Clifford Saper , M.D., Ph.D.
James Jackson Putnam Professor of Neurology
Head of the Department of Neurology at Beth Israel Deaconess Medical Center
The focus of the Saper laboratory is on the integrated functions maintained by the hypothalamus. These include regulation of wake-sleep cycles, body temperature, and feeding. These functions interact with one another extensively, and all three are driven by homeostatic mechanisms as well as by circadian influences. We attempt to identify the neuronal circuitry that is involved in regulating these responses. We use a variety of methods to analyze neuronal circuits and their functions, including axonal tracer methods combined with in situ hybridization and immunohistochemistry; physiological recordings ranging from whole animal chronic recording, to lesion and stimulation methods, single cell extracellular recording in whole animals, and to intracellular recordings in slice preparations; and we use viral vectors and transgenic approaches to introduce and manipulate genes in specific sets of neurons in the brain, and determine their function. In addition to identifying this circuitry in experimental animals, we also are interested in determining the homologous circuitry in human brians, and in determining how it may be disrupted in specific neurological and psychiatric disorders.
For a complete listing of Clifford Saper's publications on PubMed, click here.