PiN Faculty Member - Jeffrey Macklis, MD

Jeffrey Macklis, MD

Max and Anne Wien Professor of Life Sciences, Harvard University
Professor of Stem Cell and Regenerative Biology, Harvard University
Professor of Neurology and of Neurosurgery, Harvard Medical School

Harvard University
Bauer Laboratory 103
7 Divinity Avenue
Cambridge, MA 02138
Tel: 617-495-5413
Fax: 617-496-9679
Visit my lab page here.

Our laboratory is directed toward both 1) understanding molecular controls and mechanisms over neuron sub-type development, diversity, axon guidance-circuit formation, and degeneration in the cerebral cortex (e.g. corticospinal motor neurons - CSMN - in motor neuron disease - ALS, HSPs, and PLS; corticostriatal projection neurons – CStrPN - in Huntington’s disease – HD – and related corticobasal degeneration - CBD), and 2) applying developmental controls toward both brain and spinal cord regeneration (e.g. corticospinal motor neuron (CSMN) circuitry that degenerates in ALS and other “upper motor neuron” degenerative diseases, and whose injury is central to loss of motor function in spinal cord injury) and directed differentiation for in vitro therapeutic and mechanistic screening.

The lab focuses on neocortical projection neuron development and sub-type specification; neural progenitor / “stem cell” biology; induction of adult neurogenesis (the birth of new neurons); subtype-specific axonal growth cone biology; and directed neuronal subtype differentiation via molecular manipulation of neural progenitors and pluripotent cells (ES/iPS). The same biology informs understanding of neuronal subtype specificity of vulnerability of human neurodegenerative and developmental diseases, in particular ALS / motor neuron disease, HSPs, PLS, Huntington's disease, autism spectrum disorders (ASD), and Rett syndrome and ACC in particular of ASDs.

Last Update: 3/2/2015


For a complete listing of publications click here.



© 2016 President and Fellows
of Harvard College