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Joseph Majzoub, M.D.

Thomas Morgan Rotch Professor of Pediatrics

Childrens' Hospital
Karp Family Research Bldg, Rm 04-125
300 Longwood Ave
Boston, MA 02115
Telephone: 617-919-2930
Fax: 617- 730-0244
Email: joseph.majzoub@childrens.harvard.edu
Predocs: 0 Postdocs: 4 Completed PhD's: 7

 Joseph Majzoub

The specific aims of the Majzoub laboratory's studies are to determine the impact of corticotropin releasing hormone (CRH) and vasopressin excess and deficiency on regulation of the neuroendocrine and behavioral responses to stress. This work is also directed at determining how DNA variants in the gene for corticotropin releasing hormone affect stress and other behaviors, including appetite. He and his colleagues are currently working to define how transcriptional silencers interact with transciptional activators to regulate CRH gene expression.

References:

  • Seth K, Majzoub JA. REST/NRSF can act as an enhancer as well as a repressor of corticotropin-releasing hormone gene transcription. Journal of Biology Chemistry 2001; 276: 13917-13923.

  • Venihaki M, Sakihara S, Subramanian S, Dikkes P, Weninger SC, Liapakis G, Graf T, Majzoub JA. Urocortin III, a Brain Neuropeptide of the Corticotropin-Releasing Hormone Family: Modulation by Stress and Attenuation of Some Anxiety-Like Behaviors. J Neuroendocrinol 2004; 16: 411–22.

  • Jeong KH, Sakihara S, Widmaier EP, Majzoub JA. Impaired leptin expression and abnormal response to fasting in corticotropin-releasing hormone-deficient mice. Endocrinology 2004; 145: 3174–3181.


  • Silverman ES, Breault DT, Vallone J Subramanian S, Yilmaz AD, Mathew S, Subramaniam V Tantisira K, Pacák K, Weiss ST, Majzoub JA. Corticotropin-releasing hormone deficiency increases allergen-induced airway inflammation in a mouse model of asthma. J Allergy Clin Immunol 2004; 114: 747-54.