PiN Faculty Member - Jeffrey Macklis, MD

Jeffrey Macklis, MD

Max and Anne Wien Professor of Life Sciences, Harvard University
Professor of Stem Cell and Regenerative Biology, Harvard University
Professor of Neurology and of Neurosurgery, Harvard Medical School


Harvard University
Bauer Laboratory 103
7 Divinity Avenue
Cambridge, MA 02138
Tel: 617-495-5413
Fax: 617-496-9679
Email: jeffrey_macklis@harvard.edu
Visit my lab page here.



Our laboratory is directed toward both 1) understanding molecular controls and mechanisms over neuron subtype development, diversity, axon guidance-circuit formation, and degeneration-disease in the cerebral cortex [e.g. corticospinal motor neurons (CSMN) in motor neuron disease (ALS, HSPs, PLS), and associative circuitry in autism (ASD) and intellectual disability], and 2) applying developmental controls toward both brain and spinal cord regeneration [e.g. CSMN circuitry that degenerates in ALS-MND, and whose injury is central to loss of motor function in spinal cord injury] and directed differentiation for in vitro therapeutic and mechanistic screening.

The lab focuses on neocortical projection neuron development and subtype specification; new approaches to subtype-specific axonal growth cone biology; neural progenitor / “stem cell” biology; induction of adult neurogenesis (the birth of new neurons); and directed neuronal subtype differentiation via molecular manipulation of endogenous neural progenitors and pluripotent cells (ES/iPS). The same biology informs understanding of neuronal specificity of vulnerability in human neurodegenerative and developmental diseases. Relationships and application of cortical development to evolution, disease, and regeneration are frequent themes.



Last Update: 12/5/2018



Publications

For a complete listing of publications click here.

 


 



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