Scott L. Pomeroy, M.D., Ph.D.
Bronson Crothers Professor of Neurology
Chairman, Department of Neurology at Children's Hospital
Kirby Neurobiology Center
Children's Hospital
Center for Life Science Building
3 Blackfan Circle
Boston, MA 02115
Telephone: 617 919-2749
Fax: 617-730-0286
Email: scott.pomeroy@childrens.harvard.edu
Medulloblastomas are the most common malignant brain tumors of childhood, with 40-50% overall mortality. Using genomic methods, we have found that certain subtypes of medulloblastomas arise from cerebellar granule cell progenitors. Using a Ptc +/- mouse model, we discovered that tumors arise through a multistep process, starting with persistent proliferation of pre-neoplastic cells followed by emergence of neoplastic cells that progress to form tumors. We now are testing how epigenetic mechanisms promote neoplastic transformation and tumor progression.
For a complete listing of Scott Pomeroy's publications on PubMed, click here.