PiN Faculty Member - Daniel Polley, PhD

Daniel Polley, PhD

Associate Professor of Otology and Laryngology

Massachusetts Eye and Ear Infirmary
Eaton-Peabody Laboratory, Neural Plasticity Research Unit
243 Charles Street
Boston, MA 02114
Tel: 617-391-5951
Fax: 617-573-3939
Email: daniel_polley@meei.harvard.edu
Visit my lab page here.



Our research interests lie in understanding the mechanisms and clinical implications of brain plasticity. Auditory brain plasticity exhibits a fundamental duality, a yin and yang, in that it is both a source and possible solution for various types of hearing impairment. When signaling between the ear and the brain is disrupted, the balance of excitation and inhibition tips toward hyperexcitability throughout the central auditory neuroaxis, increasing the ‘central gain’ on afferent signals so as to partially compensate for a diminished input from the auditory periphery. Our work shows that excess central gain can distort the temporal coding of complex communication sounds and even induce the perception of phantom sounds, contributing to pathophysiological processes such as hyperacusis and tinnitus. This is the ‘yin’, the dark side of brain plasticity, wherein the transcriptional, physiological and neurochemical changes that compensate for the loss or degradation of peripheral input can incur debilitating perceptual costs. We are also committed to understand the ‘yang’ of brain plasticity, how the remarkable malleability of the adult brain can be harnessed and directed towards an adaptive – or even therapeutic – endpoint. Our ongoing research suggests that a cluster of cholinergic cells deep in the basal forebrain may hold the key to adjusting the volume knob in hyperactive auditory circuits. We use a combination of 2-photon calcium imaging, optogenetics, photometry and large-scale single unit recordings to tune into the dialog between the basal forebrain and key cell types in the auditory thalamus and auditory cortex of awake mice engaged in active listening tasks. In parallel, we use high-channel EEG, pupillometry and psychophysical approaches to reveal the hidden neural signatures of tinnitus and disordered speech perception in human subjects. We have developed novel audiomotor training platforms for patients with hearing loss and tinnitus that suggest new treatment avenues for these perceptual disorders.



Last Update: 12/5/2018



Publications

For a complete listing of publications click here.

 


 



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