PiN Faculty Member - Susan Dymecki, MD, PhD

Susan Dymecki, MD, PhD

Professor of Genetics

Harvard Medical School
Deptartment of Genetics
New Research Buildling, Room 358
77 Avenue Louis Pasteur
Boston, MA 02115
Tel: 617-432-7618/ 4812
Fax: 617-432-7595
Email: dymecki@genetics.med.harvard.edu
Visit my lab page here.



The Dymecki lab studies how functional modularity arises within the brain serotonergic neuronal system and dynamically controls diverse processes ranging from respiration and thermal balance to emotional mood state to coping behaviors.

Understanding how this fundamental system develops at the molecular, cellular, and functional levels will help illuminate root causes of many brain disorders, paving the way for more targeted therapeutics and effective approaches to clinical conditions such as sudden infant death, major depression, and post-traumatic stress.

Using novel genetic tools for precision neural cell mapping in the mouse brain coupled with genomic, transcriptional, electrophysiological, and behavioral analyses, we examine the developmental specialization of subtypes of serotonin-producing neurons together with their network architecture, circuitry modulation, and selective roles in behavior. We probe how such neuronal diversity is generated and maintained, exploring the extent to which it is genetically programmed versus shaped by experience. Emerging is a neuronal structure-function map of substantial heterogeneity that suggests new ways to conceptualize and design treatments for serotonin-related disorders.



Last Update: 12/5/2018



Publications

For a complete listing of publications click here.

 


 



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