 18. PubMed PMID: 20956544; PubMed Central PMCID: PMC3013038.


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Higashi-Kovtun ME, Mosca TJ, Dickman DK, Meinertzhagen IA, Schwarz TL.Importin-beta11 regulates synaptic phosphorylated mothers against decapentaplegic, and thereby influences synaptic development and function at the Drosophila neuromuscular junction. J Neurosci. 2010 Apr 14;30(15):5253-68. PubMed PMID: 20392948; PubMed Central PMCID: PMC2881940.


Paust S, Gill HS, Wang BZ, Flynn MP, Moseman EA, Senman B, Szczepanik M, Telenti A, Askenase PW, Compans RW, von Andrian UH. Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses. Nat Immunol. 2010 Dec;11(12):1127-35. Epub 2010 Oct 24. PubMed PMID: 20972432; PubMed Central PMCID: PMC2982944


Bao X, Moseman EA, Saito H, Petryanik B, Thiriot A, Hatakeyama S, Ito Y, Kawashima H, Yamaguchi Y, Lowe JB, von Andrian UH, Fukuda M. Endothelial heparan sulfate controls chemokine presentation in recruitment of lymphocytes and dendritic cells to lymph nodes. Immunity. 2010 Nov 24;33(5):817-29. PubMed PMID: 21093315; PubMed Central PMCID: PMC2996097


Iannacone M, Moseman EA, Tonti E, Bosurgi L, Junt T, Henrickson SE, Whelan SP, Guidotti LG, von Andrian UH. Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus. Nature. 2010 Jun 24;465(7301):1079-83. PubMed PMID: 20577213; PubMed Central PMCID: PMC2892812


Mamo T, Moseman EA, Kolishetti N, Salvador-Morales C, Shi J, Kuritzkes DR,Langer R, von Andrian U, Farokhzad OC. Emerging nanotechnology approaches for HIV/AIDS treatment and prevention. Nanomedicine (Lond). 2010 Feb;5(2):269-85. Review. PubMed PMID: 20148638; PubMed Central PMCID: PMC2861897


Liang X, Moseman EA, Farrar MA, Bachanova V, Weisdorf DJ, Blazar BR, Chen W. Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells. Blood. 2010 Jun 17;115(24):5041-52. Epub 2010 Mar 25. PubMed PMID: 20339095; PubMed Central PMCID: PMC2890142


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Yoshida T, Ng SY, Georgopoulos K. Awakening lineage potential by Ikaros-mediated transcriptional priming. Curr Opin Immunol. 2010 Apr;22(2):154-60. Epub 2010 Mar 17. Review. PubMed PMID: 20299195.


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Krishnan L, Matreyek KA, Oztop I, Lee K, Tipper CH, Li X, Dar MJ, Kewalramani VN, Engelman A. The requirement for cellular transportin 3 (TNPO3 or TRN-SR2) during infection maps to human immunodeficiency virus type 1 capsid and not integrase. J Virol. 2010 Jan;84(1):397-406. doi: 10.1128/JVI.01899-09. Epub 2009 Oct 21. PMID: 19846519 PMCID: PMC2798409 read article


Paik EJ, Zon LI. Hematopoietic development in the zebrafish. Int J Dev Biol. 2010;54(6-7):1127-37. doi: 10.1387/ijdb.093042ep. PMID: 20711990


Paik EJ, de Jong JL, Pugach E, Opara P, Zon LI. A chemical genetic screen in zebrafish for pathways interacting with cdx4 in primitive hematopoiesis. Zebrafish. 2010 Mar;7(1):61-8. doi: 10.1089/zeb.2009.0643. PMID: 20415644 PMCID: PMC2897134 read article


Barker BR, Gladstone MN, Gillard GO, Panas MW, Letvin NL. Critical role for IL-21 in both primary and memory anti-viral CD8+ T-cell responses..Eur J Immunol. 2010 Nov;40(11):3085-96. doi: 10.1002/eji.200939939. Epub 2010 Oct 27. PMID:21061439. PMCID: PMC3119210.


Pielak RM, Chou JJ. Kinetic analysis of the M2 proton conduction of the influenza virus. J Am Chem Soc. 2010 Dec 22;132(50):17695-7. Epub 2010 Nov 23. PubMed PMID: 21090748. PMCID: PMC3183502.


Pielak RM, Chou JJ. Solution NMR structure of the V27A drug resistant mutant of influenza A M2 channel. Biochem Biophys Res Commun. 2010 Oct 8;401(1):58-63. Epub 2010 Sep 15. PMID: 20833142. PMCID: PMC3215091.


Andreas LB, Eddy MT, Pielak RM, Chou J, Griffin RG. Magic angle spinning NMR investigation of influenza A M2(18-60): support for an allosteric mechanism of inhibition. J Am Chem Soc. 2010 Aug 18;132(32):10958-60. PMID: 20698642; PMCID: PMC2922979.


Puram SV, Kim AH, Bonni A. An old dog learns new tricks: a novel function for Cdc20-APC in dendrite morphogenesis in neurons. Cell Cycle. 2010 Feb 1;9(3):482-5. PMID: 20195072 PMCID: PMC2853878 read article


Fletcher AL, Lukacs-Kornek V, Reynoso ED, Pinner SE, Bellemare-Pelletier A, Curry MS, Collier AR, Boyd RL, Turley SJ. Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions. J Exp Med. 2010 Apr 12;207(4):689-97. Epub 2010 Mar 22. PubMed PMID: 20308362; PubMed Central PMCID: PMC2856033.


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Rodriguez-Manzanet R, Sanjuan MA, Wu HY, Quintana FJ, Xiao S, Anderson AC, Weiner HL, Green DR, Kuchroo VK. T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice. Proc Natl Acad Sci U S A. 2010 May 11;107(19):8706-11. Epub 2010 Apr 5. PMID: 20368430 PMCID: PMC2889349


Rogers TF, Lim SY, Sundsvold TJ, Chan T, Hsu A, Letvin NL. Variability in a dominant block to SIV early reverse transcription in rhesus monkey cells predicts in vivo viral replication and time to death. Virol J. 2010 Apr 26;7:79. PMID: 20416115 PMCID: PMC2874537 read article


Lim SY, Rogers T, Chan T, Whitney JB, Kim J, Sodroski J, Letvin NL. TRIM5alpha Modulates Immunodeficiency Virus Control in Rhesus Monkeys. PLoS Pathog. 2010 Jan 22;6(1):e1000738. PMID: 20107597 PMCID: PMC2809762 read article


Mayadas TN, Rosetti F, Ernandez T, Sethi S. Neutrophils: game changers in glomerulonephritis? Trends Mol Med. 2010 Aug;16(8):368-78. Epub 2010 Jul 29. Review. PMID: 20667782 PMCID: PMC2925238. read article


Cao S, Ross L, Tamayo G, Clardy J. Asterogynins: secondary metabolites from a Costa Rican endophytic fungus. Org Lett. 2010 Oct 15;12(20):4661-3. doi: 10.1021/ol101972g. PMID: 20839869 PMCID: PMC2951720 read article


Garces A, Atmakuri K, Chase MR, Woodworth JS, Krastins B, Rothchild AC, Ramsdell TL, Lopez MF, Behar SM, Sarracino DA, Fortune SM. EspA acts as a critical mediator of ESX1-dependent virulence in Mycobacterium tuberculosis by affecting bacterial cell wall integrity. PLoS Pathog. 2010 Jun 24;6(6):e1000957. doi: 10.1371/journal.ppat.1000957. PMID: 20585630 PMCID: PMC2891827 read article


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Francisco LM, Sage PT, Sharpe AH. The PD-1 pathway in tolerance and autoimmunity. Immunol Rev. 2010 Jul;236:219-42. PMCID: PMC2919275.


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Singh KK, Ge X, Mao Y, Drane L, Meletis K, Samuels BA, Tsai LH. Dixdc1 is a critical regulator of DISC1 and embryonic cortical development. Neuron. 2010 Jul 15;67(1):33-48. PubMed PMID: 20624590; PubMed Central PMCID: PMC2938013.


Schlabach MR, Hu JK, Li M, Elledge SJ. Synthetic design of strong promoters. Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2538-43. Epub 2010 Jan 21. PubMed PMID: 20133776; PubMed Central PMCID: PMC2823900.


Schmidt AG, Yang PL, Harrison SC. Peptide inhibitors of flavivirus entry derived from the E protein stem. J Virol. 2010 Dec;84(24):12549-54. Epub 2010 Sep 29. PMID: 20881042 PMCID: PMC3004314 read article


Schmidt AG, Yang PL, Harrison SC. Peptide inhibitors of dengue-virus entry target a late-stage fusion intermediate. PLoS Pathog. 2010 Apr 8;6(4):e1000851. PMID: 20386713 PMCID: PMC2851732 read article


Schneiderman JI, Goldstein S, Ahmad K. Perturbation analysis of heterochromatin-mediated gene silencing and somatic inheritance. PLoS Genet. 2010 Sep 9;6(9). pii: e1001095. PMID: 20838586; PMCID: PMC2936522.


Turke AB, Zejnullahu K, Wu YL, Song Y, Dias-Santagata D, Lifshits E, Toschi L, Rogers A, Mok T, Sequist L, Lindeman NI, Murphy C, Akhavanfard S, Yeap BY, Xiao Y, Capelletti M, Iafrate AJ, Lee C, Christensen JG, Engelman JA, Jänne PA. Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC. Cancer Cell. 2010 Jan 19;17(1):77-88. doi: 10.1016/j.ccr.2009.11.022. PMID: 20129249 PMCID: PMC2980857 read article


Turke AB, Engelman JA. PIKing the right patient. Clin Cancer Res. 2010 Jul 15;16(14):3523-5. doi: 10.1158/1078-0432.CCR-10-1201. Epub 2010 Jun 10. PMID: 20538763


Schulman S, Wang B, Li W, Rapoport TA. Vitamin K epoxide reductase prefers ER membrane-anchored thioredoxin-like redox partners. Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15027-32. doi: 10.1073/pnas.1009972107. Epub 2010 Aug 9. PMID: 20696932 PMCID: PMC2930587 read article


Li W, Schulman S, Dutton RJ, Boyd D, Beckwith J, Rapoport TA. Structure of a bacterial homologue of vitamin K epoxide reductase. Nature. 2010 Jan 28;463(7280):507-12. doi: 10.1038/nature08720. PMID: 20110994 PMCID: PMC2919313 read article


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Li S, Shankar GM, Selkoe DJ. How do Soluble Oligomers of Amyloid beta-protein Impair Hippocampal Synaptic Plasticity? Front Cell Neurosci. 2010 Mar 19;4:5. PubMed PMID: 20428510; PubMed Central PMCID: PMC2859875.


Mc Donald JM, Savva GM, Brayne C, Welzel AT, Forster G, Shankar GM, Selkoe DJ, Ince PG, Walsh DM; Medical Research Council Cognitive Function and Ageing Study. The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia. Brain. 2010 May;133(Pt 5):1328-41. Epub 2010 Apr 19. PubMed PMID: 20403962; PubMed Central PMCID: PMC2859152.


Shen J, Gilmore EC, Marshall CA, Haddadin M, Reynolds JJ, Eyaid W, Bodell A, Barry B, Gleason D, Allen K, Ganesh VS, Chang BS, Grix A, Hill RS, Topcu M, Caldecott KW, Barkovich AJ, Walsh CA. Mutations in PNKP cause microcephaly, seizures and defects in DNA repair. Nat Genet. 2010 Mar;42(3):245-9. Epub 2010 Jan 31. PubMed PMID: 20118933; PubMed Central PMCID: PMC2835984.


Sircar P, Furr KL, Dorosh LA, Letvin NL. Clonal repertoires of virus-specific CD8+ T lymphocytes are shared in mucosal and systemic compartments during chronic simian immunodeficiency virus infection in rhesus monkeys. J Immunol. 2010 Aug 15;185(4):2191-9. Epub 2010 Jul 12. PMID: 20624939.


Soghoian DZ, Streeck H. Cytolytic CD4(+) T cells in viral immunity. Expert Rev Vaccines. 2010 Dec;9(12):1453-63. doi: 10.1586/erv.10.132. PMID: 21105780 PMCID: PMC3033049 read article


Millet YA, Danna CH, Clay NK, Songnuan W, Simon MD, Werck-Reichhart D, Ausubel FM. Innate immune responses activated in Arabidopsis roots by microbe-associated molecular patterns. Plant Cell. 2010 Mar;22(3):973-90. Epub 2010 Mar 26. PubMed PMID: 20348432; PubMed Central PMCID: PMC2861455.


Smith AC, Raimondi AR, Salthouse CD, Ignatius MS, Blackburn JS, Mizgirev IV, Storer NY, de Jong JL, Chen AT, Zhou Y, Revskoy S, Zon LI, Langenau DM. High-throughput cell transplantation establishes that tumor-initiating cells are abundant in zebrafish T-cell acute lymphoblastic leukemia. Blood. 2010 Apr 22;115(16):3296-303. doi: 10.1182/blood-2009-10-246488. Epub 2010 Jan 7. PMID: 20056790 PMCID: PMC2858492 read article


Storer NY, Zon LI*. Zebrafish models of p53 functions. Cold Spring Harb Perspect Biol. 2010 Aug 1;2(8):a001123. Epub 2010 May 5. Review. PMID: 20679337.


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Zha S, Bassing CH, Sanda T, Brush JW, Patel H, Goff PH, Murphy MM, Tepsuporn S, Gatti RA, Look AT, Alt FW. ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification. J Exp Med. 2010 Jul 5;207(7):1369-80. Epub 2010 Jun 21. PubMed PMID: 20566716. PMCID: PMC2901073.


Thomas M, Lieberman J, Lal A. Desperately seeking microRNA targets. Nat Struct Mol Biol. 2010 Oct;17(10):1169-74. doi: 10.1038/nsmb.1921. PMID: 20924405


Cronican JJ, Thompson DB, Beier KT, McNaughton BR, Cepko CL, Liu DR. Potent delivery of functional proteins into Mammalian cells in vitro and in vivo using a supercharged protein. ACS Chem Biol. 2010 Aug 20;5(8):747-52. doi: 10.1021/cb1001153. PMID: 20545362 PMCID: PMC2924640 read article


Demer JL, Clark RA, Tischfield MA, Engle EC. Evidence of an asymmetrical endophenotype in congenital fibrosis of extraocular muscles type 3 resulting from TUBB3 mutations. Invest Ophthalmol Vis Sci. 2010 Sep;51(9):4600-11. Epub 2010 Apr 14. PubMed PMID: 20393110; PubMed Central PMCID: PMC2941178.


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Demer JL, Clark RA, Tischfield MA, Engle EC. Evidence of an asymmetrical endophenotype in congenital fibrosis of extraocular muscles type 3 resulting from TUBB3 mutations. Invest Ophthalmol Vis Sci. 2010 Sep;51(9):4600-11. Epub 2010 Apr 14. PubMed PMID: 20393110; PubMed Central PMCID: PMC2941178.


Tukachinsky H, Lopez LV, Salic A. A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes. J Cell Biol. 2010 Oct 18;191(2):415-28. doi: 10.1083/jcb.201004108. PMID: 20956384 PMCID: PMC2958481 read article


Vijayan S, Hale GJ, Moore CI, Brown EN, Wilson M. Activity in the barrel cortex during active behavior and sleep. J Neurophysiol. 2010 Apr;103(4):2074-84. Epub 2010 Feb 17. PubMed PMID: 20164403; PubMed Central PMCID: PMC2853270.


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Walsh RM, Hochedlinger K. Modeling Rett syndrome with stem cells. Cell. 2010 Nov 12;143(4):499-500. doi: 10.1016/j.cell.2010.10.037. PMID: 21074040 PMCID: PMC3538362  read article


Gill JC, Wang O, Kakar S, Martinelli E, Carroll RS, Kaiser UB. Reproductive hormone-dependent and -independent contributions to developmental changes in kisspeptin in GnRH-deficient hypogonadal mice. PLoS One. 2010 Jul 30;5(7):e11911. PubMed PMID: 20689830; PubMed Central PMCID: PMC2912854.


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Nishio J, Feuerer M, Wong J, Mathis D, Benoist C. Anti-CD3 therapy permits regulatory T cells to surmount T cell receptor-specified peripheral niche constraints. J Exp Med. 2010 Aug 30;207(9):1879-89. Epub 2010 Aug 2. PMID: 20679403. PMCID: PMC2931163.


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Garces A, Atmakuri K, Chase MR, Woodworth JS, Krastins B, Rothchild AC, Ramsdell TL, Lopez MF, Behar SM, Sarracino DA, Fortune SM. EspA acts as a critical mediator of ESX1-dependent virulence in Mycobacterium tuberculosis by affecting bacterial cell wall integrity. PLoS Pathog. 2010 Jun 24;6(6):e1000957. PubMed PMID: 20585630; PubMed Central PMCID: PMC2891827.


Hartwig S, Ho J, Pandey P, Macisaac K, Taglienti M, Xiang M, Alterovitz G, Ramoni M, Fraenkel E, Kreidberg JA. Genomic characterization of Wilms' tumor suppressor 1 targets in nephron progenitor cells during kidney development. Development. 2010 Apr;137(7):1189-203. doi: 10.1242/dev.045732. PMID: 20215353 PMCID: PMC2835332 read article


Alterovitz G, Xiang M, Hill DP, Lomax J, Liu J, Cherkassky M, Dreyfuss J, Mungall C, Harris MA, Dolan ME, Blake JA, Ramoni MF. Ontology engineering. Nat Biotechnol. 2010 Feb;28(2):128-30. doi: 10.1038/nbt0210-128. PMID: 20139945


Xu C, Lo A, Yammanuru A, Tallarico AS, Brady K, Murakami A, Barteneva N, Zhu Q, Marasco WA. Unique biological properties of catalytic domain directed human anti-CAIX antibodies discovered through phage-display technology. PLoS One. 2010 Mar 10;5(3):e9625. PubMed PMID: 20224781; PubMed Central PMCID: PMC2835754.


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Huang M, Kim JM, Shiotani B, Yang K, Zou L, D'Andrea AD. The FANCM/FAAP24 complex is required for the DNA interstrand crosslink-induced checkpoint response. Mol Cell. 2010 Jul 30;39(2):259-68. PubMed PMID: 20670894; PubMed Central PMCID: PMC2928996.


Yang Y, Bonni A. Releasing the brake on presynaptic development: Cdc20-APC triggers neuroD2 degradation to drive presynaptic differentiation. Cell Cycle. 2010 Jun 6;9(12). [Epub ahead of print] PubMed PMID: 20699636. PMCID: PMC3096709


de la Torre-Ubieta L, Gaudillière B, Yang Y, Ikeuchi Y, Yamada T, DiBacco S, Stegmüller J, Schüller U, Salih DA, Rowitch D, Brunet A, Bonni A. A FOXO-Pak1 transcriptional pathway controls neuronal polarity. Genes Dev. 2010 Apr 15;24(8):799-813. PubMed PMID: 20395366; PubMed Central PMCID: PMC2854394.


Yang Y, Kim AH, Bonni A. The dynamic ubiquitin ligase duo: Cdh1-APC and Cdc20-APC regulate neuronal morphogenesis and connectivity. Curr Opin Neurobiol. 2010 Feb;20(1):92-9. Epub 2010 Jan 7. Review. PubMed PMID: 20060286.


Yuan TL, Cantley LC. Introduction. Curr Top Microbiol Immunol. 2010;346:1-7. PubMed PMID: 20582535; PubMed Central PMCID: PMC3394431.


Zha S, Guo C, Boboila C, Oksenych V, Cheng HL, Zhang Y, Wesemann DR, Yuen G, Patel H, Goff PH, Dubois RL, Alt FW. ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks. Nature. 2011 Jan 13;469(7329):250-4. doi: 10.1038/nature09604. Epub 2010 Dec 15. PMID: 21160472 PMCID: PMC3058373 read article


Zeng X, Sigoillot F, Gaur S, Choi S, Pfaff KL, Oh DC, Hathaway N, Dimova N, Cuny GD, King RW. Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell. 2010 Oct 19;18(4):382-95. PubMed PMID: 20951947; PubMed Central PMCID: PMC2957475.


Zhang T, Franklin A, Boboila C, McQuay A, Gallagher MP, Manis JP, Khamlichi AA, Alt FW. Downstream class switching leads to IgE antibody production by B lymphocytes lacking IgM switch regions. Proceedings of the National Academy of Sciences USA. 2010 Feb 16;107(7):3040-5. PMCID: PMC2840363.


Lipinski MM, Hoffman G, Ng A, Zhou W, Py BF, Hsu E, Liu X, Eisenberg J, Liu J, Blenis J, Xavier RJ, Yuan J. A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions. Dev Cell. 2010 Jun 15;18(6):1041-52. doi: 10.1016/j.devcel.2010.05.005. PMID: 20627085 PMCID: PMC2935848 read article


top

2009


Azim E, Shnider SJ, Cederquist GY, Sohur US, Macklis JD. Lmo4 and Clim1 progressively delineate cortical projection neuron subtypes during development. Cereb Cortex. 2009 Jul;19 Suppl 1:i62-9. Epub 2009 Apr 14. PubMed PMID: 19366868; PubMed Central PMCID: PMC2693532.


Azim E, Jabaudon D, Fame RM, Macklis JD. SOX6 controls dorsal progenitor identity and interneuron diversity during neocortical development. Nat Neurosci. 2009 Oct;12(10):1238-47. Epub 2009 Aug 5. PubMed PMID: 19657336; PubMed Central PMCID: PMC2903203.


Agapakis CM, Silver PA. Synthetic biology: exploring and exploiting genetic modularity through the design of novel biological networks. Mol Biosyst. 2009 Jul;5(7):704-13. doi: 10.1039/b901484e. Epub 2009 May 14. PMID: 19562109


Zhang L, Agosto MA, Ivanovic T, King DS, Nibert ML, Harrison SC. Requirements for the formation of membrane pores by the reovirus myristoylated micro1N peptide. J Virol. 2009 Jul;83(14):7004-14. doi: 10.1128/JVI.00377-09. Epub 2009 May 13. PMID: 19439475 PMCID: PMC2704788 read article


Soucy ER, Albeanu DF, Fantana AL, Murthy VN, Meister M. Precision and diversity in an odor map on the olfactory bulb. Nat Neurosci. 2009 Feb;12(2):210-20. Epub 2009 Jan 18. PubMed PMID: 19151709.


Aoki ST, Settembre EC, Trask SD, Greenberg HB, Harrison SC, Dormitzer PR. Structure of rotavirus outer-layer protein VP7 bound with a neutralizing Fab. Science. 2009 Jun 12;324(5933):1444-7. PMID: 19520960 PMCID: PMC2995306 read article


Chen JZ, Settembre EC, Aoki ST, Zhang X, Bellamy AR, Dormitzer PR, Harrison SC, Grigorieff N. Molecular interactions in rotavirus assembly and uncoating seen by high-resolution cryo-EM. Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10644-8. Epub 2009 Jun 1. PMID: 19487668 PMCID: PMC2689313 read article


Ardayfio PA, Leung A, Park J, Hwang DY, Moran-Gates T, Choi YK, Carlezon WA Jr, Tarazi FI, Kim KS. Pitx3-deficient aphakia mice display unique behavioral responses to psychostimulant and antipsychotic drugs. Neuroscience. 2010 Mar 17;166(2):391-6. Epub 2009 Dec 22. PubMed PMID: 20026251; PubMed Central PMCID: PMC2842920.


Armour SM, Baur JA, Hsieh SN, Land-Bracha A, Thomas SM, Sinclair DA. Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy. Aging (Albany NY). 2009 Jun 3;1(6):515-28. PMID: 20157535 PMCID: PMC2806030 read article


Baughman JM, Nilsson R, Gohil VM, Arlow DH, Gauhar Z, Mootha VK*. A computational screen for regulators of oxidative phosphorylation implicates SLIRP in mitochondrial RNA homeostasis. PLoS Genet. 2009. e1000590. PMC2721412.


Nilsson R, Schultz IJ, Pierce EL, Soltis KA, Naranuntarat A, Ward DM, Baughman JM, Paradkar PN, Kingsley PD, Culotta VC, Kaplan J, Palis J, Paw BH, Mootha VK*. Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis. Cell Metab. 2009. 2: 119-30. PMC2745341.


Berg J, Hung YP, Yellen G. A genetically encoded fluorescent reporter of ATP:ADP ratio. Nat Methods. 2009 Feb;6(2):161-6. Epub 2009 Jan 4. PubMed PMID: 19122669; PubMed Central PMCID: PMC2633436.


Kim AH, Puram SV, Bilimoria PM, Ikeuchi Y, Keough S, Wong M, Rowitch D, Bonni A. A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons. Cell. 2009 Jan 23;136(2):322-36. PubMed PMID: 19167333; PubMed Central PMCID: PMC2707082.


Mohideen F, Capili AD, Bilimoria PM, Yamada T, Bonni A, Lima CD. A molecular basis for phosphorylation-dependent SUMO conjugation by the E2 UBC9. Nat Struct Mol Biol. 2009 Sep;16(9):945-52. Epub 2009 Aug 16. PubMed PMID: 19684601; PubMed Central PMCID: PMC2771680.


Yang Y, Kim AH, Yamada T, Wu B, Bilimoria PM, Ikeuchi Y, de la Iglesia N, Shen J, Bonni A. A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation. Science. 2009 Oct 23;326(5952):575-8. PubMed PMID: 19900895; PubMed Central PMCID: PMC2846784.


Schrum JP, Ricardo A, Krishnamurthy M, Blain JC, Szostak JW. Efficient and rapid template-directed nucleic acid copying using 2'-amino-2',3'-dideoxyribonucleoside-5'-phosphorimidazolide monomers. J Am Chem Soc. 2009 Oct 14;131(40):14560-70. PubMed PMID: 19757789; PubMed Central PMCID: PMC2759813.


Bloodgood BL, Giessel AJ, Sabatini BL. Biphasic synaptic Ca influx arising from compartmentalized electrical signals in dendritic spines. PLoS Biol. 2009 Sep;7(9):e1000190. Epub 2009 Sep 15. PubMed PMID: 19753104; PubMed Central PMCID: PMC2734993.


Akselrod-Ballin A, Bock D, Reid RC, Warfield SK. Accelerating feature based registration using the Johnson-Lindenstrauss Lemma. Med Image Comput Comput Assist Interv. 2009;12(Pt 1):632-9. PubMed PMID: 20426041.


Boutwell CL, Rowley CF, Essex M. Reduced viral replication capacity of human immunodeficiency virus type 1 subtype C caused by cytotoxic-T-lymphocyte escape mutations in HLA-B57 epitopes of capsid protein. J Virol. 2009 Mar;83(6):2460-8. doi: 10.1128/JVI.01970-08. Epub 2008 Dec 24. PMID: 19109381 PMCID: PMC2648284 read article


Bowman JJ, Schaffer PA. Origin of expression of the herpes simplex virus type 1 protein U(S)1.5. J Virol. 2009 Sep;83(18):9183-94. Epub 2009 Jul 1. PMID: 19570862 PMCID: PMC2738232 read article


Bowman JJ, Orlando JS, Davido DJ, Kushnir AS, Schaffer PA. Transient expression of herpes simplex virus type 1 ICP22 represses viral promoter activity and complements the replication of an ICP22 null virus. J Virol. 2009 Sep;83(17):8733-43. Epub 2009 Jun 17. PMID: 19535441 PMCID: PMC2738139 read article


Py BF, Boyce M, Yuan J. A critical role of eEF-2K in mediating autophagy in response to multiple cellular stresses. Autophagy. 2009 Apr;5(3):393-6. Epub 2009 Apr 6. PMID: 19221463 PMCID: PMC2756538 read article


Boyle PM, Silver PA. Harnessing nature's toolbox: regulatory elements for synthetic biology. J R Soc Interface. 2009 Aug 6;6 Suppl 4:S535-46. doi: 10.1098/rsif.2008.0521.focus. Epub 2009 Mar 4. PMID: 19324675 PMCID: PMC2843961 read article


Kennedy CJ, Boyle PM, Waks Z, Silver PA. Systems-level engineering of nonfermentative metabolism in yeast. Genetics. 2009 Sep;183(1):385-97. doi: 10.1534/genetics.109.105254. Epub 2009 Jun 29. PMID: 19564482 PMCID: PMC2746161


Brown KM, Depristo MA, Weinreich DM, Hartl DL. Temporal constraints on the incorporation of regulatory mutants in evolutionary pathways. Mol Biol Evol. 2009 Nov;26(11):2455-62. Epub 2009 Jul 14. PubMed PMID: 19602543.


Lozovsky ER, Chookajorn T, Brown KM, Imwong M, Shaw PJ, Kamchonwongpaisan S, Neafsey DE, Weinreich DM, Hartl DL. Stepwise acquisition of pyrimethamine resistance in the malaria parasite. Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12025-30. Epub 2009 Jul 8. PubMed PMID: 19587242; PubMed Central PMCID: PMC2715478.


Francisco LM, Salinas VH, Brown KE, Vanguri VK, Freeman GJ, Kuchroo VK, Sharpe AH. PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J Exp Med. 2009 Dec 21;206(13):3015-29. Epub 2009 Dec 14. PubMed PMID: 20008522; PubMed Central PMCID: PMC2806460.


Bruckner RJ, Mansy SS, Ricardo A, Mahadevan L, Szostak JW. Flip-flop-induced relaxation of bending energy: implications for membrane remodeling. Biophys J. 2009 Dec 16;97(12):3113-22. PubMed PMID: 20006948; PubMed Central PMCID: PMC2793357.


Budin I, Bruckner RJ, Szostak JW. Formation of protocell-like vesicles in a thermal diffusion column. J Am Chem Soc. 2009 Jul 22;131(28):9628-9. PubMed PMID: 19601679; PubMed Central PMCID: PMC2710859.


Blachon S, Cai X, Roberts KA, Yang K, Polyanovsky A, Church A, Avidor-Reiss T. A proximal centriole-like structure is present in Drosophila spermatids and can serve as a model to study centriole duplication. Genetics. 2009 May;182(1):133-44. doi: 10.1534/genetics.109.101709. Epub 2009 Mar 16. PMID: 19293139 PMCID: PMC2674812 read article


MacConaill LE, Campbell CD, Kehoe SM, Bass AJ, Hatton C, Niu L, Davis M, Yao K, Hanna M, Mondal C, Luongo L, Emery CM, Baker AC, Philips J, Goff DJ, Fiorentino M, Rubin MA, Polyak K, Chan J, Wang Y, Fletcher JA, Santagata S, Corso G, Roviello F, Shivdasani R, Kieran MW, Ligon KL, Stiles CD, Hahn WC, Meyerson ML, Garraway LA. Profiling critical cancer gene mutations in clinical tumor samples. PLoS One. 2009 Nov 18;4(11):e7887. PubMed PMID: 19924296; PubMed Central PMCID: PMC2774511.


Carter BC, Bean BP. Sodium entry during action potentials of mammalianneurons: incomplete inactivation and reduced metabolic efficiency in fast-spiking neurons. Neuron. 2009 Dec 24;64(6):898-909. PubMed PMID: 20064395; PubMed Central PMCID: PMC2810867.


Berriz GF, Beaver JE, Cenik C, Tasan M, Roth FP. Next generation software for functional trend analysis. Bioinformatics. 2009 Nov 15;25(22):3043-4. Epub 2009 Aug 28. PubMed PMID: 19717575; PubMed Central PMCID: PMC2800365.


Charity JC, Blalock LT, Costante-Hamm MM, Kasper DL, Dove SL. Small Molecule Control of Virulence Gene Expression in Francisella tularensis. PLoS Pathog. 2009. 5(10): e1000641. doi:10.1371/journal.ppat.1000641. PMC2763202.


Amit I, Garber M, Chevrier N, Leite AP, Donner Y, Eisenhaure T, Guttman M, Grenier JK, Li W, Zuk O, Schubert LA, Birditt B, Shay T, Goren A, Zhang X, Smith Z, Deering R, McDonald RC, Cabili M, Bernstein BE, Rinn JL, Meissner A, Root DE, Hacohen N, Regev A. Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses. Science. 2009 Oct 9;326(5950):257-63. Epub 2009 Sep 3. PMID: 19729616 PMCID: PMC2879337 read article


Chiu IM, Phatnani H, Kuligowski M, Tapia JC, Carrasco MA, Zhang M, Maniatis T, Carroll MC. Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice. Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20960-5. Epub 2009 Nov 20. PMID: 19933335. PMCID: PMC2791631.


Qiao L, Choi S, Case A, Gainer TG, Seyb K, Glicksman MA, Lo DC, Stein RL, Cuny GD. Structure-activity relationship study of EphB3 receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6122-6. Epub 2009 Sep 9. PubMed PMID: 19783434; PubMed Central PMCID: PMC2785710.


Hwang DY, Hong S, Jeong JW, Choi S, Kim H, Kim J, Kim KS. Vesicular monoamine transporter 2 and dopamine transporter are molecular targets of Pitx3 in the ventral midbrain dopamine neurons. J Neurochem. 2009 Dec;111(5):1202-12. Epub 2009 Sep 24. PubMed PMID: 19780901.


Chan JA, Balasubramanian S, Witt RM, Nazemi KJ, Choi Y, Pazyra-Murphy MF, Walsh CO, Thompson M, Segal RA. Proteoglycan interactions with Sonic Hedgehog specify mitogenic responses. Nat Neurosci. 2009 Apr;12(4):409-17. Epub 2009 Mar 15. PubMed PMID: 19287388; PubMed Central PMCID: PMC2676236.


Choo AY, Blenis J*. Not all substrates are treated equally: implications for mTOR, rapamycin-resistance and cancer therapy. Cell Cycle. 2009 Feb 15;8(4):567-72. Epub 2009 Feb 18. Review. PMID: 19197153.


Schwartz D, Chou MF, Church GM. Predicting protein post-translational modifications using meta-analysis of proteome scale data sets. Mol Cell Proteomics. 2009 Feb;8(2):365-79. Epub 2008 Oct 28. PubMed PMID: 18974045; PubMed Central PMCID: PMC2634583.


Tannous BA, Christensen AP, Pike L, Wurdinger T, Perry KF, Saydam O, Jacobs AH, García-Añoveros J, Weissleder R, Sena-Esteves M, Corey DP, Breakefield XO. Mutant sodium channel for tumor therapy. Mol Ther. 2009 May;17(5):810-9. Epub 2009 Mar 3. PubMed PMID: 19259066; PubMed Central PMCID: PMC2751883.


Kuo TT, de Muinck EJ, Claypool SM, Yoshida M, Nagaishi T, Aveson VG, Lencer WI, Blumberg RS. N-glycan moieties in FcRn determine steady-state membrane distribution and directional transport of IgG. J Biol Chem. 2009 Mar 27;284(13):8292-300. PMCID: PMC2659187.


Cohen NR, Garg S, Brenner MB. Antigen Presentation by CD1 Lipids, T Cells, and NKT Cells in Microbial Immunity. Adv Immunol. 2009;102:1-94. Review. PubMed PMID: 19477319.


Chiba, A; Cohen, N; Brigl, M; Brennan, PJ; Besra, GS & Brenner, MB. Rapid and reliable generation of invariant natural killer T cell lines in vitro. Immunology. 2009. 128(3):324-33. PMCID: PMC2770680.


Cornejo MG, Kharas MG, Werneck MB, Le Bras S, Moore SA, Rodig S, Aster JC, Lee BH, Cantor H, Gilliland DG, Mercher T. Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models. Blood, 2009 Mar 19; 113 (12); 2746-54. PMCID: PMC2661862.


Mercher T, Raffel GD, Moore SA, Cornejo MG, Baudry-Bluteau D, Cagnard N, Jesneck JL, Pikman Y, Cullen D, Williams IR, Akashi K, Shigematsu H, Bourquin JP, Giovannini M, Vainchenker W, Levine RL, Lee BH, Bernard OA, Gilliland DG.The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model. J Clin Invest. 2009 Apr; 119 (4):852-64. PMCID: PMC2662544.


Hofmann I, Stover EH, Cullen DE, Mao J, Morgan KJ, Lee BH, Kharas MG, Miller PG, Cornejo MG, Okabe R, Armstrong SA, Ghilardi N, Gould S, de Sauvage FJ, McMahon AP, Gilliland DG. Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis. Cell Stem Cell. 2009 Jun 5; 4(6):559-67. PMCID: PMC3065323.


Moellering RE, Cornejo MG, Del Bianco C, Hancock M, Aster JC, Blacklow SC, Gilliland DG, Verdine GL, Bradner JE. Direct Inhibition of the Notch Transcription Factor Complex. Nature. 2009 Nov 12; 462(7270): 182-8. PMCID: PMC2951323.


Cornejo MG, Boggon TJ, Mercher T. JAK3: a two-faced player in hematological disorders. (Int J Biochem Cell Biol. 2009 Dec; 41(12): 2376-9) PMCID: PMC2853879.


Costantino CM, Ploegh HL, Hafler DA. Cathepsin S regulates class II MHC processing in human CD4+ HLA-DR+ T cells. J Immunol. 2009 Jul 15;183(2):945-52. Epub 2009 Jun 24. PubMed PMID: 19553543; PubMed Central PMCID: PMC2752291.


Beriou G, Costantino CM, Ashley CW, Yang L, Kuchroo VK, Baecher-Allan C, Hafler DA. IL-17-producing human peripheral regulatory T cells retain suppressive function. Blood. 2009 Apr 30;113(18):4240-9. Epub 2009 Jan 26. PubMed PMID: 19171879; PubMed Central PMCID: PMC2676084.


Pazyra-Murphy MF, Hans A, Courchesne SL, Karch C, Cosker KE, Heerssen HM, Watson FL, Kim T, Greenberg ME, Segal RA. A retrograde neuronal survival response: target-derived neurotrophins regulate MEF2D and bcl w. J Neurosci. 2009 May 20;29(20):6700-9. PubMed PMID: 19458239; PubMed Central PMCID: PMC2709981.


Ramduth D, Day CL, Thobakgale CF, Mkhwanazi NP, de Pierres C, Reddy S, van der Stok M, Mncube Z, Nair K, Moodley ES, Kaufmann DE, Streeck H, Coovadia HM, Kiepiela P, Goulder PJ, Walker BD. Immunodominant HIV-1 Cd4+ T cell epitopes in chronic untreated clade C HIV-1 infection. PLoS One. 2009;4(4):e5013. doi: 10.1371/journal.pone.0005013. Epub 2009 Apr 7. PMID: 19352428 PMCID: PMC2661367  read article


Amit I, Garber M, Chevrier N, Leite AP, Donner Y, Eisenhaure T, Guttman M, Grenier JK, Li W, Zuk O, Schubert LA, Birditt B, Shay T, Goren A, Zhang X, Smith Z, Deering R, McDonald RC, Cabili M, Bernstein BE, Rinn JL, Meissner A, Root DE, Hacohen N, Regev A. Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses. Science. 2009 Oct 9;326(5950):257-63. doi: 10.1126/science.1179050. Epub 2009 Sep 3. PMID: 19729616 PMCID: PMC2879337 read article


Mahoney SJ, Dempsey JM, Blenis J. Cell signaling in protein synthesis ribosome biogenesis and translation initiation and elongation. Prog Mol Biol Transl Sci. 2009;90:53-107. doi: 10.1016/S1877-1173(09)90002-3. Epub 2009 Oct 27. PMID: 20374739


Djuretic IM, Cruz-Guilloty F, Rao A. Regulation of gene expression in peripheral T cells by Runx transcription factors. Adv Immunol. 2009;104:1-23. Epub 2009 Dec 1. Review. PubMed PMID: 20457114.


Cruz-Guilloty F, Pipkin ME, Djuretic IM, Levanon D, Lotem J, Lichtenheld MG, Groner Y, Rao A. Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs. J Exp Med. 2009 Jan 16;206(1):51-9. Epub 2009 Jan 12. PubMed PMID: 19139168; PubMed Central PMCID: PMC2626671.


Dong CK, Patel V, Yang JC, Dvorin JD, Duraisingh MT, Clardy J, Wirth DF*. Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors. Bioorg Med Chem Lett. 2009 Feb 1;19(3):972-5. Epub 2008 Nov 24. PMID: 19097788.


Dougan M, Dranoff G. The immune response to tumors. Curr Protoc Immunol. 2009 Apr;Chapter 20:Unit 20.11. PMID: 19347848


Dougan M, Dranoff G.Immune Therapy for Cancer. Annu Rev Immunol. 2009;27:83-117. Review. PMID: 19007331


Hu CC, Dougan SK, McGehee AM, Love JC, Ploegh HL. XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells. EMBO J. 2009 Jun 3;28(11):1624-36. Epub 2009 Apr 30. PubMed PMID: 19407814; PubMed Central PMCID: PMC2684024.


Dovey MC, Zon LI. Defining cancer stem cells by xenotransplantation in zebrafish. Methods Mol Biol. 2009;568:1-5. doi: 10.1007/978-1-59745-280-9_1. PMID: 19582417


Dovey M, Patton EE, Bowman T, North T, Goessling W, Zhou Y, Zon LI. Topoisomerase II alpha is required for embryonic development and liver regeneration in zebrafish. Mol Cell Biol. 2009 Jul;29(13):3746-53. doi: 10.1128/MCB.01684-08. Epub 2009 Apr 20. PMID: 19380487PMCID: PMC2698760 read article


Dovey M, White RM, Zon LI. Oncogenic NRAS cooperates with p53 loss to generate melanoma in zebrafish. Zebrafish. 2009 Dec;6(4):397-404. doi: 10.1089/zeb.2009.0606. PMID: 19954345 PMCID: PMC2943216 read article


Dutton RJ, Wayman A, Wei JR, Rubin EJ, Beckwith J, Boyd D. Inhibition of bacterial disulfide bond formation by the anticoagulant warfarin. Proc Natl Acad Sci USA. 2010 Jan 5;107(1):297-301. Epub 2009 Dec 15. PubMed PMID: 20018758; PubMed Central PMCID: PMC2806739.


Ebina W, Rowat AC, Weitz DA. Electrodes on a budget: Micropatterned electrode fabrication by wet chemical deposition. Electrodes on a budget: Micropatterned electrode fabrication by wet chemical deposition. Biomicrofluidics. 2009 Sep 8;3(3):34104. PMID: 20216960 PMCID: PMC2835278 read article


Soucy ER, Albeanu DF, Fantana AL, Murthy VN, Meister M. Precision and diversity in an odor map on the olfactory bulb. Nat Neurosci. 2009 Feb;12(2):210-20. Epub 2009 Jan 18. PubMed PMID: 19151709.


Farny NG, Kedersha N, Silver PA*. Metazoan stress granule assembly is mediated by P-eIF2alpha-dependent and independent mechanisms. RNA. 2009. Oct;15(10):1814-21. Epub 2009 Aug 6. PMC2743051. read article


Hurt JA, Obar RA, Zhai B, Farny NG, Gygi SP*, Silver PA*. A conserved CCCH-type zinc finger protein regulates mRNA nuclear adenylation and export. J Cell Biol. 2009. Apr 20;185(2):265-77. PMC2700372.


Fiore R, Khudayberdiev S, Christensen M, Siegel G, Flavell SW, Kim TK, Greenberg ME, Schratt G. Mef2-mediated transcription of the miR379-410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels. EMBO J. 2009 Mar 18;28(6):697-710. Epub 2009 Feb 5. PubMed PMID: 19197241; PubMed Central PMCID: PMC2647767.


Mao Y, Ge X, Frank CL, Madison JM, Koehler AN, Doud MK, Tassa C, Berry EM, Soda T, Singh KK, Biechele T, Petryshen TL, Moon RT, Haggarty SJ, Tsai LH*. DISC1 regulates neural progenitor proliferation via modulation of GSK3 / β-catenin signaling. Cell. 2009 Mar 20;136(6): 1017-1031. PMC2704382.


Frank CL, Tsai LH*. Alternative functions of core cell cycle regulators in neuronal migration, neuronal maturation, and synaptic plasticity. Neuron. 2009 May 14;62(3):312-26. PMC2757047.


Liu Z, Meray RK, Grammatopoulos TN, Fredenburg RA, Cookson MR, Liu Y, Logan T, Lansbury PT Jr. Membrane-associated farnesylated UCH-L1 promotes alpha-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4635-40. doi: 10.1073/pnas.0806474106. Epub 2009 Mar 4. PMID: 19261853 PMCID: PMC2651203 read article


Egyud MR, Gajdos ZK, Butler JL, Tischfield S, Le Marchand L, Kolonel LN, Haiman CA, Henderson BE, Hirschhorn JN. Use of weighted reference panels based on empirical estimates of ancestry for capturing untyped variation. Hum Genet. 2009 Apr;125(3):295-303. Epub 2009 Jan 28. PubMed PMID: 19184111.


Gajdos ZK, Hirschhorn JN, Palmert MR. What controls the timing of puberty? An update on progress from genetic investigation. Curr Opin Endocrinol Diabetes Obes. 2009 Feb;16(1):16-24. Review. PubMed PMID: 19104234.


Ganis JJ, Hsia N, Trompouki E, de Jong JL, DiBiase A, Lambert JS, Jia Z, Sabo PJ, Weaver M, Sandstrom R, Stamatoyannopoulos JA, Zhou Y, Zon LI. Zebrafish globin switching occurs in two developmental stages and is controlled by the LCR. Dev Biol. 2012 Jun 15;366(2):185-94. Epub 2012 Apr 19. PubMed PMID: 22537494; PubMed Central PMCID: PMC3378398.  read article


Cohen NR, Garg S, Brenner MB. Antigen Presentation by CD1 Lipids, T Cells, and NKT Cells in Microbial Immunity. Adv Immunol. 2009;102:1-94. Review. PMID: 19477319


Veerapen N, Brigl M, Garg S, Cerundolo V, Cox LR, Brenner MB, Besra GS. Synthesis and biological activity of alpha-galactosyl ceramide KRN7000 and galactosyl (alpha1-->2) galactosyl ceramide. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4288-91. Epub 2009 May 27. PMID: 19502056. PMCID: PMC2722241


Mao Y, Ge X, Frank CL, Madison JM, Koehler AN, Doud MK, Tassa C, Berry EM, Soda T, Singh KK, Biechele T, Petryshen TL, Moon RT, Haggarty SJ, Tsai LH. Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell. 2009 Mar 20;136(6):1017-31. PubMed PMID: 19303846; PubMed Central PMCID: PMC2704382.


Gelfand MV, Hong S, Gu C. Guidance from above: common cues direct distinct signaling outcomes in vascular and neural patterning. Trends Cell Biol. 2009 Mar;19(3):99-110. Epub 2009 Feb 4. Review. PubMed PMID: 19200729.


Bloodgood BL, Giessel AJ, Sabatini BL. Biphasic synaptic Ca influx arisingfrom compartmentalized electrical signals in dendritic spines. PLoS Biol. 2009 Sep;7(9):e1000190. Epub 2009 Sep 15. PubMed PMID: 19753104; PubMed Central PMCID: PMC2734993.


Goldman JA, Garlick JD, Kingston RE. Chromatin remodeling by imitation switch (ISWI) class ATP-dependent remodelers is stimulated by histone variant H2A.Z. J Biol Chem. 2010 Feb 12;285(7):4645-51. Epub 2009 Nov 25. PubMed PMID: 19940112; PubMed Central PMCID: PMC2836070.


Tolstorukov MY, Kharchenko PV, Goldman JA, Kingston RE, Park PJ. Comparative analysis of H2A.Z nucleosome organization in the human and yeast genomes. Genome Res. 2009 Jun;19(6):967-77. Epub 2009 Feb 26. PubMed PMID: 19246569; PubMed Central PMCID: PMC2694475.


Gouwens NW, Wilson RI. Signal propagation in Drosophila central neurons. J Neurosci. 2009 May 13;29(19):6239-49. PubMed PMID: 19439602; PubMed Central PMCID: PMC2709801.


Schafer ZT, Grassian AR, Song L, Jiang Z, Gerhart-Hines Z, Irie HY, Gao S, Puigserver P, Brugge JS. Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment. Nature. 2009 Sep 3;461(7260):109-13. Epub 2009 Aug 19. PubMed PMID: 19693011; PubMed Central PMCID: PMC2931797.


Shim JH, Greenblatt MB, Xie M, Schneider MD, Zou W, Zhai B, Gygi S, Glimcher LH. TAK1 is an essential regulator of BMP signalling in cartilage. EMBO J. 2009 Jul 22;28(14):2028-41. Epub 2009 Jun 18. PMID: 19536134


Geiben-Lynn R, Greenland JR, Frimpong-Boateng K, Letvin NL. Non-classical natural killer T cells modulate plasmid DNA vaccine antigen expression and vaccine-elicited immune responses by MCP-1 secretion after interaction with a beta2-microglobulin-independent CD1d. J Biol Chem. 2009 Dec 4;284(49):33800-6. Epub 2009 Oct 15. PMID: 19833737 PMCID: PMC2797149 read article


Scholz J, Mannion RJ, Hord DE, Griffin RS, Rawal B, Zheng H, Scoffings D, Phillips A, Guo J, Laing RJ, Abdi S, Decosterd I, Woolf CJ. A novel tool for the assessment of pain: validation in low back pain. PLoS Med. 2009 Apr 7;6(4):e1000047. Epub 2009 Apr 7. PubMed PMID: 19360087; PubMed Central PMCID: PMC2661253.


Hall JA, Bianco AC. Triumphs of the thyroid despite lesser conversion. Endocrinology. 2009 Jun;150(6):2502-4. doi: 10.1210/en.2009-0347. PMID: 19458245


Nagaraju G, Hartlerode A, Kwok A, Chandramouly G, Scully R. XRCC2 and XRCC3 regulate the balance between short- and long-tract gene conversions between sister chromatids. Mol Cell Biol. 2009. 29:4283-94. PMC2715807.


Pazyra-Murphy MF, Hans A, Courchesne SL, Karch C, Cosker KE, Heerssen HM, Watson FL, Kim T, Greenberg ME, Segal RA. A retrograde neuronal survival response: target-derived neurotrophins regulate MEF2D and bcl-w. J Neurosci. 2009 May 20;29(20):6700-9. PubMed PMID: 19458239; PubMed Central PMCID: PMC2709981.


Hemming ML, Elias JE, Gygi SP, Selkoe DJ. Identification of beta-secretase (BACE1) substrates using quantitative proteomics. PLoS One. 2009 Dec 29;4(12):e8477. PubMed PMID: 20041192; PubMed Central PMCID: PMC2793532.


Beltman JB, Henrickson SE, von Andrian UH, de Boer RJ, Marée AF. Towards estimating the true duration of dendritic cell interactions with T cells. J Immunol Methods. 2009 Aug 15;347(1-2):54-69. Epub 2009 Jun 9. PMID: 19520083


Herrington TM, Assad JA. Neural activity in the middle temporal area and lateral intraparietal area during endogenously cued shifts of attention. J Neurosci. 2009 Nov 11;29(45):14160-76. PubMed PMID: 19906965; PubMed Central PMCID: PMC2913246.


Herrington TM, Masse NY, Hachmeh KJ, Smith JE, Assad JA, Cook EP. The effect of microsaccades on the correlation between neural activity and behavior in middle temporal, ventral intraparietal, and lateral intraparietal areas. J Neurosci. 2009 May 6;29(18):5793-805. PubMed PMID: 19420247; PubMed Central PMCID: PMC2904875.


Li S, Hong S, Shepardson NE, Walsh DM, Shankar GM, Selkoe D. Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake. Neuron. 2009 Jun 25;62(6):788-801. PubMed PMID: 19555648; PubMed Central PMCID: PMC2702854.


Li C, Houser BL, Nicotra ML, Strominger JL. HLA-G homodimer-induced cytokine secretion through HLA-G receptors on human decidual macrophages and natural killer cells. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5767-72. Epub 2009 Mar 20. PMCID: PMC2667005.


Hurt JA, Obar RA, Zhai B, Farny NG, Gygi SP*, Silver PA*. A conserved CCCH-type zinc finger protein regulates mRNA nuclear adenylation and export. J Cell Biol. 2009. Apr 20;185(2):265-277. PMC2700372.


Hutti JE, Shen RR, Abbott DW, Zhou AY, Sprott KM, Asara JM, Hahn WC*, Cantley LC*. Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation. Molecular Cell. 2009. 34:461-472. PMC2746958.


Shiga K, Takayama K, Futaki S, Hutti JE, Cantley LC, Ueki K, Ono Y, Mukai H. Development of an intracellularly acting inhibitory peptide selective for PKN. Biochem J. 2009 Dec 23;425(2):445-53. doi: 10.1042/BJ20090380. PubMed PMID: 19857203; PubMed Central PMCID: PMC3755880. read article


Nichols RJ, Dzamko N, Hutti JE, Cantley LC, Deak M, Moran J, Bamborough P, Reith AD, Alessi DR. Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease. Biochem J. 2009 Oct 23;424(1):47-60. doi:
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Huynh MA, Stegmüller J, Litterman N, Bonni A. Regulation of Cdh1-APC function in axon growth by Cdh1 phosphorylation. J Neurosci. 2009 Apr 1;29(13):4322-7. doi: 10.1523/JNEUROSCI.5329-08.2009. PMID: 19339626 PMCID: PMC2839872 read article


Ikeuchi Y, Stegmüller J, Netherton S, Huynh MA, Masu M, Frank D, Bonni S, Bonni A. A SnoN-Ccd1 pathway promotes axonal morphogenesis in the mammalian brain. J Neurosci. 2009 Apr 1;29(13):4312-21. doi: 10.1523/JNEUROSCI.0126-09.2009. PMID: 19339625 PMCID: PMC2853192 read article


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Jadhav AP, Roesch K, Cepko CL. Development and neurogenic potential of Müller glial cells in the vertebrate retina. Prog Retin Eye Res. 2009 Jul;28(4):249-62. doi: 10.1016/j.preteyeres.2009.05.002. Epub 2009 May 22. PMID: 19465144 PMCID: PMC3233204 read article


Zimmermann K, Hein A, Hager U, Kaczmarek JS, Turnquist BP, Clapham DE, Reeh PW. Phenotyping sensory nerve endings in vitro in the mouse. Nat Protoc. 2009;4(2):174-96. PubMed PMID: 19180088.


Ramsey IS, Ruchti E, Kaczmarek JS, Clapham DE. Hv1 proton channels arerequired for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7642-7. Epub 2009 Apr 16. PubMed PMID: 19372380; PubMed Central PMCID: PMC2669790.


Blair NT, Kaczmarek JS, Clapham DE. Intracellular calcium strongly potentiates agonist-activated TRPC5 channels. J Gen Physiol. 2009 May;133(5):525-46. PubMed PMID: 19398778; PubMed Central PMCID: PMC2712973.


Soukas AA, Kane EA, Carr CE, Melo JA, Ruvkun G. Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans. Genes Dev. 2009 Feb 15;23(4):496-511. doi: 10.1101/gad.1775409. PMID: 19240135 PMCID: PMC2648650 read article


Trask SD, Kim IS, Harrison SC, Dormitzer PR. A rotavirus spike protein conformational intermediate binds lipid bilayers. J Virol. 2010 Feb;84(4):1764-70. Epub 2009 Dec 9. PMID: 20007281 PMCID: PMC2812363 read article


Carlezon WA Jr, Béguin C, Knoll AT, Cohen BM. Kappa-opioid ligands in the study and treatment of mood disorders. Pharmacol Ther. 2009 Sep;123(3):334-43. Epub 2009 Jun 2. Review. PubMed PMID: 19497337; PubMed Central PMCID: PMC2740476.


Sundrud MS, Koralov SB, Feuerer M, Calado DP, Kozhaya AE, Rhule-Smith A, Lefebvre RE, Unutmaz D, Mazitschek R, Waldner H, Whitman M, Keller T, Rao A. Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response. Science. 2009 Jun 5;324(5932):1334-8. PMCID: PMC2803727.


Rahmeh AA, Li J, Kranzusch PJ, Whelan SP. Ribose 2'-O methylation of the vesicular stomatitis virus mRNA cap precedes and facilitates subsequent guanine-N-7 methylation by the large polymerase protein. J Virol. 2009 Nov;83(21):11043-50. Epub 2009 Aug 26. PMID: 19710136 PMCID: PMC2772757.  read article


Kreslavsky T, Savage AK, Hobbs R, Gounari F, Bronson R, Pereira P, Pandolfi PP, Bendelac A, von Boehmer H. TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR diversity. Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12453-8. Epub 2009 Jul 15. PubMed PMID: 19617548; PubMed Central PMCID: PMC2718370.


Kurshan PT, Oztan A, Schwarz TL. Presynaptic alpha2delta-3 is required forsynaptic morphogenesis independent of its Ca2+-channel functions. Nat Neurosci. 2009 Nov;12(11):1415-23. Epub 2009 Oct 11. PubMed PMID: 19820706; PubMed Central PMCID: PMC2996863.


Schwer B, Eckersdorff M, Li Y, Silva JC, Fermin D, Kurtev MV, Giallourakis C, Comb MJ, Alt FW, Lombard DB. Calorie restriction alters mitochondrial protein acetylation. Aging Cell. 2009 Sep;8(5):604-6. doi: 10.1111/j.1474-9726.2009.00503.x. Epub 2009 Jul 9. PMID: 19594485 Central PMCID: PMC2752488.  read article


Vasudevan KM, Barbie DA, Davies MA, Rabinovsky R, McNear CJ, Kim JJ, Hennessy BT, Tseng H, Pochanard P, Kim SY, Dunn IF, Schinzel AC, Sandy P, Hoersch S, Sheng Q, Gupta PB, Boehm JS, Reiling JH, Silver S, Lu Y, Stemke-Hale K, Dutta B, Joy C, Sahin AA, Gonzalez-Angulo AM, Lluch A, Rameh LE, Jacks T, Root DE, Lander ES, Mills GB, Hahn WC, Sellers WR, Garraway LA. AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer. Cancer Cell. 2009 Jul 7;16(1):21-32. doi: 10.1016/j.ccr.2009.04.012. PMID: 19573809 PMCID: PMC2752826 read article


Emery CM, Vijayendran KG, Zipser MC, Sawyer AM, Niu L, Kim JJ, Hatton C, Chopra R, Oberholzer PA, Karpova MB, MacConaill LE, Zhang J, Gray NS, Sellers WR, Dummer R, Garraway LA. MEK1 mutations confer resistance to MEK and B-RAF inhibition. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20411-6. doi: 10.1073/pnas.0905833106. Epub 2009 Nov 13. PMID: 19915144 PMCID: PMC2777185 read article


Gogolla N, Leblanc JJ, Quast KB, Südhof TC, Fagiolini M, Hensch TK. Common circuit defect of excitatory-inhibitory balance in mouse models of autism. J Neurodev Disord. 2009 Jun;1(2):172-81. Epub 2009 Jul 11. PubMed PMID: 20664807; PubMed Central PMCID: PMC2906812.


Schweitzer MH, Zheng W, Organ CL, Avci R, Suo Z, Freimark LM, Lebleu VS, Duncan MB, Vander Heiden MG, Neveu JM, Lane WS, Cottrell JS, Horner JR, Cantley LC, Kalluri R, Asara JM. Biomolecular characterization and protein sequences of the Campanian hadrosaur B. canadensis. Science. 2009 May 1;324(5927):626-31. PubMed PMID: 19407199.


Tzur A, Kafri R, LeBleu VS, Lahav G, Kirschner MW. Cell growth and size homeostasis in proliferating animal cells. Science. 2009 Jul 10;325(5937):167-71. PubMed PMID: 19589995; PubMed Central PMCID: PMC2905160.


Shen X, Kim W, Fujiwara Y, Simon MD, Liu Y, Mysliwiec MR, Yuan GC, Lee Y, Orkin SH. Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells. Cell. 2009 Dec 24;139(7):1303-14. PubMed PMID: 20064376; PubMed Central PMCID: PMC2810107.


Dominy JE Jr, Lee Y, Gerhart-Hines Z, Puigserver P. Nutrient-dependent regulation of PGC-1alpha's acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5. Biochim Biophys Acta. 2009 Dec 11. [Epub ahead of print] PubMed PMID: 20005308.


Chien K, Cai T, Hsu H, Su T, Chang W, Chen M, Lee Y, Hu FB. A prediction model for type 2 diabetes risk among Chinese people. Diabetologia. 2009 Mar;52(3):443-50. Epub 2008 Dec 5. PubMed PMID: 19057891.


Frueh DP, Leed A, Arthanari H, Koglin A, Walsh CT, Wagner G. Time-shared HSQC-NOESY for accurate distance constraints measured at high-field in (15)N-(13)C-ILV methyl labeled proteins. J Biomol NMR. 2009 Nov;45(3):311-8. doi: 10.1007/s10858-009-9372-5. PMID: 19728110 PMCID: PMC2778061 read article


Yuan Z, Lehtinen MK, Merlo P, Villén J, Gygi S, Bonni A. Regulation of
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Clatworthy AE, Lee JS, Leibman M, Kostun Z, Davidson AJ, Hung DT. Pseudomonas aeruginosa infection of zebrafish involves both host and pathogen determinants. Infect Immun. 2009 Apr;77(4):1293-303. doi: 10.1128/IAI.01181-08. Epub 2009 Jan 21. PMID: 19168742 PMCID: PMC2663173 read article


Van Rhijn I, Young DC, De Jong A, Vazquez J, Cheng TY, Talekar R, Barral DC, León L, Brenner MB, Katz JT, Riese R, Ruprecht RM, O'Connor PB, Costello CE, Porcelli SA, Briken V, Moody DB. CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids. J Exp Med. 2009 Jun 8;206(6):1409-22. Epub 2009 May 25. Erratum in: J Exp Med. 2009 Aug 3;206(8):1831. Barral, Duarte [corrected to Barral, Duarte C]. PubMed PMID: 19468063; PubMed Central PMCID: PMC2715062.


Johnson A, Li G, Sikorski TW, Buratowski S, Woodcock CL, Moazed D*. Reconstitution of heterochromatin-dependent transcriptional gene silencing. Mol Cell. 2009 Sep 24;35(6):769-81. PubMed PMID: 19782027; PubMed Central PMCID: PMC2842978.


Naylor ML, Li JM, Osborn AJ, Elledge SJ. Mrc1 phosphorylation in response to DNA replication stress is required for Mec1 accumulation at the stalled fork. Proc Natl Acad Sci USA. 2009 Aug 4;106(31):12765-70. Epub 2009 Jun 10. PubMed PMID: 19515819; PubMed Central PMCID: PMC2722297.


Li VC, Davis JC, Lenkov K, Bolival B, Fuller MT, Petrov DA. Molecular evolution of the testis TAFs of Drosophila. Mol Biol Evol. 2009 May;26(5):1103-16. doi: 10.1093/molbev/msp030. Epub 2009 Feb 25. PMID: 19244474 PMCID: PMC2727373 read article


Libedinsky C, Savage T, Livingstone M. Perceptual and physiological evidence for a role for early visual areas in motion-induced blindness. J Vis. 2009 Jan 14;9(1):14.1-10. PubMed PMID: 19271884; PubMed Central PMCID: PMC2654591.


Huynh MA, Stegmueller J, Litterman N, Bonni A. Regulation of Cdh1-APC Function in Axon Growth by Cdh1 Phosphorylation. J Neurosci. 2009 1;29(13):4322-7. PMCID: PMC2839872.


Lu A, Hiltunen M, Romano DM, Soininen H, Hyman BT, Bertram L, Tanzi RE. Effects of ubiquilin 1 on the unfolded protein response. J Mol Neurosci. 2009 May;38(1):19-30. Epub 2008 Oct 25. PubMed PMID: 18953672.


Lu J, Min W, Conchello JA, Xie XS, Lichtman JW. Super-resolution laser scanning microscopy through spatiotemporal modulation. Nano Lett. 2009 Nov;9(11):3883-9. PubMed PMID: 19743870; PubMed Central PMCID: PMC2783786.


Lu J, Fiala JC, Lichtman JW. Semi-automated reconstruction of neural processes from large numbers of fluorescence images. PLoS One. 2009 May 21;4(5):e5655. PubMed PMID: 19479070; PubMed Central PMCID: PMC2682575.


Lu J, Tapia JC, White OL, Lichtman JW. The interscutularis muscle connectome. PLoS Biol. 2009 Feb 10;7(2):e32. Erratum in: PLoS Biol. 2009 Apr;7(4):e1000108. PubMed PMID: 19209956; PubMed Central PMCID: PMC2637925.


Maimon G, Assad JA. Beyond Poisson: increased spike-time regularity across primate parietal cortex. Neuron. 2009 May 14;62(3):426-40. PubMed PMID: 19447097; PubMed Central PMCID: PMC2743683.


Maimon G, Assad JA. A cognitive signal for the proactive timing of action in macaque LIP. Nat Neurosci. 2006 Jul;9(7):948-55. Epub 2006 Jun 4. PubMed PMID: 16751764.


Gordon WR, Vardar-Ulu D, L'Heureux S, Ashworth T, Malecki MJ, Sanchez-Irizarry C, McArthur DG, Histen G, Mitchell JL, Aster JC, Blacklow SC. Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2. PLoS One. 2009 Aug 24;4(8):e6613. doi: 10.1371/journal.pone.0006613. PMID: 19701457 PMCID: PMC2726630 read article


Samaco RC, Mandel-Brehm C, Chao HT, Ward CS, Fyffe-Maricich SL, Ren J, Hyland K, Thaller C, Maricich SM, Humphreys P, Greer JJ, Percy A, Glaze DG, Zoghbi HY, Neul JL. Loss of MeCP2 in aminergic neurons causes cell-autonomous defects in neurotransmitter synthesis and specific behavioral abnormalities. Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21966-71. doi: 10.1073/pnas.0912257106. Epub 2009 Dec 9. PMID: 20007372 PMCID: PMC2799790 read article


Manuel ER, Yeh WW, Seaman MS, Furr K, Lifton MA, Hulot SL, Autissier P, Letvin NL. Dominant CD8+ T-lymphocyte responses suppress expansion of vaccine-elicited subdominant T lymphocytes in rhesus monkeys challenged with pathogenic simian-human immunodeficiency virus. J Virol. 2009 Oct;83(19):10028-35. Epub 2009 Jul 29. PMID: 19641002 PMCID: PMC2748023 read article


Hulot SL, Seaman MS, Sen P, Autissier PA, Manuel ER, Letvin NL. Diverse cross-reactive potential and Vbeta gene usage of an epitope-specific cytotoxic T-lymphocyte population in monkeys immunized with diverse human immunodeficiency virus type 1 Env immunogens. J Virol. 2009 Oct;83(19):9803-12. Epub 2009 Jul 29. PMID: 19640988 PMCID: PMC2748000 read article


McLaughlin KA, Chitnis T, Newcombe J, Franz B, Kennedy J, McArdel S, Kuhle J, Kappos L, Rostasy K, Pohl D, Gagne D, Ness JM, Tenembaum S, O'Connor KC, Viglietta V, Wong SJ, Tavakoli NP, de Seze J, Idrissova Z, Khoury SJ, Bar-Or A, Hafler DA, Banwell B, Wucherpfennig KW. Age-dependent B cell autoimmunity to a myelin surface antigen in pediatric multiple sclerosis. J Immunol. 2009 Sep 15;183(6):4067-76. doi: 10.4049/jimmunol.0801888. Epub 2009 Aug 17. PMID: 19687098 PMCID: PMC2795331 read article


Amit I, Garber M, Chevrier N, Leite AP, Donner Y, Eisenhaure T, Guttman M, Grenier JK, Li W, Zuk O, Schubert LA, Birditt B, Shay T, Goren A, Zhang X, Smith Z, Deering R, McDonald RC, Cabili M, Bernstein BE, Rinn JL, Meissner A, Root DE, Hacohen N, Regev A. Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses. Science. 2009 Oct 9;326(5950):257-63. Epub 2009 Sep 3. PMID: 19729616 PMCID: PMC2879337 read article


McLaughlin KA, Chitnis T, Newcombe J, Franz B, Kennedy J, McArdel S, Kuhle J, Kappos L, Rostasy K, Pohl D, Gagne D, Ness JM, Tenembaum S, O'Connor KC, Viglietta V, Wong SJ, Tavakoli NP, de Seze J, Idrissova Z, Khoury SJ, Bar-Or A, Hafler DA, Banwell B, Wucherpfennig KW. Age-dependent B cell autoimmunity to a myelin surface antigen in pediatric multiple sclerosis. J Immunol. 2009 Sep 15;183(6):4067-76. Epub 2009 Aug 17. PMID: 19687098. PMCID: PMC2795331.


Brencic A, McFarland KA, McManus HR, Castang S, Mogno I, Dove SL, Lory S. The GacS/GacA signal transduction system of Pseudomonas aeruginosa acts exclusively through its control over the transcription of the RsmY and RsmZ regulatory small RNAs. Mol Microbiol. 2009 Aug;73(3):434-45. doi: 10.1111/j.1365-2958.2009.06782.x. Epub 2009 Jul 9. PMID: 19602144 PMCID: PMC2761719 read article


Haim H, Si Z, Madani N, Wang L, Courter JR, Princiotto A, Kassa A, DeGrace M, McGee-Estrada K, Mefford M, Gabuzda D, Smith AB 3rd, Sodroski J. Soluble CD4 and CD4-mimetic compounds inhibit HIV-1 infection by induction of a short-lived activated state. PLoS Pathog. 2009 Apr;5(4):e1000360. Epub 2009 Apr 3. PMID: 19343205 PMCID: PMC2655723 read article


Chiara DC, Hamouda AK, Ziebell MR, Mejia LA, Garcia G 3rd, Cohen JB. [(3)H]chlorpromazine photolabeling of the torpedo nicotinic acetylcholine receptor identifies two state-dependent binding sites in the ion channel. Biochemistry. 2009 Oct 27;48(42):10066-77. PubMed PMID: 19754159; PubMed Central PMCID: PMC2878666.


Hofmann I, Stover EH, Cullen DE, Mao J, Morgan KJ, Lee BH, Kharas MG, Miller PG, Cornejo MG, Okabe R, Armstrong SA, Ghilardi N, Gould S, de Sauvage FJ, McMahon AP, Gilliland DG. Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis. Cell Stem Cell. 2009 Jun 5;4(6):559-67. PMID: 19497284. PMCID: PMC3065323. NIHMSID: NIHMS189973


Mitra D, Fisher DE. Transcriptional regulation in melanoma. Hematol Oncol Clin North Am. 2009 Jun;23(3):447-65, viii. doi: 10.1016/j.hoc.2009.03.003. PMID: 19464596


Molyneaux BJ***, Arlotta P***, Fame RM, MacDonald JL, MacQuarrie KL, Macklis JD. Novel subtype-specific genes identify distinct subpopulations of callosal projection neurons. J Neurosci. 2009 Sep 30;29(39):12343-54. PMID: 19793993; PubMed Central PMCID: PMC2776075. ***Denotes equal contributions


DelBove J, Kuwahara Y, Mora-Blanco EL, Godfrey V, Funkhouser WK, Fletcher CD, Van Dyke T, Roberts CW, Weissman BE. Inactivation of SNF5 cooperates with p53 loss to accelerate tumor formation in Snf5(+/-);p53(+/-) mice. Mol Carcinog. 2009 Dec;48(12):1139-48. PMID: 19676100.


Morris ZS, McClatchey AI. The neurofibroma cell of origin: SKPs expand the playing field. Cell Stem Cell. 2009 May 8;4(5):371-2. doi: 10.1016/j.stem.2009.04.010. PMID: 19427284


Morris ZS, McClatchey AI. Aberrant epithelial morphology and persistent epidermal growth factor receptor signaling in a mouse model of renal carcinoma. Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9767-72. doi: 10.1073/pnas.0902031106. Epub 2009 Jun 1. PMID: 19487675 PMCID: PMC2700996 read article


Myoga MH, Beierlein M, Regehr WG. Somatic spikes regulate dendritic signaling in small neurons in the absence of backpropagating action potentials. J Neurosci. 2009 Jun 17;29(24):7803-14. PubMed PMID: 19535592; PubMed Central PMCID: PMC2840263.


Naylor ML, Li JM, Osborn AJ, Elledge SJ. Mrc1 phosphorylation in response to DNA replication stress is required for Mec1 accumulation at the stalled fork. Proc Natl Acad Sci USA. 2009 Aug 4;106(31):12765-70. Epub 2009 Jun 10. PubMed PMID: 19515819; PubMed Central PMCID: PMC2722297.


Ferland RJ, Batiz LF, Neal J, Lian G, Bundock E, Lu J, Hsiao YC, Diamond R,Mei D, Banham AH, Brown PJ, Vanderburg CR, Joseph J, Hecht JL, Folkerth R, Guerrini R, Walsh CA, Rodriguez EM, Sheen VL. Disruption of neural progenitors along the ventricular and subventricular zones in periventricular heterotopia. Hum Mol Genet. 2009 Feb 1;18(3):497-516. Epub 2008 Nov 7. PubMed PMID: 18996916; PubMed Central PMCID: PMC2722192.


Ng MR, Brugge JS. A stiff blow from the stroma: collagen crosslinking drives tumor progression. Cancer Cell. 2009 Dec 8;16(6):455-7. doi: 10.1016/j.ccr.2009.11.013. PMID: 19962663


Ng SY, Yoshida T, Zhang J, Georgopoulos K. Genome-wide lineage-specific transcriptional networks underscore Ikaros-dependent lymphoid priming in hematopoietic stem cells. Immunity. 2009 Apr 17;30(4):493-507. Epub 2009 Apr 2. PubMed PMID: 19345118; PubMed Central PMCID: PMC3012962.


Nottke A, Colaiácovo MP*, Shi Y*. Developmental roles of the histone lysine demethylases. Development. 2009. Mar;136(6):879-89. Review. PMC2692332.


Engelman A, Oztop I, Vandegraaff N, Raghavendra NK. Quantitative analysis of HIV-1 preintegration complexes. Methods. 2009 Apr;47(4):283-90. doi: 10.1016/j.ymeth.2009.02.005. Epub 2009 Feb 20. PMID: 19233280 PMCID: PMC2673482 read article


Burns CE, Galloway JL, Smith AC, Keefe MD, Cashman TJ, Paik EJ, Mayhall EA, Amsterdam AH, Zon LI. A genetic screen in zebrafish defines a hierarchical network of pathways required for hematopoietic stem cell emergence. Blood. 2009 Jun 4;113(23):5776-82. doi: 10.1182/blood-2008-12-193607. Epub 2009 Mar 30. PMID: 19332767 PMCID: PMC2700318 read article


Hovav AH, Santosuosso M, Bivas-Benita M, Plair A, Cheng A, Elnekave M, Righi E, Chen T, Kashiwagi S, Panas MW, Xiang SH, Furmanov K, Letvin NL, Poznansky MC X4 human immunodeficiency virus type 1 gp120 down-modulates expression and immunogenicity of codelivered antigens..J Virol. 2009 Nov;83(21):10941-50. Epub 2009 Aug 19.PMID:19692474. PMCID: PMC2772807.


Wang J, Pielak RM, McClintock MA, Chou JJ. Solution structure and functional analysis of the influenza B proton channel. Nat Struct Mol Biol. 2009 Dec;16(12):1267-71. Epub 2009 Nov 8. PMID: 19898475. PMCID: PMC3148584.


Pielak RM, Schnell JR, Chou JJ. Mechanism of drug inhibition and drug resistance of influenza A M2 channel. Proc Natl Acad Sci USA. 2009. May 5;106(18):7379-84. Epub 2009 Apr 21. PMC2678642.


Hagan JP, Piskounova E, Gregory RI. Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells. Nat Struct Mol Biol. 2009 Oct;16(10):1021-5. Epub 2009 Aug 27. PubMed PMID: 19713958; PubMed Central PMCID: PMC2758923.


de la Iglesia N, Puram SV, Bonni A. STAT3 regulation of glioblastoma pathogenesis. Curr Mol Med. 2009 Jun;9(5):580-90. PMID: 19601808 PMCID: PMC2712135 read article


Kim AH, Puram SV, Bilimoria PM, Ikeuchi Y, Keough S, Wong M, Rowitch D, Bonni A. A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons. Cell. 2009 Jan 23;136(2):322-36. doi: 10.1016/j.cell.2008.11.050. PMID: 19167333 PMCID: PMC2707082 read article


Gogolla N, Leblanc JJ, Quast KB, Südhof TC, Fagiolini M, Hensch TK. Common circuit defect of excitatory-inhibitory balance in mouse models of autism. J Neurodev Disord. 2009 Jun;1(2):172-81. Epub 2009 Jul 11. PubMed PMID: 20664807; PubMed Central PMCID: PMC2906812.


Raiser DM, Kim CF. Commentary: Sca-1 and Cells of the Lung: A matter of Different Sorts. Stem Cells. 2009 Mar;27(3):606-11. doi: 10.1002/stem.10. PMID: 19259938 PMCID: PMC3408081 read article


Rappley I, Myers DS, Milne SB, Ivanova PT, LaVoie MJ, Brown HA, Selkoe DJ. Lipidomic profiling in mouse brain reveals differences between ages and genders, with smaller changes associated with α-synuclein genotype. J Neurochem. 2009. 111:15-25. PMCID: PMC2752313.


Rappley I, Gitler AD, Selvy PE, LaVoie MJ, Levy BD, Brown HA, Lindquist S, Selkoe DJ. Evidence that α-synuclein does not inhibit phospholipase D. Biochemistry. 2009. 48: 1077-1083. PMCID: PMC2683767.


Chan EM, Ratanasirintrawoot S, Park IH, Manos PD, Loh YH, Huo H, Miller JD, Hartung O, Rho J, Ince TA, Daley GQ, Schlaeger TM. Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells. Nat Biotechnol. 2009 Nov;27(11):1033-7. doi: 10.1038/nbt.1580. Epub 2009 Oct 11. PMID: 19826408


Reynoso ED, Turley SJ. Unconventional antigen-presenting cells in the induction of peripheral CD8(+) T cell tolerance. J Leukoc Biol. 2009 Oct;86(4):795-801. Epub 2009 Aug 3. Review. PubMed PMID: 19652027.


Reynoso ED, Elpek KG, Francisco L, Bronson R, Bellemare-Pelletier A, Sharpe AH, Freeman GJ, Turley SJ. Intestinal tolerance is converted to autoimmune enteritis upon PD-1 ligand blockade. J Immunol. 2009 Feb 15;182(4):2102-12. PubMed PMID: 19201863.


Reynoso ED, Lee JW, Turley SJ. Peripheral tolerance induction by lymph node stroma. Adv Exp Med Biol. 2009;633:113-27. Review. PubMed PMID: 19209685.


Rhee DY, Zhao XQ, Francis RJ, Huang GY, Mably JD, Lo CW. Connexin 43 regulates epicardial cell polarity and migration in coronary vascular development. Development. 2009 Sep;136(18):3185-93. doi: 10.1242/dev.032334. PMID: 19700622 PMCID: PMC2730372 read article


Robinson KC, Fisher DE. Specification and loss of melanocyte stem cells. Semin Cell Dev Biol. 2009 Feb;20(1):111-6. doi: 10.1016/j.semcdb.2008.11.016. Epub 2008 Dec 13. PMID: 19124082


Rosen JN, Sweeney MF, Mably JD. Microinjection of zebrafish embryos to analyze gene function. J Vis Exp. 2009 Mar 9;(25). pii: 1115. doi: 10.3791/1115. PubMed PMID: 19274045.


Sage PT, Carman CV. Settings and mechanisms for trans-cellular diapedesis. Front Biosci. 2009 Jun 1;14:5066-83.


Sauvageot CM, Weatherbee JL, Kesari S, Winters SE, Barnes J, Dellagatta J,
Ramakrishna NR, Stiles CD, Kung AL, Kieran MW, Wen PY. Efficacy of the HSP90 inhibitor 17-AAG in human glioma cell lines and tumorigenic glioma stem cells. Neuro Oncol. 2009 Apr;11(2):109-21. Epub 2008 Aug 5. PubMed PMID: 18682579; PubMed Central PMCID: PMC2718982.


Luo J, Emanuele MJ, Li D, Creighton CJ, Schlabach MR, Westbrook TF, Wong KK, Elledge SJ. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Cell. 2009 May 29;137(5):835-48. PubMed PMID: 19490893; PubMed Central PMCID: PMC2768667.


Xu Q, Schlabach MR, Hannon GJ, Elledge SJ. Design of 240,000 orthogonal 25mer DNA barcode probes. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2289-94. Epub 2009 Jan 26. PubMed PMID: 19171886; PubMed Central PMCID: PMC2631075.


Schneiderman JI, Sakai A, Goldstein S, Ahmad K*. The XNP remodeler targets dynamic chromatin in Drosophila. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14472-7. Epub 2009 Aug 11. PubMed PMID: 19706533; PubMed Central PMCID: PMC2725014.


Shankar GM, Leissring MA, Adame A, Sun X, Spooner E, Masliah E, Selkoe DJ, Lemere CA, Walsh DM. Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life. Neurobiol Dis. 2009 Nov;36(2):293-302. Epub 2009 Aug 4. PubMed PMID: 19660551; PubMed Central PMCID: PMC2782414.


Li S, Hong S, Shepardson NE, Walsh DM, Shankar GM, Selkoe D. Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake. Neuron. 2009 Jun 25;62(6):788-801. PubMed PMID: 19555648; PubMed Central PMCID: PMC2702854.


Sikorski TW, Buratowski S. The basal initiation machinery: beyond the general transcription factors. Curr Opin Cell Biol. 2009 Jun;21(3):344-51. doi: 10.1016/j.ceb.2009.03.006. Epub 2009 May 4. PMID: 19411170 PMCID: PMC2692371 read article


Johnson A, Li G, Sikorski TW, Buratowski S, Woodcock CL, Moazed D. Reconstitution of heterochromatin-dependent transcriptional gene silencing. Mol Cell. 2009 Sep 24;35(6):769-81. doi: 10.1016/j.molcel.2009.07.030. PMID: 19782027 PMCID: PMC2842978 read article


Sims JS, Militello KT, Sims PA, Patel VP, Kasper JM, Wirth DF. Patterns of gene-specific and total transcriptional activity during the Plasmodium falciparum intraerythrocytic developmental cycle. Eukaryot Cell. 2009 Mar;8(3):327-38. doi: 10.1128/EC.00340-08. Epub 2009 Jan 16. PMID: 19151330 PMCID: PMC2653245 read article


Higley MJ, Soler-Llavina GJ, Sabatini BL. Cholinergic modulation of multivesicular release regulates striatal synaptic potency and integration. Nat Neurosci. 2009 Sep;12(9):1121-8. Epub 2009 Aug 9. PubMed PMID: 19668198; PubMed Central PMCID: PMC2733934.


Sturgill JF, Steiner P, Czervionke BL, Sabatini BL. Distinct domains within PSD-95 mediate synaptic incorporation, stabilization, and activity-dependent trafficking. J Neurosci. 2009 Oct 14;29(41):12845-54. PubMed PMID: 19828799; PubMed Central PMCID: PMC2787089.


Iyer LM, Tahiliani M, Rao A, Aravind L. Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids. Cell Cycle (2009) 8(11): 1698-1710. PMID: 19411852. PMCID: PMC2995806.


Tahiliani M, Koh KP, Shen Y, Pastor WA, Bandukwala H, Brudno Y, Agarwal S, Iyer LM, Liu DR, Aravind L, Rao A. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by the MLL fusion partner, TET1. Science (2009) 324 (5929): 930-5. PMID: 19372391. PMCID: PMC2715015.


Tanner NA, Loparo JJ, van Oijen AM. Visualizing Single-molecule DNA Replication with Fluorescence Microscopy. J Vis Exp. 2009 Oct 9;(32). pii: 1529. doi: 10.3791/1529. PMID: 19820685 PMCID: PMC3142874 read article


Tanner NA, van Oijen AM. Single-molecule observation of prokaryotic DNA replication. Methods Mol Biol. 2009;521:397-410. doi: 10.1007/978-1-60327-815-7_22. PMID: 19563119 PMCID: PMC2943766 read article


Tanner NA, Loparo JJ, Hamdan SM, Jergic S, Dixon NE, van Oijen AM. Real-time single-molecule observation of rolling-circle DNA replication. Nucleic Acids Res. 2009 Mar;37(4):e27. doi: 10.1093/nar/gkp006. Epub 2009 Jan 20. PMID: 19155275 PMCID: PMC2651787 read article


Medoff BD, Seung E, Hong S, Thomas SY, Sandall BP, Duffield JS, Kuperman DA, Erle DJ, Luster AD. CD11b+ myeloid cells are the key mediators of Th2 cell homing into the airway in allergic inflammation. J Immunol. 2009 Jan 1;182(1):623-35. PMID: 19109196 PMCID: PMC2718444 read article


McNaughton BR, Cronican JJ, Thompson DB, Liu DR. Mammalian cell penetration, siRNA transfection, and DNA transfection by supercharged proteins. Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6111-6. doi: 10.1073/pnas.0807883106. Epub 2009 Mar 23. PMID: 19307578 PMCID: PMC2659711 read article


Freiwald WA, Tsao DY, Livingstone MS. A face feature space in the macaque temporal lobe. Nat Neurosci. 2009 Sep;12(9):1187-96. Epub 2009 Aug 9. PubMed PMID: 19668199; PubMed Central PMCID: PMC2819705.


Uzri D, Gehrke L. Nucleotide sequences and modifications that determine RIG-I/RNA binding and signaling activities. J Virol. 2009 May;83(9):4174-84. Epub 2009 Feb 18. PMID: 19224987 PMCID: PMC2668486 read article


Riccio A, Li Y, Moon J, Kim KS, Smith KS, Rudolph U, Gapon S, Yao GL, Tsvetkov E, Rodig SJ, Van't Veer A, Meloni EG, Carlezon WA Jr, Bolshakov VY, Clapham DE. Essential role for TRPC5 in amygdala function and fear-related behavior. Cell. 2009 May 15;137(4):761-72. PMCID: .


Chen Z, Vijayan S, Barbieri R, Wilson MA, Brown EN. Discrete- and continuous-time probabilistic models and algorithms for inferring neuronal UP and DOWN states. Neural Comput. 2009 Jul;21(7):1797-862. PubMed PMID: 19323637; PubMed Central PMCID: PMC2799196.


Wai SC, Gerber SA, Li R. Multisite phosphorylation of the guanine nucleotide exchange factor Cdc24 during yeast cell polarization. PLoS One. 2009. Aug 10;4(8):e6563. PMC2718613.


Utikal J, Polo JM, Stadtfeld M, Maherali N, Kulalert W, Walsh RM, Khalil A, Rheinwald JG, Hochedlinger K. Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Nature. 2009 Aug 27;460(7259):1145-8. doi: 10.1038/nature08285. Epub 2009 Aug 9. PMID: 19668190 PMCID: PMC3987892 read article


Cornejo MG, Kharas MG, Werneck MB, Le Bras S, Moore SA, Ball B, Beylot-Barry M, Rodig SJ, Aster JC, Lee BH, Cantor H, Merlio JP, Gilliland DG, Mercher T. Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models. Blood. 2009 Mar 19;113(12):2746-54. Epub 2009 Jan 12. PubMed PMID: 19139084; PubMed Central PMCID: PMC2661862.


Fraenkel PG, Gibert Y, Holzheimer JL, Lattanzi VJ, Burnett SF, Dooley KA, Wingert RA, Zon LI. Transferrin-a modulates hepcidin expression in zebrafish embryos. Blood. 2009 Mar 19;113(12):2843-50. doi: 10.1182/blood-2008-06-165340. Epub 2008 Dec 1. PMID: 19047682 PMCID: PMC2661867 read article


Chan JA***, Balasubramanian S***, Witt RM***, Nazemi KJ, Choi Y, Pazyra-Murphy MF, Walsh CO, Thompson M, Segal RA. Proteoglycan interactions with Sonic Hedgehog specify mitogenic responses. Nat Neurosci. 2009 Apr;12(4):409-17. Epub 2009 Mar 15. PMID: 19287388. PMCID: PMC2676236. ***Denotes equal contribution


Witt RM, Galligan MM, Despinoy JR, Segal R. Olfactory behavioral testing in the adult mouse. J Vis Exp. 2009 Jan 28;(23). pii: 949. doi: 10.3791/949. PMID: 19229182. PMCID: PMC278299.


Chan JA, Balasubramanian S, Witt RM, Nazemi KJ, Choi Y, Pazyra-Murphy MF, Walsh CO, Thompson M, Segal RA. Proteoglycan interactions with Sonic Hedgehog specify mitogenic responses. Nat Neurosci. 2009 Apr;12(4):409-17. Epub 2009 Mar 15. PubMed PMID: 19287388; PubMed Central PMCID: PMC2676236.


Feuerer M, Herrero L, Cipolletta D, Naaz A, Wong J, Nayer A, Lee J, Goldfine AB, Benoist C, Shoelson S, Mathis D. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med. 2009 Aug;15(8):930-9. Epub 2009 Jul 26. PMID: 19633656. PMCID: PMC3115752.


Yang Y, Kim AH, Yamada T, Wu B, Bilimoria PM, Ikeuchi Y, de la Iglesia N, Shen J, Bonni A. A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation. Science. 2009 Oct 23;326(5952):575-8. PubMed PMID: 19900895; PubMed Central PMCID: PMC2846784.


top

2008


Lai T, Jabaudon D, Molyneaux BJ, Azim E, Arlotta P, Menezes JR, Macklis JD. SOX5 controls the sequential generation of distinct corticofugal neuron subtypes. Neuron. 2008 Jan 24;57(2):232-47. PubMed PMID: 18215621.


Abraira VE, Del Rio T, Tucker AF, Slonimsky J, Keirnes HL, Goodrich LV.Cross-repressive interactions between Lrig3 and netrin 1 shape the architecture of the inner ear. Development. 2008 Dec;135(24):4091-9. Epub 2008 Nov 12. PubMed PMID: 19004851; PubMed Central PMCID: PMC2892390.


Agosto MA, Myers KS, Ivanovic T, Nibert ML. A positive-feedback mechanism promotes reovirus particle conversion to the intermediate associated with membrane penetration. Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10571-6. doi: 10.1073/pnas.0802039105. Epub 2008 Jul 24. PMID: 18653761 PMCID: PMC2492467 read article


Ivanovic T, Agosto MA, Zhang L, Chandran K, Harrison SC, Nibert ML. Peptides released from reovirus outer capsid form membrane pores that recruit virus particles. EMBO J. 2008 Apr 23;27(8):1289-98. doi: 10.1038/emboj.2008.60. Epub 2008 Mar 27. PMID: 18369316 PMCID: PMC2367403 read article


Petzold GC, Albeanu DF, Sato TF, Murthy VN. Coupling of neural activity to blood flow in olfactory glomeruli is mediated by astrocytic pathways. Neuron. 2008 Jun 26;58(6):897-910. PubMed PMID: 18579080; PubMed Central PMCID: PMC2922004.


Albeanu DF, Soucy E, Sato TF, Meister M, Murthy VN. LED arrays as cost effective and efficient light sources for widefield microscopy. PLoS One. 2008 May 14;3(5):e2146. PubMed PMID: 18478056; PubMed Central PMCID: PMC2361193.


Anderson SB, Goldberg AL, Whitman M. Identification of a novel pool of extracellular pro-myostatin in skeletal muscle. J Biol Chem. 2008 Mar 14;283(11):7027-35. doi: 10.1074/jbc.M706678200. Epub 2008 Jan 6. PMID: 18175804


Gordon WR, Arnett KL, Blacklow SC. The molecular logic of Notch signaling-a structural and biochemical perspective. J Cell Sci. 2008 Oct 1;121(Pt 19):3109-19. Review. PubMed PMID: 18799787; PubMed Central PMCID: PMC2696053.


Arnold MM, Murray KE, Nibert ML. Formation of the factory matrix is an important, though not a sufficient function of nonstructural protein mu NS during reovirus infection. Virology. 2008 Jun 5;375(2):412-23. Epub 2008 Apr 18. PMID: 18374384 PMCID: PMC2486453 read article


Atkins BD, Yoshida S, Pellman D. Symmetry breaking: scaffold plays matchmaker for polarity signaling proteins. Curr Biol. 2008 Dec 23;18(24):R1130-2. doi: 10.1016/j.cub.2008.11.005. PMID: 19108767


Balibar CJ, Walsh CT. From thioesters to amides and back: condensation domain reversibility in the biosynthesis of vibriobactin. Chembiochem. 2008 Jan 4;9(1):42-5. PMID: 18022888


Ryan KS, Balibar CJ, Turo KE, Walsh CT, Drennan CL. The violacein biosynthetic enzyme VioE shares a fold with lipoprotein transporter proteins. J Biol Chem. 2008 Mar 7;283(10):6467-75. doi: 10.1074/jbc.M708573200. Epub 2008 Jan 2. PMID: 18171675


Villén J, Beausoleil SA, Gygi SP. Evaluation of the utility of neutral-loss-dependent MS3 strategies in large-scale phosphorylation analysis. Proteomics. 2008 Nov;8(21):4444-52. doi: 10.1002/pmic.200800283. PMID: 18972524 PMCID: PMC2745099 read article


Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP. A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. PMID: 18669648 PMCID: PMC2504835 read article


Zhai B, Villén J, Beausoleil SA, Mintseris J, Gygi SP. Phosphoproteome analysis of Drosophila melanogaster embryos. J Proteome Res. 2008 Apr;7(4):1675-82. doi: 10.1021/pr700696a. Epub 2008 Mar 8. PMID: 18327897 PMCID: PMC3063950 read article


Bilimoria PM, Bonni A. Cultures of Cerebellar Granule Neurons. CSH Protoc.2008;13:5107. PubMed PMID: 21152358; PubMed Central PMCID: PMC2996826.


Vig M, Dehaven WI, Bird GS, Billingsley JM, Wang H, Rao PE, Hutchings AB, Jouvin MH, Putney JW, Kinet JP. 2008. Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels. Nat. Immunol. 9(1); 89-96. PMCID: PMC2377025.


Lin Y, Bloodgood BL, Hauser JL, Lapan AD, Koon AC, Kim TK, Hu LS, Malik AN, Greenberg ME. Activity-dependent regulation of inhibitory synapse development by Npas4. Nature. 2008 Oct 30;455(7217):1198-204. Epub 2008 Sep 24. PubMed PMID: 18815592; PubMed Central PMCID: PMC2637532.


Franco S, Murphy MM, Li G, Borjeson T, Boboila C, Alt FW. DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination. J Exp Med. 2008 Mar 17;205(3):557-64. Epub 2008 Mar 3. PubMed PMID: 18316419; PubMed Central PMCID: PMC2275379.


Cariappa A, Takematsu H, Liu H, Diaz S, Haider K, Boboila C, Kalloo G, Connole M, Shi HN, Varki N, Varki A, Pillai S. B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase. J Exp Med. 2009 Jan 16;206(1):125-38. Epub 2008 Dec 22. PubMed PMID: 19103880; PubMed Central PMCID: PMC2626685.


Bortnick RA, Gaufberg E. Injustice. Med Educ. 2008 Nov;42(11):1108-9. PubMed PMID: 19141010.


Rowley CF, Boutwell CL, Lockman S, Essex M. Improvement in allele-specific PCR assay with the use of polymorphism-specific primers for the analysis of minor variant drug resistance in HIV-1 subtype C. J Virol Methods. 2008 Apr;149(1):69-75. doi: 10.1016/j.jviromet.2008.01.005. Epub 2008 Mar 4. PMID: 18295909 PMCID: PMC2927209 read article


Boyce M, Py BF, Ryazanov AG, Minden JS, Long K, Ma D, Yuan J. A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death. Cell Death Differ. 2008 Mar;15(3):589-99. doi: 10.1038/sj.cdd.4402296. Epub 2008 Jan 11. PMID: 18188169


Bryant KF, Macari ER, Malik N, Boyce M, Yuan J, Coen DM. ICP34.5-dependent and -independent activities of salubrinal in herpes simplex virus-1 infected cells. Virology. 2008 Sep 30;379(2):197-204. doi: 10.1016/j.virol.2008.06.028. Epub 2008 Aug 6. PMID: 18684481 PMCID: PMC2665023 read article


Brown CR, Kennedy CJ, Delmar VA, Forbes DJ, Silver PA*. Globalhistone acetylation induces functional genomic reorganization at mammalian nuclear pore complexes. Genes and Development. 2008. March 1:22(5):627-639. PMC2259032.


Brown KM, Landry CR, Hartl DL, Cavalieri D. Cascading transcriptional effects of a naturally occurring frameshift mutation in Saccharomyces cerevisiae. Mol Ecol. 2008 Jun;17(12):2985-97. Epub 2008 Apr 18. PubMed PMID: 18422925.


Buchman JJ, Tsai LH. Putting a notch in our understanding of nuclear migration. Cell. 2008 Sep 19;134(6):912-4. PubMed PMID: 18805082.


Burrows AE, Elledge SJ. How ATR turns on: TopBP1 goes on ATRIP with ATR. Genes Dev. 2008 Jun 1;22(11):1416-21. doi: 10.1101/gad.1685108. PMID: 18519633 PMCID: PMC2732414 read article


Butty V, Campbell C, Mathis D, Benoist C; DPT-1 Study Group. Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1).Diabetes. 2008 Sep;57(9):2348-59. Epub 2008 Jun 12. PMID:18556337. PMCID: PMC2518486.


Johnsen AK, Plenge RM, Butty V, Campbell C, Dieguez-Gonzalez R, Gomez-Reino JJ, Shadick N, Weinblatt M, Gonzalez A, Gregersen PK, Benoist C, Mathis D. A broad analysis of IL1 polymorphism and rheumatoid arthritis. Arthritis Rheum. 2008 Jul;58(7):1947-57. PMID:18576312. PMCID: PMC2533126.


Xu C, Gagnon E, Call ME, Schnell JR, Schwieters CD, Carman CV, Chou JJ, Wucherpfennig KW. Regulation of T cell receptor activation by dynamic membrane binding of the CD3epsilon cytoplasmic tyrosine-based motif. Cell. 2008 Nov 14;135(4):702-13. PubMed PMID: 19013279; PubMed Central PMCID: PMC2597348.


Catapano LA, Magavi SS, Macklis JD. Neuroanatomical tracing of neuronal projections with Fluoro-Gold. Methods Mol Biol. 2008;438:353-9. PubMed PMID: 18369770.


Cedeno-Laurent F, Bryant J, Fishelevich R, Jones OD, Deng A, Eng ML, Gaspari AA, Trujillo JR. Inflammatory papillomatous hyperplasia and epidermal necrosis in a transgenic rat for HIV-1. J Dermatol Sci. 2009 Feb;53(2):112-9. Epub 2008 Nov 11. PubMed PMID: 19004620; PubMed Central PMCID: PMC3125122.


Hett EC, Chao MC, Deng LL, Rubin EJ. A mycobacterial enzyme essential for cell division synergizes with resuscitation-promoting factor. PLoS Pathog. 2008 Feb 29;4(2):e1000001. PubMed PMID: 18463693; PubMed Central PMCID: PMC2262848.


Young-Pearse TL, Chen AC, Chang R, Marquez C, Selkoe DJ. Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1. Neural Dev. 2008 Jun 23;3:15. PubMed PMID: 18573216; PubMed Central PMCID: PMC2442059.


Cheung V, Chua G, Batada NN, Landry CR, Michnick SW, Hughes TR, Winston F. Chromatin- and transcription-related factors repress transcription from within coding regions throughout the Saccharomyces cerevisiae genome. PLoS Biol. 2008 Nov 11;6(11):e277. PubMed PMID: 18998772; PubMed Central PMCID: PMC2581627.


Chiang CW, Derti A, Schwartz D, Chou MF, Hirschhorn JN, Wu CT. Ultraconserved elements: analyses of dosage sensitivity, motifs and boundaries. Genetics. 2008 Dec;180(4):2277-93. Epub 2008 Oct 28. PubMed PMID: 18957701; PubMed Central PMCID: PMC2600958.


Keating BJ, Tischfield S, Murray SS, Bhangale T, Price TS, Glessner JT, Galver L, Barrett JC, Grant SF, Farlow DN, Chandrupatla HR, Hansen M, Ajmal S, Papanicolaou GJ, Guo Y, Li M, Derohannessian S, de Bakker PI, Bailey SD, Montpetit A, Edmondson AC, Taylor K, Gai X, Wang SS, Fornage M, Shaikh T, Groop L, Boehnke M, Hall AS, Hattersley AT, Frackelton E, Patterson N, Chiang CW, Kim CE, Fabsitz RR, Ouwehand W, Price AL, Munroe P, Caulfield M, Drake T, Boerwinkle E, Reich D, Whitehead AS, Cappola TP, Samani NJ, Lusis AJ, Schadt E, Wilson JG, Koenig W, McCarthy MI, Kathiresan S, Gabriel SB, Hakonarson H, Anand SS, Reilly M, Engert JC, Nickerson DA, Rader DJ, Hirschhorn JN, Fitzgerald GA. Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One. 2008;3(10):e3583. Epub 2008 Oct 31. PubMed PMID: 18974833; PubMed Central PMCID: PMC2571995.


Chiu IM, Chen A, Zheng Y, Kosaras B, Tsiftsoglou SA, Vartanian TK, Brown RH Jr, Carroll MC. T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS. Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17913-8. Epub 2008 Nov 7. PMID: 18997009. PMCID: PMC2581614.


Cutler C, Stevenson K, Kim HT, Richardson P, Ho VT, Linden E, Revta C, Ebert R, Warren D, Choi S, Koreth J, Armand P, Alyea E, Carter S, Horowitz M, Antin JH, Soiffer R. Sirolimus is associated with veno-occlusive disease of the liver after myeloablative allogeneic stem cell transplantation. Blood. 2008 Dec 1;112(12):4425-31. Epub 2008 Sep 5. PubMed PMID: 18776081; PubMed Central PMCID: PMC2597119.


Mitnick CD, Shin SS, Seung KJ, Rich ML, Atwood SS, Furin JJ, Fitzmaurice GM, Alcantara Viru FA, Appleton SC, Bayona JN, Bonilla CA, Chalco K, Choi S, Franke MF, Fraser HS, Guerra D, Hurtado RM, Jazayeri D, Joseph K, Llaro K, Mestanza L, Mukherjee JS, Muñoz M, Palacios E, Sanchez E, Sloutsky A, Becerra MC. Comprehensive treatment of extensively drug-resistant tuberculosis. N Engl J Med. 2008 Aug 7;359(6):563-74. PubMed PMID: 18687637; PubMed Central PMCID: PMC2673722.


Liu M, Choi S, Cuny GD, Ding K, Dobson BC, Glicksman MA, Auerbach K, Stein RL. Kinetic studies of Cdk5/p25 kinase: phosphorylation of tau and complex inhibition by two prototype inhibitors. Biochemistry. 2008 Aug 12;47(32):8367-77. Epub 2008 Jul 18. PubMed PMID: 18636751.


Choo AY, Yoon SO, Kim SG, Roux PP, Blenis J*. Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation. Proc Natl Acad Sci USA. 2008. 105:17414-9. PMC2582304.


Muthumani K**, Choo AY**, Shedlock DJ, Laddy DJ, Sundaram SG, Hirao L, Wu L, Thieu KP, Chung CW, Lankaraman KM, Tebas P, Silvestri G, Weiner DB. Human immunodeficiency virus type 1 Nef induces programmed death 1 expression through a p38 mitogen-activated protein kinase-dependent mechanism. J. Virol. 2008. 82:11536-44. PMC2583658.
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Chiang CW, Derti A, Schwartz D, Chou MF, Hirschhorn JN, Wu CT. Ultraconserved elements: analyses of dosage sensitivity, motifs and boundaries. Genetics. 2008 Dec;180(4):2277-93. Epub 2008 Oct 28. PubMed PMID: 18957701; PubMed Central PMCID: PMC2600958.


Hitomi J, Christofferson DE, Ng A, Yao J, Degterev A, Xavier RJ, Yuan J. Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell. 2008 Dec 26;135(7):1311-23. doi: 10.1016/j.cell.2008.10.044. PMID: 19109899 PMCID: PMC2621059 read article


Chun DK, McEwen JM, Burbea M, Kaplan JM. UNC-108/Rab2 regulates postendocytic trafficking in Caenorhabditis elegans. Mol Biol Cell. 2008 Jul;19(7):2682-95. doi: 10.1091/mbc.E07-11-1120. Epub 2008 Apr 23. PMID: 18434599 PMCID: PMC2441656 read article


Dickinson BL, Claypool SM, Aiken ML, D'Angelo JA, Venu N, Yen EH, Wagner JS, Borawski JA, Pierce AT, Hershberg R, Blumberg RS, Lencer WI. Ca2+-dependent calmodulin-binding to FcRn sorts between the transcytotic and lysosomal pathways. Mol Biol Cell. 2008 Jan;19(1):414-23. PMCID: PMC2174181.


Leadbetter EA, Brigl M, Illarionov P, Cohen N, Luteran MC, Pillai S, Besra GS, Brenner MB. NK T cells provide lipid antigen-specific cognate help for B cells. Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8339-44. Epub 2008 Jun 11. PMID: 18550809 PMCID: PMC2448838


Hava DL, van der Wel N, Cohen N, Dascher CC, Houben D, León L, Agarwal S, Sugita M, van Zon M, Kent SC, Shams H, Peters PJ, Brenner MB. Evasion of peptide, but not lipid antigen presentation, through pathogen-induced dendritic cell maturation. Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11281-6. Epub 2008 Aug 6. PMID: 18685099 PMCID: PMC2516216


Kindler T, Cornejo MG, Scholl C, Liu J, Leeman DS, Haydu JE, Fröhling S, Lee BH, Gilliland DG. K-RasG12D-induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to gamma-secretase inhibitors. Blood. 2008 Oct 15;112(8):3373-82. Epub 2008 Jul 28. PubMed PMID: 18663146; PubMed Central PMCID: PMC2569181.


Costantino CM, Hang HC, Kent SC, Hafler DA, Ploegh HL. Lysosomal cysteine and aspartic proteases are heterogeneously expressed and act redundantly to initiate human invariant chain degradation. J Immunol. 2008 Mar 1;180(5):2876-85. PubMed PMID: 18292509.


Costantino CM, Baecher-Allan C, Hafler DA. Multiple sclerosis and regulatory T cells. J Clin Immunol. 2008 Nov;28(6):697-706. Epub 2008 Sep 2. Review. PubMed PMID: 18763026; PubMed Central PMCID: PMC2752287.


Costantino CM, Baecher-Allan CM, Hafler DA. Human regulatory T cell and autoimmunity. Eur J Immunol. 2008 Apr;38(4):921-4. Review. PubMed PMID: 18395861; PubMed Central PMCID: PMC2752283.


Cosker KE, Courchesne SL, Segal RA. Action in the axon: generation and transport of signaling endosomes. Curr Opin Neurobiol. 2008 Jun;18(3):270-5. Review. PubMed PMID: 18778772; PubMed Central PMCID: PMC2693191.


Raiser DM, Zacharek SJ, Roach RR, Curtis SJ, Sinkevicius KW, Gludish DW, Kim CF. Stem cell biology in the lung and lung cancers: using pulmonary context and classic approaches. Cold Spring Harb Symp Quant Biol. 2008;73:479-90. Epub 2008 Nov 21. Review. PubMed PMID: 19028984.


Papadia S, Soriano FX, Léveillé F, Martel MA, Dakin KA, Hansen HH, Kaindl A,Sifringer M, Fowler J, Stefovska V, McKenzie G, Craigon M, Corriveau R, Ghazal P, Horsburgh K, Yankner BA, Wyllie DJ, Ikonomidou C, Hardingham GE. Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses. Nat Neurosci. 2008 Apr;11(4):476-87. Epub 2008 Mar 23. PubMed PMID: 18344994; PubMed Central PMCID: PMC2556874.


Loerch PM, Lu T, Dakin KA, Vann JM, Isaacs A, Geula C, Wang J, Pan Y, Gabuzda DH, Li C, Prolla TA, Yankner BA. Evolution of the aging brain transcriptome and synaptic regulation. PLoS One. 2008 Oct 2;3(10):e3329. PubMed PMID: 18830410; PubMed Central PMCID: PMC2553198.


Day CL, Mkhwanazi N, Reddy S, Mncube Z, van der Stok M, Klenerman P, Walker BD. Detection of polyfunctional Mycobacterium tuberculosis-specific T cells and association with viral load in HIV-1-infected persons. J Infect Dis. 2008 Apr 1;197(7):990-9. doi: 10.1086/529048. PMID: 18419535


Ramduth D, Thobakgale CF, Mkhwanazi NP, De Pierres C, Reddy S, van der Stok M, Mncube Z, Mphatswe W, Blanckenberg N, Cengimbo A, Prendergast A, Tudor-Williams G, Dong K, Jeena P, Coovadia HM, Day CL, Kiepiela P, Goulder PJ, Walker BD. Detection of HIV type 1 gag-specific CD4(+) T cell responses in acutely infected infants. AIDS Res Hum Retroviruses. 2008 Feb;24(2):265-70. doi: 10.1089/aid.2007.0096. PMID: 18284325


Ngumbela KC, Day CL, Mncube Z, Nair K, Ramduth D, Thobakgale C, Moodley E, Reddy S, de Pierres C, Mkhwanazi N, Bishop K, van der Stok M, Ismail N, Honeyborne I, Crawford H, Kavanagh DG, Rousseau C, Nickle D, Mullins J, Heckerman D, Korber B, Coovadia H, Kiepiela P, Goulder PJ, Walker BD. Targeting of a CD8 T cell env epitope presented by HLA-B*5802 is associated with markers of HIV disease progression and lack of selection pressure. AIDS Res Hum Retroviruses. 2008 Jan;24(1):72-82. doi: 10.1089/aid.2007.0124. PMID: 18275350


de la Torre-Ubieta L, Bonni A. Combinatorial assembly of neurons: from chromatin to dendrites. Trends Cell Biol. 2008 Feb;18(2):48-51. Epub 2008 Jan 28. PubMed PMID: 18222691.


Dong CK, Patel V, Yang JC, Dvorin JD, Duraisingh MT, Clardy J, Wirth DF. Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and itsinhibitors. Bioorg Med Chem Lett. 2009 Feb 1;19(3):972-5. doi:
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Dougan M, Dranoff G. Inciting inflammation: the RAGE about tumor promotion.J Exp Med. 2008 Feb 18;205(2):267-70. Epub 2008 Feb 11. PMID: 18268042


Hussain MM, Rava P, Pan X, Dai K, Dougan SK, Iqbal J, Lazare F, Khatun I. Microsomal triglyceride transfer protein in plasma and cellular lipid metabolism. Curr Opin Lipidol. 2008 Jun;19(3):277-84. Review. PubMed PMID: 18460919.


White RM, Sessa A, Burke C, Bowman T, LeBlanc J, Ceol C, Bourque C, Dovey M, Goessling W, Burns CE, Zon LI. Transparent adult zebrafish as a tool for in vivo transplantation analysis. Cell Stem Cell. 2008 Feb 7;2(2):183-9. doi: 10.1016/j.stem.2007.11.002. PMID: 18371439 PMCID: PMC2292119 read article


Jinushi M, Nakazaki Y, Carrasco DR, Draganov D, Souders N, Johnson M, Mihm MC,Dranoff G. Milk fat globule EGF-8 promotes melanoma progression through coordinated Akt and twist signaling in the tumor microenvironment. Cancer Res. 2008 Nov 1;68(21):8889-98. PubMed PMID: 18974133.


Dallabrida SM, Ismail NS, Pravda EA, Parodi EM, Dickie R, Durand EM, Lai J,Cassiola F, Rogers RA, Rupnick MA. Integrin binding angiopoietin-1 monomers reduce cardiac hypertrophy. FASEB J. 2008 Aug;22(8):3010-23. Epub 2008 May 23. PubMed PMID: 18502941; PubMed Central PMCID: PMC2493452.


Dutton RJ, Boyd D, Berkmen M, Beckwith J. Bacterial species exhibit diversity in their mechanisms and capacity for protein disulfide bond formation. Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11933-8. Epub 2008 Aug 11. PubMed PMID: 18695247; PubMed Central PMCID: PMC2575290.


Erlandson KJ, Or E, Osborne AR, Rapoport TA. Analysis of polypeptide movement in the SecY channel during SecA-mediated protein translocation. J Biol Chem. 2008 Jun 6;283(23):15709-15. Epub 2008 Mar 21. PMID: 18359943 PMCID: PMC2409214 read article


Erlandson KJ, Miller SB, Nam Y, Osborne AR, Zimmer J, Rapoport TA. A role for the two-helix finger of the SecA ATPase in protein translocation. Nature. 2008 Oct 16;455(7215):984-7. PMID: 18923526


Zhao J, Sun BK, Erwin JA, Song JJ, Lee JT. Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome. Science. 2008 Oct 31;322(5902):750-6. PubMed PMID: 18974356; PubMed Central PMCID: PMC2748911.


Erwin JA, Lee JT. New twists in X-chromosome inactivation. Curr Opin Cell Biol. 2008 Jun;20(3):349-55. Epub 2008 May 26. Review. PubMed PMID: 18508252; PubMed Central PMCID: PMC2491718.


Bakalarski CE, Elias JE, Villén J, Haas W, Gerber SA, Everley PA, Gygi SP. The impact of peptide abundance and dynamic range on stable-isotope-based quantitative proteomic analyses. J Proteome Res. 2008 Nov;7(11):4756-65. doi: 10.1021/pr800333e. Epub 2008 Sep 18. PMID: 18798661 PMCID: PMC2746028


Fantana AL, Soucy ER, Meister M. Rat olfactory bulb mitral cells receive sparse glomerular inputs. Neuron. 2008 Sep 11;59(5):802-14. PubMed PMID: 18786363.


Farny NG, Hurt JA, Silver PA*. Definition of global and transcript-specific mRNA export pathways in metazoans. Genes Dev. 2008. Jan 1;22(1):66-78. PMC2151015.


Heng TS, Painter MW; Immunological Genome Project Consortium (Elpek K, Lukacs-Kornek V, Mauermann N, Turley SJ, Koller D, Kim FS, Wagers AJ, Asinovski N, Davis S, Fassett M, Feuerer M, Gray DH, Haxhinasto S, Hill JA, Hyatt G, Laplace C, Leatherbee K, Mathis D, Benoist C, Jianu R, Laidlaw DH, Best JA, Knell J, Goldrath AW, Jarjoura J, Sun JC, Zhu Y, Lanier LL, Ergun A, Li Z, Collins JJ, Shinton SA, Hardy RR, Friedline R, Sylvia K, Kang J.) The Immunological Genome Project: networks of gene expression in immune cells.Nat Immunol. 2008 Oct;9(10):1091-4.PMID: 18800157


Flavell SW, Kim TK, Gray JM, Harmin DA, Hemberg M, Hong EJ, Markenscoff-Papadimitriou E, Bear DM, Greenberg ME. Genome-wide analysis of MEF2 transcriptional program reveals synaptic target genes and neuronal activity-dependent polyadenylation site selection. Neuron. 2008 Dec 26;60(6):1022-38. PubMed PMID: 19109909; PubMed Central PMCID: PMC2630178.


Morrow EM, Yoo SY, Flavell SW, Kim TK, Lin Y, Hill RS, Mukaddes NM, Balkhy S, Gascon G, Hashmi A, Al-Saad S, Ware J, Joseph RM, Greenblatt R, Gleason D, Ertelt JA, Apse KA, Bodell A, Partlow JN, Barry B, Yao H, Markianos K, Ferland RJ, Greenberg ME, Walsh CA. Identifying autism loci and genes by tracing recent shared ancestry. Science. 2008 Jul 11;321(5886):218-23. Erratum in: Science. 2010 Dec 24;330(6012):1746. PubMed PMID: 18621663; PubMed Central PMCID: PMC2586171.


Flavell SW, Greenberg ME. Signaling mechanisms linking neuronal activity to gene expression and plasticity of the nervous system. Annu Rev Neurosci. 2008;31:563-90. Review. PubMed PMID: 18558867; PubMed Central PMCID: PMC2728073.


Fontaine-Rodriguez EC, Knipe DM. Herpes simplex virus ICP27 increases translation of a subset of viral late mRNAs. J Virol. 2008 Apr;82(7):3538-45. Epub 2008 Jan 23. PMID: 18216091 PMCID: PMC2268449 read article


Kim D, Frank CL, Dobbin MM, Tsunemoto RK, Tu W, Peng PL, Guan J, Lee BH, Moy LY, Giusti P, Broodie N, Mazitschek R, Delalle I, Haggarty SJ, Neve RL, Lu Y, Tsai LH*. Deregulation of HDAC1 by p25/cdk5 inneurotoxicity. Neuron. 2008 Dec 10; 60(5):803-817. PMC2912147.


Paleologou KE, Schmid AW, Rospigliosi CC, Kim HY, Lamberto GR, Fredenburg RA, Lansbury PT Jr, Fernandez CO, Eliezer D, Zweckstetter M, Lashuel HA. Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein. J Biol Chem. 2008 Jun 13;283(24):16895-905. doi: 10.1074/jbc.M800747200. Epub 2008 Mar 14. PMID: 18343814 PMCID: PMC2423264 read article


Gabel HW, Ruvkun G. The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi. Nat Struct Mol Biol. 2008 May;15(5):531-3. Epub 2008 Apr 27. PubMed PMID: 18438419.


Pierce ML, Weston MD, Fritzsch B, Gabel HW, Ruvkun G, Soukup GA. MicroRNA-183 family conservation and ciliated neurosensory organ expression. Evol Dev. 2008 Jan-Feb;10(1):106-13. PubMed PMID: 18184361; PubMed Central PMCID: PMC2637451.


Gajdos ZK, Butler JL, Henderson KD, He C, Supelak PJ, Egyud M, Price A, Reich D, Clayton PE, Le Marchand L, Hunter DJ, Henderson BE, Palmert MR, Hirschhorn JN Association studies of common variants in 10 hypogonadotropic hypogonadism genes with age at menarche. J Clin Endocrinol Metab. 2008 Nov;93(11):4290-8. Epub 2008 Aug 26. PubMed PMID: 18728166; PubMed Central PMCID: PMC2582573.


Barral DC, Cavallari M, McCormick PJ, Garg S, Magee AI, Bonifacino JS, De Libero G, Brenner MB. CD1a and MHC class I follow a similar endocytic recycling pathway.Traffic. 2008 Sep;9(9):1446-57. Epub 2008 Jun 28. PMID: 18564371. PMCID: PMC3839101


Kim D, Frank CL, Dobbin MM, Tsunemoto RK, Tu W, Peng PL, Guan JS, Lee BH, Moy LY, Giusti P, Broodie N, Mazitschek R, Delalle I, Haggarty SJ, Neve RL, Lu Y, Tsai LH*. Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity. Neuron. 2008 Dec 10;60(5):803-17. PMC2912147. read article


Gomila RC, Gehrke L. Biochemical approaches for characterizing RNA-protein complexes in preparation for high resolution structure analysis. Methods Mol Biol. 2008;451:279-91. doi: 10.1007/978-1-59745-102-4_20. PMID: 18370263


Wilson-Grady JT, Villén J, Gygi SP. Phosphoproteome analysis of fission yeast. J Proteome Res. 2008 Mar;7(3):1088-97. doi: 10.1021/pr7006335. Epub 2008 Feb 8. PMID: 18257517


Geiben-Lynn R, Greenland JR, Frimpong-Boateng K, Letvin NL. Kinetics of recombinant adenovirus type 5, vaccinia virus, modified vaccinia ankara virus, and DNA antigen expression in vivo and the induction of memory T-lymphocyte responses. Clin Vaccine Immunol. 2008 Apr;15(4):691-6. Epub 2008 Feb 13. PMID: 18272665 PMCID: PMC2292663 read article


Geiben-Lynn R, Greenland JR, Frimpong-Boateng K, van Rooijen N, Hovav AH, Letvin NL. CD4+ T lymphocytes mediate in vivo clearance of plasmid DNA vaccine antigen expression and potentiate CD8+ T-cell immune responses. Blood. 2008 Dec 1;112(12):4585-90. Epub 2008 Sep 10. PMID: 18784371 PMCID: PMC2597129 read article


Yuan AH, Gregory BD, Sharp JS, McCleary KD, Dove SL, Hochschild A. Rsd family proteins make simultaneous interactions with regions 2 and 4 of the primary sigma factor. Mol Microbiol. 2008 Dec;70(5):1136-51. doi: 10.1111/j.1365-2958.2008.06462.x. Epub 2008 Sep 30. PMID: 18826409 PMCID: PMC2581641 read article


Kim JM, Kee Y, Gurtan A, D'Andrea AD. Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24. Blood. 2008 May 15;111(10):5215-22. doi: 10.1182/blood-2007-09-113092. Epub 2008 Jan 3. PMID: 18174376 PMCID: PMC2384144 read article


Hafler BP, Choi MY, Shivdasani RA, Rowitch DH. Expression and function of Nkx6.3 in vertebrate hindbrain. Brain Res. 2008 Jul 30;1222:42-50. Epub 2008 May 6. PubMed PMID: 18586225; PubMed Central PMCID: PMC2555971.


Trimarchi JM, Harpavat S, Billings NA, Cepko CL. Thyroid hormone components are expressed in three sequential waves during development of the chick retina. BMC Dev Biol. 2008 Oct 14;8:101. PubMed PMID: 18854032; PubMed Central PMCID: PMC2579430.


Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, Park SK, Hartlerode A, Stegmuller J, Hafner A, Loerch P, Wright SM, Mills KD, Bonni A*, Yankner BA, Scully R, Prolla TA, Alt FW, Sinclair DA*. SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell. 2008. 135:907-18. PMC2853975


Haushofer J, Livingstone MS, Kanwisher N. Multivariate patterns in object-selective cortex dissociate perceptual and physical shape similarity. PLoS Biol. 2008 Jul 29;6(7):e187. PubMed PMID: 18666833; PubMed Central PMCID: PMC2486311.


Haushofer J, Baker CI, Livingstone MS, Kanwisher N. Privileged coding of convex shapes in human object-selective cortex. J Neurophysiol. 2008 Aug;100(2):753-62. Epub 2008 Jun 25. PubMed PMID: 18579661; PubMed Central PMCID: PMC2525726.


Op de Beeck HP, Haushofer J, Kanwisher NG. Interpreting fMRI data: maps, modules and dimensions. Nat Rev Neurosci. 2008 Feb;9(2):123-35. Review. PubMed PMID: 18200027; PubMed Central PMCID: PMC2731480.


Yoshida T, Hazan I, Zhang J, Ng SY, Naito T, Snippert HJ, Heller EJ, Qi X, Lawton LN, Williams CJ, Georgopoulos K. The role of the chromatin remodeler Mi-2beta in hematopoietic stem cell self-renewal and multilineage differentiation. Genes Dev. 2008 May 1;22(9):1174-89. doi: 10.1101/gad.1642808. PMID: 18451107 PMCID: PMC2335314 read article


Hemming ML, Elias JE, Gygi SP, Selkoe DJ. Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements. PLoS Biol. 2008 Oct 21;6(10):e257. PubMed PMID: 18942891; PubMed Central PMCID: PMC2570425.


Henrickson SE, Mempel TR, Mazo IB, Liu B, Artyomov MN, Zheng H, Peixoto A, Flynn MP, Senman B, Junt T, Wong HC, Chakraborty AK, von Andrian UH. T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation.Nat Immunol. 2008 Mar;9(3):282-91. Epub 2008 Jan 20. PMID: 18204450. PMCID: PMC2698867


Henrickson SE, Mempel TR, Mazo IB, Liu B, Artyomov MN, Zheng H, Peixoto A, Flynn M, Senman B, Junt T, Wong HC, Chakraborty AK, von Andrian UH. In vivo imaging of T cell priming. Sci Signal. 2008 Mar 25;1(12):pt2. PMID: 18364513


Zheng H, Jin B, Henrickson SE, Perelson AS, von Andrian UH, Chakraborty AK. How antigen quantity and quality determine T-cell decisions in lymphoid tissue.Mol Cell Biol. 2008 Jun;28(12):4040-51. Epub 2008 Apr 21. PMID: 18426917. PMCID: PMC2423119


Hill SJ, Berkowitz R, Granter SR, Hirsch MS. Pagetoid lesions of the vulva: a collision between malignant melanoma and extramammary Paget disease.Int J Gynecol Pathol. 2008 Apr;27(2):292-6. PMID: 18317209


Flavell SW, Kim TK, Gray JM, Harmin DA, Hemberg M, Hong EJ, Markenscoff-Papadimitriou E, Bear DM, Greenberg ME. Genome-wide analysis of MEF2 transcriptional program reveals synaptic target genes and neuronal activity-dependent polyadenylation site selection. Neuron. 2008 Dec 26;60(6):1022-38. PubMed PMID: 19109909; PubMed Central PMCID: PMC2630178.


Hong EJ, McCord AE, Greenberg ME. A biological function for the neuronal activity-dependent component of Bdnf transcription in the development of cortical inhibition. Neuron. 2008 Nov 26;60(4):610-24. PubMed PMID: 19038219; PubMed Central PMCID: PMC2873221.


Singh KK, Park KJ, Hong EJ, Kramer BM, Greenberg ME, Kaplan DR, Miller FD. Developmental axon pruning mediated by BDNF-p75NTR-dependent axon degeneration. Nat Neurosci. 2008 Jun;11(6):649-58. Epub 2008 Apr 1. PubMed PMID: 18382462.


Nazer B, Hong S, Selkoe DJ. LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-beta peptide in a blood-brain barrier in vitro model. Neurobiol Dis. 2008 Apr;30(1):94-102. Epub 2008 Jan 5. PubMed PMID: 18289866; PubMed Central PMCID: PMC2376120.


Hooks BM, Chen C. Vision Triggers an Experience-Dependent Sensitive Period at the Retinogeniculate Synapse. Journal of Neuroscience. 2008. 28: 4807-17. PMCID: PMC2793334.


Hu CK, Coughlin M, Field CM, Mitchison TJ. Cell polarization during monopolar cytokinesis. J Cell Biol. 2008 Apr 21;181(2):195-202. doi: 10.1083/jcb.200711105. Epub 2008 Apr 14. PMID: 18411311  read article


Hurt JA, Silver PA*. mRNA nuclear export and human disease. Disease Models and Mech. 2008. Sep- Oct;1(2-3):103-108. PMC2562179.


Farny NG**, Hurt JA**, Silver PA*. Definition of global and transcript-specific mRNA export pathways in metazoans. Genes Dev. 2008. Jan 1;22(1):66-78. PMC2151015.
**-Denotes co-first author manuscript


Stegmüller J, Huynh MA, Yuan Z, Konishi Y, Bonni A. TGFbeta-Smad2 signaling regulates the Cdh1-APC/SnoN pathway of axonal morphogenesis. J Neurosci. 2008 Feb 20;28(8):1961-9. doi: 10.1523/JNEUROSCI.3061-07.2008. PMID: 18287512


Sarker KP, Kataoka H, Chan A, Netherton SJ, Pot I, Huynh MA, Feng X, Bonni A, Riabowol K, Bonni S. ING2 as a novel mediator of transforming growth factor-beta-dependent responses in epithelial cells. J Biol Chem. 2008 May 9;283(19):13269-79. doi: 10.1074/jbc.M708834200. Epub 2008 Mar 11. PMID: 18334480 PMCID: PMC2442333 read article


Sullivan S, Ichida JK, Umezawa A, Akutsu H. Elucidating nuclear reprogramming mechanisms: taking a synergistic approach. Reprod Biomed Online. 2008 Jan;16(1):41-50. Review. PubMed PMID: 18252046.


Roesch K, Jadhav AP, Trimarchi JM, Stadler MB, Roska B, Sun BB, Cepko CL. The transcriptome of retinal Müller glial cells. J Comp Neurol. 2008 Jul 10;509(2):225-38. doi: 10.1002/cne.21730. PMID: 18465787 PMCID: PMC2665263 read article


Damiani D, Alexander JJ, O'Rourke JR, McManus M, Jadhav AP, Cepko CL, Hauswirth WW, Harfe BD, Strettoi E. Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina. J Neurosci. 2008 May 7;28(19):4878-87. doi: 10.1523/JNEUROSCI.0828-08.2008. PMID: 18463241 PMCID: PMC3325486 read article


Johnson KE, Song B, Knipe DM. Role for herpes simplex virus 1 ICP27 in the inhibition of type I interferon signaling. Virology. 2008 May 10;374(2):487-94. Epub 2008 Feb 14. PMID: 18279905 PMCID: PMC2638114 read article


Courtois-Cox S, Jones SL, Cichowski K. Many roads lead to oncogene-induced senescence. Oncogene. 2008 May 1;27(20):2801-9. doi: 10.1038/sj.onc.1210950. Epub 2008 Jan 14. PMID: 18193093


Koh AS, Kuo AJ, Park SY, Cheung P, Abramson J, Bua D, Carney D, Shoelson SE, Gozani O, Kingston RE, Benoist C, Mathis D. Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15878-83. Epub 2008 Oct 7. PMID: 18840680 PMCID: PMC2572939


de la Iglesia N, Konopka G, Puram SV, Chan JA, Bachoo RM, You MJ, Levy DE, Depinho RA, Bonni A. Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway. Genes Dev. 2008 Feb 15;22(4):449-62. Epub 2008 Feb 7. PubMed PMID: 18258752; PubMed Central PMCID: PMC2238667.


de la Iglesia N, Konopka G, Lim KL, Nutt CL, Bromberg JF, Frank DA, Mischel PS, Louis DN, Bonni A. Deregulation of a STAT3-interleukin 8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness. J Neurosci. 2008 Jun 4;28(23):5870-8. PubMed PMID: 18524891; PubMed Central PMCID: PMC2700037.


Mesaros A***, Koralov SB***, Rother E, Wunderlich FT, Ernst MB, Barsh GS, Rajewsky K, Brüning JC. Activation of Stat3 signaling in AgRP neurons promotes locomotor activity. Cell Metab. 2008 Mar;7(3):236-48. ***Denotes equal contribution.


Koralov SB, Muljo SA, Galler GR, Krek A, Chakraborty T, Kanellopoulou C, Jensen K, Cobb BS, Merkenschlager M, Rajewsky N, Rajewsky K. Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage. Cell. 2008 Mar 7;132(5):860-74.


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Egawa T, Kreslavsky T, Littman DR, von Boehmer H. Lineage diversion of T cell receptor transgenic thymocytes revealed by lineage fate mapping. PLoS One. 2008 Jan 30;3(1):e1512. PubMed PMID: 18231598; PubMed Central PMCID: PMC2211402.


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Dickman DK, Kurshan PT, Schwarz TL. Mutations in a Drosophila alpha2delta voltage-gated calcium channel subunit reveal a crucial synaptic function. J Neurosci. 2008 Jan 2;28(1):31-8. PubMed PMID: 18171920.


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Ancuta P, Kamat A, Kunstman KJ, Kim EY, Autissier P, Wurcel A, Zaman T, Stone D, Mefford M, Morgello S, Singer EJ, Wolinsky SM, Gabuzda D. Microbial translocation is associated with increased monocyte activation and dementia in AIDS patients. PLoS One. 2008 Jun 25;3(6):e2516. PMID: 18575590 PMCID: PMC2424175 read article


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Bracken CM, Mizeracka K, McLaughlin KA. Patterning the embryonic kidney: BMP signaling mediates the differentiation of the pronephric tubules and duct in Xenopus laevis. Dev Dyn. 2008 Jan;237(1):132-44. PMID: 18069689


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Perlis RH, Moorjani P, Fagerness J, Purcell S, Trivedi MH, Fava M, Rush AJ, Smoller JW. Pharmacogenetic analysis of genes implicated in rodent models of antidepressant response: association of TREK1 and treatment resistance in the STAR(*)D study. Neuropsychopharmacology. 2008 Nov;33(12):2810-9. Epub 2008 Feb 20. PubMed PMID: 18288090.


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Yoshida T, Hazan I, Zhang J, Ng SY, Naito T, Snippert HJ, Heller EJ, Qi X, Lawton LN, Williams CJ, Georgopoulos K. The role of the chromatin remodeler Mi-2beta in hematopoietic stem cell self-renewal and multilineage differentiation. Genes Dev. 2008 May 1;22(9):1174-89. PubMed PMID: 18451107; PubMed Central PMCID: PMC2335314.


Nguyen CL, Münger K. Direct association of the HPV16 E7 oncoprotein with cyclin A/CDK2 and cyclin E/CDK2 complexes. Virology. 2008 Oct 10;380(1):21-5. Epub 2008 Aug 21. PMID: 18718623PMCID: PMC2574417 read article


Nguyen CL, McLaughlin-Drubin ME, Münger K. Delocalization of the microtubule motor Dynein from mitotic spindles by the human papillomavirus E7 oncoprotein is not sufficient for induction of multipolar mitoses. Cancer Res. 2008 Nov 1;68(21):8715-22. PMID: 18974113 PMCID: PMC2597155 read article


Nguyen CL, Münger K. Human papillomavirus E7 protein deregulates mitosis via an association with nuclear mitotic apparatus protein 1. J Virol. 2009 Feb;83(4):1700-7. Epub 2008 Dec 3. PMID: 19052088 PMCID: PMC2643759 read article


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Lan F**, Nottke AC**, Shi Y*. Mechanisms involved in the regulation of histone lysine demethylases. Curr Opin Cell Biol. 2008 Jun;20(3):316-25. Epub 2008 Apr 25. Review. PMC2674377. **these authors contributed equally


Olsen SR, Wilson RI. Cracking neural circuits in a tiny brain: new approaches for understanding the neural circuitry of Drosophila. Trends Neurosci. 2008 Oct;31(10):512-20. Epub 2008 Sep 3. Review. PubMed PMID: 18775572; PubMed Central PMCID: PMC2845908.


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Westbrook TF, Hu G, Ang XL, Mulligan P, Pavlova NN, Liang A, Leng Y, Maehr R, Shi Y, Harper JW, Elledge SJ. SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation. Nature. 2008 Mar 20;452(7185):370-4. doi: 10.1038/nature06780. PMID: 18354483 PMCID: PMC2688689 read article


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Xie L, Palmsten K, MacDonald B, Kieran MW, Potenta S, Vong S, Kalluri R. Basement membrane derived fibulin-1 and fibulin-5 function as angiogenesis inhibitors and suppress tumor growth. Exp Biol Med (Maywood). 2008 Feb;233(2):155-62. doi: 10.3181/0706-RM-167. PMID: 18222970


Potenta S, Zeisberg E, Kalluri R. The role of endothelial-to-mesenchymal transition in cancer progression. Br J Cancer. 2008 Nov 4;99(9):1375-9. doi: 10.1038/sj.bjc.6604662. Epub 2008 Sep 16. PMID: 18797460 PMCID: PMC2579683 read article


Zeisberg EM, Potenta SE, Sugimoto H, Zeisberg M, Kalluri R. Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition. J Am Soc Nephrol. 2008 Dec;19(12):2282-7. doi: 10.1681/ASN.2008050513. Epub 2008 Nov 5. PMID: 18987304 PMCID: PMC2588112 read article


de la Iglesia N, Konopka G, Puram SV, Chan JA, Bachoo RM, You MJ, Levy DE, Depinho RA, Bonni A. Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway. Genes Dev. 2008 Feb 15;22(4):449-62. doi: 10.1101/gad.1606508. Epub 2008 Feb 7. PMID: 18258752 PMCID: PMC2238667 read article


Raiser DM, Zacharek SJ, Roach RR, Curtis SJ, Sinkevicius KW, Gludish DW, Kim CF. Stem cell biology in the lung and lung cancers: using pulmonary context and classic approaches. Cold Spring Harb Symp Quant Biol. 2008;73:479-90. doi: 10.1101/sqb.2008.73.036. Epub 2008 Nov 21. PMID: 19028984


Ramdya P, Engert F. Emergence of binocular functional properties in a monocular neural circuit. Nat Neurosci. 2008 Sep;11(9):1083-90. PubMed PMID: 19160507; PubMed Central PMCID: PMC2958220.


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Zhou B, von Gise A, Ma Q, Rivera-Feliciano J, Pu WT. Nkx2-5- and Isl1-expressing cardiac progenitors contribute to proepicardium. Biochem Biophys Res Commun. 2008 Oct 24;375(3):450-3. doi: 10.1016/j.bbrc.2008.08.044. Epub 2008 Aug 21. PMID: 18722343 PMCID: PMC2610421 read article


Zhou B, Ma Q, Rajagopal S, Wu SM, Domian I, Rivera-Feliciano J, Jiang D, von Gise A, Ikeda S, Chien KR, Pu WT. Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature. 2008 Jul 3;454(7200):109-13. doi: 10.1038/nature07060. Epub 2008 Jun 22. PMID: 18568026 PMCID: PMC2574791 read article


Patel V, Booker M, Kramer M, Ross L, Celatka CA, Kennedy LM, Dvorin JD, Duraisingh MT, Sliz P, Wirth DF, Clardy J. Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem. 2008 Dec 12;283(50):35078-85. doi: 10.1074/jbc.M804990200. Epub 2008 Oct 8. PMID: 18842591 PMCID: PMC2596402 read article


Runner VM, Podolny V, Buratowski S. The Rpb4 subunit of RNA polymerase II contributes to cotranscriptional recruitment of 3' processing factors. Mol Cell Biol. 2008 Mar;28(6):1883-91. doi: 10.1128/MCB.01714-07. Epub 2008 Jan 14. PMID: 18195044 PMCID: PMC2268395 read article


Safo P, Regehr WG. Timing dependence of the induction of cerebellar LTD. Neuropharmacology. 2008 Jan;54(1):213-8. Epub 2007 Jun 26. PubMed PMID: 17669443; PubMed Central PMCID: PMC2266067.


Shim SY, Samuels BA, Wang J, Neumayer G, Belzil C, Ayala R, Shi Y, Shi Y, Tsai LH, Nguyen MD. Ndel1 controls the dynein-mediated transport of vimentin during neurite outgrowth. J Biol Chem. 2008 May 2;283(18):12232-40. Epub 2008 Feb 26. PubMed PMID: 18303022.


Schlabach MR, Luo J, Solimini NL, Hu G, Xu Q, Li MZ, Zhao Z, Smogorzewska A, Sowa ME, Ang XL, Westbrook TF, Liang AC, Chang K, Hackett JA, Harper JW, Hannon GJ, Elledge SJ. Cancer proliferation gene discovery through functional genomics. Science. 2008 Feb 1;319(5863):620-4. Erratum in: Science.2008 Apr 18;320(5874):316. PubMed PMID: 18239126.


Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJ. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med. 2008 Aug;14(8):837-42. Epub 2008 Jun 22. PubMed PMID: 18568035; PubMed Central PMCID: PMC2772133.


Simon DJ, Madison JM, Conery AL, Thompson-Peer KL, Soskis M, Ruvkun GB, Kaplan JM, Kim JK. The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions. Cell. 2008 May 30;133(5):903-15. PubMed PMID: 18510933; PubMed Central PMCID: PMC2553566.


Bentley AM, Artavanis-Tsakonas S, Stanford JS. Nanocourses: a short course format as an educational tool in a biological sciences graduate curriculum. CBE Life Sci Educ. 2008 Summer;7(2):175-83. doi: 10.1187/cbe.07-07-0049. PMID: 18519608 PMCID: PMC2424306 read article


Langenau DM, Keefe MD, Storer NY, Jette CA, Smith AC, Ceol CJ, Bourque C, Look AT, Zon LI. Co-injection strategies to modify radiation sensitivity and tumor initiation in transgenic Zebrafish. Oncogene. 2008 Jul 10;27(30):4242-8. doi: 10.1038/onc.2008.56. Epub 2008 Mar 17. PMID: 18345029 PMCID: PMC2680704 read article


Sural TH, Peng S, Li B, Workman JL, Park PJ, Kuroda MI. The MSL3 chromodomain directs a key targeting step for dosage compensation of the Drosophila melanogaster X chromosome. Nat Struct Mol Biol. 2008 Dec;15(12):1318-25. Epub 2008 Nov 23. PubMed PMID: 19029895; PubMed Central PMCID: PMC2636508.


Swinburne IA, Miguez DG, Landgraf D, Silver PA. Intron length increases oscillatory periods of gene expression in animal cells. Genes Dev. 2008 Sep 1;22(17):2342-6. doi: 10.1101/gad.1696108. Epub 2008 Aug 14. PMID: 18703678 PMCID: PMC2532923 read article


Swinburne IA, Silver PA. Intron delays and transcriptional timing during development. Dev Cell. 2008 Mar;14(3):324-30. doi: 10.1016/j.devcel.2008.02.002. PMID: 18331713 PMCID: PMC2825037 read article


Cironi P, Swinburne IA, Silver PA. Enhancement of cell type specificity by quantitative modulation of a chimeric ligand. PMID: 18230610 PMCID: PMC2417160 read article


Ansel KM, Pastor WA, Rath N, Lapan AD, Glasmacher E, Wolf C, Smith LC, Papadopoulou N, Lamperti ED, Tahiliani M, Ellwart J, Shi YJ, Kremmer E, Rao A, Heissmeyer V. Mouse ERI-1 interacts with the ribosome and catalyzes 5.8S rRNA processing. Nature Structural Biology (2008) 15(5): 523-30. PMID: 18438418. PMCID: PMC3032500.


Tanner NA, Hamdan SM, Jergic S, Loscha KV, Schaeffer PM, Dixon NE, van Oijen AM. Single-molecule studies of fork dynamics in Escherichia coli DNA replication. Nat Struct Mol Biol. 2008 Feb;15(2):170-6. doi: 10.1038/nsmb.1381. Epub 2008 Jan 27. PMID: 18223657 PMCID: PMC2651573 read article


Campanella GS, Tager AM, El Khoury JK, Thomas SY, Abrazinski TA, Manice LA, Colvin RA, Luster AD. Chemokine receptor CXCR3 and its ligands CXCL9 and CXCL10 are required for the development of murine cerebral malaria. Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4814-9. doi: 10.1073/pnas.0801544105. Epub 2008 Mar 17. PMID: 18347328 PMCID: PMC2290783 read article


Medoff BD, Thomas SY, Luster AD. T cell trafficking in allergic asthma: the ins and outs. Annu Rev Immunol. 2008;26:205-32. doi: 10.1146/annurev.immunol.26.021607.090312. PMID: 18304002


Vashlishan AB, Madison JM, Dybbs M, Bai J, Sieburth D, Ch'ng Q, Tavazoie M, Kaplan JM. An RNAi screen identifies genes that regulate GABA synapses. Neuron. 2008 May 8;58(3):346-61. PubMed PMID: 18466746.


Venanzi ES, Melamed R, Mathis D, Benoist C. The variable immunological self: genetic variation and nongenetic noise in Aire-regulated transcription. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15860-5. Epub 2008 Oct 6. PubMed PMID: 18838677; PubMed Central PMCID: PMC2572942.


Villaseñor J, Besse W, Benoist C, Mathis D. Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiated. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15854-9. Epub 2008 Oct 3. PubMed PMID: 18836079; PubMed Central PMCID: PMC2572966.


Xie L, Palmsten K, MacDonald B, Kieran MW, Potenta S, Vong S, Kalluri R. Basement membrane derived fibulin-1 and fibulin-5 function as angiogenesis inhibitors and suppress tumor growth. Exp Biol Med (Maywood). 2008 Feb;233(2):155-62. doi: 10.3181/0706-RM-167. PMID: 18222970


Nelson EA, Walker SR, Kepich A, Gashin LB, Hideshima T, Ikeda H, Chauhan D, Anderson KC, Frank DA*. Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3. Blood. 2008. 112(13):5095-102. PMC2597607.


Alekseyenko AA, Peng S, Larschan E, Gorchakov AA, Lee OK, Kharchenko P, McGrath SD, Wang CI, Mardis ER, Park PJ, Kuroda MI. A sequence motif within chromatin entry sites directs MSL establishment on the Drosophila X chromosome. Cell. 2008 Aug 22;134(4):599-609. PubMed PMID: 18724933; PubMed Central PMCID: PMC2613042.


Wein MN, Jones DC, Glimcher LH. Lentivirus delivery of shRNA constructs into osteoblasts.Methods Mol Biol. 2008;455:149-55. PMID: 18463817


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Werneck MB, Lugo-Villarino G, Hwang ES, Cantor H, Glimcher LH. T-bet plays a key role in NK-mediated control of melanoma metastatic disease. J Immunol. 2008 Jun 15;180(12):8004-10. PubMed PMID: 18523263.


Lu L, Kim HJ, Werneck MB, Cantor H. Regulation of CD8+ regulatory T cells: Interruption of the NKG2A-Qa-1 interaction allows robust suppressive activity and resolution of autoimmune disease. Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19420-5. Epub 2008 Dec 1. PubMed PMID: 19047627; PubMed Central PMCID: PMC2614776.


Dooley KA, Fraenkel PG, Langer NB, Schmid B, Davidson AJ, Weber G, Chiang K, Foott H, Dwyer C, Wingert RA, Zhou Y, Paw BH, Zon LI; Tübingen 2000 Screen Consortium. montalcino, A zebrafish model for variegate porphyria. Exp Hematol. 2008 Sep;36(9):1132-42. doi: 10.1016/j.exphem.2008.04.008. Epub 2008 Jun 11. PMID: 18550261 PMCID: PMC2630115 read article


Han S, Witt RM, Santos TM, Polizzano C, Sabatini BL, Ramesh V. Pam (Protein associated with Myc) functions as an E3 ubiquitin ligase and regulates TSC/mTOR signaling. Cell Signal. 2008 Jun;20(6):1084-91. Epub 2008 Feb 1. PMID: 18308511. PubMed Central PMCID: PMC2435383.


Woodworth JS, Fortune SM, Behar SM. Bacterial protein secretion is required for priming of CD8+ T cells specific for the Mycobacterium tuberculosis antigen CFP10. Infect Immun. 2008 Sep;76(9):4199-205. Epub 2008 Jun 30. PubMed PMID: 18591224; PubMed Central PMCID: PMC2519428.


Wu Y, Woodworth JS, Shin DS, Morris S, Behar SM. Vaccine-elicited 10-kilodalton culture filtrate protein-specific CD8+ T cells are sufficient to mediate protection against Mycobacterium tuberculosis infection. Infect Immun. 2008 May;76(5):2249-55. Epub 2008 Mar 10. PubMed PMID: 18332205; PubMed Central PMCID: PMC2346695.


Woodworth JS, Wu Y, Behar SM. Mycobacterium tuberculosis-specific CD8+ T cells require perforin to kill target cells and provide protection in vivo. J Immunol. 2008 Dec 15;181(12):8595-603. PubMed PMID: 19050279; PubMed Central PMCID: PMC3133658.


Choi MY, Romer AI, Wang Y, Wu MP, Ito S, Leiter AB, Shivdasani RA. Requirement of the tissue-restricted homeodomain transcription factor Nkx6.3 in differentiation of gastrin-producing G cells in the stomach antrum. Mol Cell Biol. 2008 May;28(10):3208-18. doi: 10.1128/MCB.01737-07. Epub 2008 Mar 17. PMID: 18347062 PMCID: PMC2423174 read article


Wang B, Yanez A, Novina CD. MicroRNA-repressed mRNAs contain 40S but not 60S components. Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5343-8. doi: 10.1073/pnas.0801102105. Epub 2008 Apr 4. PMID: 18390669 PMCID: PMC2291078 read article


Yuan TL, Choi HS, Matsui A, Benes C, Lifshits E, Luo J, Frangioni JV, Cantley LC*, Class 1A PI3K regulates vessel integrity during development and tumorigenesis. Proc Natl Acad Sci U S A. 2008. Jul 15;105(28):9739-44. PMC2453070.


Yuan TL, Cantley LC. PI3K pathway alterations in cancer: variations on a theme. Oncogene. 2008 Sep 18;27(41):5497-510. Review. PubMed PMID: 18794884; PubMed Central PMCID: PMC3398461.


Choi PS, Zakhary L, Choi WY, Caron S, Alvarez-Saavedra E, Miska EA, McManus M, Harfe B, Giraldez AJ, Horvitz HR, Schier AF, Dulac C. Members of the miRNA-200 family regulate olfactory neurogenesis. Neuron. 2008 Jan 10;57(1):41-55. PubMed PMID: 18184563; PubMed Central PMCID: PMC2204047.


top

2007


Abraira VE, Hyun N, Tucker AF, Coling DE, Brown MC, Lu C, Hoffman GR, Goodrich LV. Changes in Sef levels influence auditory brainstem development and function. J Neurosci. 2007 Apr 18;27(16):4273-82. PubMed PMID: 17442811.


Agosto MA, Middleton JK, Freimont EC, Yin J, Nibert ML. Thermolabilizing pseudoreversions in reovirus outer-capsid protein micro 1 rescue the entry defect conferred by a thermostabilizing mutation. J Virol. 2007 Jul;81(14):7400-9. Epub 2007 May 16. PMID: 17507494 PMCID: PMC1933377 read article


Ivanovic T, Agosto MA, Chandran K, Nibert ML. A role for molecular chaperone Hsc70 in reovirus outer capsid disassembly. J Biol Chem. 2007 Apr 20;282(16):12210-9. Epub 2007 Feb 6. PMID: 17284448


Middleton JK, Agosto MA, Severson TF, Yin J, Nibert ML. Thermostabilizing mutations in reovirus outer-capsid protein mu1 selected by heat inactivation of infectious subvirion particles. Virology. 2007 May 10;361(2):412-25. Epub 2007 Jan 17. PMID: 17208266 PMCID: PMC1913285 read article


Koundakjian EJ, Appler JL, Goodrich LV. Auditory neurons make stereotypedwiring decisions before maturation of their targets. J Neurosci. 2007 Dec19;27(51):14078-88. PubMed PMID: 18094247.


Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, Puigserver P, Sinclair DA, Tsai LH. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J. 2007 Jul 11;26(13):3169-79. Epub 2007 Jun 21. PMID: 17581637 PMCID: PMC1914106 read article


Carvalho J, Arnold MM, Nibert ML. Silencing and complementation of reovirus core protein mu2: functional correlations with mu2-microtubule association and differences between virus- and plasmid-derived mu2. Virology. 2007 Aug 1;364(2):301-16. Epub 2007 Apr 23. PMID: 17451769 PMCID: PMC2486448 read article


Miller CL, Arnold MM, Broering TJ, Eichwald C, Kim J, Dinoso JB, Nibert ML. Virus-derived platforms for visualizing protein associations inside cells. Mol Cell Proteomics. 2007 Jun;6(6):1027-38. Epub 2007 Mar 5. PMID: 17339631


Wang JP, Asher DR, Chan M, Kurt-Jones EA, Finberg RW. Cutting Edge: Antibody-mediated TLR7-dependent recognition of viral RNA. Journal of Immunology (2007) 178: 3363-3367.


Asthana S, Roytberg M, Stamatoyannopoulos J, Sunyaev S. Analysis of sequence conservation at nucleotide resolution. PLoS Comput Biol. 2007 Dec;3(12):e254. doi: 10.1371/journal.pcbi.0030254. Epub 2007 Nov 14. PMID: 18166073 PMCID: PMC2230682 read article


Asthana S, Noble WS, Kryukov G, Grant CE, Sunyaev S, Stamatoyannopoulos JA. Widely distributed noncoding purifying selection in the human genome. Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12410-5. Epub 2007 Jul 17. PMID: 17640883 PMCID: PMC1941483 read article


Balibar CJ, Garneau-Tsodikova S, Walsh CT. Covalent CouN7 enzyme intermediate for acyl group shuttling in aminocoumarin biosynthesis. Chem Biol. 2007 Jun;14(6):679-90. PMID: 17584615


Fridman M, Balibar CJ, Lupoli T, Kahne D, Walsh CT, Garneau-Tsodikova S. Chemoenzymatic formation of novel aminocoumarin antibiotics by the enzymes CouN1 and CouN7. Biochemistry. 2007 Jul 17;46(28):8462-71. Epub 2007 Jun 20. PMID: 17580964


Balibar CJ, Howard-Jones AR, Walsh CT. Terrequinone A biosynthesis through L-tryptophan oxidation, dimerization and bisprenylation. Nat Chem Biol. 2007 Sep;3(9):584-92. Epub 2007 Aug 12. PMID: 17704773


Barker BR, Parvani JG, Meyer D, Hey AS, Skak K, Letvin NL. IL-21 Induces Apoptosis of Antigen-Specific CD8+ T Lymphocytes. Journal of Immunology, 2007; 179: 3596-3603.


Stokes MP, Rush J, Macneill J, Ren JM, Sprott K, Nardone J, Yang V, Beausoleil SA, Gygi SP, Livingstone M, Zhang H, Polakiewicz RD, Comb MJ. Profiling of UV-induced ATM/ATR signaling pathways. Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19855-60. Epub 2007 Dec 6. PMID: 18077418 PMCID: PMC2148387 read article


Li X, Gerber SA, Rudner AD, Beausoleil SA, Haas W, Villén J, Elias JE, Gygi SP. Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae. J Proteome Res. 2007 Mar;6(3):1190-7. PMID: 17330950


Villén J, Beausoleil SA, Gerber SA, Gygi SP. Large-scale phosphorylation analysis of mouse liver. Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1488-93. Epub 2007 Jan 22. PMID: 17242355 PMCID: PMC1785252 read article


Ma W, Berg J, Yellen G. Ketogenic diet metabolites reduce firing in central neurons by opening K(ATP) channels. J Neurosci. 2007 Apr 4;27(14):3618-25. PubMed PMID: 17409226.


Fu WY, Chen Y, Sahin M, Zhao XS, Shi L, Bikoff JB, Lai KO, Yung WH, Fu AK, Greenberg ME, Ip NY. Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. Nat Neurosci. 2007 Jan;10(1):67-76. Epub 2006 Dec 3. PubMed PMID: 17143272.


Tolias KF, Bikoff JB, Kane CG, Tolias CS, Hu L, Greenberg ME. The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development. Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7265-70. Epub 2007 Apr 17. PubMed PMID: 17440041; PubMed Central PMCID: PMC1855368.


Shalizi A, Bilimoria PM, Stegmüller J, Gaudillière B, Yang Y, Shuai K, BonniA. PIASx is a MEF2 SUMO E3 ligase that promotes postsynaptic dendriticmorphogenesis. J Neurosci. 2007 Sep 12;27(37):10037-46. PubMed PMID: 17855618.


Bloodgood BL, Sabatini BL. Nonlinear regulation of unitary synaptic signals by CaV(2.3) voltage-sensitive calcium channels located in dendritic spines. Neuron. 2007 Jan 18;53(2):249-60. PubMed PMID: 17224406.


Shankar GM, Bloodgood BL, Townsend M, Walsh DM, Selkoe DJ, Sabatini BL. Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J Neurosci. 2007 Mar 14;27(11):2866-75. PubMed PMID: 17360908.


Bloodgood BL, Sabatini BL. Ca(2+) signaling in dendritic spines. Curr Opin Neurobiol. 2007 Jun;17(3):345-51. Epub 2007 Apr 23. Review. PubMed PMID: 17451936.


Bloodgood BL, Sabatini BL. Regulation of synaptic signalling by postsynaptic, non-glutamate receptor ion channels. J Physiol. 2008 Mar 15;586(6):1475-80. Epub 2007 Dec 20. Review. PubMed PMID: 18096597; PubMed Central PMCID: PMC2375695.


Moran ST, Cariappa A, Liu H, Muir B, Sgroi D, Boboila C, Pillai S. Synergism between NF-kappa B1/p50 and Notch2 during the development of marginal zone B lymphocytes. J Immunol. 2007;179(1):195-200


Cariappa A, Boboila C, Moran ST, Liu H, Shi HN, Pillai S. The recirculating B cell pool contains two functionally distinct, long-lived, posttransitional, follicular B cell populations. J Immunol. 2007;179(4):2270-81


Yan CT, Boboila C, Souza EK, Franco S, Hickernell TR, Murphy M, Gumaste S, Geyer M, Zarrin AA, Manis JP, Rajewsky K, Alt FW. IgH class switching and translocations use a robust non-classical end-joining pathway. Nature. 2007;449(7161):478-82.


Dauguet J, Bock D, Reid RC, Warfield SK. Alignment of large image series using cubic B-splines tessellation: application to transmission electron microscopy data. Med Image Comput Comput Assist Interv. 2007;10(Pt 2):710-7. PubMed PMID: 18044631.


Gauguet JM, Bonasio R and von Andrian UH. High endothelial venules. In: The Endothelium: A Comprehensive Reference. (2007) Aird WC (ed.). Cambridge University Press (ISBN 9780521853767), pp. 1568-1588.


Bonasio R, Carman CV, Kim E, Sage PT, Love KR, Mempel TR, Springer TA, von Andrian UH (2007). Specific and covalent labeling of a membrane protein with organic fluorochromes and quantum dots. Proceedings of the National Academy of Sciences 104:14753-8. PMID: 17785425; PMCID: PMC1976196.


Hughes ME, Bortnick R, Tsubouchi A, Bäumer P, Kondo M, Uemura T, Schmucker D. Homophilic Dscam interactions control complex dendrite morphogenesis. Neuron. 2007 May 3;54(3):417-27. PubMed PMID: 17481395; PubMed Central PMCID: PMC1963440.


Boutwell CL, Essex M. Identification of HLA class I-associated amino acid polymorphisms in the HIV-1C proteome. AIDS Res Hum Retroviruses. 2007 Jan;23(1):165-74. PMID: 17263647


Yi CH, Sogah DK, Boyce M, Degterev A, Christofferson DE, Yuan J. A genome-wide RNAi screen reveals multiple regulators of caspase activation. J Cell Biol. 2007 Nov 19;179(4):619-26. Epub 2007 Nov 12. PMID: 17998402 PMCID: PMC2080898 read article


Cnop M, Ladriere L, Hekerman P, Ortis F, Cardozo AK, Dogusan Z, Flamez D, Boyce M, Yuan J, Eizirik DL. Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis. J Biol Chem. 2007 Feb 9;282(6):3989-97. Epub 2006 Dec 8. PMID: 17158450


Kiel DP, Magaziner J, Zimmerman S, Ball L, Barton BA, Brown KM, Stone JP, Dewkett D, Birge SJ. Efficacy of a hip protector to prevent hip fracture in nursing home residents: the HIP PRO randomized controlled trial. JAMA. 2007 Jul 25;298(4):413-22. PubMed PMID: 17652295.


Xie Z, Moy LY, Sanada K, Zhou Y, Buchman JJ, Tsai LH. Cep120 and TACCs control interkinetic nuclear migration and the neural progenitor pool. Neuron. 2007 Oct 4;56(1):79-93. PubMed PMID: 17920017; PubMed Central PMCID: PMC2642594.


Buchman JJ, Tsai LH. Spindle regulation in neural precursors of flies andmammals. Nat Rev Neurosci. 2007 Feb;8(2):89-100. Epub 2007 Jan 17. Review. PubMed PMID: 17228329.


Colmenares SU, Buker SM, Buhler M, Dlakić M, Moazed D. Coupling of double-stranded RNA synthesis and siRNA generation in fission yeast RNAi. Mol Cell. 2007 Aug 3;27(3):449-61. Epub 2007 Jul 19. PubMed PMID: 17658285.


Buker SM, Iida T, Bühler M, Villén J, Gygi SP, Nakayama J, Moazed D. Two different Argonaute complexes are required for siRNA generation and heterochromatin assembly in fission yeast. Nat Struct Mol Biol. 2007 Mar;14(3):200-7. Epub 2007 Feb 25. PubMed PMID: 17310250.


Rodacki M, Svoren B, Butty V, Besse W, Laffel L, Benoist C, Mathis D. Altered natural killer cells in type 1 diabetic patients. Diabetes. 2007 Jan;56(1):177-85. PMID:17192480.


Butty V, Roy M, Sabeti P, Besse W, Benoist C, Mathis D. Signatures of strong population differentiation shape extended haplotypes across the human CD28, CTLA4, and ICOS costimulatory genes. Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):570-5. Epub 2006 Dec 29. PMID:17197413.


Garibyan L, Lobito AA, Siegel RM, Call ME, Wucherpfennig KW, Geha RS. Dominant-negative effect of the heterozygous C104R TACI mutation in common variable immunodeficiency (CVID). J Clin Invest. 2007 Jun;117(6):1550-7. Epub 2007 May 10. PubMed PMID: 17492055; PubMed Central PMCID: PMC1865037.


Call ME, Wucherpfennig KW. Common themes in the assembly and architecture of activating immune receptors. Nat Rev Immunol. 2007 Nov;7(11):841-50. Review. PubMed PMID: 17960150.


Crowley JJ, Carter AG, Regehr WG. Fast vesicle replenishment and rapid recovery from desensitization at a single synaptic release site. J Neurosci. 2007 May 16;27(20):5448-60. PubMed PMID: 17507567.


Carter AG, Soler-Llavina GJ, Sabatini BL. Timing and location of synaptic inputs determine modes of subthreshold integration in striatal medium spiny neurons. J Neurosci. 2007 Aug 15;27(33):8967-77. PubMed PMID: 17699678.


Catic A, Misaghi S, Korbel GA, Ploegh HL. ElaD, a deubiquitinating protease expressed by E. coli. PLoS ONE. 2007 Apr;2(4):e381.


Catic A, Sun ZY, Ratner D, Misaghi S, Galardy PG, Korbel GA, Spooner E, Samuelson J, Wagner G, Ploegh HL. Sequence and structure evolved separately in a ribosomal ubiquitin variant. EMBO J. 2007 Jul;26(14):3474-83.


Catic A, Fiebiger E, Korbel GA, Blom D, Galardy PJ, Ploegh HL. Screen for ISG15-crossreactive deubiquitinases. PLoS ONE. 2007 Jul;2(7):e679.


Love KR, Catic A, Schlieker C, Ploegh HL. Mechanism, biology and inhibitors of deubiquitinating enzymes. Nat. Chem. Biol. 2007 Nov;3(11):697-705. Review.


Chae TH, Walsh CA. Genes that control the size of the cerebral cortex. Novartis Found Symp. 2007;288:79-90; discussion 91-8. Review. PubMed PMID: 18494253.


Hett EC, Chao MC, Steyn AJ, Fortune SM, Deng LL, Rubin EJ. A partner for the resuscitation-promoting factors of Mycobacterium tuberculosis. Mol Microbiol. 2007 Nov;66(3):658-68. Epub 2007 Oct 4. PubMed PMID: 17919286.


Charity JC, Costante-Hamm MM, Balon EL, Boyd DH, Rubin EJ, Dove SL. Twin RNA Polymerase-Associated Proteins Control Virulence Gene Expression in Francisella tularensis. PLoS Pathog. 2007. 3(6): e84. doi:10.1371/journal.ppat.0030084. PMC1891329.


Charity JC, Katz E, Moss B. Amino acid substitutions at multiple sites within the vaccinia virus D13 scaffold protein confer resistance to rifampicin. Virology. 2007. 359: 227-232. PMC1817899.


Chen AC, Selkoe DJ. Response to: Pardossi-Piquard et al., "Presenilin-Dependent Transcriptional Control of the Abeta-Degrading Enzyme Neprilysin by Intracellular Domains of betaAPP and APLP." Neuron 46, 541-554. Neuron. 2007 Feb 15;53(4):479-83. PubMed PMID: 17296549.


Yang H, Baur JA, Chen A, Miller C, Adams JK, Kisielewski A, Howitz KT, Zipkin RE, Sinclair DA. Design and synthesis of compounds that extend yeast replicative lifespan. Aging Cell. 2007 Feb;6(1):35-43. Epub 2006 Dec 5. Erratum in: Aging Cell. 2007 Aug;6(4):593. Adams, Jeffrey K [added]; Kisielewski, Anne [added]; Howitz, Konrad T [added]; Zipkin, Robert E [added]. PubMed PMID: 17156081.


Zhou P, Porcionatto M, Pilapil M, Chen Y, Choi Y, Tolias KF, Bikoff JB, Hong
EJ, Greenberg ME, Segal RA. Polarized signaling endosomes coordinate BDNF-induced chemotaxis of cerebellar precursors. Neuron. 2007 Jul 5;55(1):53-68. PubMed PMID: 17610817; PubMed Central PMCID: PMC2661852.


Christensen AP, Corey DP. TRP channels in mechanosensation: direct or indirect activation? Nat Rev Neurosci. 2007 Jul;8(7):510-21. Review. PubMed PMID: 17585304.


Yi CH, Sogah DK, Boyce M, Degterev A, Christofferson DE, Yuan J. A genome-wide RNAi screen reveals multiple regulators of caspase activation. J Cell Biol. 2007 Nov 19;179(4):619-26. Epub 2007 Nov 12. PMID: 17998402 PMCID: PMC2080898 read article


Pack-Chung E, Kurshan PT, Dickman DK, Schwarz TL. A Drosophila kinesin required for synaptic bouton formation and synaptic vesicle transport. Nat Neurosci. 2007 Aug;10(8):980-9. Epub 2007 Jul 22. PubMed PMID: 17643120.


Matthews AG, Kuo AJ, Ramón-Maiques S, Han S, Champagne KS, Ivanov D, Gallardo M, Carney D, Cheung P, Ciccone DN, Walter KL, Utz PJ, Shi Y, Kutateladze TG, Yang W, Gozani O, Oettinger MA. RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. Nature. 2007 Dec 13;450(7172):1106-10. Epub 2007 Nov 21. PubMed PMID: 18033247; PubMed Central PMCID: PMC2988437.


Colmenares SU, Buker SM, Buhler M, Dlakić M, Moazed D. Coupling of double-stranded RNA synthesis and siRNA generation in fission yeast RNAi. Mol Cell. 2007 Aug 3;27(3):449-61. Epub 2007 Jul 19. PubMed PMID: 17658285.


Gu TL, Mercher T, Tyner JW, Goss VL, Walters DK, Cornejo MG, Reeves C, Popova L, Lee K, Rush J, Daibata M, Miyoshi I, Gilliland DG, Druker BJ, Polakiewicz RD. A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia. Blood, 2007 Jul 1; 110 (1): 323-33.


Day CL, Kiepiela P, Leslie AJ, van der Stok M, Nair K, Ismail N, Honeyborne I, Crawford H, Coovadia HM, Goulder PJ, Walker BD, Klenerman P. Proliferative capacity of epitope-specific CD8 T-cell responses is inversely related to viral load in chronic human immunodeficiency virus type 1 infection. J Virol. 2007 Jan;81(1):434-8. Epub 2006 Oct 18. PMID: 17050606 PMCID: PMC1797250 read article


Iwase S, Lan F, Bayliss P, de la Torre-Ubieta L, Huarte M, Qi HH, Whetstine JR, Bonni A, Roberts TM, Shi Y. The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell. 2007 Mar 23;128(6):1077-88. Epub 2007 Feb 22. PubMed PMID: 17320160.


Geffen MN, de Vries SE, Meister M. Retinal ganglion cells can rapidly change polarity from Off to On. PLoS Biol. 2007 Mar;5(3):e65. Erratum in: PLoS Biol. 2007 May;5(5):e136. PLoS Biol. 2007 Jul;5(7):e188. PubMed PMID: 17341132; PubMed Central PMCID: PMC1808116.


Deans MR, Antic D, Suyama K, Scott MP, Axelrod JD, Goodrich LV. Asymmetric distribution of prickle-like 2 reveals an early underlying polarization of vestibular sensory epithelia in the inner ear. J Neurosci. 2007 Mar 21;27(12):3139-47. PubMed PMID: 17376975


Djuretic IM, Levanon D, Negreanu V, Groner Y, Rao A, Ansel KM. Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells. Nat Immunol. 2007 Feb;8(2):145-53. Epub 2006 Dec 31. PubMed PMID: 17195845.


Hu H, Djuretic I, Sundrud MS, Rao A. Transcriptional partners in regulatory T cells: Foxp3, Runx and NFAT. Trends Immunol. 2007 Aug;28(8):329-32. Epub 2007 Jul 6. PubMed PMID: 17618833.


Daily JP, Scanfeld D, Pochet N, Le Roch K, Plouffe D, Kamal M, Sarr O, Mboup S, Ndir O, Wypij D, Levasseur K, Thomas E, Tamayo P, Dong C, Zhou Y, Lander ES, Ndiaye D, Wirth D*, Winzeler EA, Mesirov JP, Regev A. Distinct physiological states of Plasmodium falciparum in malaria-infected patients. Nature. 2007. Dec 13;450(7172):1091- 5, PMID: 18046333.


Gunasekera AM, Myrick A, Militello KT, Sims JS, Dong CK, Gierahn T, Le Roch K, Winzeler E, Wirth DF*. Regulatory motifs uncovered among gene expression clusters in Plasmodium falciparum. Mol Biochem Parasitol. 2007. May;153(1):19-30, PMID: 17307259.


Jinushi M, Nakazaki Y, Dougan M, Carrasco DR, Mihm M, Dranoff G. MFG-E8-mediated uptake of apoptotic cells by APCs links the pro- and antiinflammatory activities of GM-CSF. J Clin Invest. 2007 Jul;117(7):1902-13. PMID: 17557120 PMCID: PMC1884688


Enzler T, Gillessen S, Dougan M, Allison JP, Neuberg D, Oble DA, Mihm M, Dranoff G. Functional deficiencies of granulocyte-macrophage colony stimulating factor and interleukin-3 contribute to insulitis and destruction of {beta}-cells. Blood. 2007 May 4; [Epub ahead of print] PMID: 17483299 PMCID: PMC1924767


Dougan SK, Rava P, Hussain MM, Blumberg RS. MTP regulated by an alternate promoter is essential for NKT cell development. J Exp Med. 2007 Mar 19;204(3):533-45. Epub 2007 Feb 20. PubMed PMID: 17312007; PubMed Central PMCID: PMC2137905.


Dougan SK, Kaser A, Blumberg RS. CD1 expression on antigen-presenting cells. Curr Top Microbiol Immunol. 2007;314:113-41. Review. PubMed PMID: 17593659. Zeissig S, Kaser A, Dougan SK, Nieuwenhuis EE, Blumberg RS. Role of NKT cells in the digestive system. III. Role of NKT cells in intestinal immunity. Am J Physiol Gastrointest Liver Physiol. 2007 Dec;293(6):G1101-5. Epub 2007 Aug 23. PubMed PMID: 17717040.


Zeissig S, Kaser A, Dougan SK, Nieuwenhuis EE, Blumberg RS. Role of NKT cells in the digestive system. III. Role of NKT cells in intestinal immunity. Am J Physiol Gastrointest Liver Physiol. 2007 Dec;293(6):G1101-5. Epub 2007 Aug 23. PubMed PMID: 17717040.


Newton IL, Woyke T, Auchtung TA, Dilly GF, Dutton RJ, Fisher MC, Fontanez KM, Lau E, Stewart FJ, Richardson PM, Barry KW, Saunders E, Detter JC, Wu D, Eisen JA, Cavanaugh CM. The Calyptogena magnifica chemoautotrophic symbiont genome.Science. 2007 Feb 16;315(5814):998-1000. PubMed PMID: 17303757.


Gates J, Mahaffey JP, Rogers SL, Emerson M, Rogers EM, Sottile SL, Van Vactor D, Gertler FB, Peifer M. Enabled plays key roles in embryonic epithelial morphogenesis in Drosophila. Development. 2007 Jun;134(11):2027-39. PubMed PMID: 17507404.


Saparov SM, Erlandson K, Cannon K, Schaletzky J, Schulman S, Rapoport TA, Pohl P. Determining the conductance of the SecY protein translocation channel for small molecules. Mol Cell. 2007 May 25;26(4):501-9. PMID: 17531809


Li W, Schulman S, Boyd D, Erlandson K, Beckwith J, Rapoport TA. The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal. Mol Cell. 2007 May 25;26(4):511-21. PMID: 17531810


Cohen DE, Davidow LS, Erwin JA, Xu N, Warshawsky D, Lee JT. The DXPas34 repeat regulates random and imprinted X inactivation. Dev Cell. 2007 Jan;12(1):57-71. PubMed PMID: 17199041.


Lu HA, Sun TX, Matsuzaki T, Yi XH, Eswara J, Bouley R, McKee M, Brown D. Heat shock protein 70 interacts with aquaporin-2 and regulates its trafficking. J Biol Chem. 2007 Sep 28;282(39):28721-32. Epub 2007 Jul 18. PMID: 17636261


Everley PA, Gartner CA, Haas W, Saghatelian A, Elias JE, Cravatt BF, Zetter BR, Gygi SP. Assessing enzyme activities using stable isotope labeling and mass spectrometry. Mol Cell Proteomics. 2007 Oct;6(10):1771-7. Epub 2007 Jul 11. PMID: 17627935


Komili S, Farny NG, Roth FP, Silver PA*. Functional specificity among ribosomal proteins regulates gene expression. Cell. 2007. Nov 2;131(3):557-71. PMC2443060.


Fredenburg RA, Rospigliosi C, Meray RK, Kessler JC, Lashuel HA, Eliezer D, Lansbury PT Jr. The impact of the E46K mutation on the properties of alpha-synuclein in its monomeric and oligomeric states. Biochemistry. 2007 Jun 19;46(24):7107-18. Epub 2007 May 26. PMID: 17530780


Dapprich J, Witter K, Gabel HW, Murphy NB, Albert ED. Identification of a new HLA-B allele (B*1576) by haplotype specific extraction. Hum Immunol. 2007 May;68(5):418-21. Epub 2007 Feb 15. PubMed PMID: 17462508; PubMed Central PMCID: PMC1945813.


Mougous JD, Gifford CA, Ramsdell TL, Mekalanos JJ. Threonine phosphorylation post-translationally regulates protein secretion in Pseudomonas aeruginosa. Nat Cell Biol. 2007 Jul;9(7):797-803. Epub 2007 Jun 10. PMID: 17558395


Giraud J, Haas M, Feener EP, Copps KD, Dong X, Dunn SL, White MF. Phosphorylation of Irs1 at SER-522 inhibits insulin signaling. Mol Endocrinol. 2007 Sep;21(9):2294-302. Epub 2007 Jun 19. PMID: 17579213


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Pacholec M, Sello JK, Walsh CT, Thomas MG. Formation of an aminoacyl-S-enzyme intermediate is a key step in the biosynthesis of chloramphenicol. Org Biomol Chem. 2007 Jun 7;5(11):1692-4. Epub 2007 Apr 26. PMID: 17520135


Hovav AH, Panas MW, Osuna CE, Cayabyab MJ, Autissier P, Letvin NL.The impact of a boosting immunogen on the differentiation of secondary memory CD8+ T cells. J Virol. 2007 Dec;81(23):12793-802. Epub 2007 Sep 19. PMID:17881444. PMCID: PMC2169130.


Hovav AH, Panas MW, Rahman S, Sircar P, Gillard G, Cayabyab MJ, Letvin NL.Duration of antigen expression in vivo following DNA immunization modifies the magnitude, contraction, and secondary responses of CD8+ T lymphocytes. J Immunol. 2007 Nov 15;179(10):6725-33. PMID:17982062


Cinar B, Fang PK, Lutchman M, Di Vizio D, Adam RM, Pavlova N, Rubin MA, Yelick PC, Freeman MR. The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1. EMBO J. 2007 Oct 31;26(21):4523-34. Epub 2007 Oct 11. PMID: 17932490 PMCID: PMC2063482 read article


Storch KF, Paz C, Signorovitch J, Raviola E, Pawlyk B, Li T, Weitz CJ. Intrinsic circadian clock of the mammalian retina: importance for retinal processing of visual information. Cell. 2007 Aug 24;130(4):730-41. PMID: 17719549 PMCID: PMC2040024 read article


Storch KF, Paz C, Signorovitch J, Raviola E, Pawlyk B, Li T, Weitz CJ. Physiological importance of a circadian clock outside the suprachiasmatic nucleus. Cold Spring Harb Symp Quant Biol. 2007;72:307-18. doi: 10.1101/sqb.2007.72.053. PMID: 18419288


Pesola JM, Coen DM. In vivo fitness and virulence of a drug-resistant herpes simplex virus 1 mutant. J Gen Virol. 2007 May;88(Pt 5):1410-4. PMID: 17412967


Ajo-Franklin CM, Drubin DA, Eskin JA, Gee EP, Landgraf D, Phillips I, Silver PA. Rational design of memory in eukaryotic cells. Genes Dev. 2007 Sep 15;21(18):2271-6.PMID: 17875664 PMCID: PMC1973140  read article


Zeisberg EM, Potenta S, Xie L, Zeisberg M, Kalluri R. Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts. Cancer Res. 2007 Nov 1;67(21):10123-8. PMID: 17974953


Seale P, Kajimura S, Yang W, Chin S, Rohas LM, Uldry M, Tavernier G, Langin D, Spiegelman BM. Transcriptional control of brown fat determination by PRDM16. Cell Metab. 2007 Jul;6(1):38-54. PMID: 17618855 PMCID: PMC2564846 read article


Rohas LM, St-Pierre J, Uldry M, Jäger S, Handschin C, Spiegelman BM. A fundamental system of cellular energy homeostasis regulated by PGC-1alpha. Proc Natl Acad Sci U S A. 2007 May 8;104(19):7933-8. Epub 2007 Apr 30. PMID: 17470778 PMCID: PMC1876550 read article


Samuels BA, Hsueh YP, Shu T, Liang H, Tseng HC, Hong CJ, Su SC, Volker J, Neve RL, Yue DT, Tsai LH. Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK. Neuron. 2007 Dec 6;56(5):823-37. PubMed PMID: 18054859; PubMed Central PMCID: PMC2151975.


Sauvageot CM, Kesari S, Stiles CD. Molecular pathogenesis of adult brain
tumors and the role of stem cells. Neurol Clin. 2007 Nov;25(4):891-924, vii.
Review. PubMed PMID: 17964020.


Saparov SM, Erlandson K, Cannon K, Schaletzky J, Schulman S, Rapoport TA, Pohl P. Determining the conductance of the SecY protein translocation channel for small molecules. Mol Cell. 2007 May 25;26(4):501-9. PMID: 17531809


Li W, Schulman S, Boyd D, Erlandson K, Beckwith J, Rapoport TA. The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal. Mol Cell. 2007 May 25;26(4):511-21. PMID: 17531810


Schwabish MA, Struhl K. The Swi/Snf complex is important for histone eviction during transcriptional activation and RNA polymerase II elongation in vivo. Mol Cell Biol. 2007 Oct;27(20):6987-95. Epub 2007 Aug 20. PMID: 17709398 PMCID: PMC2168902 read article


Li J, Brieher WM, Scimone ML, Kang SJ, Zhu H, Yin H, von Andrian UH, Mitchison T, Yuan J. Caspase-11 regulates cell migration by promoting Aip1 Cofilin-mediated actin depolymerization. Nat Cell Biol. 2007 Mar;9(3):276-86. Epub 2007 Feb 11. Erratum in: Nat Cell Biol. 2007 Apr;9(4):480. PubMed PMID: 17293856.


Shankar GM, Bloodgood BL, Townsend M, Walsh DM, Selkoe DJ, Sabatini BL. Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J Neurosci. 2007 Mar 14;27(11):2866-75. PubMed PMID: 17360908.


Gunasekera AM, Myrick A, Militello KT, Sims JS, Dong CK, Gierahn T, Le Roch K, Winzeler E, Wirth DF. Regulatory motifs uncovered among gene expression clusters in Plasmodium falciparum. Mol Biochem Parasitol. 2007 May;153(1):19-30. Epub 2007 Jan 18. PMID: 17307259


Deitsch K, Duraisingh M, Dzikowski R, Gunasekera A, Khan S, Le Roch K, Llinás M, Mair G, McGovern V, Roos D, Shock J, Sims J, Wiegand R, Winzeler E.


Hovav AH, Panas MW, Rahman S, Sircar P, Gillard G, Cayabyab MJ, Letvin NL. Duration of antigen expression in vivo following DNA immunization modifies the magnitude, contraction, and secondary responses of CD8+ T lymphocytes. J Immunol. 2007 Nov 15;179(10):6725-33. PMC2190620.


Smith JG, Cunningham JM. Receptor-induced thiolate couples Env activation to retrovirus fusion and infection. PLoS Pathog. 2007 Dec 21;3(12):e198. PubMed PMID: 18260686; PubMed Central PMCID: PMC2151085.


Yi CH, Sogah DK, Boyce M, Degterev A, Christofferson DE, Yuan J. A genome-wide RNAi screen reveals multiple regulators of caspase activation. J Cell Biol. 2007 Nov 19;179(4):619-26. Epub 2007 Nov 12. PMID: 17998402 PMCID: PMC2080898 read article


Carter AG, Soler-Llavina GJ, Sabatini BL. Timing and location of synaptic inputs determine modes of subthreshold integration in striatal medium spiny neurons. J Neurosci. 2007 Aug 15;27(33):8967-77. PubMed PMID: 17699678.


Langenau DM, Keefe MD, Storer NY, Guyon JR, Kutok JL, Le X, Goessling W, Neuberg DS, Kunkel LM, Zon LI. Effects of RAS on the genesis of embryonal rhabdomyosarcoma. Genes Dev. 2007 Jun 1;21(11):1382-95. Epub 2007 May 17. PMID: 17510286 PMCID: PMC1877750 read article


Bihl F, Narayan M, Chisholm JV 3rd, Henry LM, Suscovich TJ, Brown EE, Welzel TM, Kaufmann DE, Zaman TM, Dollard S, Martin JN, Wang F, Scadden DT, Kaye KM, Brander C. Lytic and latent antigens of the human gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus induce T-cell responses with similar functional properties and memory phenotypes. J Virol. 2007 May;81(9):4904-8. Epub 2007 Feb 28. PMID: 17329344 PMCID: PMC1900166 read article


Tahiliani M, Mei P, Fang R, Leonor T, Rutenberg M, Shimizu F, Li J, Rao A, Shi Y. The Histone H3K4 Demethylase SMCX Links REST Target Genes to X-Linked Mental Retardation. Nature (2007) 447: 601-5. PMID: 17468742.


Hamdan SM, Johnson DE, Tanner NA, Lee JB, Qimron U, Tabor S, van Oijen AM, Richardson CC. Dynamic DNA helicase-DNA polymerase interactions assure processive replication fork movement. Mol Cell. 2007 Aug 17;27(4):539-49. PMID: 17707227


Dodson AW, Taylor TJ, Knipe DM, Coen DM. Inhibitors of the sodium potassium ATPase that impair herpes simplex virus replication identified via a chemical screening approach. Virology. 2007 Sep 30;366(2):340-8. Epub 2007 Jun 1.PMID: 17544048 PMCID: PMC2099250 read article


Thomas SY, Banerji A, Medoff BD, Lilly CM, Luster AD. Multiple chemokine receptors, including CCR6 and CXCR3, regulate antigen-induced T cell homing to the human asthmatic airway. J Immunol. 2007 Aug 1;179(3):1901-12. PMID: 17641057


Bosley TM, Salih MA, Alorainy IA, Oystreck DT, Nester M, Abu Amero KK, Tischfield MA, Engle EC. Clinical characterization of the HOXA1 syndrome BSAS variant. Neurology. 2007 Sep 18;69(12):1245-53. PubMed PMID: 17875913; PubMed Central PMCID: PMC2826214.


Tse JC, Kalluri R. Mechanisms of metastasis: epithelial-to-mesenchymal transition and contribution of tumor microenvironment. J Cell Biochem. 2007 Jul 1;101(4):816-29. PMID: 17243120


Ulm JW, Perron M, Sodroski J, C Mulligan R. Complex determinants within the Moloney murine leukemia virus capsid modulate susceptibility of the virus to Fv1 and Ref1-mediated restriction. Virology. 2007 Jul 5;363(2):245-55. Epub 2007 Mar 6. PMID: 17343889


Venanzi ES, Gray DH, Benoist C, Mathis D. Lymphotoxin pathway and Aire influences on thymic medullary epithelial cells are unconnected. J Immunol. 2007 Nov 1;179(9):5693-700. PubMed PMID: 17947641.


Walker, SR, Nelson, EA, Frank, DA*. STAT5 Represses BCL6 Expression by Binding to a Regulatory Region Frequently Mutated in Lymphomas. Oncogene. 2007. 26(2):224-233. PMID: 16819511.


Glimcher LH, Jones DC, Wein MN. Control of postnatal bone mass by the zinc finger adapter protein Schnurri-3.Ann N Y Acad Sci. 2007 Nov;1116:174-81. Review. PMID: 18083927


Jones DC, Wein MN, Glimcher LH. Schnurri-3 is an essential regulator of osteoblast function and adult bone mass.Ann Rheum Dis. 2007 Nov;66 Suppl 3:iii49-51. Review. PMID: 17934096


Jones DC, Wein MN, Glimcher LH. Schnurri-3: a key regulator of postnatal skeletal remodeling. Adv Exp Med Biol. 2007;602:1-13. PMID: 17966382


Lu L, Ikizawa K, Hu D, Werneck MB, Wucherpfennig KW, Cantor H. Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. Immunity. 2007 May;26(5):593-604. PubMed PMID: 17509909.


Moza B, Varma AK, Buonpane RA, Zhu P, Herfst CA, Nicholson MJ, Wilbuer AK, Seth NP, Wucherpfennig KW, McCormick JK, Kranz DM, Sundberg EJ. Structural basis of T-cell specificity and activation by the bacterial superantigen TSST-1. EMBO J. 2007 Feb 21;26(4):1187-97. Epub 2007 Feb 1. PMID: 17268555 PMCID: PMC1852840


Williams BR, Bateman, JR, Novikov, ND, Wu, CT. Disruption of Topoisomerase II perturbs pairing in Drosophila cell culture. Genetics 2007. 177: 31-46. PMC2013714.


Cheng J, Zhou X, Miller E, Witt RM, Zhu J, Sabatini BL, Wong ST. A novel computational approach for automatic dendrite spines detection in two-photon laser scan microscopy. J Neurosci Methods. 2007 Sep 15;165(1):122-34. Epub 2007 May 24. PMID: 17629570. PubMed Central PMCID: PMC1989684.


Zhang Y, Zhou X, Witt RM, Sabatini BL, Adjeroh D, Wong ST. Dendritic spine detection using curvilinear structure detector and LDA classifier. Neuroimage. 2007 Jun;36(2):346-60. Epub 2007 Mar 13. PMID: 17448688.


Wong J, Obst R, Correia-Neves M, Losyev G, Mathis D, Benoist C. Adaptation of TCR repertoires to self-peptides in regulatory and nonregulatory CD4+ T cells. J Immunol. 2007 Jun 1;178(11):7032-41. PMID: 17513752.


Wong J, Mathis D, Benoist C. TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets. J Exp Med. 2007 Sep 3;204(9):2039-45. Epub 2007 Aug 27. PMID: 17724131.


Behar SM, Woodworth JS, Wu Y. Next generation: tuberculosis vaccines that elicit protective CD8+ T cells. Expert Rev Vaccines. 2007 Jun;6(3):441-56. Review. PubMed PMID: 17542758; PubMed Central PMCID: PMC3134449.


Yoon S, Molloy MJ, Wu MP, Cowan DB, Gussoni E. C6ORF32 is upregulated during muscle cell differentiation and induces the formation of cellular filopodia. Dev Biol. 2007 Jan 1;301(1):70-81. Epub 2006 Nov 7. PMID: 17150207 PMCID: PMC1779902 read article


"Zhao WN, Malinin N, Yang FC, Staknis D, Gekakis N, Maier B, Reischl S, Kramer A, Weitz CJ. CIPC is a mammalian circadian clock protein without invertebrate homologues. Nat Cell Biol. 2007 Mar;9(3):268-75. Epub 2007 Feb 18. PubMed PMID: 17310242.
"


Shalizi A, Bilimoria PM, Stegmüller J, Gaudillière B, Yang Y, Shuai K, Bonni A. PIASx is a MEF2 SUMO E3 ligase that promotes postsynaptic dendritic morphogenesis. J Neurosci. 2007 Sep 12;27(37):10037-46. PubMed PMID: 17855618.


top

2006


Agosto MA, Ivanovic T, Nibert ML. Mammalian reovirus, a nonfusogenic nonenveloped virus, forms size-selective pores in a model membrane. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16496-501. Epub 2006 Oct 19. PMID: 17053074 PMCID: PMC1637610 read article


Pau AK, McLaughlin MM, Hu Z, Agyemang AF, Polis MA, Kottilil S. Predictors for Hematopoietic Growth Factors Use in HIV/HCV-Coinfected Patients Treated with Peginterferon Alfa 2b and Ribavirin. AIDS Patient Care STDS. 2006 Sep;20(9):612-9. PMID: 16987047


Keir ME, Liang SC, Guleria I, Latchman YE, Qipo A, Albacker LA, Koulmanda M, Freeman GJ, Sayegh MH, Sharpe AH. Tissue expression of PD-L1 mediates peripheral T cell tolerance. J Exp Med. 2006 Apr 17;203(4):883-95. Epub 2006 Apr 10. PMID: 16606670 PMCID: PMC2118286


Alvarez JV, Greulich H, Sellers WR, Meyerson M, Frank DA. Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptor. Cancer Res. 2006 Mar 15;66(6):3162-8. PMID: 16540667


Liddle FJ, Alvarez JV, Poli V, Frank DA. Tyrosine phosphorylation is required for functional activation of disulfide-containing constitutively active STAT mutants. Biochemistry. 2006 May 2;45(17):5599-605. PMID: 16634641


Appleton BA, Brooks J, Loregian A, Filman DJ, Coen DM, Hogle JM. Crystal structure of the cytomegalovirus DNA polymerase subunit UL44 in complex with the C terminus from the catalytic subunit. Differences in structure and function relative to unliganded UL44. J Biol Chem. 2006 Feb 24;281(8):5224-32. Epub 2005 Dec 20. PMID: 16371349


Balibar CJ, Walsh CT. GliP, a multimodular nonribosomal peptide synthetase in Aspergillus fumigatus, makes the diketopiperazine scaffold of gliotoxin. Biochemistry. 2006 Dec 19;45(50):15029-38. PMID: 17154540


Balibar CJ, Walsh CT. In vitro biosynthesis of violacein from L-tryptophan by the enzymes VioA-E from Chromobacterium violaceum. Biochemistry. 2006 Dec 26;45(51):15444-57. Epub 2006 Dec 19. PMID: 17176066


Balsara ZR, Roan NR, Steele LN, Starnbach MN. Developmental regulation of Chlamydia trachomatis class I accessible protein-1, a CD8+ T cell antigen. J Infect Dis. 2006 May 15;193(10):1459-63. Epub 2006 Apr 12. PMID: 16619195.


Balsara ZR, Misaghi S, Lafave JN, Starnbach MN. Chlamydia trachomatis infection induces cleavage of the mitotic cyclin B1. Infect Immun. 2006 Oct;74(10):5602-8. PMC1594933.


Bernstein-Hanley I, Coers J, Balsara ZR, Taylor GA, Starnbach MN, Dietrich WF. The p47 GTPases Igtp and Irgb10 map to the Chlamydia trachomatis susceptibility locus Ctrq-3 and mediate cellular resistance in mice. Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14092-7. Epub 2006 Sep 7. PMC1599917.


Letvin NL, Mascola JR, Sun Y, Gorgone DA, Buzby AP, Xu L, Yang Z, Chakrabarti B, Rao SS, Schmitz JE, Montefiori DC, Barker BR, Bookstein FL, Nabel GJ. Preserved CD4+ Central Memory T Cells and Survival in Vaccinated SIV-Challenged Monkeys. Science, 2006; 312:1530-1533.


Sun Y, Schmitz JE, Buzby AP, Barker BR, Rao SS, Xu L, Yang Z, Mascola JR, Nabel GJ, Letvin NL. Virus-specific Cellular Immune Correlates of Survival in Vaccinated Monkeys After Simian Immunodeficiency Virus Challenge. Journal of Virology, 2006; 80(22):10950-6. PMCID: PMC1642180.


Yurkovic A, Wang O, Basu AC, Kravitz EA. Learning and memory associated with aggression in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17519-24. Epub 2006 Nov 6. PubMed PMID: 17088536; PubMed Central PMCID: PMC1634832.


Baughman JM, Mootha VK*. Buffering mitochondrial DNA variation. Nat Genet. 2006. 11:1232-3. Review. PMID: 17072298.


Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Nat Biotechnol. 2006 Oct;24(10):1285-92. Epub 2006 Sep 10. PMID: 16964243


Everley PA, Bakalarski CE, Elias JE, Waghorne CG, Beausoleil SA, Gerber SA, Faherty BK, Zetter BR, Gygi SP. Enhanced analysis of metastatic prostate cancer using stable isotopes and high mass accuracy instrumentation. J Proteome Res. 2006 May;5(5):1224-31. PMID: 16674112


Haas W, Faherty BK, Gerber SA, Elias JE, Beausoleil SA, Bakalarski CE, Li X, Villén J, Gygi SP. Optimization and use of peptide mass measurement accuracy in shotgun proteomics. Mol Cell Proteomics. 2006 Jul;5(7):1326-37. Epub 2006 Apr 23. PMID: 16635985


Vig M***, Beck A***, Billingsley JM***, Lis A, Parvez S, Peinelt C, Koomoa DL, Soboloff J, Gill DL, Fleig A, Kinet JP, Penner R. 2006. CRACM1 multimers form the ion-selective pore of the CRAC channel. Curr Biol. 16(20):2073-9. PMID: 16978865.***Equal Contribution.


Moran ST, Cariappa A, Liu H, Boboila C, Shi HN, Holland PM, Peschon JJ, Pillai S. Protein kinase C-associated kinase is not required for the development of peripheral B lymphocyte populations. Mol Immunol. 2006;43(10):1694-9.


Bonasio R, von Andrian UH. (2006). Origin, destination and function of circulating dendritic cells. Current Opinions in Immunology 18:503-11. PMID: 16777395.


Bonasio R, Scimone ML, Schaerli P, Grabie N, Lichtman AH, von Andrian UH (2006). Clonal deletion of autoreactive thymocytes by circulating dendritic cells homing to the thymus. Nature Immunology 7:1092-100. PMID: 16951687.


Wu Y, Borde M, Heissmeyer V, Feuerer M, Lapan AD, Stroud JC, Bates DL, Guo L, Han A, Ziegler SF, Mathis D, Benoist C, Chen L, Rao A. FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell. 2006 Jul 28;126(2):375-87.PubMed PMID: 16873067.


Barrington RA, Borde M, Rao A, Carroll MC. Involvement of NFAT1 in B cell self-tolerance. J Immunol. 2006 Aug 1;177(3):1510-5. PubMed PMID: 16849457.


Hu H, Wang B, Borde M, Nardone J, Maika S, Allred L, Tucker PW, Rao A. Foxp1 is an essential transcriptional regulator of B cell development. Nat Immunol. 2006 Aug;7(8):819-26. Epub 2006 Jul 2. PubMed PMID: 16819554.


Boyce M, Yuan J. Cellular response to endoplasmic reticulum stress: a matter of life or death. Cell Death Differ. 2006 Mar;13(3):363-73. PMID: 16397583


Boyce M, Scott F, Guogas LM, Gehrke L. Base-pairing potential identified by in vitro selection predicts the kinked RNA backbone observed in the crystal structure of the alfalfa mosaic virus RNA-coat protein complex. J Mol Recognit. 2006 Jan-Feb;19(1):68-78. PMID: 16312015


Tsankov AM, Brown CR, Yu, MC, Win, MZ, Silver PA*, Casolari, J.M. Communication between levels of transcriptional control improves robustness and adaptivity. Molecular Systems Biology. 2006. Nov; 2:65. PMC1682026.


Brown CR, Silver PA*. Pore-ing the right dose. Nature Cell Biology. 2006. May;8(5):430-1. PMID: 16691206.


Auld KL, Brown CR, Casolari JM, Komili S, Silver PA*. Genomic association of the proteasome demonstrates overlapping gene regulatory activity with transcription factor substrates. Molecular Cell. 2006. Mar 17;21(6):861-71. PMID: 16543154.


Tomczak MF, Gadjeva M, Wang YY, Brown K, Maroulakou I, Tsichlis PN, Erdman SE, Fox JG, Horwitz BH. Defective activation of ERK in macrophages lacking the p50/p105 subunit of NF-kappaB is responsible for elevated expression of IL-12 p40 observed after challenge with Helicobacter hepaticus. J Immunol. 2006 Jan 15;176(2):1244-51. PubMed PMID: 16394015.


Moazed D, Bühler M, Buker SM, Colmenares SU, Gerace EL, Gerber SA, Hong EJ, Motamedi MR, Verdel A, Villén J, Gygi SP. Studies on the mechanism of RNAi-dependent heterochromatin assembly. Cold Spring Harb Symp Quant Biol. 2006;71:461-71. Review. PubMed PMID: 17381328.


Yeh WW, Cale EM, Jaru-Ampornpan P, Lord CI, Peyerl FW, Letvin NL. Compensatory substitutions restore normal core assembly in simian immunodeficiency virus isolates with Gag epitope cytotoxic T-lymphocyte escape mutations. J Virol. 2006 Aug;80(16):8168-77. PMID: 16873273 PMCID: PMC1563819


Wang B, Love TM, Call ME, Doench JG, Novina CD. Recapitulation of short RNA-directed translational gene silencing in vitro. Mol Cell. 2006 May 19;22(4):553-60. PubMed PMID: 16713585.


Xu C, Call ME, Wucherpfennig KW. A membrane-proximal tetracysteine motif contributes to assembly of CD3deltaepsilon and CD3gammaepsilon dimers with the T cell receptor. J Biol Chem. 2006 Dec 1;281(48):36977-84. Epub 2006 Oct 5. PubMed PMID: 17023417.


Call ME, Schnell JR, Xu C, Lutz RA, Chou JJ, Wucherpfennig KW. The structure of the zetazeta transmembrane dimer reveals features essential for its assembly with the T cell receptor. Cell. 2006 Oct 20;127(2):355-68. PubMed PMID: 17055436.


Feng J, Call ME, Wucherpfennig KW. The assembly of diverse immune receptors is focused on a polar membrane-embedded interaction site. PLoS Biol. 2006 May;4(5):e142. Epub 2006 Apr 25. PubMed PMID: 16623599; PubMed Central PMCID: PMC1440944.


DiBacco A, Ouyang J, Lee HY, Catic A, Ploegh H, Gill G. The SUMO-specific protease SENP5 is required for cell division. Mol. Cell. Biol. 2006 Jun;26(12):4489-98.


Misaghi S, Balsara ZR, Catic A, Spooner E, Ploegh HL, Starnbach MN. Chlamydia trachomatis-derived deubiquitinating enzymes in mammalian cells during infection. Mol. Microbiol. 2006 Jul;61(1):142-150.


Artavanis-Tsakonas K, Misaghi S, Comeaux CA, Catic A, Spooner E, Duraisingh MT, Ploegh H. Identification by functional proteomics of a deubiquitinating/deNeddylating enzyme in Plasmodium falciparum. Mol. Microbiol. 2006 Sep;61(5):1187-95.


Ghosh S, Chackerian AA, Parker CM, Ballantyne CM, Behar SM. The LFA-1 adhesion molecule is required for protective immunity during pulmonary Mycobacterium tuberculosis infection. J Immunol. 2006 Apr 15;176(8):4914-22. PubMed PMID: 16585587.


Ma Y, Li J, Chiu I, Wang Y, Sloane JA, Lü J, Kosaras B, Sidman RL, Volpe JJ, Vartanian T. Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis. J Cell Biol. 2006 Oct 23;175(2):209-15. PMID: 17060494.


Zhang M, Alicot EM, Chiu I, Li J, Verna N, Vorup-Jensen T, Kessler B, Shimaoka M, Chan R, Friend D, Mahmood U, Weissleder R, Moore FD, Carroll MC. Identification of the target self-antigens in reperfusion injury. J Exp Med. 2006 Jan 23;203(1):141-52. Epub 2006 Jan 3. PMID: 16390934.


Choo AY, Roux PP, Blenis J*. Mind the GAP: Wnt steps onto the mTORC1 train. Cell. 2006. 126:834-6. PMID: 16959561.


Choo AY, Blenis J*. TORgeting oncogene addiction for cancer therapy. Cancer Cell. 2006. 9:77-9. PMID: 16473275.


Kwan KY, Allchorne AJ, Vollrath MA, Christensen AP, Zhang DS, Woolf CJ, Corey DP. TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. Neuron. 2006 Apr 20;50(2):277-89. PubMed PMID: 16630838.


Yoshida M, Kobayashi K, Kuo TT, Bry L, Glickman JN, Claypool SM, Kaser A, Nagaishi T, Higgins DE, Mizoguchi E, Wakatsuki Y, Roopenian DC, Mizoguchi A, Lencer WI, and Blumberg RS. 2006. Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria. J. Clin. Invest. 2006 Aug;116(8): 2142-2151. PMCID: PMC1501111.


Yoshida M, Masuda A, Kuo TT, Kobayashi K, Claypool SM, Takagawa T, Kutsumi H, Azuma T, Lencer WI, Blumberg RS. IgG transport across mucosal barriers by neonatal Fc receptor for IgG and mucosal immunity. Springer Semin. Immunopathol. 2006 Dec; 28(4): 397-403. PMID: 17051393.


Moazed D, Bühler M, Buker SM, Colmenares SU, Gerace EL, Gerber SA, Hong EJ, Motamedi MR, Verdel A, Villén J, Gygi SP. Studies on the mechanism of RNAi-dependent heterochromatin assembly. Cold Spring Harb Symp Quant Biol. 2006;71:461-71. Review. PubMed PMID: 17381328.


Zhao B, Maruo S, Cooper A, R Chase M, Johannsen E, Kieff E, Cahir-McFarland E. RNAs induced by Epstein-Barr virus nuclear antigen 2 in lymphoblastoid cell lines. Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1900-5. Epub 2006 Jan 30. PMID: 16446431 PMCID: PMC1413661. read article


von Arnim CA, Spoelgen R, Peltan ID, Deng M, Courchesne S, Koker M, Matsui T, Kowa H, Lichtenthaler SF, Irizarry MC, Hyman BT. GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing. J Neurosci. 2006. Sep 27;26(39):9913-22. PubMed PMID: 17005855.


Leslie A, Price DA, Mkhize P, Bishop K, Rathod A, Day C, Crawford H, Honeyborne I, Asher TE, Luzzi G, Edwards A, Rousseau CM, Mullins JI, Tudor-Williams G, Novelli V, Brander C, Douek DC, Kiepiela P, Walker BD, Goulder PJ. Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype. J Immunol. 2006 Oct 1;177(7):4699-708. PMID: 16982909


Wherry EJ, Day CL, Draenert R, Miller JD, Kiepiela P, Woodberry T, Brander C, Addo M, Klenerman P, Ahmed R, Walker BD. HIV-specific CD8 T cells express low levels of IL-7Ralpha: implications for HIV-specific T cell memory. Virology. 2006 Sep 30;353(2):366-73. Epub 2006 Jul 24. PMID: 16860834


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Gadea BB, Ruderman JV. Aurora B is required for mitotic chromatin-induced phosphorylation of Op18/Stathmin. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4493-8. Epub 2006 Mar 14. PMID: 16537398 PMCID: PMC1401233 read article


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Jadhav AP, Mason HA, Cepko CL. Notch 1 inhibits photoreceptor production in the developing mammalian retina. Development. 2006 Mar;133(5):913-23. Epub 2006 Feb 1. PMID: 16452096


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Maimon G, Assad JA. Parietal area 5 and the initiation of self-timed movements versus simple reactions. J Neurosci. 2006 Mar 1;26(9):2487-98. PubMed PMID: 16510727.


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Miller AJ, Mihm MC Jr. Melanoma. N Engl J Med. 2006 Jul 6;355(1):51-65. PMID: 16822996


Misaghi S, Korbel GA, Kessler B, Spooner E, Ploegh HL. z-VAD-fmk inhibits peptide:N-glycanase and may result in ER stress. Cell Death Differ. 2006 Jan;13(1):163-5. PMID: 16003388


Misaghi S, Balsara ZR, Catic A, Spooner E, Ploegh HL, Starnbach MN. Chlamydia trachomatis-derived deubiquitinating enzymes in mammalian cells during infection. Mol Microbiol. 2006 Jul;61(1):142-50. PMID: 16824101


Artavanis-Tsakonas K, Misaghi S, Comeaux CA, Catic A, Spooner E, Duraisingh MT, Ploegh HL. Identification by functional proteomics of a deubiquitinating/deNeddylating enzyme in Plasmodium falciparum. Mol Microbiol. 2006 Sep;61(5):1187-95. PMID: 16925553


Balsara ZR, Misaghi S, Lafave JN, Starnbach MN. Chlamydia trachomatis infection induces cleavage of the mitotic cyclin B1. Infect Immun. 2006 Oct;74(10):5602-8. PMID: 16988235 PMCID: PMC1594933 read article


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Neal J, Apse K, Sahin M, Walsh CA, Sheen VL. Deletion of chromosome 1p36 is associated with periventricular nodular heterotopia. Am J Med Genet A. 2006 Aug 1;140(15):1692-5. PubMed PMID: 16835933.


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Yoshida T, Ng SY, Zuniga-Pflucker JC, Georgopoulos K. Early hematopoietic lineage restrictions directed by Ikaros. Nat Immunol. 2006 Apr;7(4):382-91. Epub 2006 Mar 5. PubMed PMID: 16518393.


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Sardi SP, Murtie J, Koirala S, Patten BA, Corfas G. Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain. Cell. 2006 Oct 6;127(1):185-97. PMID: 17018285


Patten BA, Sardi SP, Koirala S, Nakafuku M, Corfas G. Notch1 signaling regulates radial glia differentiation through multiple transcriptional mechanisms. J Neurosci. 2006 Mar 22;26(12):3102-8.PMID: 16554461.


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Ramdya P, Reiter B, Engert F. Reverse correlation of rapid calcium signals in the zebrafish optic tectum in vivo. J Neurosci Methods. 2006 Oct 30;157(2):230-7. Epub 2006 Jun 12. PubMed PMID: 16765450.


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Rivera-Feliciano J, Tabin CJ*. Bmp2 instructs cardiac progenitors to form the heart-valve-inducing field. Dev Biol. 2006 Jul 15;295(2):580-8. Epub 2006 Apr 4. PMID: 16730346 PMCID: PMC2680002 read article


Cooper MP, Qu L, Rohas LM, Lin J, Yang W, Erdjument-Bromage H, Tempst P, Spiegelman BM. Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex. Genes Dev. 2006 Nov 1;20(21):2996-3009. Epub 2006 Oct 18. PMID: 17050673 PMCID: PMC1620022 read article


Butty V, Roy M, Sabeti P, Besse W, Benoist C, Mathis D. Signatures of strong population differentiation shape extended haplotypes across the human CD28, CTLA4, and ICOS costimulatory genes. Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):570-5. Epub 2006 Dec 29. PubMed PMID: 17197413; PubMed Central PMCID: PMC1766426.


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Safo PK, Cravatt BF, Regehr WG. Retrograde endocannabinoid signaling in the cerebellar cortex. Cerebellum. 2006;5(2):134-45. Review. PubMed PMID: 16818388.


Xie Z, Samuels BA, Tsai LH. Cyclin-dependent kinase 5 permits efficient cytoskeletal remodeling--a hypothesis on neuronal migration. Cereb Cortex. 2006 Jul;16 Suppl 1:i64-8. Review. PubMed PMID: 16766709.


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Townsend M, Shankar GM, Mehta T, Walsh DM, Selkoe DJ. Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers. J Physiol. 2006 Apr 15;572(Pt 2):477-92. Epub 2006 Feb 9. PubMed PMID: 16469784; PubMed Central PMCID: PMC1779683.


Soler-Llavina GJ, Sabatini BL. Synapse-specific plasticity and compartmentalized signaling in cerebellar stellate cells. Nat Neurosci. 2006 Jun;9(6):798-806. Epub 2006 May 7. PubMed PMID: 16680164.


Balsara ZR, Roan NR, Steele LN, Starnbach MN. Developmental regulation of Chlamydia trachomatis class I accessible protein-1, a CD8+ T cell antigen. J Infect Dis. 2006 May 15;193(10):1459-63. Epub 2006 Apr 12. PubMed PMID: 16619195.


Swinburne IA, Meyer CA, Liu XS, Silver PA, Brodsky AS. Genomic localization of RNA binding proteins reveals links between pre-mRNA processing and transcription. Genome Res. 2006 Jul;16(7):912-21. Epub 2006 Jun 12. PMID: 16769980 PMCID: PMC1484458 read article


Franco S, Gostissa M, Zha S, Lombard DB, Murphy MM, Zarrin AA, Yan C, Tepsuporn S, Morales JC, Adams MM, Lou Z, Bassing CH, Manis JP, Chen J, Carpenter PB, Alt FW. H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell. 2006 Jan 20;21(2):201-14. PubMed PMID: 16427010.


Yan CT, Kaushal D, Murphy M, Zhang Y, Datta A, Chen C, Monroe B, Mostoslavsky G, Coakley K, Gao Y, Mills KD, Fazeli AP, Tepsuporn S, Hall G, Mulligan R, Fox E, Bronson R, De Girolami U, Lee C, Alt FW. XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice. Proc Natl Acad Sci U S A. 2006 May 9;103(19):7378-83. Epub 2006 May 2. PubMed PMID: 16670198.


Khan IA, Thomas SY, Moretto MM, Lee FS, Islam SA, Combe C, Schwartzman JD, Luster AD. CCR5 is essential for NK cell trafficking and host survival following Toxoplasma gondii infection. PLoS Pathog. 2006 Jun;2(6):e49. Epub 2006 Jun 9. PMID: 16789839 PMCID: PMC1475660  read article


Thomas SY, Lilly CM, Luster AD. Invariant natural killer T cells in bronchial asthma. N Engl J Med. 2006 Jun 15;354(24):2613-6; author reply 2613-6. PMID: 16775244


Mikhak Z, Fleming CM, Medoff BD, Thomas SY, Tager AM, Campanella GS, Luster AD. STAT1 in peripheral tissue differentially regulates homing of antigen-specific Th1 and Th2 cells. J Immunol. 2006 Apr 15;176(8):4959-67. PMID: 16585592


Islam SA, Thomas SY, Hess C, Medoff BD, Means TK, Brander C, Lilly CM, Tager AM, Luster AD. The leukotriene B4 lipid chemoattractant receptor BLT1 defines antigen-primed T cells in humans. Blood. 2006 Jan 15;107(2):444-53. Epub 2005 Sep 22. PMID: 16179368 PMCID: PMC1490027  read article


Tischfield MA, Chan WM, Grunert JF, Andrews C, Engle EC. HOXA1 mutations are not a common cause of Duane anomaly. Am J Med Genet A. 2006 Apr 15;140(8):900-2. Review. PubMed PMID: 16528738; PubMed Central PMCID: PMC2553396.


Tsao DY, Freiwald WA, Tootell RB, Livingstone MS. A cortical region consisting entirely of face-selective cells. Science. 2006 Feb 3;311(5761):670-4. PubMed PMID: 16456083; PubMed Central PMCID: PMC2678572.


Tsao DY, Freiwald WA. What's so special about the average face? Trends Cogn Sci. 2006 Sep;10(9):391-3. Epub 2006 Aug 8. PubMed PMID: 16899396.


Nelson EA, Walker SR, Li W, Liu XS, Frank DA*. Identification of human STAT5-dependent gene regulator elements based on inter-species homology. J Biol Chem. 2006. 281(36):26216-26224. PMID: 16840779.


Jones DC*, Wein MN*, Oukka M, Hofstaetter J, Glimcher M, Glimcher LH. Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3. Science. 2006 May 26;312(5777):1223-7. PMID: 16728642


Lu L, Werneck MB, Cantor H. The immunoregulatory effects of Qa-1. Immunol Rev. 2006 Aug;212:51-9. Review. PubMed PMID: 16903905.


Shinohara ML, Lu L, Bu J, Werneck MB, Kobayashi KS, Glimcher LH, Cantor H. Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells. Nat Immunol. 2006 May;7(5):498-506. Epub 2006 Apr 9. PubMed PMID: 16604075.


Daniels R, Rusan NM, Wilbuer AK, Norkin LC, Wadsworth P, Hebert DN. Simian virus 40 late proteins possess lytic properties that render them capable of permeabilizing cellular membranes. J Virol. 2006 Jul;80(13):6575-87. PMID: 16775344 PMCID: PMC1488938


Shaw GC, Cope JJ, Li L, Corson K, Hersey C, Ackermann GE, Gwynn B, Lambert AJ, Wingert RA, Traver D, Trede NS, Barut BA, Zhou Y, Minet E, Donovan A, Brownlie A, Balzan R, Weiss MJ, Peters LL, Kaplan J, Zon LI, Paw BH. Mitoferrin is essential for erythroid iron assimilation. Nature. 2006 Mar 2;440(7080):96-100. PMID: 16511496


Kamath A, Woodworth JS, Behar SM. Antigen-specific CD8+ T cells and the development of central memory during Mycobacterium tuberculosis infection. J Immunol. 2006 Nov 1;177(9):6361-9. PubMed PMID: 17056567; PubMed Central PMCID: PMC3133654.


Woodworth JS, Behar SM. Mycobacterium tuberculosis-specific CD8+ T cells and their role in immunity. Crit Rev Immunol. 2006;26(4):317-52. Review. PubMed PMID: 17073557; PubMed Central PMCID: PMC3134450.


Lehtinen MK, Yuan Z, Boag PR, Yang Y, Villén J, Becker EB, DiBacco S, de la Iglesia N, Gygi S, Blackwell TK, Bonni A. A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell. 2006 Jun 2;125(5):987-1001. PubMed PMID: 16751106.


Kaneko S, Wang J, Kaneko M, Yiu G, Hurrell JM, Chitnis T, Khoury SJ, He Z. Protecting axonal degeneration by increasing nicotinamide adenine dinucleotide levels in experimental autoimmune encephalomyelitis models. J Neurosci. 2006 Sep 20;26(38):9794-804. PMID: 16988050.


Yiu G, He Z. Glial Inhibition of CNS Axon Regeneration. Nat Rev Neurosci. 2006 Aug; 7(8):617-27. PMID: 16858390. PMCID: PMC2693386.


Zhang T, Sun Y, Tian E, Deng H, Zhang Y, Luo X, Cai Q, Wang H, Chai J, Zhang H. RNA-binding proteins SOP-2 and SOR-1 form a novel PcG-like complex in C.elegans. Development. 2006 Mar;133(6):1023-33.


top

2005


Nibert ML, Odegard AL, Agosto MA, Chandran K, Schiff LA. Putative autocleavage of reovirus mu1 protein in concert with outer-capsid disassembly and activation for membrane permeabilization. J Mol Biol. 2005 Jan 21;345(3):461-74. PMID: 15581891


Dougan SK, Salas A, Rava P, Agyemang A, Kaser A, Morrison J, Khurana A, Kronenberg M, Johnson C, Exley M, Hussain MM, Blumberg RS. Microsomal triglyceride transfer protein lipidation and control of CD1d on antigen-presenting cells. J Exp Med. 2005 Aug 15;202(4):529-39. PMID: 16087713 PMCID: PMC2212858


Li Z, Burrone J, Tyler WJ, Hartman KN, Albeanu DF, Murthy VN. Synaptic vesicle recycling studied in transgenic mice expressing synaptopHluorin. Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6131-6. Epub 2005 Apr 18. PubMed PMID: 15837917; PubMed Central PMCID: PMC1087931.


Alvarez JV, Febbo PG, Ramaswamy S, Loda M, Richardson A, Frank DA. Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors. Cancer Res. 2005 Jun 15;65(12):5054-62. PMID: 15958548


Greulich H, Chen TH, Feng W, Jänne PA, Alvarez JV, Zappaterra M, Bulmer SE, Frank DA, Hahn WC, Sellers WR, Meyerson M. Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants. PLoS Med. 2005 Nov;2(11):e313. Epub 2005 Oct 4. PMID: 16187797 PMCID: PMC1240052 read article


Selak MA, Armour SM, MacKenzie ED, Boulahbel H, Watson DG, Mansfield KD, Pan Y, Simon MC, Thompson CB, Gottlieb E. Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. Cancer Cell. 2005 Jan;7(1):77-85. PMID: 15652751


Broering TJ, Arnold MM, Miller CL, Hurt JA, Joyce PL, Nibert ML. Carboxyl-proximal regions of reovirus nonstructural protein muNS necessary and sufficient for forming factory-like inclusions. J Virol. 2005 May;79(10):6194-206. PMID: 15858004 PMCID: PMC1091696 read article


Repik A, Pincus SE, Ghiran I, Nicholson-Weller A, Asher DR, Cerny AM, Casey LS, Jones SM, Jones SN, Mohamed N, Klickstein LB, Spitalny G, Finberg RW. A transgenic mouse model for studying the clearance of blood-borne pathogens via human complement receptor 1 (CR1). Clin Exp Immunol. (2005) 140:230-40.


Asher DR, Cerny AM, Weiler SR, Horner JW, Keeler ML, Neptune MA, Jones SN, Bronson RT, Depinho RA, Finberg RW. Coxsackievirus and adenovirus receptor is essential for cardiomyocyte development. Genesis (2005) 42:77-85.


Asher DR, Cerny AM, Finberg RW. The erythrocyte viral trap: transgenic expression of viral receptor on erythrocytes attenuates coxsackievirus B infection. Proc Natl Acad Sci U S A. (2005) 102:12897-902.


Asthana S, Schmidt S, Sunyaev S. A limited role for balancing selection. Trends Genet. 2005 Jan;21(1):30-2. PMID: 15680511


Balibar CJ, Vaillancourt FH, Walsh CT. Generation of D amino acid residues in assembly of arthrofactin by dual condensation/epimerization domains. Chem Biol. 2005 Nov;12(11):1189-200. PMID: 16298298


Hernáindez-Falcón J, Basu AC, Govindasamy S, Kravitz EA. Changes in heart rate associated with contest outcome in agonistic encounters in lobsters. Cell Mol Neurobiol. 2005 Mar;25(2):329-43. PubMed PMID: 16047545.


Baughman JM, Geijsen N. In vitro generation of germ cells: new techniques to solve current issues. Ann N Y Acad Sci. 2005. 1061:33-40. Review. PMID: 16467255.


Dieguez-Acuna FJ, Gerber SA, Kodama S, Elias JE, Beausoleil SA, Faustman D, Gygi SP. Characterization of mouse spleen cells by subtractive proteomics. Mol Cell Proteomics. 2005 Oct;4(10):1459-70. Epub 2005 Jul 21. PMID: 16037072


Bianchetta MJ, Betensky RA, Cohen JB. Cell-surface MuSK self-association: a crucial role for the putative signal sequence. Biochemistry. 2005 Dec
13;44(49):16229-38. PubMed PMID: 16331983.


Tolias KF, Bikoff JB, Burette A, Paradis S, Harrar D, Tavazoie S, Weinberg RJ, Greenberg ME. The Rac1-GEF Tiam1 couples the NMDA receptor to the activity-dependent development of dendritic arbors and spines. Neuron. 2005 Feb 17;45(4):525-38. PubMed PMID: 15721239.


Kraft S, Fleming T, Billingsley JM, Lin SY, Jouvin MH, Storz P, Kinet JP. Anti-CD63 antibodies suppress IgE-dependent allergic reactions in vitro and in vivo. J Exp Med. 2005 Feb 7;201(3):385-96. Epub 2005 Jan 31. PubMed PMID: 15684326; PubMed Central PMCID: PMC2213034.


Ngo-Anh TJ, Bloodgood BL, Lin M, Sabatini BL, Maylie J, Adelman JP. SK channels and NMDA receptors form a Ca2+-mediated feedback loop in dendritic spines. Nat Neurosci. 2005 May;8(5):642-9. Epub 2005 Apr 24. PubMed PMID: 15852011.


Bloodgood BL, Sabatini BL. Neuronal activity regulates diffusion across the neck of dendritic spines. Science. 2005 Nov 4;310(5749):866-9. PubMed PMID: 16272125.


Gauguet JM, Bonasio R and von Andrian UH. High endothelial venules. In: Endothelial Cells in Health and Disease. (2005) Aird WC (ed.). Taylor & Francis, Boca Raton, FL. pp. 77-103.


Mazo IB, Honczarenko M, Leung H, Cavanagh LL, Bonasio R, Weninger W, Engelke K, Xia L, McEver RP, Koni PA, Silberstein LE, von Andrian UH (2005). Bone marrow is a major reservoir and site of recruitment for central memory CD8+ T cells. Immunity 22:259-70. PMID: 15723813.


Halin C*, Scimone ML*, Bonasio R, Gauguet JM, Mempel TR, Quackenbush E, Proia RL, Mandala S, von Andrian UH (2005). The S1P-analog FTY720 differentially modulates T cell homing via HEV: T cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer's patches. Blood 106:1314-22. PMID: 15870184; PMCID: PMC1895188.


Cavanagh LL***, Bonasio R***, Mazo IB, Halin C, Cheng G, van der Velden AW, Cariappa A, Chase C, Russell P, Starnbach MN, Koni PA, Pillai S, Weninger W, von Andrian UH (2005). Activation of bone marrow-resident memory T cells by circulating, antigen-bearing dendritic cells. Nature Immunology 6:1029-37. PMID: 16155571; PMCID: PMC1780273.


Mandal M, Borowski C, Palomero T, Ferrando AA, Oberdoerffer P, Meng F, Ruiz-Vela A, Ciofani M, Zuniga-Pflucker JC, Screpanti I, Look AT, Korsmeyer SJ, Rajewsky K, von Boehmer H, Aifantis I. The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J Exp Med. 2005 Feb 21;201(4):603-14.


Oberdoerffer P, Kanellopoulou C, Heissmeyer V, Paeper C, Borowski C, Aifantis I, Rao A, Rajewsky K. Efficiency of RNA interference in the mouse hematopoietic system varies between cell types and developmental stages. Mol Cell Biol. 2005 May;25(10):3896-905.


Boyce M, Bryant KF, Jousse C, Long K, Harding HP, Scheuner D, Kaufman RJ, Ma D, Coen DM, Ron D, Yuan J. A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science. 2005 Feb 11;307(5711):935-9. PMID: 15705855


Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N, Cuny GD, Mitchison TJ, Moskowitz MA, Yuan J. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol. 2005 Jul;1(2):112-9. Epub 2005 May 29. PMID: 16408008


Casolari JM, Brown CR, Drubin DA, Rando OJ, Silver PA*. Developmentally induced changes in transcriptional program alter spatial organization across chromosomes. Genes and Development. 2005. May 15;19(10):1188-98. PMID: 15905407.


Beaulieu V, Da Silva N, Pastor-Soler N, Brown CR, Smith PJ, Brown D, Breton S. Modulation of the actin cytoskeleton via gelsolin regulates vacuolar H+-ATPase recycling. Journal of Biological Chemistry. 2005. March 4; 280(9):8452-8463. PMID:15591047.


Ibrahim AS, Bowman JC, Avanessian V, Brown K, Spellberg B, Edwards JE Jr, Douglas CM. Caspofungin inhibits Rhizopus oryzae 1,3-beta-D-glucan synthase, lowers burden in brain measured by quantitative PCR, and improves survival at a low but not a high dose during murine disseminated zygomycosis. Antimicrob Agents Chemother. 2005 Feb;49(2):721-7. PubMed PMID: 15673756; PubMed Central PMCID: PMC547300.


Call ME, Wucherpfennig KW. The T cell receptor: critical role of the membrane environment in receptor assembly and function. Annu Rev Immunol. 2005;23:101-25. Review. PubMed PMID: 15771567.


Feng J, Garrity D, Call ME, Moffett H, Wucherpfennig KW. Convergence on a distinctive assembly mechanism by unrelated families of activating immune receptors. Immunity. 2005 Apr;22(4):427-38. PubMed PMID: 15845448.


O'Connor KC, Appel H, Bregoli L, Call ME, Catz I, Chan JA, Moore NH, Warren KG, Wong SJ, Hafler DA, Wucherpfennig KW. Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoprotein. J Immunol. 2005 Aug 1;175(3):1974-82. PubMed PMID: 16034142.


Garrity D, Call ME, Feng J, Wucherpfennig KW. The activating NKG2D receptor assembles in the membrane with two signaling dimers into a hexameric structure. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7641-6. Epub 2005 May 13. PubMed PMID: 15894612; PubMed Central PMCID: PMC1140444.


Catic A, Ploegh HL. Ubiquitin--conserved protein or selfish gene? Trends Biochem. Sci. 2005 Nov;30(11):600-4.


Ohki K, Chung S, Ch'ng YH, Kara P, Reid RC. Functional imaging with cellular resolution reveals precise micro-architecture in visual cortex. Nature. 2005 Feb 10;433(7026):597-603. Epub 2005 Jan 19. PubMed PMID: 15660108.


Chan B, Greenan G, McKeon F, Ellenberger T. Identification of a peptide fragment of DSCR1 that competitively inhibits calcineurin activity in vitro and in vivo. Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13075-80. Epub 2005 Aug 30. PMID: 16131541 PMCID: PMC1201586 read article


Choi Y, Borghesani PR, Chan JA, Segal RA. Migration from a mitogenic niche
promotes cell-cycle exit.
J Neurosci. 2005 Nov 9;25(45):10437-45. PubMed PMID: 16280582.


Saper CB, Lu J, Chou TC, Gooley J. The hypothalamic integrator for circadian rhythms. Trends Neurosci. 2005 Mar;28(3):152-7. Review. PubMed PMID: 15749169.


Clatworthy AE, Valencia-Burton MA, Haber JE, Oettinger MA. The MRE11-RAD50-XRS2 complex, in addition to other non-homologous end-joining factors, is required for V(D)J joining in yeast. J Biol Chem. 2005 May 27;280(21):20247-52. Epub 2005 Mar 9. PubMed PMID: 15757898.


Stirling CM, Charleston B, Takamatsu H, Claypool S, Lencer W, Blumberg RS, Wileman TE. Characterization of the porcine neonatal Fc receptor-potential use for trans-epithelial protein delivery. Immunology. 2005 Apr;114(4): 542-53. PMCID: PMC1782108.


Colodner KJ, Montana RA, Anthony DC, Folkerth RD, Girolami UD, Feany MB. Proliferative potential of human astrocytes. Journal of Neuropathology and Experimental Neurology, 2005 Feb 64(2): 163-9. PMID: 15751231.


Maruo S, Johannsen E, Illanes D, Cooper A, Zhao B, Kieff E. Epstein-Barr virus nuclear protein 3A domains essential for growth of lymphoblasts: transcriptional regulation through RBP-Jkappa/CBF1 is critical. J Virol. 2005 Aug;79(16):10171-9. PMID: 16051810 PMCID: PMC1182629. read article


Hua F, Cornejo MG, Cardone MH, Stokes CL, Lauffenburger DA. Effects of Bcl-2 levels on Fas signaling-induced caspase-3 activation: molecular genetic tests of computational model prediction. Journal of Immunology, 2005 Jul 15;175 (2):985-95.


Currier SC, Lee CK, Chang BS, Bodell AL, Pai GS, Job L, Lagae LG, Al-Gazali LI, Eyaid WM, Enns G, Dobyns WB, Walsh CA. Mutations in POMT1 are found in a minority of patients with Walker-Warburg syndrome. Am J Med Genet A. 2005 Feb 15;133A(1):53-7. PubMed PMID: 15637732.


Ramduth D, Chetty P, Mngquandaniso NC, Nene N, Harlow JD, Honeyborne I, Ntumba N, Gappoo S, Henry C, Jeena P, Addo MM, Altfeld M, Brander C, Day C, Coovadia H, Kiepiela P, Goulder P, Walker B. Differential immunogenicity of HIV-1 clade C proteins in eliciting CD8+ and CD4+ cell responses. J Infect Dis. 2005 Nov 1;192(9):1588-96. Epub 2005 Sep 30 .PMID: 16206073


Lauer GM, Lucas M, Timm J, Ouchi K, Kim AY, Day CL, Schulze Zur Wiesch J, Paranhos-Baccala G, Sheridan I, Casson DR, Reiser M, Gandhi RT, Li B, Allen TM, Chung RT, Klenerman P, Walker BD. Full-breadth analysis of CD8+ T-cell responses in acute hepatitis C virus infection and early therapy. J Virol. 2005 Oct;79(20):12979-88. PMID: 16189000 PMCID: PMC1235828 read article


Schulze zur Wiesch J, Lauer GM, Day CL, Kim AY, Ouchi K, Duncan JE, Wurcel AG, Timm J, Jones AM, Mothe B, Allen TM, McGovern B, Lewis-Ximenez L, Sidney J, Sette A, Chung RT, Walker BD. Broad repertoire of the CD4+ Th cell response in spontaneously controlled hepatitis C virus infection includes dominant and highly promiscuous epitopes. J Immunol. 2005 Sep 15;175(6):3603-13. PMID: 16148104


Kosaka T, Deans MR, Paul DL, Kosaka K. Neuronal gap junctions in the mouse main olfactory bulb: morphological analyses on transgenic mice. Neuroscience. 2005;134(3):757-69. PubMed PMID: 15979807.


Dietz SB, Murthy VN. Contrasting short-term plasticity at two sides of the
mitral-granule reciprocal synapse in the mammalian olfactory bulb. J Physiol.
2005 Dec 1;569(Pt 2):475-88. Epub 2005 Sep 15. PubMed PMID: 16166156; PubMed Central PMCID: PMC1464232.


Dong CK, Masutomi K, Hahn WC*. Telomerase: regulation, function and transformation. Crit Rev Oncol Hematol. 2005. May;54(2):85-93, PMID: 15843091.


Dougan SK, Salas A, Rava P, Agyemang A, Kaser A, Morrison J, Khurana A, Kronenberg M, Johnson C, Exley M, Hussain MM, Blumberg RS. Microsomal triglyceride transfer protein lipidation and control of CD1d on antigen-presenting cells. J Exp Med. 2005 Aug 15;202(4):529-39. Epub 2005 Aug 8. PubMed PMID: 16087713; PubMed Central PMCID: PMC2212858.


Garraway LA, Widlund HR, Rubin MA, Getz G, Berger AJ, Ramaswamy S, Beroukhim R, Milner DA, Granter SR, Du J, Lee C, Wagner SN, Li C, Golub TR, Rimm DL, Meyerson ML, Fisher DE, Sellers WR. Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature. 2005 Jul 7;436(7047):117-22. PMID: 16001072


Dudley DD, Chaudhuri J, Bassing CH, Alt FW. Mechanism and Control of V(D)J Recombination versus Class Switch Recombination: Similarities and Differences. Adv Immunol. 2005;86:43-112. PMID: 15705419.


Benes CH, Wu N, Elia AE, Dharia T, Cantley LC, Soltoff SP. The C2 domain of PKCdelta is a phosphotyrosine binding domain. Cell. 2005 Apr 22;121(2):271-80. PMID: 15851033


Everley PA, Zetter BR. Proteomics in tumor progression and metastasis. Ann N Y Acad Sci. 2005 Nov;1059:1-10. PMID: 16382037


McEwen E, Kedersha N, Song B, Scheuner D, Gilks N, Han A, Chen JJ, Anderson P, Kaufman RJ. Heme-regulated inhibitor kinase-mediated phosphorylation of eukaryotic translation initiation factor 2 inhibits translation, induces stress granule formation, and mediates survival upon arsenite exposure. J Biol Chem. 2005. Apr 29;280(17):16925-33. PMID: 15684421.


Li J, Fontaine-Rodriguez EC, Whelan SP. Amino acid residues within conserved domain VI of the vesicular stomatitis virus large polymerase protein essential for mRNA cap methyltransferase activity. J Virol. 2005 Nov;79(21):13373-84. PMID: 16227259 PMCID: PMC1262600 read article


Foster KA, Crowley JJ, Regehr WG. The influence of multivesicular release and postsynaptic receptor saturation on transmission at granule cell to Purkinje cell synapses. J Neurosci. 2005 Dec 14;25(50):11655-65. PubMed PMID: 16354924.


Wang D, Kennedy S, Conte D Jr, Kim JK, Gabel HW, Kamath RS, Mello CC, Ruvkun G. Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants. Nature. 2005 Jul 28;436(7050):593-7. PubMed PMID: 16049496.


Kim JK, Gabel HW, Kamath RS, Tewari M, Pasquinelli A, Rual JF, Kennedy S, Dybbs M, Bertin N, Kaplan JM, Vidal M, Ruvkun G. Functional genomic analysis of RNA interference in C. elegans. Science. 2005 May 20;308(5725):1164-7. Epub 2005 Mar 24. PubMed PMID: 15790806.


Gadea BB, Ruderman JV. Aurora kinase inhibitor ZM447439 blocks chromosome-induced spindle assembly, the completion of chromosome condensation, and the establishment of the spindle integrity checkpoint in Xenopus egg extracts. Mol Biol Cell. 2005 Mar;16(3):1305-18. Epub 2004 Dec 22. PMID: 15616188 PMCID: PMC551494 read article


van den Elzen P, Garg S, Leon L, Brigl M, Leadbetter EA, Gumperz JE, Dascher CC, Cheng TY, Sacks FM, Illarionov PA, Besra GS, Kent SC, Moody DB, Brenner MB. Apolipoprotein-mediated pathways of lipid antigen presentation. Nature. 2005 Oct 6;437(7060):906-10. PMID:16208376


Hong EJ, Villén J, Gerace EL, Gygi SP, Moazed D. A cullin E3 ubiquitin ligase complex associates with Rik1 and the Clr4 histone H3-K9 methyltransferase and is required for RNAi-mediated heterochromatin formation. RNA Biol. 2005 Jul-Sep;2(3):106-11. Epub 2005 Jul 30. PubMed PMID: 17114925.


Greenland JR, Liu H, Berry D, Anderson DG, Kim WK, Irvine DJ, Langer R, Letvin NL. Beta-amino ester polymers facilitate in vivo DNA transfection and adjuvant plasmid DNA immunization. Mol Ther. 2005 Jul;12(1):164-70. PMID: 15963932


Gregory BD, Nickels BE, Darst SA, Hochschild A. An altered-specificity DNA-binding mutant of Escherichia coli sigma70 facilitates the analysis of sigma70 function in vivo. Mol Microbiol. 2005 Jun;56(5):1208-19. PMID: 15882415


Gregory BD, Deighan P, Hochschild A. An artificial activator that contacts a normally occluded surface of the RNA polymerase holoenzyme. J Mol Biol. 2005 Oct 28;353(3):497-506. Epub 2005 Sep 2. PMID: 16185714


Griffin RS. An Epac-dependent pain pathway. J Neurosci. 2005 Sep 7;25(36):8113-4. Review. PubMed PMID: 16148218.


Sen J, Harpavat S, Peters MA, Cepko CL. Retinoic acid regulates the expression of dorsoventral topographic guidance molecules in the chick retina. Development. 2005 Dec;132(23):5147-59. Epub 2005 Oct 26. PubMed PMID: 16251210.


Tolias KF, Bikoff JB, Burette A, Paradis S, Harrar D, Tavazoie S, Weinberg RJ, Greenberg ME. The Rac1-GEF Tiam1 couples the NMDA receptor to the activity-dependent development of dendritic arbors and spines. Neuron. 2005 Feb 17;45(4):525-38. PubMed PMID: 15721239.


Li Z, Burrone J, Tyler WJ, Hartman KN, Albeanu DF, Murthy VN. Synaptic vesicle recycling studied in transgenic mice expressing synaptopHluorin. Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6131-6. Epub 2005 Apr 18. PubMed PMID: 15837917; PubMed Central PMCID: PMC1087931.


Hass MR, Yankner BA. A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein. J Biol Chem. 2005 Nov 4;280(44):36895-904. Epub 2005 Aug 15. PubMed PMID: 16103124; PubMed Central PMCID: PMC1562327.


Schiller PH, Haushofer J. What is the coordinate frame utilized for the generation of express saccades in monkeys? Exp Brain Res. 2005 Nov;167(2):178-86. Epub 2005 Nov 15. PubMed PMID: 16041513.


Farris W, Leissring MA, Hemming ML, Chang AY, Selkoe DJ. Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein. Biochemistry. 2005 May 3;44(17):6513-25. PubMed PMID: 15850385.


Hemming ML, Selkoe DJ. Amyloid beta-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor. J Biol Chem. 2005 Nov 11;280(45):37644-50. Epub 2005 Sep 9. PubMed PMID: 16154999; PubMed Central PMCID: PMC2409196.


Thompson MA, Stumph J, Henrickson SE, Rosenwald A, Wang Q, Olson S, Brandt SJ, Roberts J, Zhang X, Shyr Y, Kinney MC. Differential gene expression in anaplastic lymphoma kinase-positive and anaplastic lymphoma kinase-negative anaplastic large cell lymphomas. Hum Pathol. 2005 May;36(5):494-504. PMID: 15948116


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Wang QY, Zhou C, Johnson KE, Colgrove RC, Coen DM, Knipe DM. Herpesviral latency-associated transcript gene promotes assembly of heterochromatin on viral lytic-gene promoters in latent infection. Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):16055-9. Epub 2005 Oct 24. PMID: 16247011 PMCID: PMC1266038 read article


Chong JA, Moran MM, Teichmann M, Kaczmarek JS, Roeder R, Clapham DE. TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP. Mol Cell Biol. 2005 Apr;25(7):2632-43. PubMed PMID: 15767669; PubMed Central PMCID: PMC1061635.


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Khurana V, Fulga TA, Feany MB. Senseless makes sense for spinocerebellar ataxia-1. Nat Neurosci. 2005 Nov;8(11):1422-4. PubMed PMID: 16251977.


Kimberly WT, Zheng JB, Town T, Flavell RA, Selkoe DJ. Physiological regulation of the beta-amyloid precursor protein signaling domain by c-Jun N-terminal kinase JNK3 during neuronal differentiation. J Neurosci. 2005 Jun 8;25(23):5533-43. PubMed PMID: 15944381.


Chang H, Gwack Y, Kingston D, Souvlis J, Liang X, Means RE, Cesarman E, Hutt-Fletcher L, Jung JU. Activation of CD21 and CD23 gene expression by Kaposi's sarcoma-associated herpesvirus RTA. J Virol. 2005 Apr;79(8):4651-63. PMID: 15795251 PMCID: PMC1069543 read article


Koprivica V, Cho KS, Park JB, Yiu G, Atwal J, Gore B, Kim JA, Lin E, Tessier-Lavigne M, Chen DF, He Z. EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans. Science. 2005 Oct 7;310(5745):106-10. PubMed PMID: 16210539.


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Zigman JM, Nakano Y, Coppari R, Balthasar N, Marcus JN, Lee CE, Jones JE, Deysher AE, Waxman AR, White RD, Williams TD, Lachey JL, Seeley RJ, Lowell BB, Elmquist JK. Mice lacking ghrelin receptors resist the development of diet-induced obesity. J Clin Invest. 2005 Dec;115(12):3564-72. PubMed PMID: 16322794; PubMed Central PMCID: PMC1297251.


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Molyneaux BJ***, Arlotta P***, Hirata T, Hibi M, Macklis JD. Fezl Is Required for the Birth and Specification of Corticospinal Motor Neurons. Neuron. 2005. 47: 817-831. ***Denotes equal contributions.


Arlotta P***, Molyneaux BJ***, Chen J, Inoue J, Kominami R, Macklis JD. Neuronal Subtype Specific Genes that Control Corticospinal Motor Neuron Development in vivo. Neuron. 2005. 45: 207-21. (With preview and cover). ***Denotes equal contributions.


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Chong JA, Moran MM, Teichmann M, Kaczmarek JS, Roeder R, Clapham DE. TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP. Mol Cell Biol. 2005 Apr;25(7):2632-43. PubMed PMID: 15767669; PubMed Central PMCID: PMC1061635.


Olveczky BP, Andalman AS, Fee MS. Vocal experimentation in the juvenile songbird requires a basal ganglia circuit. PLoS Biol. 2005 May;3(5):e153. Epub 2005 Mar 29. PubMed PMID: 15826219; PubMed Central PMCID: PMC1069649.


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Pacholec M, Freel Meyers CL, Oberthür M, Kahne D, Walsh CT. Characterization of the aminocoumarin ligase SimL from the simocyclinone pathway and tandem incubation with NovM,P,N from the novobiocin pathway. Biochemistry. 2005 Mar 29;44(12):4949-56. PMID: 15779922


Pacholec M, Hillson NJ, Walsh CT. NovJ/NovK catalyze benzylic oxidation of a beta-hydroxyl tyrosyl-S-pantetheinyl enzyme during aminocoumarin ring formation in novobiocin biosynthesis. Biochemistry. 2005 Sep 27;44(38):12819-26. PMID: 16171397


Pacholec M, Tao J, Walsh CT. CouO and NovO: C-methyltransferases for tailoring the aminocoumarin scaffold in coumermycin and novobiocin antibiotic biosynthesis. Biochemistry. 2005 Nov 15;44(45):14969-76. PMID: 16274243


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Landsberg RL, Awatramani RB, Hunter NL, Farago AF, DiPietrantonio HJ, Rodriguez CI, Dymecki SM. Hindbrain rhombic lip is comprised of discrete progenitor cell populations allocated by Pax6. Neuron. 2005 Dec 22;48(6):933-47. PubMed PMID: 16364898.


Song B, Diaz-Griffero F, Park DH, Rogers T, Stremlau M, Sodroski J. TRIM5alpha association with cytoplasmic bodies is not required for antiretroviral activity. Virology. 2005 Dec 20;343(2):201-11. Epub 2005 Sep 22. PMID: 16183097


Rooney S, Alt FW, Sekiguchi J, Manis JP. Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and development. Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2471-5. Epub 2005 Feb 7. PMID: 15699324.


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Ohmura K, Johnsen A, Ortiz-Lopez A, Desany P, Roy M, Besse W, Rogus J, Bogue M, Puech A, Lathrop M, Mathis D, Benoist C. Variation in IL-1beta gene expression is a major determinant of genetic differences in arthritis aggressivity in mice. Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12489-94. Epub 2005 Aug 19. PubMed PMID: 16113081; PubMed Central PMCID: PMC1194932.


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Chakravarti S, Sabatos CA, Xiao S, Illes Z, Cha EK, Sobel RA, Zheng XX, Strom TB, Kuchroo VK. Tim-2 regulates T helper type 2 responses and autoimmunity. J Exp Med. 2005 Aug 1;202(3):437-44. Epub 2005 Jul 25. Erratum in: J Exp Med. 2005 Sep 19;202(6):877. PubMed PMID: 16043519; PubMed Central PMCID: PMC2213076.


Safo PK, Regehr WG. Endocannabinoids control the induction of cerebellar LTD. Neuron. 2005 Nov 23;48(4):647-59. PubMed PMID: 16301180.


Westbrook TF, Martin ES, Schlabach MR, Leng Y, Liang AC, Feng B, Zhao JJ, Roberts TM, Mandel G, Hannon GJ, Depinho RA, Chin L, Elledge SJ. A genetic screen for candidate tumor suppressors identifies REST. Cell. 2005 Jun 17;121(6):837-48. PubMed PMID: 15960972.


Halin C, Scimone ML, Bonasio R, Gauguet JM, Mempel TR, Quackenbush E, Proia RL, Mandala S, von Andrian UH. The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches. Blood. 2005 Aug 15;106(4):1314-22. Epub 2005 May 3. PubMed PMID: 15870184; PubMed Central PMCID: PMC1895188.


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Klyubin I, Walsh DM, Lemere CA, Cullen WK, Shankar GM, Betts V, Spooner ET, Jiang L, Anwyl R, Selkoe DJ, Rowan MJ. Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo. Nat Med. 2005 May;11(5):556-61. Epub 2005 Apr 17. PubMed PMID: 15834427.


Walsh DM, Townsend M, Podlisny MB, Shankar GM, Fadeeva JV, El Agnaf O, Hartley DM, Selkoe DJ. Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation. J Neurosci. 2005 Mar 9;25(10):2455-62. Erratum in: J Neurosci. 2005 May 4;25(18):4658. PubMed PMID: 15758153.


Cleary JP, Walsh DM, Hofmeister JJ, Shankar GM, Kuskowski MA, Selkoe DJ, Ashe KH. Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function. Nat Neurosci. 2005 Jan;8(1):79-84. Epub 2004 Dec 19. PubMed PMID: 15608634.


Shen J, Walsh CA. Targeted disruption of Tgif, the mouse ortholog of a human holoprosencephaly gene, does not result in holoprosencephaly in mice. Mol Cell Biol. 2005 May;25(9):3639-47. PubMed PMID: 15831469; PubMed Central PMCID: PMC1084278.


Shen J, Eyaid W, Mochida GH, Al-Moayyad F, Bodell A, Woods CG, Walsh CA. ASPM mutations identified in patients with primary microcephaly and seizures. J Med Genet. 2005 Sep;42(9):725-9. PubMed PMID: 16141009; PubMed Central PMCID: PMC1736131.


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Stanford JS, Ruderman JV. Changes in regulatory phosphorylation of Cdc25C Ser287 and Wee1 Ser549 during normal cell cycle progression and checkpoint arrests. Mol Biol Cell. 2005 Dec;16(12):5749-60. Epub 2005 Sep 29. PMID: 16195348 PMCID: PMC1289418 read article


Stolt PC, Chen Y, Liu P, Bock HH, Blacklow SC, Herz J. Phosphoinositide binding by the disabled-1 PTB domain is necessary for membrane localization and Reelin signal transduction. J Biol Chem. 2005 Mar 11;280(10):9671-7. Epub 2005 Jan 4. PMID: 15632144


Lord GM, Rao RM, Choe H, Sullivan BM, Lichtman AH, Luscinskas FW, Glimcher LH. T-bet is required for optimal pro-inflammatoy CD4+ T cell trafficking. Blood. 106(10):3432-9, 2005.


Sullivan BM***, Jobe O***, Lazarevic V***, Vasquez K, Bronson R, Glimcher LH, Kramnik Increased susceptibility of mice lacking T-bet to infection with Mycobacterium tuberculosis correlates with increased IL-10 and decreased IFN-gamma production. J. Immunol. 175(7):4593-602, 2005.


Woodberry T, Suscovich TJ, Henry LM, Davis JK, Frahm N, Walker BD, Scadden DT, Wang F, Brander C. Differential targeting and shifts in the immunodominance of Epstein-Barr virus--specific CD8 and CD4 T cell responses during acute and persistent infection. J Infect Dis. 2005 Nov 1;192(9):1513-24. Epub 2005 Sep 26. PMID: 16206065


Woodberry T, Suscovich TJ, Henry LM, Martin JN, Dollard S, O'Connor PG, Davis JK, Osmond D, Lee TH, Kedes DH, Khatri A, Lee J, Walker BD, Scadden DT, Brander C. Impact of Kaposi sarcoma-associated herpesvirus (KSHV) burden and HIV coinfection on the detection of T cell responses to KSHV ORF73 and ORF65 proteins. J Infect Dis. 2005 Aug 15;192(4):622-9. Epub 2005 Jul 15. PMID: 16028131


Brodsky AS, Meyer CA, Swinburne IA, Hall G, Keenan BJ, Liu XS, Fox EA, Silver PA. Genomic mapping of RNA polymerase II reveals sites of co-transcriptional regulation in human cells. PMID: 16086846 PMCID: PMC1273631 read article


Tolias KF, Bikoff JB, Burette A, Paradis S, Harrar D, Tavazoie S, Weinberg RJ, Greenberg ME. The Rac1-GEF Tiam1 couples the NMDA receptor to the activity-dependent development of dendritic arbors and spines. Neuron. 2005 Feb 17;45(4):525-38. PubMed PMID: 15721239.


Tavazoie SF, Alvarez VA, Ridenour DA, Kwiatkowski DJ, Sabatini BL. Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2. Nat Neurosci. 2005 Dec;8(12):1727-34. Epub 2005 Nov 6. PubMed PMID: 16286931.


Olesky M, McNamee EE, Zhou C, Taylor TJ, Knipe DM. Evidence for a direct interaction between HSV-1 ICP27 and ICP8 proteins. Virology. 2005 Jan 5;331(1):94-105. PMID: 15582656


Medoff BD, Thomas SY, Banerji A, Wain JC, Zhang H, Lilly CM, Ginns LC, Luster AD. Pathogenic T-cell recruitment into the airway in human disease. Ann N Y Acad Sci. 2005 Dec;1062:220-41. PMID: 16461804


Bromley SK, Thomas SY, Luster AD. Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics. Nat Immunol. 2005 Sep;6(9):895-901. Epub 2005 Aug 14. PMID: 16116469


Medoff BD, Seung E, Wain JC, Means TK, Campanella GS, Islam SA, Thomas SY, Ginns LC, Grabie N, Lichtman AH, Tager AM, Luster AD. BLT1-mediated T cell trafficking is critical for rejection and obliterative bronchiolitis after lung transplantation. J Exp Med. 2005 Jul 4;202(1):97-110. PMID: 15998790 PMCID: PMC2212891 read article


Tischfield MA, Bosley TM, Salih MA, Alorainy IA, Sener EC, Nester MJ, Oystreck DT, Chan WM, Andrews C, Erickson RP, Engle EC. Homozygous HOXA1 mutations disrupt human brainstem, inner ear, cardiovascular and cognitive development. Nat Genet. 2005 Oct;37(10):1035-7. Epub 2005 Sep 11. PubMed PMID: 16155570.


Conway BR, Tsao DY. Color architecture in alert macaque cortex revealed by FMRI. Cereb Cortex. 2006 Nov;16(11):1604-13. Epub 2005 Dec 28. Erratum in: Cereb Cortex. 2006 Dec;16(12):1820. PubMed PMID: 16400160.


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Johnnidis JB, Venanzi ES, Taxman DJ, Ting JP, Benoist CO, Mathis DJ. Chromosomal clustering of genes controlled by the aire transcription factor. Proc Natl Acad Sci U S A. 2005 May 17;102(20):7233-8. Epub 2005 May 9. PubMed PMID: 15883360; PubMed Central PMCID: PMC1129145.


Anderson MS, Venanzi ES, Chen Z, Berzins SP, Benoist C, Mathis D. The cellular mechanism of Aire control of T cell tolerance. Immunity. 2005 Aug;23(2):227-39. PubMed PMID: 16111640.


Villaseñor J, Benoist C, Mathis D. AIRE and APECED: molecular insights into an autoimmune disease. Immunol Rev. 2005 Apr;204:156-64. Review. PubMed PMID: 15790357.


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Wang D, Kennedy S, Conte D Jr, Kim JK, Gabel HW, Kamath RS, Mello CC, Ruvkun G. Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants. Nature. 2005 Jul 28;436(7050):593-7. PubMed PMID: 16049496.


Zheng G, Patolsky F, Cui Y, Wang WU, Lieber CM. Multiplexed electrical detection of cancer markers with nanowire sensor arrays. Nat Biotechnol. 2005 Oct;23(10):1294-301. Epub 2005 Sep 18. PMID: 16170313


Wang WU, Chen C, Lin KH, Fang Y, Lieber CM. Label-free detection of small-molecule-protein interactions by using nanowire nanosensors. Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3208-12. Epub 2005 Feb 16. PMID: 15716362 PMCID: PMC548960 read article


Wein MN, Jones DC, Glimcher LH. Turning down the system: counter-regulatory mechanisms in bone and adaptive immunity. Immunol Rev. 2005 Dec;208:66-79. Review. PMID: 16313341


Shinohara ML, Jansson M, Hwang ES, Werneck MB, Glimcher LH, Cantor H.T-bet- dependent expression of osteopontin contributes to T cell polarization. Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17101-6. Epub 2005 Nov 14. PubMed PMID: 16286640; PubMed Central PMCID: PMC1288014.


Whalen BM, Selkoe DJ, Hartley DM. Small non-fibrillar assemblies of amyloid
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Galloway JL, Wingert RA, Thisse C, Thisse B, Zon LI. Loss of gata1 but not gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos. Dev Cell. 2005 Jan;8(1):109-16. PMID: 15621534


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Koprivica V, Cho KS, Park JB, Yiu G, Atwal J, Gore B, Kim JA, Lin E, Tessier-Lavigne M, Chen DF, He Z. EGFR Activation Mediates Inhibition of Axon Regeneration by Myelin and Chondroitin Sulfate Proteoglycans. Science. 2005 Oct 7;310(5745):106-10. PMID: 16210539.


Park JB**, Yiu G**, Kaneko S, Wang J, Chang J, He Z. A TNF Receptor Family Member, TROY, Is a Coreceptor with Nogo Receptor in Mediating the Inhibitory Activity of Myelin Inhibitors. Neuron. 2005 Feb 3;45(3):345-51. Cover Article. PMID: 15694321. **Denotes equal contribution.


Zhang Y, Reid RC. Single-neuron responses and neuronal decisions in a vernier task. Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3507-12. Epub 2005 Feb 22. PubMed PMID: 15728369; PubMed Central PMCID: PMC552948.


top

2004


Sklar PA, Agyemang AF, Monastra R, Kress DR, Metcalf JA, Robinson MR, Masur H, Polis MA.. Five-year follow-up of a cohort of profoundly immunosuppressed patients discontinuing therapy for cytomegalovirus retinitis. AIDS. 2004 Feb 20;18(3):567-9. PMID: 15090813


Altevogt BM, Paul DL. Four classes of intercellular channels between glial cells in the CNS. J Neurosci. 2004 May 5;24(18):4313-23. PubMed PMID: 15128845.


Nelson EA, Walker SR, Alvarez JV, Frank DA. Isolation of unique STAT5 targets by chromatin immunoprecipitation-based gene identification. J Biol Chem. 2004 Dec 24;279(52):54724-30. Epub 2004 Oct 20. PMID: 15498775


Alvarez JV, Frank DA. Genome-wide analysis of STAT target genes: elucidating the mechanism of STAT-mediated oncogenesis. Cancer Biol Ther. 2004 Nov;3(11):1045-50. Epub 2004 Nov 22. PMID: 15539936


Loregian A, Appleton BA, Hogle JM, Coen DM. Specific residues in the connector loop of the human cytomegalovirus DNA polymerase accessory protein UL44 are crucial for interaction with the UL54 catalytic subunit. J Virol. 2004 Sep;78(17):9084-92. PMID: 15308704 PMCID: PMC506919  read article


Appleton BA, Loregian A, Filman DJ, Coen DM, Hogle JM. The cytomegalovirus DNA polymerase subunit UL44 forms a C clamp-shaped dimer. Mol Cell. 2004 Jul 23;15(2):233-44. PMID: 15260974


Loregian A, Appleton BA, Hogle JM, Coen DM. Residues of human cytomegalovirus DNA polymerase catalytic subunit UL54 that are necessary and sufficient for interaction with the accessory protein UL44. J Virol. 2004 Jan;78(1):158-67. PMID: 14671097 PMCID: PMC303418 read article


Arnett KL, Harrison SC, Wiley DC. Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment. Proc Natl Acad Sci U S A. 2004 Nov 16;101(46):16268-73. Epub 2004 Nov 8. PubMed PMID: 15534202; PubMed Central PMCID: PMC528977.


Yin P, Keirstead ND, Broering TJ, Arnold MM, Parker JS, Nibert ML, Coombs KM. Comparisons of the M1 genome segments and encoded mu2 proteins of different reovirus isolates. Virol J. 2004 Sep 23;1:6. PMID: 15507160 PMCID: PMC524354 read article


Kurt-Jones EA, Chan M, Zhou S, Wang J, Reed G, Bronson R, Arnold MM, Knipe DM, Finberg RW. Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis. Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1315-20. Epub 2004 Jan 22. PMID: 14739339 PMCID: PMC337050 read article


Asthana S, King OD, Gibbons FD, Roth FP. Predicting protein complex membership using probabilistic network reliability. Genome Res. 2004 Jun;14(6):1170-5. Epub 2004 May 12. PMID: 15140827 PMCID: PMC419795 read article


Hillson NJ, Balibar CJ, Walsh CT. Catalytically inactive condensation domain C1 is responsible for the dimerization of the VibF subunit of vibriobactin synthetase. Biochemistry. 2004 Sep 7;43(35):11344-51. PMID: 15366944


Steele LN, Balsara ZR, Starnbach MN. Hematopoietic cells are required to initiate a Chlamydia trachomatis-specific CD8+ T cell response. J Immunol. 2004 Nov 15;173(10):6327-37. PMID: 15528372.


Rutishauser RL, Basu AC, Cromarty SI, Kravitz EA. Long-term consequences of agonistic interactions between socially naive juvenile American lobsters (Homarus americanus). Biol Bull. 2004 Dec;207(3):183-7. PubMed PMID: 15616347.


Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP. Phosphoproteomic analysis of the developing mouse brain. Mol Cell Proteomics. 2004 Nov;3(11):1093-101. Epub 2004 Sep 2. PMID: 5345747


Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP. Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12130-5. Epub 2004 Aug 9. PMID: 15302935 PMCID: PMC514446 read article


On M, Billingsley JM, Jouvin MH, Kinet JP. Molecular dissection of the FcRbeta signaling amplifier. J Biol Chem. 2004 Oct 29;279(44):45782-90. Epub 2004 Aug 30. PubMed PMID: 15339926.


Repasky J, Corbett E, Boboila C, Schatz DG. Mutational analysis of terminal ofdeoxynucleotidyl transferase-mediated N-nucleotide addition in V(D)J recombination, J Immunol. 2004;172(9):5478-88. J Immunol. 2004;172(9):5478-88.


Borowski C, Li X, Aifantis I, Gounari F, von Boehmer H. Pre-TCRalpha and TCRalpha are not interchangeable partners of TCRbeta during T lymphocyte development. J Exp Med. 2004 Mar 1;199(5):607-15.


Boyce M, Degterev A, Yuan J. Caspases: an ancient cellular sword of Damocles. Cell Death Differ. 2004 Jan;11(1):29-37. PMID: 14647235


Casolari JM, Brown CR, Komili S, West J, Hieronymus H, Silver PA*. Genome-wide localization of the nuclear transport machinery reveals coupling of transcriptional status and nuclear organization. Cell. 2004. May 14; 117(4):427-39. PMID: 15137937.


Chen J, Wall NR, Kocher K, Duclos N, Fabbro D, Neuberg D, Griffin JD, Shi Y, Gilliland DG. Stable expression of small interfering RNA sensitizes TEL-PDGFbetaR to inhibition with imatinib or rapamycin. J Clin Invest. 2004 Jun;113(12):1784-91. PubMed PMID: 15199413; PubMed Central PMCID: PMC420507.


Call ME, Wucherpfennig KW. Molecular mechanisms for the assembly of the T cell receptor-CD3 complex. Mol Immunol. 2004 Apr;40(18):1295-305. Review. PubMed PMID: 15072848.


Call ME, Pyrdol J, Wucherpfennig KW. Stoichiometry of the T-cell receptor-CD3 complex and key intermediates assembled in the endoplasmic reticulum. EMBO J. 2004 Jun 16;23(12):2348-57. Epub 2004 May 20. PubMed PMID: 15152191; PubMed Central PMCID: PMC423287.


Carter AG, Sabatini BL. State-dependent calcium signaling in dendritic spines of striatal medium spiny neurons. Neuron. 2004 Oct 28;44(3):483-93. PubMed PMID: 15504328.


Catapano LA, Arlotta P, Cage TA, Macklis JD. Stage-specific and opposing roles of BDNF, NT-3 and bFGF in differentiation of purified callosal projection neurons toward cellular repair of complex circuitry. Eur J Neurosci. 2004 May;19(9):2421-34. PubMed PMID: 15128396.


Chae TH, Kim S, Marz KE, Hanson PI, Walsh CA. The hyh mutation uncovers roles for alpha Snap in apical protein localization and control of neural cell fate. Nat Genet. 2004 Mar;36(3):264-70. Epub 2004 Feb 1. Erratum in: Nat Genet. 2004 Apr;36(4):427. PubMed PMID: 14758363.


Hamar P, Song E, Kokeny G, Chen A, Ouyang N, Lieberman J. Small interfering RNA targeting Fas protects mice against renal ischemia-reperfusion injury. Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14883-8.


Deng LW, Chiu I, Strominger JL. MLL 5 protein forms intranuclear foci, and overexpression inhibits cell cycle progression. Proc Natl Acad Sci U S A. 2004 Jan 20;101(3):757-62. Epub 2004 Jan 12. PMID: 14718661.


Zhang M, Austen WG Jr, Chiu I, Alicot EM, Hung R, Ma M, Verna N, Xu M, Hechtman HB, Moore FD Jr, Carroll MC. Identification of a specific self-reactive IgM antibody that initiates intestinal ischemia/reperfusion injury. Proc Natl Acad Sci U S A. 2004 Mar 16;101(11):3886-91. Epub 2004 Mar 3. PMID: 14999103.


Takahashi TS, Yiu P, Chou MF, Gygi S, Walter JC. Recruitment of Xenopus Scc2 and cohesin to chromatin requires the pre-replication complex. Nat Cell Biol. 2004 Oct;6(10):991-6. Epub 2004 Sep 26. PubMed PMID: 15448702.


Chou TC, Rotman SR, Saper CB. Lateral hypothalamic acetylcholinesterase-immunoreactive neurons co-express either orexin or melanin concentrating hormone. Neurosci Lett. 2004 Nov 11;370(2-3):123-6. PubMed PMID: 15488307.


Gerashchenko D, Chou TC, Blanco-Centurion CA, Saper CB, Shiromani PJ. Effects of lesions of the histaminergic tuberomammillary nucleus on spontaneous sleep in rats. Sleep. 2004 Nov 1;27(7):1275-81. PubMed PMID: 15586780; PubMed Central PMCID: PMC1249486.


Chyung JH, Raper DM, Selkoe DJ. Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage. J Biol Chem. 2005 Feb 11;280(6):4383-92. Epub 2004 Nov 29. PubMed PMID: 15569674.


Ciccone DN, Morshead KB, Oettinger MA. Chromatin immunoprecipitation in the analysis of large chromatin domains across murine antigen receptor loci. Methods Enzymol. 2004;376:334-48. Review. PubMed PMID: 14975316.


Claypool SM, Dickinson BL, Wagner J, Johansen FE, Nanda Venu, Borawski J, Lencer WI, Blumberg RS. Bi-directional Transepithelial IgG Transport by a Strongly Polarized Basolateral Membrane Fcg-Receptor. Mol. Biol. Cell. 2004 Apr;15(4): 1746-59. PMCID: PMC379272.


Yoshida M, Claypool SM, Wagner JS, Mizoguchi E, Mizoguchi A, Roopenian DC, Lencer WI, Blumberg RS. Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells. Immunity. 2004 Jun;20(6): 769-83. PMID: 1518974.


Motamedi MR, Verdel A, Colmenares SU, Gerber SA, Gygi SP, Moazed D*. Two RNAi complexes, RITS and RDRC, physically interact and localize to noncoding centromeric RNAs. Cell. 2004 Dec 17;119(6):789-802. PubMed PMID: 15607976.


Cooper EM, Hudson AW, Amos J, Wagstaff J, Howley PM. Biochemical analysis of Angelman syndrome-associated mutations in the E3 ubiquitin ligase E6-associated protein. J Biol Chem. 2004 Sep 24;279(39):41208-17. Epub 2004 Jul 19. PubMed PMID: 15263005.


Cortés M, Georgopoulos K. Aiolos is required for the generation of high affinity bone marrow plasma cells responsible for long-term immunity. J Exp Med. 2004 Jan 19;199(2):209-19. Epub 2004 Jan 12. PubMed PMID: 14718515; PubMed Central PMCID: PMC2211773.


Kiepiela P, Leslie AJ, Honeyborne I, Ramduth D, Thobakgale C, Chetty S, Rathnavalu P, Moore C, Pfafferott KJ, Hilton L, Zimbwa P, Moore S, Allen T, Brander C, Addo MM, Altfeld M, James I, Mallal S, Bunce M, Barber LD, Szinger J, Day C, Klenerman P, Mullins J, Korber B, Coovadia HM, Walker BD, Goulder PJ. Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA. Nature. 2004 Dec 9;432(7018):769-75. PMID 15592417


Lauer GM, Barnes E, Lucas M, Timm J, Ouchi K, Kim AY, Day CL, Robbins GK, Casson DR, Reiser M, Dusheiko G, Allen TM, Chung RT, Walker BD, Klenerman P. High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection. Gastroenterology. 2004 Sep;127(3):924-36. PMID: 15362047


Völgyi B, Deans MR, Paul DL, Bloomfield SA. Convergence and segregation of the multiple rod pathways in mammalian retina. J Neurosci. 2004 Dec
8;24(49):11182-92. PubMed PMID: 15590935; PubMed Central PMCID: PMC2834589.


Dekker JP, Fodor A, Aldrich RW, Yellen G. A perturbation-based method for calculating explicit likelihood of evolutionary co-variance in multiple sequence alignments. Bioinformatics. 2004 Jul 10;20(10):1565-72. Epub 2004 Feb 12. PubMed PMID: 14962924.


Webster SM, Del Camino D, Dekker JP, Yellen G. Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges. Nature. 2004 Apr 22;428(6985):864-8. PubMed PMID: 15103379.


Ansel KM, Greenwald RJ, Agarwal S, Bassing CH, Monticelli S, Interlandi J, Djuretic IM, Lee DU, Sharpe AH, Alt FW, Rao A. Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity. Nat Immunol. 2004 Dec;5(12):1251-9. Epub 2004 Oct 31. PubMed PMID: 15516924.


Do MT, Bean BP. Sodium currents in subthalamic nucleus neurons from Nav1.6-null mice. J Neurophysiol. 2004 Aug;92(2):726-33. Epub 2004 Mar 31. PubMed PMID: 15056687.


Miller AJ, Du J, Rowan S, Hershey CL, Widlund HR, Fisher DE. Transcriptional regulation of the melanoma prognostic marker melastatin (TRPM1) by MITF in melanocytes and melanoma. Cancer Res. 2004 Jan 15;64(2):509-16. PMID: 14744763


Vetrini F, Auricchio A, Du J, Angeletti B, Fisher DE, Ballabio A, Marigo V. The microphthalmia transcription factor (Mitf) controls expression of the ocular albinism type 1 gene: link between melanin synthesis and melanosome biogenesis. Mol Cell Biol. 2004 Aug;24(15):6550-9. PMID: 15254223 PMCID: PMC444869 read article


Du J, Widlund HR, Horstmann MA, Ramaswamy S, Ross K, Huber WE, Nishimura EK, Golub TR, Fisher DE. Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF. Cancer Cell. 2004 Dec;6(6):565-76. PMID: 15607961


Bentires-Alj M, Paez JG, David FS, Keilhack H, Halmos B, Naoki K, Maris JM, Richardson A, Bardelli A, Sugarbaker DJ, Richards WG, Du J, Girard L, Minna JD, Loh ML, Fisher DE, Velculescu VE, Vogelstein B, Meyerson M, Sellers WR, Neel BG. Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia. Cancer Res. 2004 Dec 15;64(24):8816-20. PMID: 15604238


Talukder SR, Dudley DD, Alt FW, Takahama Y, Akamatsu Y. Increased frequency of aberrant V(D)J recombination products in core RAG-expressing mice. Nucleic Acids Res. 2004 Aug 24;32(15):4539-49. Print 2004. PMID: 15328366.


Everley PA, Krijgsveld J, Zetter BR, Gygi SP. Quantitative cancer proteomics: stable isotope labeling with amino acids in cell culture (SILAC) as a tool for prostate cancer research. Mol Cell Proteomics. 2004 Jul;3(7):729-35. Epub 2004 Apr 21. PMID: 15102926


Gilks N, Kedersha N, Ayodele M, Shen L, Stoecklin G, Dember LM, Anderson P. Stress granule assembly is mediated by prion-like aggregation of TIA-1. Mol Biol Cell. 2004. Dec;15(12):5383-98. PMC532018.


Li W, Kedersha N, Chen S, Gilks N, Lee G, Anderson P. FAST is a BCL-X(L)-associated mitochondrial protein. Biochem Biophys Res Commun. 2004. May 21;318(1):95-102. PMID: 15110758.


Fontaine-Rodriguez EC, Taylor TJ, Olesky M, Knipe DM. Proteomics of herpes simplex virus infected cell protein 27: association with translation initiation factors. Virology. 2004 Dec 20;330(2):487-92. PMID: 15567442


Foster KA, Regehr WG. Variance-mean analysis in the presence of a rapid antagonist indicates vesicle depletion underlies depression at the climbing fiber synapse. Neuron. 2004 Jul 8;43(1):119-31. PubMed PMID: 15233922.


Cuervo AM, Stefanis L, Fredenburg R, Lansbury PT, Sulzer D. Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science. 2004 Aug 27;305(5688):1292-5. PMID: 15333840


Li S, Armstrong CM, Bertin N, Ge H, Milstein S, Boxem M, Vidalain PO, Han JD, Chesneau A, Hao T, Goldberg DS, Li N, Martinez M, Rual JF, Lamesch P, Xu L, Tewari M, Wong SL, Zhang LV, Berriz GF, Jacotot L, Vaglio P, Reboul J, Hirozane-Kishikawa T, Li Q, Gabel HW, Elewa A, Baumgartner B, Rose DJ, Yu H, Bosak S, Sequerra R, Fraser A, Mango SE, Saxton WM, Strome S, Van Den Heuvel S, Piano F, Vandenhaute J, Sardet C, Gerstein M, Doucette-Stamm L, Gunsalus KC, Harper JW, Cusick ME, Roth FP, Hill DE, Vidal M. A map of the interactome network of the metazoan C. elegans. Science. 2004 Jan 23;303(5657):540-3. Epub 2004 Jan 2. PubMed PMID: 14704431; PubMed Central PMCID: PMC1698949.


Crane R, Gadea B, Littlepage L, Wu H, Ruderman JV. Aurora A, meiosis and mitosis. Biol Cell. 2004 Apr;96(3):215-29. PMID: 15182704


Giraud J, Leshan R, Lee YH, White MF. Nutrient-dependent and insulin-stimulated phosphorylation of insulin receptor substrate-1 on serine 302 correlates with increased insulin signaling. J Biol Chem. 2004 Jan 30;279(5):3447-54. Epub 2003 Nov 17. PMID: 14623899


Gregory BD, Nickels BE, Garrity SJ, Severinova E, Minakhin L, Urbauer RJ, Urbauer JL, Heyduk T, Severinov K, Hochschild A. A regulator that inhibits transcription by targeting an intersubunit interaction of the RNA polymerase holoenzyme. PMID: 15070756 PMCID: PMC384785 read article


Pineda M, Gregory BD, Szczypinski B, Baxter KR, Hochschild A, Miller ES, Hinton DM. A family of anti-sigma70 proteins in T4-type phages and bacteria that are similar to AsiA, a Transcription inhibitor and co-activator of bacteriophage T4. J Mol Biol. 2004 Dec 10;344(5):1183-97. PMID: 15561138


Bezzerides VJ, Ramsey IS, Kotecha S, Greka A, Clapham DE. Rapid vesicular translocation and insertion of TRP channels. Nat Cell Biol. 2004 Aug;6(8):709-20. Epub 2004 Jul 18. PubMed PMID: 15258588.


Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL. Genomic analysis of mouse retinal development. PLoS Biol. 2004 Sep;2(9):E247. Epub 2004 Jun 29. PubMed PMID: 15226823; PubMed Central PMCID: PMC439783.


Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G. Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):360-5. Epub 2003 Dec 22. PMID: 14691248 PMCID: PMC314190 read article


Heerssen HM, Pazyra MF, Segal RA. Dynein motors transport activated Trks to promote survival of target-dependent neurons. Nat Neurosci. 2004 Jun;7(6):596-604. Epub 2004 May 2. PubMed PMID: 15122257.


Mempel TR, Henrickson SE, Von Andrian UH. T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature. 2004 Jan 8;427(6970):154-9. PMID: 14712275


Cahir-McFarland ED, Carter K, Rosenwald A, Giltnane JM, Henrickson SE, Staudt LM, Kieff E. Role of NF-kappa B in cell survival and transcription of latent membrane protein 1-expressing or Epstein-Barr virus latency III-infected cells. J Virol. 2004 Apr;78(8):4108-19. PMID: 15047827 PMCID: PMC374271


Andres PG, Howland KC, Nirula A, Kane LP, Barron L, Dresnek D, Sadra A, Imboden J, Weiss A, Abbas AK. Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation. Nat Immunol. 2004 Apr;5(4):435-42. Epub 2004 Mar 7.


Andres PG, Howland KC, Dresnek D, Edmondson S, Abbas AK, Krummel MF. CD28 signals in the immature immunological synapse. J Immunol. 2004 May 15;172(10):5880-6.


Hutti JE, Jarrell ET, Chang JD, Abbott DW, Storz P, Toker A, Cantley LC*, Turk BE. A rapid method for determining protein kinase specificity. Nature Methods. 2004. 1(1):27-29. PMID: 15782149.


Jackson AC, Yao GL, Bean BP. Mechanism of spontaneous firing in dorsomedial suprachiasmatic nucleus neurons. J Neurosci. 2004 Sep 15;24(37):7985-98. PubMed PMID: 15371499.


Seaman MS, Peyerl FW, Jackson SS, Lifton MA, Gorgone DA, Schmitz JE, Letvin NL. Subsets of memory cytotoxic T lymphocytes elicited by vaccination influence the efficiency of secondary expansion in vivo. J Virol. 2004 Jan;78(1):206-15. PubMed PMID: 14671102; PubMed Central PMCID: PMC303428.


Sumida SM, Truitt DM, Kishko MG, Arthur JC, Jackson SS, Gorgone DA, Lifton MA, Koudstaal W, Pau MG, Kostense S, Havenga MJ, Goudsmit J, Letvin NL, Barouch DH. Neutralizing antibodies and CD8+ T lymphocytes both contribute to immunity to adenovirus serotype 5 vaccine vectors. J Virol. 2004 Mar;78(6):2666-73. PubMed PMID: 14990686; PubMed Central PMCID: PMC353774.


McKay PF, Barouch DH, Santra S, Sumida SM, Jackson SS, Gorgone DA, Lifton MA, Letvin NL. Recruitment of different subsets of antigen-presenting cells selectively modulates DNA vaccine-elicited CD4+ and CD8+ T lymphocyte responses. Eur J Immunol. 2004 Apr;34(4):1011-20. PubMed PMID: 15048711.


Sumida SM, McKay PF, Truitt DM, Kishko MG, Arthur JC, Seaman MS, Jackson SS, Gorgone DA, Lifton MA, Letvin NL, Barouch DH. Recruitment and expansion of dendritic cells in vivo potentiate the immunogenicity of plasmid DNA vaccines. J Clin Invest. 2004 Nov;114(9):1334-42. PubMed PMID: 15520866; PubMed Central PMCID: PMC524232.


Peacock JW, Nordone SK, Jackson SS, Liao HX, Letvin NL, Yafal AG, Gritz L, Mazzara GP, Haynes BF, Staats HF. Gender differences in human immunodeficiency virus type 1-specific CD8 responses in the reproductive tract and colon following nasal peptide priming and modified vaccinia virus Ankara boosting. J Virol. 2004 Dec;78(23):13163-72. PubMed PMID: 15542668; PubMed Central PMCID: PMC524967.


Sumida SM, Truitt DM, Kishko MG, Arthur JC, Jackson SS, Gorgone DA, Lifton MA, Koudstaal W, Pau MG, Kostense S, Havenga MJ, Goudsmit J, Letvin NL, Barouch DH. Neutralizing antibodies and CD8+ T lymphocytes both contribute to immunity to adenovirus serotype 5 vaccine vectors. J Virol. 2004 Mar;78(6):2666-73. PubMed PMID: 14990686; PubMed Central PMCID: PMC353774.


Sakata Y, Xiang F, Chen Z, Kiriyama Y, Kamei CN, Simon DI, Chin MT. Transcription factor CHF1/Hey2 regulates neointimal formation in vivo and vascular smooth muscle proliferation and migration in vitro. Arterioscler Thromb Vasc Biol. 2004 Nov;24(11):2069-74. Epub 2004 Sep 2. PubMed PMID: 15345511.


Mitra P, Zhang Y, Rameh LE, Ivshina MP, McCollum D, Nunnari JJ, Hendricks GM, Kerr ML, Field SJ, Cantley LC, Ross AH. A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast. J Cell Biol. 2004 Jul 19;166(2):205-11. Epub 2004 Jul 12. PubMed PMID: 15249580; PubMed Central PMCID: PMC2172303.


Fraering PC, LaVoie MJ, Ye W, Ostaszewski BL, Kimberly WT, Selkoe DJ, Wolfe MS. Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex. Biochemistry. 2004 Jan 20;43(2):323-33. PubMed PMID: 14717586.


Beffert U, Weeber EJ, Morfini G, Ko J, Brady ST, Tsai LH, Sweatt JD, Herz J. Reelin and cyclin-dependent kinase 5-dependent signals cooperate in regulating neuronal migration and synaptic transmission. J Neurosci. 2004 Feb 25;24(8):1897-906. PubMed PMID: 14985430.


Chylack LT Jr, Fu L, Mancini R, Martin-Rehrmann MD, Saunders AJ, Konopka G, Tian D, Hedley-Whyte ET, Folkerth RD, Goldstein LE. Lens epithelium-derived growth factor (LEDGF/p75) expression in fetal and adult human brain. Exp Eye Res. 2004 Dec;79(6):941-8. PubMed PMID: 15642333.


He Z, Koprivica V. The Nogo signaling pathway for regeneration block. Annu Rev Neurosci. 2004;27:341-68. Review. PubMed PMID: 15217336.


Morris JR, Petrov DA, Lee AM, Wu CT. Enhancer choice in cis and in trans in Drosophila melanogaster: role of the promoter. Genetics. 2004 Aug;167(4):1739-47. PubMed PMID: 15342512; PubMed Central PMCID: PMC1471007.


Kowalski MP, Pier GB. Localization of cystic fibrosis transmembrane conductance regulator to lipid rafts of epithelial cells is required for Pseudomonas aeruginosa-induced cellular activation. J Immunol. 2004 Jan 1;172(1):418-25. PMID: 14688350


Labonte ML, Letvin NL. Variable NKG2 expression in the peripheral blood lymphocytes of rhesus monkeys. Clin Exp Immunol. 2004 Nov;138(2):205-12. PMID: 15498028 PMCID: PMC1809222 read article


LaBonte ML, Choi EI, Letvin NL. Molecular determinants regulating the pairing of NKG2 molecules with CD94 for cell surface heterodimer expression. J Immunol. 2004 Jun 1;172(11):6902-12. PMID: 15153509


Nardone J, Lee DU, Ansel KM, Rao A. Bioinformatics for the 'bench biologist': how to find regulatory regions in genomic DNA. Nat Immunol. 2004 Aug;5(8):768-74. Review. PubMed PMID: 15282556.


Lee DU, Rao A. Molecular analysis of a locus control region in the T helper 2 cytokine gene cluster: a target for STAT6 but not GATA3. Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):16010-5. Epub 2004 Oct 26. PubMed PMID: 15507491; PubMed Central PMCID: PMC528768.


Ansel KM, Greenwald RJ, Agarwal S, Bassing CH, Monticelli S, Interlandi J, Djuretic IM, Lee DU, Sharpe AH, Alt FW, Rao A. Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity. Nat Immunol. 2004 Dec;5(12):1251-9. Epub 2004 Oct 31. PubMed PMID: 15516924.


Yuan H, Liddle FJ, Mahajan S, Frank DA. IL-6-induced survival of colorectal carcinoma cells is inhibited by butyrate through down-regulation of the IL-6 receptor. Carcinogenesis. 2004 Nov;25(11):2247-55. Epub 2004 Jul 29. PMID: 15284182


Matthews AG, Elkin SK, Oettinger MA. Ordered DNA release and target capture in RAG transposition. EMBO J. 2004 Mar 10;23(5):1198-206. Epub 2004 Feb 26. PubMed PMID: 14988730; PubMed Central PMCID: PMC380985.


McKee AE, Silver PA. REF-ereeing the cytoplasmic fate of mRNA via nuclear export. Dev Cell. 2004 Jun;6(6):740-2. PMID: 15177019


Melroe GT, DeLuca NA, Knipe DM. Herpes simplex virus 1 has multiple mechanisms for blocking virus-induced interferon production. J Virol. 2004 Aug;78(16):8411-20. PMID: 15280450 PMCID: PMC479070 read article


Misaghi S, Sun ZY, Stern P, Gaudet R, Wagner G, Ploegh H. Structural and functional analysis of human cytomegalovirus US3 protein. J Virol. 2004 Jan;78(1):413-23. PMID: 14671122 PMCID: PMC303419 read article


Hirsch C, Misaghi S, Blom D, Pacold ME, Ploegh HL. Yeast N-glycanase distinguishes between native and non-native glycoproteins. EMBO Rep. 2004 Feb;5(2):201-6. Epub 2004 Jan 9. PMID: 14726951 PMCID: PMC1298977 read article


Misaghi S, Pacold ME, Blom D, Ploegh HL, Korbel GA. Using a small molecule inhibitor of peptide: N-glycanase to probe its role in glycoprotein turnover. Chem Biol. 2004 Dec;11(12):1677-87. PMID: 15610852


Miyamoto DT, Perlman ZE, Burbank KS, Groen AC, Mitchison TJ. The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindles. J Cell Biol. 2004 Dec 6;167(5):813-8. PMID: 15583027 PMCID: PMC2172449 read article


Groen AC, Cameron LA, Coughlin M, Miyamoto DT, Mitchison TJ, Ohi R. XRHAMM functions in ran-dependent microtubule nucleation and pole formation during anastral spindle assembly. Curr Biol. 2004 Oct 26;14(20):1801-11. PMID: 15498487


Natarajan A, Moerke N, Fan YH, Chen H, Christ WJ, Wagner G, Halperin JA. Synthesis of fluorescein labeled 7-methylguanosinemonophosphate. Bioorg Med Chem Lett. 2004 May 17;14(10):2657-60. PMID: 15109672


Norris PJ, Moffett HF, Brander C, Allen TM, O'Sullivan KM, Cosimi LA, Kaufmann DE, Walker BD, Rosenberg ES. Fine specificity and cross-clade reactivity of HIV type 1 Gag-specific CD4+ T cells. AIDS Res Hum Retroviruses. 2004 Mar;20(3):315-25. PMID: 15117455.


SenGupta D, Norris PJ, Suscovich TJ, Hassan-Zahraee M, Moffett HF, Trocha A, Draenert R, Goulder PJ, Binder RJ, Levey DL, Walker BD, Srivastava PK, Brander C. Heat shock protein-mediated cross-presentation of exogenous HIV antigen on HLA class I and class II. J Immunol. 2004 Aug 1;173(3):1987-93. PMID: 15265933


Norris PJ, Moffett HF, Yang OO, Kaufmann DE, Clark MJ, Addo MM, Rosenberg ES. Beyond help: direct effector functions of human immunodeficiency virus type 1-specific CD4(+) T cells. J Virol. 2004 Aug;78(16):8844-51. PMID: 15280492


Pillai S, Cariappa A, Moran ST. Positive selection and lineage commitment during peripheral B-lymphocyte development. Immunol Rev. 2004. Feb;197:206-18. PMID:14962197.


Moran MM, Xu H, Clapham DE. TRP ion channels in the nervous system. Curr Opin Neurobiol. 2004 Jun;14(3):362-9. Review. PubMed PMID: 15194117.


Ciccone DN, Morshead KB, Oettinger MA. Chromatin immunoprecipitation in the analysis of large chromatin domains across murine antigen receptor loci. Methods Enzymol. 2004;376:334-48. Review. PubMed PMID: 14975316.


Helander A, Miller CL, Myers KS, Neutra MR, Nibert ML. Protective immunoglobulin A and G antibodies bind to overlapping intersubunit epitopes in the head domain of type 1 reovirus adhesin sigma1. J Virol. 2004 Oct;78(19):10695-705. PMID: 15367636 PMCID: PMC516417 read article


Münger K, Baldwin A, Edwards KM, Hayakawa H, Nguyen CL, Owens M, Grace M, Huh K. Mechanisms of human papillomavirus-induced oncogenesis. J Virol. 2004 Nov;78(21):11451-60. Review. PMID: 15479788 PMCID: PMC523272 read article


Schratt GM, Nigh EA, Chen WG, Hu L, Greenberg ME. BDNF regulates the
translation of a select group of mRNAs by a mammalian target of
rapamycin-phosphatidylinositol 3-kinase-dependent pathway during neuronal development. J Neurosci. 2004 Aug 18;24(33):7366-77. PubMed PMID: 15317862.


On M, Billingsley JM, Jouvin MH, Kinet JP. Molecular dissection of the FcRbeta signaling amplifier. J Biol Chem. 2004 Oct 29;279(44):45782-90. Epub 2004 Aug 30. PubMed PMID: 15339926.


Pi N, Meyers CL, Pacholec M, Walsh CT, Leary JA. Mass spectrometric characterization of a three-enzyme tandem reaction for assembly and modification of the novobiocin skeleton. Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10036-41. Epub 2004 Jun 24. PMID: 15218104 PMCID: PMC454160 read article


Paust S, Lu L, McCarty N, Cantor H. Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease. Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10398-403. Epub 2004 Jul 2. PubMed PMID: 15235129; PubMed Central PMCID: PMC478583.


McCarty N, Paust S, Ikizawa K, Dan I, Li X, Cantor H. Signaling by the kinase MINK is essential in the negative selection of autoreactive thymocytes. Nat Immunol. 2005 Jan;6(1):65-72. Epub 2004 Dec 19. Erratum in: Nat Immunol. 2005 Feb;6(2):219. PubMed PMID: 15608642.


Poulin DL, Kung AL, DeCaprio JA. p53 targets simian virus 40 large T antigen for acetylation by CBP. J Virol. 2004 Aug;78(15):8245-53. PMID: 15254196 PMCID: PMC446111 read article


Radosevich M, Song Z, Gorga JC, Ksander B, Ono SJ. Epigenetic silencing of the CIITA gene and posttranscriptional regulation of class II MHC genes in ocular melanoma cells. Invest Ophthalmol Vis Sci. 2004 Sep;45(9):3185-95. PMID: 15326139


Radosevich M, Ono SJ. MHC class II gene expression is not induced in HPIV3-infected respiratory epithelial cells. Immunol Res. 2004;30(2):125-38. PMID: 15477655.


Kraft S, Rana S, Jouvin MH, Kinet JP. The role of the FcepsilonRI beta-chain in allergic diseases. Int Arch Allergy Immunol. 2004 Sep;135(1):62-72. Epub 2004 Aug 13. Review. PMID: 15316148.


Ghosh AK, Reddi AL, Rao NL, Duan L, Band V, Band H. Biochemical basis for the requirement of kinase activity for Cbl-dependent ubiquitinylation and degradation of a target tyrosine kinase. J Biol Chem. 2004 Aug 20;279(34):36132-41. Epub 2004 Jun 18. PubMed PMID: 15208330.


Lin J, Wu PH, Tarr PT, Lindenberg KS, St-Pierre J, Zhang CY, Mootha VK, Jäger S, Vianna CR, Reznick RM, Cui L, Manieri M, Donovan MX, Wu Z, Cooper MP, Fan MC, Rohas LM, Zavacki AM, Cinti S, Shulman GI, Lowell BB, Krainc D, Spiegelman BM. Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell. 2004 Oct 1;119(1):121-35. PMID: 15454086


Rooney S, Sekiguchi J, Whitlow S, Eckersdorff M, Manis JP, Lee C, Ferguson DO, Alt FW. Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells. Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2410-5. PMID: 14983023.


Rooney S, Chaudhuri J, Alt FW. The role of the non-homologous end-joining pathway in lymphocyte development. Immunol Rev. 2004 Aug;200:115-31. Review. PMID: 15242400.


Brown SP, Safo PK, Regehr WG. Endocannabinoids inhibit transmission at granule cell to Purkinje cell synapses by modulating three types of presynaptic calcium channels. J Neurosci. 2004 Jun 16;24(24):5623-31. PubMed PMID: 15201335.


Samuels BA, Tsai LH. Nucleokinesis illuminated. Nat Neurosci. 2004 Nov;7(11):1169-70. PubMed PMID: 15508010.


Schwabish MA, Struhl K. Evidence for eviction and rapid deposition of histones upon transcriptional elongation by RNA polymerase II. Mol Cell Biol. 2004 Dec;24(23):10111-7. PMID: 15542822 PMCID: PMC529037 read article


Scimone ML, Felbinger TW, Mazo IB, Stein JV, Von Andrian UH, Weninger W. CXCL12 mediates CCR7-independent homing of central memory cells, but not naive T cells, in peripheral lymph nodes. J Exp Med. 2004 Apr 19;199(8):1113-20. PubMed PMID: 15096537; PubMed Central PMCID: PMC2211897.


Smith JG, Mothes W, Blacklow SC, Cunningham JM. The mature avian leucosis virus subgroup A envelope glycoprotein is metastable, and refolding induced by the synergistic effects of receptor binding and low pH is coupled to infection. J Virol. 2004 Feb;78(3):1403-10. PubMed PMID: 14722295; PubMed Central PMCID: PMC321377.


Monticelli S, Solymar DC, Rao A. Role of NFAT proteins in IL13 gene transcription in mast cells. J Biol Chem. 2004 Aug 27;279(35):36210-8. Epub 2004 Jun 30. PMID: 15229217.


Steele LN, Balsara ZR, Starnbach MN. Hematopoietic cells are required to initiate a Chlamydia trachomatis-specific CD8+ T cell response. J Immunol. 2004 Nov 15;173(10):6327-37. PubMed PMID: 15528372.


Stolt PC, Vardar D, Blacklow SC. The dual-function disabled-1 PTB domain exhibits site independence in binding phosphoinositide and peptide ligands. Biochemistry. 2004 Aug 31;43(34):10979-87. PMID: 15323557


Su MW, Pyarajan S, Chang JH, Yu CL, Jin YJ, Stierhof YD, Walden P, Burakoff SJ. Fratricide of CD8+ cytotoxic T lymphocytes is dependent on cellular activation and perforin-mediated killing. Eur J Immunol. 2004 Sep;34(9):2459-70. PMID: 15307178.


Bettelli E, Sullivan B, Szabo SJ, Sobel RA, Glimcher LH, Kuchroo VK. Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis. J. Exp. Med. 200(1):79-87, 2004.


INVITED PUBLICATIONS (non-peer reviewed): Glimcher LH, Townsend MJ, Sullivan BM, Lord GM. Recent developments in the transcriptional regulation of cytolytic effector cells. Nat. Rev. Immunol. 4(11):900-11, 2004.


Lu Q, Sun EE, Flanagan JG. Analysis of PDZ-RGS3 function in ephrin-B reverse signaling. Methods Enzymol. 2004;390:120-8. PMID: 15488174


Suscovich TJ, Paulose-Murphy M, Harlow JD, Chen Y, Thomas SY, Mellott TJ, Walker BD, Scadden DT, Zeichner S, Brander C. Defective immune function of primary effusion lymphoma cells is associated with distinct KSHV gene expression profiles. Leuk Lymphoma. 2004 Jun;45(6):1223-38. PMID: 15360006


Fontaine-Rodriguez EC, Taylor TJ, Olesky M, Knipe DM. Proteomics of herpes simplex virus infected cell protein 27: association with translation initiation factors. Virology. 2004 Dec 20;330(2):487-92. PMID: 15567442


Taylor TJ, Knipe DM. Proteomics of herpes simplex virus replication compartments: association of cellular DNA replication, repair, recombination, and chromatin remodeling proteins with ICP8. J Virol. 2004 Jun;78(11):5856-66. PMID: 15140983 PMCID: PMC415816 read article


Hess C, Altfeld M, Thomas SY, Addo MM, Rosenberg ES, Allen TM, Draenert R, Eldrige RL, van Lunzen J, Stellbrink HJ, Walker BD, Luster AD. HIV-1 specific CD8+ T cells with an effector phenotype and control of viral replication. Lancet. 2004 Mar 13;363(9412):863-6. PMID: 15031033


Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science. 2004 Mar 26;303(5666):2011-5. Epub 2004 Feb 19. PubMed PMID: 14976264.
"


Trinidad JC, Cohen JB. Neuregulin inhibits acetylcholine receptor aggregation in myotubes. J Biol Chem. 2004 Jul 23;279(30):31622-8. Epub 2004 May 20. PubMed PMID: 15155732.


Tseng CC, McLoughlin SM, Kelleher NL, Walsh CT. Role of the active site cysteine of DpgA, a bacterial type III polyketide synthase. Biochemistry. 2004 Feb 3;43(4):970-80.


Tseng CC, Vaillancourt FH, Bruner SD, Walsh CT. DpgC is a metal- and cofactor-free 3,5-dihydroxyphenylacetyl-CoA 1,2-dioxygenase in the vancomycin biosynthetic pathway. Chem Biol. 2004 Sep;11(9):1195-203. PMID: 15380180


Perron MJ, Stremlau M, Song B, Ulm W, Mulligan RC, Sodroski J. TRIM5alpha mediates the postentry block to N-tropic murine leukemia viruses in human cells. Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11827-32. Epub 2004 Jul 27. PMID: 15280539 PMCID: PMC511059 read article


Venanzi ES, Benoist C, Mathis D. Good riddance: Thymocyte clonal deletion prevents autoimmunity. Curr Opin Immunol. 2004 Apr;16(2):197-202. PubMed PMID: 15023413.


Li R, Wai SC. Bacterial cell polarity: a "swarmer-stalked" tale of actin. Trends Cell Biol. 2004. Oct;14(10):532-6. Review. PMID: 15450975.


Wedlich-Soldner R, Wai SC, Schmidt T, Li R. Robust cell polarity is a dynamic state established by coupling transport and GTPase signaling. J Cell Biol. 2004. Sep 3;166(6):889-900. Epub 2004 Sep 7. PMC2172129.


Nelson EA, Walker SR, Alvarez JV, Frank DA*. Isolation of unique STAT5 targets by chromatin immunoprecipitation-based gene identification. J Biol Chem. 2004 279(52): 54724-30. PMID: 15498775.


Keese CR, Wegener J, Walker SR, Giaever I. Electrical wound-healing assay for cells in vitro. Proc Natl Acad Sci USA. 2004 101(6):1554-9. PMC341773.


Kennedy S, Wang D, Ruvkun G. A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans. Nature. 2004 Feb 12;427(6975):645-9. PubMed PMID: 14961122.


Wang D, Ruvkun G. Regulation of Caenorhabditis elegans RNA interference by the daf-2 insulin stress and longevity signaling pathway. Cold Spring Harb Symp Quant Biol. 2004;69:429-31. PubMed PMID: 16117677.


Sivasankaran R, Pei J, Wang KC, Zhang YP, Shields CB, Xu XM, He Z. PKC mediates inhibitory effects of myelin and chondroitin sulfate proteoglycans on axonal regeneration. Nat Neurosci. 2004 Mar;7(3):261-8. Epub 2004 Feb 8. PubMed PMID: 14770187.


Webster SM, Del Camino D, Dekker JP, Yellen G. Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges. Nature. 2004 Apr 22;428(6985):864-8. PubMed PMID: 15103379.


Oukka M, Wein MN, Glimcher LH. Schnurri-3 (KRC) Interacts with c-Jun to Regulate the IL-2 Gene in T Cells. J Exp Med. 2004 Jan 5;199(1):15-24.PMID: 14707112 PMCID: PMC1887724


Williams BR, Wu, C-T. Does random X-inactivation reflect random choice between two X chromosomes? Genetics 2004. 167:1525-8. PMC1470940.


Wingert RA, Brownlie A, Galloway JL, Dooley K, Fraenkel P, Axe JL, Davidson AJ, Barut B, Noriega L, Sheng X, Zhou Y, Zon LI. The chianti zebrafish mutant provides a model for erythroid-specific disruption of transferrin receptor 1. Development. 2004 Dec;131(24):6225-35. PMID: 15563524


Kamath AB, Woodworth J, Xiong X, Taylor C, Weng Y, Behar SM. Cytolytic CD8+ T cells recognizing CFP10 are recruited to the lung after Mycobacterium tuberculosis infection. J Exp Med. 2004 Dec 6;200(11):1479-89. Epub 2004 Nov 22. PubMed PMID: 15557351; PubMed Central PMCID: PMC2211947.


top

2003


Miller CL, Broering TJ, Parker JS, Arnold MM, Nibert ML. Reovirus sigma NS protein localizes to inclusions through an association requiring the mu NS amino terminus. J Virol. 2003 Apr;77(8):4566-76. PMID: 12663763 PMCID: PMC152138 read article


Basu AC, Kravitz EA. Morphology and monoaminergic modulation of Crustacean Hyperglycemic Hormone-like immunoreactive neurons in the lobster nervous system. J Neurocytol. 2003 Mar;32(3):253-63. PubMed PMID: 14724388.


Blair NT, Bean BP. Role of tetrodotoxin-resistant Na+ current slow inactivation in adaptation of action potential firing in small-diameter dorsal root ganglion neurons. J Neurosci. 2003 Nov 12;23(32):10338-50. PubMed PMID: 14614093.


Schott E, Bonasio R, Ploegh HL (2003). Elimination in vivo of developing T cells by natural killer cells. Journal of Experimental Medicine 198:1213-24. PMID: 14568980; PMCID: PMC2194238.


Sicinska E, Aifantis I, Le Cam L, Swat W, Borowski C, Yu Q, Ferrando AA, Levin SD, Geng Y, von Boehmer H, Sicinski P. Requirement for cyclin D3 in lymphocyte development and T cell leukemias. Cancer Cell. 2003 Dec;4(6):451-61.


Degterev A, Boyce M, Yuan J. A decade of caspases. Oncogene. 2003 Nov 24;22(53):8543-67. PMID: 14634618


Mitra RD, Butty VL, Shendure J, Williams BR, Housman DE, Church GM. Digital genotyping and haplotyping with polymerase colonies. Proc Natl Acad Sci U S A. 2003 May 13;100(10):5926-31. Epub 2003 May 2. PMID: 12730373.


Butty VL, Roux-Lombard P, Garbino J, Dayer JM, Ricou B; Geneva Sepsis Network. Anti-inflammatory response after infusion of p55 soluble tumor necrosis factor receptor fusion protein for severe sepsis. Eur Cytokine Netw. 2003 Jan-Mar;14(1):15-9. PMID:12799209.


Carter AR, Berry EM, Segal RA. Regional expression of p75NTR contributes to neurotrophin regulation of cerebellar patterning. Mol Cell Neurosci. 2003 Jan;22(1):1-13. PubMed PMID: 12595234.


Traver D, Herbomel P, Patton EE, Murphey RD, Yoder JA, Litman GW, Catic A, Amemiya CT, Zon LI, Trede NS. The zebrafish as a model organism to study development of the immune system. Adv. Immunol. 2003;81:253-330. Review.


Chan B, Lanyi A, Song HK, Griesbach J, Simarro-Grande M, Poy F, Howie D, Sumegi J, Terhorst C, Eck MJ. SAP couples Fyn to SLAM immune receptors. Nat Cell Biol. 2003 Feb;5(2):155-60. PMID: 12545174


Chamberlin NL, Arrigoni E, Chou TC, Scammell TE, Greene RW, Saper CB. Effects of adenosine on gabaergic synaptic inputs to identified ventrolateral preoptic neurons. Neuroscience. 2003;119(4):913-8. PubMed PMID: 12831851.


Chou TC, Scammell TE, Gooley JJ, Gaus SE, Saper CB, Lu J. Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms. J Neurosci. 2003 Nov 19;23(33):10691-702. PubMed PMID: 14627654.


Chyung JH, Selkoe DJ. Inhibition of receptor-mediated endocytosis demonstrates generation of amyloid beta-protein at the cell surface. J Biol Chem. 2003 Dec 19;278(51):51035-43. Epub 2003 Oct 2. PubMed PMID: 14525989.


Ng HH, Ciccone DN, Morshead KB, Oettinger MA, Struhl K. Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: a potential mechanism for position-effect variegation. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1820-5. Epub 2003 Feb 6. PubMed PMID: 12574507; PubMed Central PMCID: PMC149917.


Morshead KB, Ciccone DN, Taverna SD, Allis CD, Oettinger MA. Antigen receptor loci poised for V(D)J rearrangement are broadly associated with BRG1 and flanked by peaks of histone H3 dimethylated at lysine 4. Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11577-82. Epub 2003 Sep 19. PubMed PMID: 14500909; PubMed Central PMCID: PMC208800.


Clatworthy AE, Valencia MA, Haber JE, Oettinger MA. V(D)J recombination and RAG-mediated transposition in yeast. Mol Cell. 2003 Aug;12(2):489-99. PubMed PMID: 14536087.


Maruo S, Johannsen E, Illanes D, Cooper A, Kieff E. Epstein-Barr Virus nuclear protein EBNA3A is critical for maintaining lymphoblastoid cell line growth. J Virol. 2003 Oct;77(19):10437-47. PMID: 12970429 PMCID: PMC228516 read article


Cooper A, Johannsen E, Maruo S, Cahir-McFarland E, Illanes D, Davidson D, Kieff E. EBNA3A association with RBP-Jkappa down-regulates c-myc and Epstein-Barr virus-transformed lymphoblast growth. J Virol. 2003 Jan;77(2):999-1010. PMID: 12502816 PMCID: PMC140836. read article


Subbramanian RA, Kuroda MJ, Charini WA, Barouch DH, Costantino C, Santra S, Schmitz JE, Martin KL, Lifton MA, Gorgone DA, Shiver JW, Letvin NL. Magnitude and diversity of cytotoxic-T-lymphocyte responses elicited by multiepitope DNA vaccination in rhesus monkeys. J Virol. 2003 Sep;77(18):10113-8. PubMed PMID: 12941922; PubMed Central PMCID: PMC224609.


Day CL, Walker BD. Progress in defining CD4 helper cell responses in chronic viral infections. J Exp Med. 2003 Dec 15;198(12):1773-7. PMID: 14676292 PMCID: PMC2194149  read article


Day CL, Seth NP, Lucas M, Appel H, Gauthier L, Lauer GM, Robbins GK, Szczepiorkowski ZM, Casson DR, Chung RT, Bell S, Harcourt G, Walker BD, Klenerman P, Wucherpfennig KW. Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers. J Clin Invest. 2003 Sep;112(6):831-42. PMID: 12975468 PMCID: PMC193667 read article


Somsouk M, Lauer GM, Casson D, Terella A, Day CL, Walker BD, Chung RT. Spontaneous resolution of chronic hepatitis C virus disease after withdrawal of immunosuppression. Gastroenterology. 2003 Jun;124(7):1946-9. PMID: 12806627


Do MT, Bean BP. Subthreshold sodium currents and pacemaking of subthalamic neurons: modulation by slow inactivation. Neuron. 2003 Jul 3;39(1):109-20. PubMed PMID: 12848936.


Zhou P, Fernandes N, Dodge IL, Reddi AL, Rao N, Safran H, DiPetrillo TA, Wazer DE, Band V, Band H. ErbB2 degradation mediated by the co-chaperone protein CHIP. J Biol Chem. 2003 Apr 18;278(16):13829-37. Epub 2003 Feb 6. PubMed PMID:12574167.


Dodge IL, Carr MW, Cernadas M, Brenner MB. IL-6 production by pulmonary dendritic cells impedes Th1 immune responses. J Immunol. 2003 May 1;170(9):4457-64. PubMed PMID: 12707321.


Duan L, Miura Y, Dimri M, Majumder B, Dodge IL, Reddi AL, Ghosh A, Fernandes N, Zhou P, Mullane-Robinson K, Rao N, Donoghue S, Rogers RA, Bowtell D, Naramura M, Gu H, Band V, Band H. Cbl-mediated ubiquitinylation is required for lysosomal sorting of epidermal growth factor receptor but is dispensable for endocytosis. J Biol Chem. 2003 Aug 1;278(31):28950-60. Epub 2003 May 18. PubMed PMID: 12754251.


Du J, Miller AJ, Widlund HR, Horstmann MA, Ramaswamy S, Fisher DE. MLANA/MART1 and SILV/PMEL17/GP100 are transcriptionally regulated by MITF in melanocytes and melanoma. Am J Pathol. 2003 Jul;163(1):333-43. PMID: 12819038 PMCID: PMC1868174 read article


Huber WE, Price ER, Widlund HR, Du J, Davis IJ, Wegner M, Fisher DE. A tissue-restricted cAMP transcriptional response: SOX10 modulates alpha-melanocyte-stimulating hormone-triggered expression of microphthalmia-associated transcription factor in melanocytes. J Biol Chem. 2003 Nov 14;278(46):45224-30. Epub 2003 Aug 27. PMID: 12944398


Akamatsu Y, Monroe R, Dudley DD, Elkin SK, Gartner F, Talukder SR, Takahama Y, Alt FW, Bassing CH, Oettinger MA. Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1209-14. Epub 2003 Jan 16. PMID: 12531919.


Dudley DD, Sekiguchi J, Zhu C, Sadofsky MJ, Whitlow S, DeVido J, Monroe RJ, Bassing CH, Alt FW. Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice. J Exp Med. 2003 Nov 3;198(9):1439-50. Epub 2003 Oct 27. PMID: 14581608.


Elia AE, Rellos P, Haire LF, Chao JW, Ivins FJ, Hoepker K, Mohammad D, Cantley LC, Smerdon SJ, Yaffe MB. The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain. Cell. 2003 Oct 3;115(1):83-95.PMID: 14532005


Elia AE, Cantley LC, Yaffe MB. Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates. Science. 2003 Feb 21;299(5610):1228-31. PMID: 12595692


Fragoso R, Ren D, Zhang X, Su MW, Burakoff SJ, Jin YJ. Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling. J Immunol, 170(2):913-21. 2003.


Furman MH, Loureiro J, Ploegh HL, Tortorella D. Ubiquitinylation of the cytosolic domain of a type I membrane protein is not required to initiate its dislocation from the endoplasmic reticulum. J Biol Chem. 2003 Sep 12;278(37):34804-11. Epub 2003 Jun 27. PubMed PMID: 12832421.


Tirosh B, Furman MH, Tortorella D, Ploegh HL. Protein unfolding is not a prerequisite for endoplasmic reticulum-to-cytosol dislocation. J Biol Chem. 2003 Feb 28;278(9):6664-72. Epub 2002 Dec 12. PubMed PMID: 12482753.


Chou TC, Scammell TE, Gooley JJ, Gaus SE, Saper CB, Lu J. Critical role of
dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms.J Neurosci. 2003 Nov 19;23(33):10691-702. PubMed PMID: 14627654.


Chou TC, Scammell TE, Gooley JJ, Gaus SE, Saper CB, Lu J. Critical role of
dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms. J Neurosci. 2003 Nov 19;23(33):10691-702. PubMed PMID: 14627654.


Lee YH, Giraud J, Davis RJ, White MF. c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade. J Biol Chem. 2003 Jan 31;278(5):2896-902. Epub 2002 Nov 1. PMID: 12417588


Cruz JC, Tseng HC, Goldman JA, Shih H, Tsai LH. Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles. Neuron. 2003 Oct 30;40(3):471-83. PubMed PMID: 14642273.


Lu C, Huang X, Ma HF, Gooley JJ, Aparacio J, Roof DJ, Chen C, Chen DF, Li T. Normal retinal development and retinofugal projections in mice lacking the retina-specific variant of actin-binding LIM domain protein. Neuroscience. 2003;120(1):121-31. PubMed PMID: 12849746.q


Gooley JJ, Lu J, Fischer D, Saper CB. A broad role for melanopsin in nonvisual photoreception. J Neurosci. 2003 Aug 6;23(18):7093-106. PubMed PMID: 12904470.


Chou TC, Scammell TE, Gooley JJ, Gaus SE, Saper CB, Lu J. Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms. J Neurosci. 2003 Nov 19;23(33):10691-702. PubMed PMID: 14627654.


Greka A, Navarro B, Oancea E, Duggan A, Clapham DE. TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. Nat Neurosci. 2003 Aug;6(8):837-45. PubMed PMID: 12858178.


Oancea E, Bezzerides VJ, Greka A, Clapham DE. Mechanism of persistent protein kinase D1 translocation and activation. Dev Cell. 2003 Apr;4(4):561-74. PubMed PMID: 12689594.


Griffin RS, Mills CD, Costigan M, Woolf CJ. Exploiting microarrays to reveal differential gene expression in the nervous system. Genome Biol. 2003;4(2):105. Epub 2003 Jan 29. PubMed PMID: 12620110; PubMed Central PMCID: PMC151293.


Harpavat S, Cepko CL. Thyroid hormone and retinal development: an emerging field. Thyroid. 2003 Nov;13(11):1013-9. Review. PubMed PMID: 14651785.


Grad Y, Aach J, Hayes GD, Reinhart BJ, Church GM, Ruvkun G, Kim J. Computational and experimental identification of C. elegans microRNAs. Mol Cell. 2003 May;11(5):1253-63. PMID: 12769849


Hurt JA**, Thibodeau SA**, Hirsh AS, Pabo CO, Joung JK. Highly specific zinc finger proteins obtained by directed domain shuffling and cell-based selection. Proc Natl Acad Sci. USA. 2003. Oct 14;100(21):12271-6. PMID: 14527993
**Denotes Equal Contribution


Chaput JC, Ichida JK, Szostak JW. DNA polymerase-mediated DNA synthesis on a TNA template. J Am Chem Soc. 2003 Jan 29;125(4):856-7. PubMed PMID: 12537469.


Barouch DH, McKay PF, Sumida SM, Santra S, Jackson SS, Gorgone DA, Lifton MA, Chakrabarti BK, Xu L, Nabel GJ, Letvin NL. Plasmid chemokines and colony-stimulating factors enhance the immunogenicity of DNA priming-viral vector boosting human immunodeficiency virus type 1 vaccines. J Virol. 2003 Aug;77(16):8729-35. PubMed PMID: 12885892; PubMed Central PMCID: PMC167238.


Kessler JC, Rochet JC, Lansbury PT Jr. The N-terminal repeat domain of alpha-synuclein inhibits beta-sheet and amyloid fibril formation. Biochemistry. 2003 Jan 28;42(3):672-8. PMID: 12534279


Micchelli CA, Esler WP, Kimberly WT, Jack C, Berezovska O, Kornilova A, Hyman BT, Perrimon N, Wolfe MS. Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila. FASEB J. 2003 Jan;17(1):79-81. Epub 2002 Nov 1. PubMed PMID: 12424225.


Kimberly WT, Esler WP, Ye W, Ostaszewski BL, Gao J, Diehl T, Selkoe DJ, Wolfe MS. Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s). Biochemistry. 2003 Jan 14;42(1):137-44. PubMed PMID: 12515548.


Kimberly WT, LaVoie MJ, Ostaszewski BL, Ye W, Wolfe MS, Selkoe DJ. Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6382-7. Epub 2003 May 9. PubMed PMID: 12740439; PubMed Central PMCID: PMC164455.


Walsh DM, Fadeeva JV, LaVoie MJ, Paliga K, Eggert S, Kimberly WT, Wasco W, Selkoe DJ. gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins. Biochemistry. 2003 Jun 10;42(22):6664-73. PubMed PMID: 12779321.


LaVoie MJ, Fraering PC, Ostaszewski BL, Ye W, Kimberly WT, Wolfe MS, Selkoe DJ. Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin. J Biol Chem. 2003 Sep 26;278(39):37213-22. Epub 2003 Jul 11. PubMed PMID: 12857757.


Baulac S, LaVoie MJ, Kimberly WT, Strahle J, Wolfe MS, Selkoe DJ, Xia W. Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates. Neurobiol Dis. 2003 Nov;14(2):194-204. PubMed PMID: 14572442.


Kimberly WT, Wolfe MS. Identity and function of gamma-secretase. J Neurosci Res. 2003 Nov 1;74(3):353-60. Review. PubMed PMID: 14598311.


Konopka G, Bonni A. Signaling pathways regulating gliomagenesis. Curr Mol Med. 2003 Feb;3(1):73-84. Review. PubMed PMID: 12558076.


Cannon CL, Kowalski MP, Stopak KS, Pier GB. Pseudomonas aeruginosa-induced apoptosis is defective in respiratory epithelial cells expressing mutant cystic fibrosis transmembrane conductance regulator. Am J Respir Cell Mol Biol. 2003 Aug;29(2):188-97. PMID: 12878584


Kaufmann C, Yoshida T, Perotti EA, Landhuis E, Wu P, Georgopoulos K. A complex network of regulatory elements in Ikaros and their activity during hemo-lymphopoiesis. EMBO J. 2003 May 1;22(9):2211-23. PubMed PMID: 12727887; PubMed Central PMCID: PMC156063.


Ansel KM, Lee DU, Rao A. An epigenetic view of helper T cell differentiation. Nat Immunol. 2003 Jul;4(7):616-23. Review. PubMed PMID: 12830136.


Lee DU, Avni O, Chen L, Rao A. A distal enhancer in the interferon-gamma (IFN-gamma) locus revealed by genome sequence comparison. J Biol Chem. 2004 Feb 6;279(6):4802-10. Epub 2003 Nov 8. PubMed PMID: 14607827.


Shalizi A, Lehtinen M, Gaudilliere B, Donovan N, Han J, Konishi Y, Bonni A.
Characterization of a neurotrophin signaling mechanism that mediates neuron survival in a temporally specific pattern. J Neurosci. 2003 Aug
13;23(19):7326-36. PubMed PMID: 12917366.


Major DE, Rodman HR, Libedinsky C, Karten HJ. Pattern of retinal projections in the California ground squirrel (Spermophilus beecheyi): anterograde tracing study using cholera toxin. J Comp Neurol. 2003 Aug 25;463(3):317-40. PubMed PMID: 12820165.


Kircher MF, Allport JR, Graves EE, Love V, Josephson L, Lichtman AH, Weissleder R. In vivo high resolution three-dimensional imaging of antigen-specific cytotoxic T-lymphocyte trafficking to tumors. Cancer Res. 2003 Oct 15;63(20):6838-46.


Grabie N, Delfs MW, Westrich JR, Love VA, Stavrakis G, Ahmad F, Seidman CE, Seidman JG, Lichtman AH. IL-12 is required for differentiation of pathogenic CD8+ T cell effectors that cause myocarditis. J Clin Invest. 2003 Mar;111(5):671-80. PubMed PMID: 12618521; PubMed Central PMCID: PMC151896.


Lugo-Villarino G, Maldonado-Lopez R, Possemato R, Penaranda C, Glimcher LH. T-bet is required for optimal production of IFN-gamma and antigen-specific T cell activation by dendritic cells. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7749-54. Epub 2003 Jun 11. PubMed PMID: 12802010; PubMed Central PMCID: PMC164659.


Llewellyn-Smith IJ, Martin CL, Marcus JN, Yanagisawa M, Minson JB, Scammell TE. Orexin-immunoreactive inputs to rat sympathetic preganglionic neurons. Neurosci Lett. 2003 Nov 13;351(2):115-9. PubMed PMID: 14583395.


Willie JT, Chemelli RM, Sinton CM, Tokita S, Williams SC, Kisanuki YY, Marcus JN, Lee C, Elmquist JK, Kohlmeier KA, Leonard CS, Richardson JA, Hammer RE, Yanagisawa M. Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes. Neuron. 2003 Jun 5;38(5):715-30. PubMed PMID: 12797957.


Elmquist JK, Marcus JN. Rethinking the central causes of diabetes. Nat Med. 2003 Jun;9(6):645-7. PubMed PMID: 12778157.


Martin CH, Aifantis I, Scimone ML, von Andrian UH, Reizis B, von Boehmer H, Gounari F. Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potential. Nat Immunol. 2003 Sep;4(9):866-73. Epub 2003 Aug 17. PubMed PMID: 12925850.


Elkin SK, Matthews AG, Oettinger MA. The C-terminal portion of RAG2 protects against transposition in vitro. EMBO J. 2003 Apr 15;22(8):1931-8. PubMed PMID: 12682025; PubMed Central PMCID: PMC154476.


Montalbano A, Ogwaro KM, Tang A, Matthews AG, Larijani M, Oettinger MA, Feeney AJ. V(D)J recombination frequencies can be profoundly affected by changes in the spacer sequence. J Immunol. 2003 Nov 15;171(10):5296-304. PubMed PMID: 14607931.


Du J, Miller AJ, Widlund HR, Horstmann MA, Ramaswamy S, Fisher DE. MLANA/MART1 and SILV/PMEL17/GP100 are transcriptionally regulated by MITF in melanocytes and melanoma. Am J Pathol. 2003 Jul;163(1):333-43. PMID: 12819038 PMCID: PMC1868174 read article


Gupta A, Sanada K, Miyamoto DT, Rovelstad S, Nadarajah B, Pearlman AL, Brunstrom J, Tsai LH. Layering defect in p35 deficiency is linked to improper neuronal-glial interaction in radial migration. Nat Neurosci. 2003 Dec;6(12):1284-91. Epub 2003 Nov 9. PMID: 14608361


Miyamoto DT, Perlman ZE, Mitchison TJ, Shirasu-Hiza M. Dynamics of the mitotic spindle--potential therapeutic targets. Prog Cell Cycle Res. 2003;5:349-60. PMID: 14593729


Gross JD, Moerke NJ, von der Haar T, Lugovskoy AA, Sachs AB, McCarthy JE, Wagner G. Ribosome loading onto the mRNA cap is driven by conformational coupling between eIF4G and eIF4E. Cell. 2003 Dec 12;115(6):739-50. PMID: 14675538


Moran ST, Haider K, Ow Y, Milton P, Chen L, Pillai S. Protein kinase C-associated kinase can activate NFkappaB in both a kinase-dependent and a kinase-independent manner. J Biol Chem. 2003. Jun 13;278(24):21526-33. PMID:12676934.


Cariappa A, Chen L, Haider K, Tang M, Nebelitskiy E, Moran ST, Pillai S. A catalytically inactive form of protein kinase C-associated kinase/receptor interacting protein 4, a protein kinase C beta-associated kinase that mediates NF-kappa B activation, interferes with early B cell development. J Immunol. 2003. Aug 15;171(4):1875-80. PMID:12902489.


Ng HH, Ciccone DN, Morshead KB, Oettinger MA, Struhl K. Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: a potential mechanism for position-effect variegation. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1820-5. Epub 2003 Feb 6. PubMed PMID: 12574507; PubMed Central PMCID: PMC149917.


Morshead KB, Ciccone DN, Taverna SD, Allis CD, Oettinger MA. Antigen receptor loci poised for V(D)J rearrangement are broadly associated with BRG1 and flanked by peaks of histone H3 dimethylated at lysine 4. Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11577-82. Epub 2003 Sep 19. PubMed PMID: 14500909; PubMed Central PMCID: PMC208800.


Thayer SP, di Magliano MP, Heiser PW, Nielsen CM, Roberts DJ, Lauwers GY, Qi YP, Gysin S, Fernández-del Castillo C, Yajnik V, Antoniu B, McMahon M, Warshaw AL, Hebrok M. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature. 2003 Oct 23;425(6960):851-6. Epub 2003 Sep 14. PubMed PMID: 14520413.


Olveczky BP, Baccus SA, Meister M. Segregation of object and background motion in the retina. Nature. 2003 May 22;423(6938):401-8. Epub 2003 May 11. PubMed PMID: 12754524.


Smallwood PM, Olveczky BP, Williams GL, Jacobs GH, Reese BE, Meister M, Nathans J. Genetically engineered mice with an additional class of cone photoreceptors: implications for the evolution of color vision. Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11706-11. Epub 2003 Sep 19. PubMed PMID: 14500905; PubMed Central PMCID: PMC208822.


Tao J, Hu S, Pacholec M, Walsh CT. Synthesis of proposed oxidation-cyclization-methylation intermediates of the coumarin antibiotic biosynthetic pathway. Org Lett. 2003 Sep 4;5(18):3233-6. PMID: 12943395


Patten BA, Peyrin JM, Weinmaster G, Corfas G. Sequential signaling through Notch1 and erbB receptors mediates radial glia differentiation. J Neurosci. 2003 Jul 9;23(14):6132-40. PMID: 12853432.


Radosevich M, Ono SJ. Novel mechanisms of class II major histocompatibility complex gene regulation. Immunol Res. 2003;27(1):85-106. Review. PMID: 12637770.


Lleó A, Berezovska O, Ramdya P, Fukumoto H, Raju S, Shah T, Hyman BT. Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression. J Biol Chem. 2003 Nov 28;278(48):47370-5. Epub 2003 Sep 5. PubMed PMID: 12960155.


Berezovska O, Ramdya P, Skoch J, Wolfe MS, Bacskai BJ, Hyman BT. Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging. J Neurosci. 2003 Jun 1;23(11):4560-6. PubMed PMID: 12805296.


Ramdya P, Skoch J, Bacskai BJ, Hyman BT, Berezovska O. Activated Notch1 associates with a presenilin-1/gamma-secretase docking site. J Neurochem. 2003 Nov;87(4):843-50. PubMed PMID: 14622115.


Donnadieu E, Jouvin MH, Rana S, Moffatt MF, Mockford EH, Cookson WO, Kinet JP. Competing functions encoded in the allergy-associated F(c)epsilon RI beta gene. Immunity. 2003 May;18(5):665-74. PMID: 12753743.


Miura-Shimura Y, Duan L, Rao NL, Reddi AL, Shimura H, Rottapel R, Druker BJ, Tsygankov A, Band V, Band H. Cbl-mediated ubiquitinylation and negative regulation of Vav. J Biol Chem. 2003 Oct 3;278(40):38495-504. Epub 2003 Jul 24. PubMed PMID: 12881521.


Awatramani R, Soriano P, Rodriguez C, Mai JJ, Dymecki SM. Cryptic boundaries in roof plate and choroid plexus identified by intersectional gene activation. Nat Genet. 2003 Sep;35(1):70-5. Epub 2003 Aug 17. PubMed PMID: 12923530.


Rooney S, Alt FW, Lombard D, Whitlow S, Eckersdorff M, Fleming J, Fugmann S, Ferguson DO, Schatz DG, Sekiguchi J. Defective DNA repair and increased genomic instability in Artemis-deficient murine cells. J Exp Med. 2003 Mar 3;197(5):553-65. PMID: 12615897.


Sánchez-Fueyo A, Tian J, Picarella D, Domenig C, Zheng XX, Sabatos CA, Manlongat N, Bender O, Kamradt T, Kuchroo VK, Gutiérrez-Ramos JC, Coyle AJ, Strom TB. Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. Nat Immunol. 2003 Nov;4(11):1093-101. Epub 2003 Oct 12. PubMed PMID: 14556005.


Sabatos CA, Chakravarti S, Cha E, Schubart A, Sánchez-Fueyo A, Zheng XX, Coyle AJ, Strom TB, Freeman GJ, Kuchroo VK. Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nat Immunol. 2003 Nov;4(11):1102-10. Epub 2003 Oct 12. PubMed PMID: 14556006.


Samuels BA, Tsai LH. Cdk5 is a dynamo at the synapse. Nat Cell Biol. 2003 Aug;5(8):689-90. PubMed PMID: 12894171.


Xie Z, Sanada K, Samuels BA, Shih H, Tsai LH. Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement, and neuronal migration. Cell. 2003 Aug 22;114(4):469-82. PubMed PMID: 12941275.


Martin CH, Aifantis I, Scimone ML, von Andrian UH, Reizis B, von Boehmer H, Gounari F. Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potential. Nat Immunol. 2003 Sep;4(9):866-73. Epub 2003 Aug 17. PubMed PMID: 12925850.


Soler-Llavina GJ, Holmgren M, Swartz KJ. Defining the conductance of the closed state in a voltage-gated K+ channel. Neuron. 2003 Apr 10;38(1):61-7. PubMed PMID: 12691664.


Allan DW, St Pierre SE, Miguel-Aliaga I, Thor S. Specification of neuropeptide cell identity by the integration of retrograde BMP signaling and a combinatorial transcription factor code. Cell. 2003 Apr 4;113(1):73-86. PubMed PMID: 12679036.


Stanford JS, Lieberman SL, Wong VL, Ruderman JV. Regulation of the G2/M transition in oocytes of xenopus tropicalis. Dev Biol. 2003 Aug 15;260(2):438-48. PMID: 12921744


Stolt PC, Jeon H, Song HK, Herz J, Eck MJ, Blacklow SC. Origins of peptide selectivity and phosphoinositide binding revealed by structures of disabled-1 PTB domain complexes. Structure. 2003 May;11(5):569-79. PMID: 2737822


Fragoso R, Ren D, Zhang X, Su MW, Burakoff SJ, Jin YJ. Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling. J Immunol. 2003 Jan 15;170(2):913-21. PMID: 12517957.


Sullivan BM, Juedes A, Szabo SJ, von Herrath M, Glimcher LH. Antigen-driven effector CD8 T cell function regulated by T-bet. PNAS 100(26):15818-23, 2003.


INVITED PUBLICATIONS (non-peer reviewed): Szabo SJ, Sullivan BM, Peng SL, Glimcher LH. Molecular mechanisms regulating Th1 immune responses. Annnu. Rev. Immunol. 21:713-58, 2003.


Thomas SM, Zeng Q, Dyer KF, Suscovich TJ, Kanter PM, Whalen JD, Watkins SF, Grandis JR. Tissue distribution of liposome-mediated epidermal growth factor receptor antisense gene therapy. Cancer Gene Ther. 2003 Jul;10(7):518-28. PMID: 12833132


Field SJ, Madson N, Kerr M, Galbraith K, Kennedy C, Tahiliani M, Cantley L. Functions at the Cleavage Furrow During Cytokinesis. Current Biology (2003) 15 (15): 1407-12.


Taylor TJ, McNamee EE, Day C, Knipe DM. Herpes simplex virus replication compartments can form by coalescence of smaller compartments. Virology. 2003 May 10;309(2):232-47. PMID: 12758171


Taylor TJ, Knipe DM. C-terminal region of herpes simplex virus ICP8 protein needed for intranuclear localization. Virology. 2003 May 10;309(2):219-31. PMID: 12758170


Thomas SY, Hou R, Boyson JE, Means TK, Hess C, Olson DP, Strominger JL, Brenner MB, Gumperz JE, Wilson SB, Luster AD. CD1d-restricted NKT cells express a chemokine receptor profile indicative of Th1-type inflammatory homing cells. J Immunol. 2003 Sep 1;171(5):2571-80. PMID: 12928408


Tran H, Brunet A, Griffith EC, Greenberg ME. The many forks in FOXO's road.
Sci STKE. 2003 Mar 4;2003(172):RE5. Review. PubMed PMID: 12621150.


Chiara DC, Trinidad JC, Wang D, Ziebell MR, Sullivan D, Cohen JB. Identification of amino acids in the nicotinic acetylcholine receptor agonist binding site and ion channel photolabeled by 4-[(3-trifluoromethyl)-3H-diazirin-3-yl]benzoylcholine, a novel photoaffinity antagonist. Biochemistry. 2003 Jan 21;42(2):271-83. PubMed PMID: 12525154.


Tsao DY, Conway BR, Livingstone MS. Receptive fields of disparity-tuned simple cells in macaque V1. Neuron. 2003 Apr 10;38(1):103-14. PubMed PMID: 12691668.


Tsao DY, Vanduffel W, Sasaki Y, Fize D, Knutsen TA, Mandeville JB, Wald LL, Dale AM, Rosen BR, Van Essen DC, Livingstone MS, Orban GA, Tootell RB. Stereopsis activates V3A and caudal intraparietal areas in macaques and humans. Neuron. 2003 Jul 31;39(3):555-68. PubMed PMID: 12895427.


Tsao DY, Freiwald WA, Knutsen TA, Mandeville JB, Tootell RB. Faces and objects in macaque cerebral cortex. Nat Neurosci. 2003 Sep;6(9):989-95. PubMed PMID: 12925854.


Berzins SP, Venanzi ES, Benoist C, Mathis D. T-cell compartments of prediabetic NOD mice. Diabetes. 2003 Feb;52(2):327-34. PubMed PMID: 12540604.


Gozani O, Karuman P, Jones DR, Ivanov D, Cha J, Lugovskoy AA, Baird CL, Zhu H, Field SJ, Lessnick SL, Villasenor J, Mehrotra B, Chen J, Rao VR, Brugge JS, Ferguson CG, Payrastre B, Myszka DG, Cantley LC, Wagner G, Divecha N, Prestwich GD, Yuan J. The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell. 2003 Jul 11;114(1):99-111. PubMed PMID: 12859901.


Chiara DC, Trinidad JC, Wang D, Ziebell MR, Sullivan D, Cohen JB. Identification of amino acids in the nicotinic acetylcholine receptor agonist binding site and ion channel photolabeled by 4-[(3-trifluoromethyl)-3H-diazirin-3-yl]benzoylcholine, a novel photoaffinity antagonist. Biochemistry. 2003 Jan 21;42(2):271-83. PubMed PMID: 12525154.


He XL, Bazan JF, McDermott G, Park JB, Wang K, Tessier-Lavigne M, He Z, Garcia KC. Structure of the Nogo receptor ectodomain: a recognition module implicated in myelin inhibition. Neuron. 2003 Apr 24;38(2):177-85. PubMed PMID: 12718853.


McAlpine MC, Friedman RS, Jin S, Lin K, Wang WU, Lieber CM, High-Performance Nanowire Electronics and Photonics on Glass and Plastic Substrates. Nano Lett. 2003. 3, 1531-1535.


Cui Y, Zhong Z, Wang D, Wang WU, Lieber CM. High Performance Silicon Nanowire Field Effect Transistors. Nano Lett. 2003. 3, 149-152.


Mitra, RD, Butty, V, Shendure, J, Williams, BR, Housman, DE, Church, GM. Digital Genotyping and Haplotyping with Polymerase Colonies. Proc Natl Acad Sci USA. 2003. May 13;100(10):5926-31. PMC156303.


Kramer A, Yang FC, Snodgrass P, Li X, Scammell TE, Davis FC, Weitz CJ.
Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor
signalling. Novartis Found Symp. 2003;253:250-62; discussion 102-9, 263-6, 281-4. PubMed PMID: 14712926.


Yiu G, He Z. Signaling mechanisms of the myelin inhibitors of axon regeneration. Curr Opin Neurobiol. 2003 Oct;13(5):545-51. PMID: 14630216.


Teillon SM, Yiu G, Walsh CA. Reelin is expressed in the accessory olfactory system, but is not a guidance cue for vomeronasal axons. Brain Res Dev Brain Res. 2003 Feb 16;140(2):303-7. PMID: 12586436.


Tietjen I, Rihel JM, Cao Y, Koentges G, Zakhary L, Dulac C. Single-cell transcriptional analysis of neuronal progenitors. Neuron. 2003 Apr 24;38(2):161-75. PubMed PMID: 12718852.


top

2002


Altevogt BM, Kleopa KA, Postma FR, Scherer SS, Paul DL. Connexin29 is uniquely distributed within myelinating glial cells of the central and peripheral nervous systems. J Neurosci. 2002 Aug 1;22(15):6458-70. PubMed PMID: 12151525.


Blair NT, Bean BP. Roles of tetrodotoxin (TTX)-sensitive Na+ current, TTX-resistant Na+ current, and Ca2+ current in the action potentials of nociceptive sensory neurons. J Neurosci. 2002 Dec 1;22(23):10277-90. PubMed PMID: 12451128.


Borowski C, Martin C, Gounari F, Haughn L, Aifantis I, Grassi F, von Boehmer H. On the brink of becoming a T cell. Curr Opin Immunol. 2002 Apr;14(2):200-6. Review.


Aifantis I, Borowski C, Gounari F, Lacorazza HD, Nikolich-Zugich J, von Boehmer H. A critical role for the cytoplasmic tail of pTalpha in T lymphocyte development. Nat Immunol. 2002 May;3(5):483-8.


Gozani O, Boyce M, Yoo L, Karuman P, Yuan J. Life and death in paradise. PMID: 12042835


Brittis PA, Lu Q, Flanagan JG. Axonal protein synthesis provides a mechanism for localized regulation at an intermediate target. Cell. 2002 Jul 26;110(2):223-35. PubMed PMID: 12150930.


Call ME, Pyrdol J, Wiedmann M, Wucherpfennig KW. The organizing principle in the formation of the T cell receptor-CD3 complex. Cell. 2002 Dec 27;111(7):967-79. PubMed PMID: 12507424.


Carter AG, Vogt KE, Foster KA, Regehr WG. Assessing the role of calcium-induced calcium release in short-term presynaptic plasticity at excitatory central synapses. J Neurosci. 2002 Jan 1;22(1):21-8. PubMed PMID: 11756484.


Kreitzer AC, Carter AG, Regehr WG. Inhibition of interneuron firing extends the spread of endocannabinoid signaling in the cerebellum. Neuron. 2002 May 30;34(5):787-96. PubMed PMID: 12062024.


Carter AG, Regehr WG. Quantal events shape cerebellar interneuron firing. Nat Neurosci. 2002 Dec;5(12):1309-18. PubMed PMID: 12411959.


Borghesani PR, Peyrin JM, Klein R, Rubin J, Carter AR, Schwartz PM, Luster A, Corfas G, Segal RA. BDNF stimulates migration of cerebellar granule cells. Development. 2002 Mar;129(6):1435-42. PubMed PMID: 11880352.


Carter AR, Chen C, Schwartz PM, Segal RA. Brain-derived neurotrophic factor modulates cerebellar plasticity and synaptic ultrastructure. J Neurosci. 2002 Feb 15;22(4):1316-27. PubMed PMID: 11850459.


Fricker-Gates RA, Shin JJ, Tai CC, Catapano LA, Macklis JD. Late-stage immature neocortical neurons reconstruct interhemispheric connections and form synaptic contacts with increased efficiency in adult mouse cortex undergoing targeted neurodegeneration. J Neurosci. 2002 May 15;22(10):4045-56. PubMed PMID: 12019324.


Catapano LA, Magavi SS, Macklis JD. Neuroanatomical tracing of neuronal projections with Fluoro-Gold. Methods Mol Biol. 2002;198:299-304. PubMed PMID: 11951632.


Chackerian AA, Alt JM, Perera TV, Dascher CC, Behar SM. Dissemination of Mycobacterium tuberculosis is influenced by host factors and precedes the initiation of T-cell immunity. Infect Immun. 2002 Aug;70(8):4501-9. PubMed PMID: 12117962; PubMed Central PMCID: PMC128141.


Chackerian A, Alt J, Perera V, Behar SM. Activation of NKT cells protects mice from tuberculosis. Infect Immun. 2002 Nov;70(11):6302-9. PubMed PMID: 12379709; PubMed Central PMCID: PMC130331.


Chae TH, Allen KM, Davisson MT, Sweet HO, Walsh CA. Mapping of the mouse hyh gene to a YAC/BAC contig on proximal Chromosome 7. Mamm Genome. 2002 May;13(5):239-44. PubMed PMID: 12016511.


Froy O, Chang DC, Reppert SM. Redox potential: differential roles in dCRY and mCRY1 functions. Curr Biol. 2002 Jan 22;12(2):147-52. PubMed PMID: 11818067.


Ye H, Arron JR, Lamothe B, Cirilli M, Kobayashi T, Shevde NK, Segal D, Dzivenu OK, Vologodskaia M, Yim M, Du K, Singh S, Pike JW, Darnay BG, Choi Y, Wu H. Distinct molecular mechanism for initiating TRAF6 signalling. Nature. 2002 Jul 25;418(6896):443-7. PubMed PMID: 12140561.


Rubin JB, Choi Y, Segal RA. Cerebellar proteoglycans regulate sonic hedgehog responses during development. Development. 2002 May;129 9):2223-32. PubMed PMID: 11959830.


Saper CB, Chou TC, Elmquist JK. The need to feed: homeostatic and hedonic control of eating. Neuron. 2002 Oct 10;36(2):199-211. Review. PubMed PMID: 12383777.


Bassing CH, Chua KF, Sekiguchi J, Suh H, Whitlow SR, Fleming JC, Monroe BC, Ciccone DN, Yan C, Vlasakova K, Livingston DM, Ferguson DO, Scully R, Alt FW. Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8173-8. Epub 2002 May 28. PubMed PMID: 12034884; PubMed Central PMCID: PMC123040.


Claypool SM, Dickinson BL, Yoshida M, Lencer WI, Blumberg RS. Functional reconstitution of human FcRn in Madin-Darby canine kidney cells requires co-expressed human beta 2-microglobulin. J. Biol. Chem. 2002 Aug 2; 277(31):28038-50. PMID: 12023961.


Harker N, Naito T, Cortes M, Hostert A, Hirschberg S, Tolaini M, Roderick K, Georgopoulos K, Kioussis D. The CD8alpha gene locus is regulated by the Ikaros family of proteins. Mol Cell. 2002 Dec;10(6):1403-15. PubMed PMID: 12504015.


Lauer GM, Ouchi K, Chung RT, Nguyen TN, Day CL, Purkis DR, Reiser M, Kim AY, Lucas M, Klenerman P, Walker BD. Comprehensive analysis of CD8(+)-T-cell responses against hepatitis C virus reveals multiple unpredicted specificities. J Virol. 2002 Jun;76(12):6104-13. PMID: 12021343 PMCID: PMC136241 read article


Lauer GM, Nguyen TN, Day CL, Robbins GK, Flynn T, McGowan K, Rosenberg ES, Lucas M, Klenerman P, Chung RT, Walker BD. Human immunodeficiency virus type 1-hepatitis C virus coinfection: intraindividual comparison of cellular immune responses against two persistent viruses. J Virol. 2002 Mar;76(6):2817-26. PMID: 11861849 PMCID: PMC135971 read article


Landisman CE, Long MA, Beierlein M, Deans MR, Paul DL, Connors BW. Electrical synapses in the thalamic reticular nucleus. J Neurosci. 2002 Feb 1;22(3):1002-9. PubMed PMID: 11826128.


Deans MR, Volgyi B, Goodenough DA, Bloomfield SA, Paul DL. Connexin36 is
essential for transmission of rod-mediated visual signals in the mammalian
retina. Neuron. 2002 Nov 14;36(4):703-12. PubMed PMID: 12441058; PubMed Central PMCID: PMC2834592.


Long MA, Deans MR, Paul DL, Connors BW. Rhythmicity without synchrony in the electrically uncoupled inferior olive. J Neurosci. 2002 Dec 15;22(24):10898-905. PubMed PMID: 12486184; PubMed Central PMCID: PMC2834587.


Desai BN, Myers BR, Schreiber SL. FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction. Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4319-24. PubMed PMID: 11930000; PubMed Central PMCID: PMC123646.


Corbo JC, Deuel TA, Long JM, LaPorte P, Tsai E, Wynshaw-Boris A, Walsh CA. Doublecortin is required in mice for lamination of the hippocampus but not the neocortex. J Neurosci. 2002 Sep 1;22(17):7548-57. PubMed PMID: 12196578.


Rao N, Miyake S, Reddi AL, Douillard P, Ghosh AK, Dodge IL, Zhou P, Fernandes ND, Band H. Negative regulation of Lck by Cbl ubiquitin ligase. Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3794-9. PubMed PMID: 11904433; PubMed Central PMCID: PMC122603.


Rao N, Dodge I, Band H. The Cbl family of ubiquitin ligases: critical negative regulators of tyrosine kinase signaling in the immune system. J Leukoc Biol. 2002 May;71(5):753-63. Review. PubMed PMID: 11994499.


Dascher CC, Hiromatsu K, Xiong X, Sugita M, Buhlmann JE, Dodge IL, Lee SY, Roura-Mir C, Watts GF, Roy CJ, Behar SM, Clemens DL, Porcelli SA, Brenner MB. Conservation of CD1 intracellular trafficking patterns between mammalian species. J Immunol. 2002 Dec 15;169(12):6951-8. PubMed PMID: 12471129.


Du J, Fisher DE. Identification of Aim-1 as the underwhite mouse mutant and its transcriptional regulation by MITF. J Biol Chem. 2002 Jan 4;277(1):402-6. Epub 2001 Nov 7. PMID: 11700328


McGill GG, Horstmann M, Widlund HR, Du J, Motyckova G, Nishimura EK, Lin YL, Ramaswamy S, Avery W, Ding HF, Jordan SA, Jackson IJ, Korsmeyer SJ, Golub TR, Fisher DE. Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell. 2002 Jun 14;109(6):707-18. PMID: 2086670


Baksh S, Widlund HR, Frazer-Abel AA, Du J, Fosmire S, Fisher DE, DeCaprio JA, Modiano JF, Burakoff SJ. NFATc2-mediated repression of cyclin-dependent kinase 4 expression. Mol Cell. 2002 Nov;10(5):1071-81. PMID: 12453415


Dudley DD, Manis JP, Zarrin AA, Kaylor L, Tian M, Alt FW. Internal IgH class switch region deletions are position-independent and enhanced by AID expression. Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9984-9. Epub 2002 Jul 11. PMID: 12114543.


Wills Z, Emerson M, Rusch J, Bikoff J, Baum B, Perrimon N, Van Vactor D. A Drosophila homolog of cyclase-associated proteins collaborates with the Abl tyrosine kinase to control midline axon pathfinding. Neuron. 2002 Nov 14;36(4):611-22. PubMed PMID: 12441051.


Carter AG, Vogt KE, Foster KA, Regehr WG. Assessing the role of calcium-induced calcium release in short-term presynaptic plasticity at excitatory central synapses. J Neurosci. 2002 Jan 1;22(1):21-8. PubMed PMID: 11756484.


Foster KA, Kreitzer AC, Regehr WG. Interaction of postsynaptic receptor saturation with presynaptic mechanisms produces a reliable synapse. Neuron. 2002 Dec 19;36(6):1115-26. PubMed PMID: 12495626.


Halamay KE, Kirkman RL, Sun L, Yamada A, Fragoso RC, Shimizu K, Mitchell RN, McKay DB. CD8 T cells are sufficient to mediate allorecognition and allograft rejection. Cell Immunol, 216(1-2): 6-14. 2002.


Furman MH, Ploegh HL. Lessons from viral manipulation of protein disposal pathways. J Clin Invest. 2002 Oct;110(7):875-9. Review. PubMed PMID: 12370262; PubMed Central PMCID: PMC151163.


Furman MH, Dey N, Tortorella D, Ploegh HL. The human cytomegalovirus US10 gene product delays trafficking of major histocompatibility complex class I molecules. J Virol. 2002 Nov;76(22):11753-6. PubMed PMID: 12388737; PubMed Central PMCID: PMC136774.


Vugmeyster Y, Borodovsky A, Maurice MM, Maehr R, Furman MH, Ploegh HL. The ubiquitin-proteasome pathway in thymocyte apoptosis: caspase-dependent processing of the deubiquitinating enzyme USP7 (HAUSP). Mol Immunol. 2002 Nov;39(7-8):431-41. PubMed PMID: 12413694.


Chou TC, Bjorkum AA, Gaus SE, Lu J, Scammell TE, Saper CB. Afferents to the ventrolateral preoptic nucleus. J Neurosci. 2002 Feb 1;22(3):977-90. PubMed PMID: 11826126.


Chou TC, Bjorkum AA, Gaus SE, Lu J, Scammell TE, Saper CB. Afferents to the ventrolateral preoptic nucleus. J Neurosci. 2002 Feb 1;22(3):977-90. PubMed PMID: 11826126.


Lu J, Bjorkum AA, Xu M, Gaus SE, Shiromani PJ, Saper CB. Selective activation of the extended ventrolateral preoptic nucleus during rapid eye movement sleep. J Neurosci. 2002 Jun 1;22(11):4568-76. PubMed PMID: 12040064.


Gaus SE, Strecker RE, Tate BA, Parker RA, Saper CB. Ventrolateral preoptic
nucleus contains sleep-active, galaninergic neurons in multiple mammalian
species. Neuroscience. 2002;115(1):285-94. PubMed PMID: 12401341.


Gewurz, BE, Ploegh, HL, Tortorella, D. US2, a Human Cytomegalovirus-Encoded Type I Membrane Protein, Contains a Non-cleavable Amino-terminal Signal Peptide. J. Biological Chemistry. 2002 277(13): 11306-13. PMID: 11790769.


Aguirre V, Werner ED, Giraud J, Lee YH, Shoelson SE, White MF. Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J Biol Chem. 2002 Jan 11;277(2):1531-7. Epub 2001 Oct 17. PMID: 11606564


Costigan M, Befort K, Karchewski L, Griffin RS, D'Urso D, Allchorne A, Sitarski J, Mannion JW, Pratt RE, Woolf CJ. Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury. BMC Neurosci. 2002 Oct 25;3:16. Epub 2002 Oct 25. PubMed PMID: 12401135; PubMed Central PMCID: PMC139981.


Renger JJ, Hartman KN, Tsuchimoto Y, Yokoi M, Nakanishi S, Hensch TK. Experience-dependent plasticity without long-term depression by type 2 metabotropic glutamate receptors in developing visual cortex. Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):1041-6. PubMed PMID: 11805343; PubMed Central PMCID: PMC117426.


Heerssen HM, Segal RA. Location, location, location: a spatial view of neurotrophin signal transduction. Trends Neurosci. 2002 Mar;25(3):160-5. Review. PubMed PMID: 11852149.


Koipally J, Heller EJ, Seavitt JR, Georgopoulos K. Unconventional potentiation of gene expression by Ikaros. J Biol Chem. 2002 Apr 12;277(15):13007-15. Epub 2002 Jan 17. PMID: 11799125


Barouch DH, Santra S, Tenner-Racz K, Racz P, Kuroda MJ, Schmitz JE, Jackson SS, Lifton MA, Freed DC, Perry HC, Davies ME, Shiver JW, Letvin NL. Potent CD4+ T cell responses elicited by a bicistronic HIV-1 DNA vaccine expressing gp120 and GM-CSF. J Immunol. 2002 Jan 15;168(2):562-8. PubMed PMID: 11777947.


Sakata Y, Kamei CN, Nakagami H, Bronson R, Liao JK, Chin MT. Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2. Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16197-202. Epub 2002 Nov 26. PubMed PMID: 12454287; PubMed Central PMCID: PMC138588.


Esler WP, Kimberly WT, Ostaszewski BL, Ye W, Diehl TS, Selkoe DJ, Wolfe MS. Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2720-5. Epub 2002 Feb 26. PubMed PMID: 11867728; PubMed Central PMCID: PMC122414.


Esler WP, Das C, Campbell WA, Kimberly WT, Kornilova AY, Diehl TS, Ye W, Ostaszewski BL, Xia W, Selkoe DJ, Wolfe MS. Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase. Nat Cell Biol. 2002 May;4(5):E110-1; author reply E111-2. PubMed PMID: 11988746.


Kimberly WT, LaVoie MJ, Ostaszewski BL, Ye W, Wolfe MS, Selkoe DJ. Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation. J Biol Chem. 2002 Sep 20;277(38):35113-7. Epub 2002 Jul 18. PubMed PMID: 12130643.


He Z, Wang KC, Koprivica V, Ming G, Song HJ. Knowing how to navigate: mechanisms of semaphorin signaling in the nervous system. Sci STKE. 2002 Feb 12;2002(119):re1. Review. PubMed PMID: 11842242.


Wang KC, Koprivica V, Kim JA, Sivasankaran R, Guo Y, Neve RL, He Z. Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth. Nature. 2002 Jun 27;417(6892):941-4. Epub 2002 Jun 16. PubMed PMID: 12068310.


Lee DU, Agarwal S, Rao A. Th2 lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene. Immunity. 2002 May;16(5):649-60. PubMed PMID: 12049717.


Avni O, Lee D, Macian F, Szabo SJ, Glimcher LH, Rao A. T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nat Immunol. 2002 Jul;3(7):643-51. Epub 2002 Jun 10. PubMed PMID: 12055628.


Konishi Y, Lehtinen M, Donovan N, Bonni A. Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery. Mol Cell. 2002 May;9(5):1005-16. PubMed PMID: 12049737.


Heisler LK, Cowley MA, Tecott LH, Fan W, Low MJ, Smart JL, Rubinstein M, Tatro JB, Marcus JN, Holstege H, Lee CE, Cone RD, Elmquist JK. Activation of central melanocortin pathways by fenfluramine. Science. 2002 Jul 26;297(5581):609-11. PubMed PMID: 12142539.


Yamamoto H, Lee CE, Marcus JN, Williams TD, Overton JM, Lopez ME, Hollenberg AN, Baggio L, Saper CB, Drucker DJ, Elmquist JK. Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons. J Clin Invest. 2002 Jul;110(1):43-52. PubMed PMID: 12093887; PubMed Central PMCID: PMC151031.


Gounari F, Aifantis I, Martin C, Fehling HJ, Hoeflinger S, Leder P, von Boehmer H, Reizis B. Tracing lymphopoiesis with the aid of a pTalpha-controlled reporter gene. Nat Immunol. 2002 May;3(5):489-96. Epub 2002 Apr 1. PubMed PMID: 11927910.


Mundy CL, Patenge N, Matthews AG, Oettinger MA. Assembly of the RAG1/RAG2 synaptic complex. Mol Cell Biol. 2002 Jan;22(1):69-77. PubMed PMID: 11739723; PubMed Central PMCID: PMC134220.


Meyers JH, Ryu A, Monney L, Nguyen K, Greenfield EA, Freeman GJ, Kuchroo VK. Cutting edge: CD94/NKG2 is expressed on Th1 but not Th2 cells and costimulates Th1 effector functions. J Immunol. 2002 Nov 15;169(10):5382-6. PubMed PMID: 12421909.


McDonald WH, Ohi R, Miyamoto DT, Mitchison TJ, and Yates JR 3rd. Comparison of three directly coupled HPLC MS/MS strategies for identification of proteins from complex mixtures: single-dimensional LC-MS/MS, 2-phase MudPIT, and 3-phase MudPIT. International Journal of Mass Spectrometry. 2002; 219, 245-251.


Pillai S, Moran ST. Tec kinase pathways in lymphocyte development and transformation. Biochim Biophys Acta. 2002 Jun 21;1602(2):162-7. PMID:12020802.


Xu H, Ramsey IS, Kotecha SA, Moran MM, Chong JA, Lawson D, Ge P, Lilly J, Silos-Santiago I, Xie Y, DiStefano PS, Curtis R, Clapham DE. TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature. 2002 Jul 11;418(6894):181-6. Epub 2002 Jun 23. PubMed PMID: 12077604.


Reppas JB, Usrey WM, Reid RC. Saccadic eye movements modulate visual responses in the lateral geniculate nucleus. Neuron. 2002 Aug 29;35(5):961-74. PubMed PMID: 12372289.


Dymecki SM, Rodriguez CI, Awatramani RB. Switching on lineage tracers using site-specific recombination. Methods Mol Biol. 2002;185:309-34. Review. PubMed PMID: 11768998.


Rooney S, Sekiguchi J, Zhu C, Cheng HL, Manis J, Whitlow S, DeVido J, Foy D, Chaudhuri J, Lombard D, Alt FW. Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice. Mol Cell. 2002 Dec;10(6):1379-90. PMID: 12504013.


Monney L, Sabatos CA, Gaglia JL, Ryu A, Waldner H, Chernova T, Manning S,Greenfield EA, Coyle AJ, Sobel RA, Freeman GJ, Kuchroo VK. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature. 2002 Jan 31;415(6871):536-41. PubMed PMID: 11823861.


Sauvageot CM, Stiles CD. Molecular mechanisms controlling cortical
gliogenesis. Curr Opin Neurobiol. 2002 Jun;12(3):244-9. Review. PubMed PMID: 12049929.


Solymar DC, Agarwal S, Bassing CH, Alt FW, Rao A. A 3' enhancer in the IL-4 gene regulates cytokine production by Th2 cells and mast cells. Immunity. 2002 Jul;17(1):41-50. PMID: 12150890.


St Pierre SE, Galindo MI, Couso JP, Thor S. Control of Drosophila imaginal disc development by rotund and roughened eye: differentially expressed transcripts of the same gene encoding functionally distinct zinc finger proteins. Development. 2002 Mar;129(5):1273-81. PubMed PMID: 11874922.


Duckworth BC, Weaver JS, Ruderman JV. G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16794-9. Epub 2002 Dec 11. PMID: 12477927 PMCID: PMC139223 read article


Neurath MF, Weigmann B, Finotto S, Glickman J, Nieuwenhuis E, Iijima H, Mizoguchi A, Mizoguchi E, Mudter J, Galle PR, Bhan A, Autschbach F, Sullivan BM, Szabo SJ, Glimcher LH, Blumberg RS. The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease. J Exp Med. 2002 May 6;195(9):1129-43. Erratum in: J Exp Med 2002 Jun 3;195(11):1513. PubMed PMID: 11994418; PubMed Central PMCID: PMC2193714.


Szabo SJ, Sullivan BM, Stemmann C, Satoskar AR, Sleckman BP, Glimcher LH. Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science 295(5553):338-42, 2002.


Taddese A, Bean BP. Subthreshold sodium current from rapidly inactivating sodium channels drives spontaneous firing of tuberomammillary neurons. Neuron. 2002 Feb 14;33(4):587-600. PubMed PMID: 11856532.


Taylor TJ, Brockman MA, McNamee EE, Knipe DM. Herpes simplex virus. Front Biosci. 2002 Mar 1;7:d752-64. PMID: 11861220


Tran H, Brunet A, Grenier JM, Datta SR, Fornace AJ Jr, DiStefano PS, Chiang
LW, Greenberg ME. DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science. 2002 Apr 19;296(5567):530-4. PubMed PMID: 11964479.


Tseng CC, Bruner SD, Kohli RM, Marahiel MA, Walsh CT, Sieber SA. Characterization of the surfactin synthetase C-terminal thioesterase domain as a cyclic depsipeptide synthase. Biochemistry. 2002 Nov 12;41(45):13350-9. PMID: 12416979


Hoyer KK, French SW, Turner DE, Nguyen MT, Renard M, Malone CS, Knoetig S, Qi CF, Su TT, Cheroutre H, Wall R, Rawlings DJ, Morse HC 3rd, Teitell MA. Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14392-7. Epub 2002 Oct 14. PubMed PMID: 12381789; PubMed Central PMCID: PMC137894.


Anderson MS, Venanzi ES, Klein L, Chen Z, Berzins SP, Turley SJ, von Boehmer H, Bronson R, Dierich A, Benoist C, Mathis D. Projection of an immunological self shadow within the thymus by the aire protein. Science. 2002 Nov 15;298(5597):1395-401. Epub 2002 Oct 10. PubMed PMID: 12376594.


Caplan D, Vijayan S, Kuperberg G, West C, Waters G, Greve D, Dale AM. Vascular responses to syntactic processing: event-related fMRI study of relative clauses. Hum Brain Mapp. 2002 Jan;15(1):26-38. PubMed PMID: 11747098.


Domeniconi M, Cao Z, Spencer T, Sivasankaran R, Wang K, Nikulina E, Kimura N, Cai H, Deng K, Gao Y, He Z, Filbin M. Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth. Neuron. 2002 Jul 18;35(2):283-90. PubMed PMID: 12160746.


Wang KC, Koprivica V, Kim JA, Sivasankaran R, Guo Y, Neve RL, He Z. Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth. Nature. 2002 Jun 27;417(6892):941-4. Epub 2002 Jun 16. PubMed PMID: 12068310.


Croker BA, Tarlinton DM, Cluse LA, Tuxen AJ, Light A, Yang FC, Williams DA,
Roberts AW. The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes. J Immunol. 2002 Apr 1;168(7):3376-86. PubMed PMID: 11907095.


top

2001


Ramarao MK, Bianchetta MJ, Lanken J, Cohen JB. Role of rapsyn
tetratricopeptide repeat and coiled-coil domains in self-association and
nicotinic acetylcholine receptor clustering. J Biol Chem. 2001 Mar
9;276(10):7475-83. Epub 2000 Nov 21. PubMed PMID: 11087759.


Degterev A, Boyce M, Yuan J. The channel of death. J Cell Biol. 2001 Nov 26;155(5):695-8. Epub 2001 Nov 26. PMID: 11724809 PMCID: PMC2150877 read article


Brittis PA, Flanagan JG. Nogo domains and a Nogo receptor: implications for axon regeneration. Neuron. 2001 Apr;30(1):11-4. Review. PubMed PMID: 11343640.


Catapano LA, Arnold MW, Perez FA, Macklis JD. Specific neurotrophic factors support the survival of cortical projection neurons at distinct stages of development. J Neurosci. 2001 Nov 15;21(22):8863-72. PubMed PMID: 11698598.


Chackerian AA, Perera TV, Behar SM. Gamma interferon-producing CD4+ T lymphocytes in the lung correlate with resistance to infection with Mycobacterium tuberculosis. Infect Immun. 2001 Apr;69(4):2666-74. PubMed PMID: 11254633; PubMed Central PMCID: PMC98205.


Chang DC, Reppert SM. The circadian clocks of mice and men. Neuron. 2001 Mar;29(3):555-8. Review. PubMed PMID: 11301014.


Estabrooke IV, McCarthy MT, Ko E, Chou TC, Chemelli RM, Yanagisawa M, Saper CB, Scammell TE. Fos expression in orexin neurons varies with behavioral state. J Neurosci. 2001 Mar 1;21(5):1656-62. PubMed PMID: 11222656.


Lu J, Zhang YH, Chou TC, Gaus SE, Elmquist JK, Shiromani P, Saper CB. Contrasting effects of ibotenate lesions of the paraventricular nucleus and subparaventricular zone on sleep-wake cycle and temperature regulation. J Neurosci. 2001 Jul 1;21(13):4864-74. PubMed PMID: 11425913.


Chou TC, Lee CE, Lu J, Elmquist JK, Hara J, Willie JT, Beuckmann CT, Chemelli RM, Sakurai T, Yanagisawa M, Saper CB, Scammell TE. Orexin (hypocretin) neurons contain dynorphin. J Neurosci. 2001 Oct 1;21(19):RC168. PubMed PMID: 11567079.


Gooley JJ, Lu J, Chou TC, Scammell TE, Saper CB. Melanopsin in cells of origin of the retinohypothalamic tract. Nat Neurosci. 2001 Dec;4(12):1165. PubMed PMID: 11713469.


Saper CB, Chou TC, Scammell TE. The sleep switch: hypothalamic control of sleep and wakefulness. Trends Neurosci. 2001 Dec;24(12):726-31. Review. PubMed PMID: 11718878.


Schweitzer R, Chyung JH, Murtaugh LC, Brent AE, Rosen V, Olson EN, Lassar A, Tabin CJ. Analysis of the tendon cell fate using Scleraxis, a specific marker for tendons and ligaments. Development. 2001 Oct;128(19):3855-66. PubMed PMID: 11585810.


Murtaugh LC, Zeng L, Chyung JH, Lassar AB. The chick transcriptional repressor Nkx3.2 acts downstream of Shh to promote BMP-dependent axial chondrogenesis. Dev Cell. 2001 Sep;1(3):411-22. PubMed PMID: 11702952.


Ranganathan V, Heine WF, Ciccone DN, Rudolph KL, Wu X, Chang S, Hai H, Ahearn IM, Livingston DM, Resnick I, Rosen F, Seemanova E, Jarolim P, DePinho RA, Weaver DT. Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit. Curr Biol. 2001 Jun 26;11(12):962-6. PubMed PMID: 11448772.


Blumberg RS, van de Wal Y, Claypool S, Corazza N, Dickinson B, Nieuwenhuis E, Pitman R, Spiekermann G, Zhu X, Colgan S, Lencer WI. The multiple roles of major histocompatibility complex class-I-like molecules in mucosal immune function. Acta Odontol. Scand. 2001 Jun; 59(3): 139-44. PMID: 11501882.


Kelley, C., Koipally, J., Cortés, M. and Georgopoulos, K. 2001. Role of Ikaros Proteins in Lymphocyte Development and Function. In: Hematopoiesis, A Developmental Approach, Leonard I. Zon, ed. (Oxford University Press New York, NY).


Day CL, Shea AK, Altfeld MA, Olson DP, Buchbinder SP, Hecht FM, Rosenberg ES, Walker BD, Kalams SA. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J Virol. 2001 Jul;75(14):6279-91. PMID: 11413294 PMCID: PMC114350  read article


Deans MR, Gibson JR, Sellitto C, Connors BW, Paul DL. Synchronous activity of inhibitory networks in neocortex requires electrical synapses containing
connexin36. Neuron. 2001 Aug 16;31(3):477-85. PubMed PMID: 11516403.


Deans MR, Paul DL. Mouse horizontal cells do not express connexin26 or
connexin36. Cell Commun Adhes. 2001;8(4-6):361-6. PubMed PMID: 12064619; PubMed Central PMCID: PMC2834531.


Nghiem P, Park PK, Kim Ys YS, Desai BN, Schreiber SL. ATR is not required for p53 activation but synergizes with p53 in the replication checkpoint. J BiolChem. 2002 Feb 8;277(6):4428-34. Epub 2001 Nov 15. PubMed PMID: 11711532.


Wong DK, Dudley DD, Dohrenwend PB, Lauer GM, Chung RT, Thomas DL, Walker BD. Detection of diverse hepatitis C virus (HCV)-specific cytotoxic T lymphocytes in peripheral blood of infected persons by screening for responses to all translated proteins of HCV. J Virol. 2001 Feb;75(3):1229-35. PMID: 11152496.


Chiu HT, Hubbard BK, Shah AN, Eide J, Fredenburg RA, Walsh CT, Khosla C. Molecular cloning and sequence analysis of the complestatin biosynthetic gene cluster. Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8548-53. Epub 2001 Jul 10. PMID: 11447274 PMCID: PMC37473 read article


Furman MH, Ploegh HL, Tortorella D. Membrane-specific, host-derived factors are required for US2- and US11-mediated degradation of major histocompatibility complex class I molecules. J Biol Chem. 2002 Feb 1;277(5):3258-67. Epub 2001 Nov 20. PubMed PMID: 11717308.


Gewurz, BE, Wang, EW, Tortorella, D, Schust, DJ, Ploegh, HL. The Human Cytomegalovirus US2 Endoplasmic Reticulum-lumenal Domain Dictates Association with Major Histocompatibility Complex Class I in a Locus-specific Manner. J. Virology. 2001 75(11): 5197-204. PMID: 11333901.


Gewurz, BE, Gaudet, R, Tortorella, D, Wang, EW, Ploegh, HL. Virus Immune-evasion: a Structural Perspective. Current Opinion in Immunology. 2001 13(4):442-50. PMID 11498300.


Gewurz, BE, Gaudet, R, Tortorella, D, Wang, EW, Ploegh, HL, Wiley, DC. Antigen Presentation Subverted: Structure of the Human Cytomegalovirus Protein US2 Bound to the Class I Molecule HLA-A2. Proc Natl Acad Sci USA. 2001 98(12): 6794-6799. PMID: 11391001.


Gooley JJ, Lu J, Chou TC, Scammell TE, Saper CB. Melanopsin in cells of origin of the retinohypothalamic tract. Nat Neurosci. 2001 Dec;4(12):1165. PubMed PMID: 11713469.


Watson FL, Heerssen HM, Bhattacharyya A, Klesse L, Lin MZ, Segal RA. Neurotrophins use the Erk5 pathway to mediate a retrograde survival response. Nat Neurosci. 2001 Oct;4(10):981-8. Erratum in: Nat Neurosci 2002 Oct;5(10):1017. PubMed PMID: 11544482.


LaBonte ML, Hershberger KL, Korber B, Letvin NL. The KIR and CD94/NKG2 families of molecules in the rhesus monkey. Immunol Rev. 2001 Oct;183:25-40. PMID: 11782245


Hershberger KL, Shyam R, Miura A, Letvin NL. Diversity of the killer cell Ig-like receptors of rhesus monkeys. J Immunol. 2001 Apr 1;166(7):4380-90. PMID: 11254692


Kane LP, Andres PG, Howland KC, Abbas AK, Weiss A. Akt provides the CD28 costimulatory signal for the up-regulation of IL-2 and IFN-gamma but not TH2 cytokines. Nat Immunol. 2001 Jan;2(1):37-44.


Staats HF, Bradney CP, Gwinn WM, Jackson SS, Sempowski GD, Liao HX, Letvin NL, Haynes BF. Cytokine requirements for induction of systemic and mucosal CTL after nasal immunization. J Immunol. 2001 Nov 1;167(9):5386-94. PubMed PMID: 11673557.


Sun J, Kamei CN, Layne MD, Jain MK, Liao JK, Lee ME, Chin MT. Regulation of myogenic terminal differentiation by the hairy-related transcription factor CHF2. J Biol Chem. 2001 May 25;276(21):18591-6. Epub 2001 Feb 22. PubMed PMID: 11279181.


Volles MJ, Lee SJ, Rochet JC, Shtilerman MD, Ding TT, Kessler JC, Lansbury PT Jr. Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease. Biochemistry. 2001 Jul 3;40(26):7812-9. PMID: 11425308


Kimberly WT, Zheng JB, Guénette SY, Selkoe DJ. The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner. J Biol Chem. 2001 Oct 26;276(43):40288-92. Epub 2001 Sep 5. PubMed PMID: 11544248.


Ko J, Humbert S, Bronson RT, Takahashi S, Kulkarni AB, Li E, Tsai LH. p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment. J Neurosci. 2001 Sep 1;21(17):6758-71. PubMed PMID: 11517264.


Puglielli L, Konopka G, Pack-Chung E, Ingano LA, Berezovska O, Hyman BT, Chang TY, Tanzi RE, Kovacs DM. Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide. Nat Cell Biol. 2001 Oct;3(10):905-12. PubMed PMID: 11584272.


LaBonte ML, Hershberger KL, Korber B, Letvin NL. The KIR and CD94/NKG2 families of molecules in the rhesus monkey. Immunol Rev. 2001 Oct;183:25-40. PMID: 11782245


Marcus JN, Aschkenasi CJ, Lee CE, Chemelli RM, Saper CB, Yanagisawa M, Elmquist JK. Differential expression of orexin receptors 1 and 2 in the rat brain. J Comp Neurol. 2001 Jun 18;435(1):6-25. PubMed PMID: 11370008.


Sun Y, Nadal-Vicens M, Misono S, Lin MZ, Zubiaga A, Hua X, Fan G, Greenberg ME. Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms. Cell. 2001 Feb 9;104(3):365-76. PubMed PMID: 11239394.


Karuman P, Gozani O, Odze RD, Zhou XC, Zhu H, Shaw R, Brien TP, Bozzuto CD, Ooi D, Cantley LC, Yuan J. The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death. Mol Cell. 2001 Jun;7(6):1307-19. PMID: 11430832


Seth KA, Majzoub JA. Repressor element silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) can act as an enhancer as well as a repressor of corticotropin-releasing hormone gene transcription. J Biol Chem. 2001 Apr 27;276(17):13917-23. Epub 2001 Feb 1. PubMed PMID: 11278361.


Fling SP, Sutherland RA, Steele LN, Hess B, D'Orazio SE, Maisonneuve J, Lampe MF, Probst P, Starnbach MN. CD8+ T cells recognize an inclusion membrane-associated protein from the vacuolar pathogen Chlamydia trachomatis. Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1160-5. PubMed PMID: 11158611; PubMed Central PMCID: PMC14725.


Su MW, Yu CL, Burakoff SJ, Jin YJ. Targeting Src homology 2 domain-containing tyrosine phosphatase (SHP-1) into lipid rafts inhibits CD3-induced T cell activation. J Immunol. 2001 Mar 15;166(6):3975-82. PMID: 11238643.


Lu Q, Sun EE, Klein RS, Flanagan JG. Ephrin-B reverse signaling is mediated by a novel PDZ-RGS protein and selectively inhibits G protein-coupled chemoattraction. Cell. 2001 Apr 6;105(1):69-79. PMID: 11301003


Brander C, O'Connor P, Suscovich T, Jones NG, Lee Y, Kedes D, Ganem D, Martin J, Osmond D, Southwood S, Sette A, Walker BD, Scadden DT. Definition of an optimal cytotoxic T lymphocyte epitope in the latently expressed Kaposi's sarcoma-associated herpesvirus kaposin protein. J Infect Dis. 2001 Jul 15;184(2):119-26. Epub 2001 Jun 18. PMID: 11424007


Brunet A, Park J, Tran H, Hu LS, Hemmings BA, Greenberg ME. Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). Mol Cell Biol. 2001 Feb;21(3):952-65. PubMed PMID: 11154281; PubMed Central PMCID: PMC86685.


Suo Z, Tseng CC, Walsh CT. Purification, priming, and catalytic acylation of carrier protein domains in the polyketide synthase and nonribosomal peptidyl synthetase modules of the HMWP1 subunit of yersiniabactin synthetase. Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):99-104. PMID: 11134531 PMCID: PMC14551 read article


Chen H, Tseng CC, Hubbard BK, Walsh CT. Glycopeptide antibiotic biosynthesis: enzymatic assembly of the dedicated amino acid monomer (S)-3,5-dihydroxyphenylglycine. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):14901-6. PMID: 11752437 PMCID: PMC64956 read article


Kramer A, Yang FC, Snodgrass P, Li X, Scammell TE, Davis FC, Weitz CJ.
Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor
signaling. Science. 2001 Dec 21;294(5551):2511-5. PubMed PMID: 11752569.


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2000


Carter AG, Regehr WG. Prolonged synaptic currents and glutamate spillover at the parallel fiber to stellate cell synapse. J Neurosci. 2000 Jun 15;20(12):4423-34. PubMed PMID: 10844011.


Wu X, Ranganathan V, Weisman DS, Heine WF, Ciccone DN, O'Neill TB, Crick KE, Pierce KA, Lane WS, Rathbun G, Livingston DM, Weaver DT. ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response. Nature. 2000 May 25;405(6785):477-82. PubMed PMID: 10839545.


Melián A, Watts GF, Shamshiev A, De Libero G, Clatworthy A, Vincent M, Brenner MB, Behar S, Niazi K, Modlin RL, Almo S, Ostrov D, Nathenson SG, Porcelli SA. Molecular recognition of human CD1b antigen complexes: evidence for a common pattern of interaction with alpha beta TCRs. J Immunol. 2000 Oct 15;165(8):4494-504. PubMed PMID: 11035089.


Tortorella D, Gewurz BE, Furman MH, Schust DJ, Ploegh HL. Viral subversion of the immune system. Annu Rev Immunol. 2000;18:861-926. Review. PubMed PMID: 10837078.


Furman MH, Ploegh HL, Schust DJ. Can viruses help us to understand and classify the MHC class I molecules at the maternal-fetal interface? Hum Immunol. 2000 Nov;61(11):1169-76. Review. PubMed PMID: 11137223.


McAdam AJ, Farkash EA, Gewurz BE, Sharpe AH. B7 costimulation is critical for antibody class switching and CD8(+) cytotoxic T-lymphocyte generation in the host response to vesicular stomatitis virus. J. Virology. 2000 74(1): 203-8. PMID: 10590107.


McAdam, AJ, Gewurz BE, Farkash, EA, Sharpe, AH. Either B7 costimulation or IL-2 can elicit generation of primary alloreactive CTL. J. Immunology. 2000 165(6): 3088-93. PMID: 10975820.


Tortorella D, Gewurz BE, Schust DJ, Furman MH, Ploegh HL. Down-regulation of MHC Class I Antigen Presentation by HCMV; Lessons for Tumor Immunology. Immunol. Invest. 2000. 29(2): 97-100. PMID 10854174.


Tortorella, D, Gewurz, BE, Furman, MH, Schust, DJ and Ploegh, HL. Viral Subversion of the Immune System. Ann Rev Immunology. 2000 18: 861-926. PMID 10837078.


Etemad-Moghadam B, Sun Y, Nicholson EK, Fernandes M, Liou K, Gomila R, Lee J, Sodroski J. Envelope glycoprotein determinants of increased fusogenicity in a pathogenic simian-human immunodeficiency virus (SHIV-KB9) passaged in vivo. J Virol. 2000 May;74(9):4433-40. PMID: 10756060 PMCID: PMC111962 read article


Howland KC, Ausubel LJ, London CA, Abbas AK. The roles of CD28 and CD40 ligand in T cell activation and tolerance. J Immunol. 2000 May 1;164(9):4465-70.


Santra S, Barouch DH, Jackson SS, Kuroda MJ, Schmitz JE, Lifton MA, Sharpe AH, Letvin NL. Functional equivalency of B7-1 and B7-2 for costimulating plasmid DNA vaccine-elicited CTL responses. J Immunol. 2000 Dec 15;165(12):6791-5. PubMed PMID: 11120800.


Kimberly WT, Xia W, Rahmati T, Wolfe MS, Selkoe DJ. The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation. J Biol Chem. 2000 Feb 4;275(5):3173-8. PubMed PMID: 10652302.


Esler WP, Kimberly WT, Ostaszewski BL, Diehl TS, Moore CL, Tsai JY, Rahmati T, Xia W, Selkoe DJ, Wolfe MS. Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1. Nat Cell Biol. 2000 Jul;2(7):428-34. PubMed PMID: 10878808.


Berezovska O, Jack C, McLean P, Aster JC, Hicks C, Xia W, Wolfe MS, Kimberly WT, Weinmaster G, Selkoe DJ, Hyman BT. Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling. J Neurochem. 2000 Aug;75(2):583-93. PubMed PMID: 10899933.


Xia W, Ray WJ, Ostaszewski BL, Rahmati T, Kimberly WT, Wolfe MS, Zhang J, Goate AM, Selkoe DJ. Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation. Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9299-304. PubMed PMID: 10922078; PubMed Central PMCID: PMC16862.


Xia W, Ostaszewski BL, Kimberly WT, Rahmati T, Moore CL, Wolfe MS, Selkoe DJ. FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex. Neurobiol Dis. 2000 Dec;7(6 Pt B):673-81. PubMed PMID: 11114265


Niethammer M, Smith DS, Ayala R, Peng J, Ko J, Lee MS, Morabito M, Tsai LH. NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein. Neuron. 2000 Dec;28(3):697-711. PubMed PMID: 11163260.


Chen Z, Koralov SB, Gendelman M, Carroll MC, Kelsoe G. Humoral immune responses in Cr2-/- mice: enhanced affinity maturation but impaired antibody persistence . J Immunol. 2000. 164(9):4522-32.


Review Article: Chen Z, Koralov SB, Kelsoe G. Regulation of humoral immune responses by CD21/CD35. Immunol Rev. 2000;176:194-204. PMID: 11043778.


LaBonte ML, Levy DB, Letvin NL. Characterization of rhesus monkey CD94/NKG2 family members and identification of novel transmembrane-deleted forms of NKG2-A, B, C, and D. Immunogenetics. 2000 May;51(6):496-9. PMID: 10866118


Lin JW, Ju W, Foster K, Lee SH, Ahmadian G, Wyszynski M, Wang YT, Sheng M. Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization. Nat Neurosci. 2000 Dec;3(12):1282-90. PubMed PMID: 11100149.


Man HY, Lin JW, Ju WH, Ahmadian G, Liu L, Becker LE, Sheng M, Wang YT. Regulation of AMPA receptor-mediated synaptic transmission by clathrin-dependent receptor internalization. Neuron. 2000 Mar;25(3):649-62. Erratum in: Neuron 2001 Jan;29(1):307. PubMed PMID: 10774732.


Haggarty SJ, Mayer TU, Miyamoto DT, Fathi R, King RW, Mitchison TJ, Schreiber SL. Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis. Chem Biol. 2000 Apr;7(4):275-86. PMID: 10780927


Kwon J, Morshead KB, Guyon JR, Kingston RE, Oettinger MA. Histone acetylation and hSWI/SNF remodeling act in concert to stimulate V(D)J cleavage of nucleosomal DNA. Mol Cell. 2000 Nov;6(5):1037-48. PubMed PMID: 11106743.


Rodriguez CI, Dymecki SM. Origin of the precerebellar system. Neuron. 2000 Sep;27(3):475-86. PubMed PMID: 11055431.


Brander C, Suscovich T, Lee Y, Nguyen PT, O'Connor P, Seebach J, Jones NG, van Gorder M, Walker BD, Scadden DT. Impaired CTL recognition of cells latently infected with Kaposi's sarcoma-associated herpes virus. J Immunol. 2000 Aug 15;165(4):2077-83. PMID: 10925292


Tavazoie SF, Reid RC. Diverse receptive fields in the lateral geniculate nucleus during thalamocortical development. Nat Neurosci. 2000 Jun;3(6):608-16. PubMed PMID: 10816318.


Jones CA, Taylor TJ, Knipe DM. Biological properties of herpes simplex virus 2 replication-defective mutant strains in a murine nasal infection model. Virology. 2000 Dec 5;278(1):137-50. PMID: 11112490


McNamee EE, Taylor TJ, Knipe DM. A dominant-negative herpesvirus protein inhibits intranuclear targeting of viral proteins: effects on DNA replication and late gene expression. J Virol. 2000 Nov;74(21):10122-31. PMID: 11024141 PMCID: PMC102051 read article


Trinidad JC, Fischbach GD, Cohen JB. The Agrin/MuSK signaling pathway is spatially segregated from the neuregulin/ErbB receptor signaling pathway at the neuromuscular junction. J Neurosci. 2000 Dec 1;20(23):8762-70. PubMed PMID: 11102484.


Vedantham V, Cannon SC. Rapid and slow voltage-dependent conformational changes in segment IVS6 of voltage-gated Na(+) channels. Biophys J. 2000 Jun;78(6):2943-58. PubMed PMID: 10827974; PubMed Central PMCID: PMC1300879.


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