Naoshige Uchida , Ph.D.
Assistant Professor of Molecular and Cellular Biology
Sherman Fairchild Biochemistry Bldg
7 Divinity Ave
Cambridge, MA 2138
Visit my lab page here.
Our laboratory is interested in neuronal mechanisms by which sensory information and memory about previous experiences guide behavior of the animal. Our main questions are:
* How is odor information coded and processed by an ensemble of neurons?
* What kinds of circuit dynamics underlie decision-making processes?
* What are the mechanisms for learning based on rewards and punishments?
We have developed an odor-guided perceptual decision task in mice and rats. This behavioral paradigm was recently combined with a multi-electrode recording technique (tetrodes) which allows us to monitor activity of multiple neurons simultaneously while animals are performing a behavioral task. Particular emphasis will be made on the use of behavior. First, behavioral paradigms specify computations (e.g. extracting relevant information in the sensory stimulus) and behavioral goals (e.g. maximizing rewards in a certain period) to be achieved. This in turn guides the way neuronal activities are analyzed. Furthermore, behavioral experiments are necessary to test relevance of certain activity of neurons or hypothesis about “neural codes” obtained in neuronal recordings. We will use various molecular and genetic tools available in mice to further test specific hypotheses experimentally. By combining the above approaches, we wish to establish a causal link between activity of specific neuronal circuits and the dynamics of behavior and learning.
For a complete listing of publications click here.