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Bradley Hyman, M.D., Ph.D.

John B. Penney, Jr. Professor of Neurology

Massachsetts General Hospital-East
Dept. of Neurology
114 16th Street
Charlestown, MA 02129
Telephone: 617-726-2299
Fax: 617- 724-1480
Email:bhyman@partners.org
Predocs: 3 Postdocs: 12 Completed PhD's: 1


Bradley Hyman

Dr. Hyman’s laboratory studies the anatomical and molecular basis of dementia in Alzheimer’s disease and dementia with Lewy bodies.  Approaches focus on transgenic mouse models and human neuropathological samples, using advanced microscopy techniques for in vivo imaging, and quantitative approaches to clinical pathological and genotype/phenotype analyses.  Recent studies have developed the use of multiphoton microscopy for in vivo anatomical and functional imaging in transgenic mouse models of Alzheimer’s disease and the utilization of gene transfer techniques to introduce potentially disease-modifying genes into specific cortical regions.  We have also developed fluoresence resonance energy transfer (FRET) approaches to allow observation of protein-protein interactions with subcellular resolution, both in vitro and in vivo.  These techniques are utilized to examine the alterations that occur in Alzheimer’s disease brain, and in mouse models expressing genetic mutants that are linked to Alzheimer’s disease.

 

References:

  • Spires TL, Meyer-Luehmann M, Stern EA, McLean PJ, Skoch J, Nguyen PT, Bacskai BJ, and Hyman BT Dendritic spine abnormalities in APP transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy. J Neurosci 2005; 25(31):7278-87

  • Spoelgen R, Arnim CV, Thomas AV, Peltan I, Koker M, Deng M, Irizarry MC, Andersen O, Willnow T, Hyman BT Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein and ? secretase, BACE.  J Neurosci 2006 Jan 11;26(2):418-28.

  • Spires TL, Orne JD,  SantaCruz K, Pitstick R, Carlson GA,  Hsiao Ashe K, Hyman BT.  Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy.  Am J Pathol 2006 May;168(5):1598-607.

  • Klucken J, Outeiro TF, Nyugen P, McLean PJ, and Hyman BT. Detection of novel intracellular alpha-synuclein oligomeric species by fluorescence lifetime imaging. FASEB J 2006 Oct;20(12):2050-7.

  • Outeiro T, Kontopoulos E,  Altman S, Kufareva I, Strathearn KE, Amore AM, Volk CB, Maxwell MM, Rochet JC, McLean PM, Young AB, Abagyan R,. Feany MB, Hyman BT, and Kazantsev A. Sirtuin 2 Inhibitors Rescue Alpha-Synuclein-Mediated Toxicity in Models of Parkinson’s Disease. Science 2007 Jul 27; 317(5837):516-519.