PiN Faculty Member - Jun Huh

Jun Huh

Assistant Professor of Microbiology and Iimmunobiology

Harvard Medical School
77 Avenue Louis Pasteur, NRB 1054e

Boston, MA 02115
Tel: 617-432-5355
Email: jun_huh@hms.harvard.edu
Visit my lab page here.



Inflammation is critical to protect us from dangers within (e.g. cancer) and without (e.g. microbes). However, uncontrolled immune responses can also lead to pathological conditions, including autoimmune and neurodevelopmental/ neuropathological diseases. In this regard, immune cell modulation could be an attractive strategy for treating various disease states.

The Huh lab is studying the dynamic interplay between the host immune system and gut-residing bacteria in pregnant mothers and in adult mice with the goal of understanding how such interactions dictate neural development of the developing fetus and shape animal behaviors.Furthermore, we are interested in uncovering underappreciated roles of immune molecules in modulating neural function and, thus, animal behaviors in both healthy and diseased conditions. Lastly, we are interested in identifying host- and bacteria-derived small molecules that modulate inflammatory responses by directly acting on specific receptors of immune cells.

To address these questions, we utilize various immunological techniques, genetically engineered mouse lines and various behavioral assays. These tools are used in conjunction with germ-free or gnotobiotic mice colonized with defined gut bacteria.



Last Update: 2/8/2018



Publications

For a complete listing of publications click here.

 


 



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