PiN Faculty Member - Anna Greka, MD, PhD

Anna Greka, MD, PhD

Assistant Professor of Medicine

Brigham and Women's Hospital
Harvard Institute of Medicine
4 Blackfan Circle, 5th Floor
Boston, MA 02115
Tel: 617-510-5070
Fax: 617-726-5669
Email: agreka@bwh.harvard.edu
Visit my lab page here.




Our laboratory is broadly interested in the biology of ion channels and calcium signaling in health and disease.

Ion channels are critical to cellular physiology because they are uniquely adapted to rapidly transduce signals across functional compartments separated by membranes. This is clear in the range and severity of diseases caused by ion channel mutations (channelopathies) particularly in the central nervous system, the cardiovascular system, kidney disease, diabetes and muscle disease, to name a few.

Traditionally channels have been studied using extremely high resolution but low throughput methods such as patch clamp electrophysiology. Our recent efforts in the lab are aimed at leveraging systems and circuit-based investigative approaches to develop a platform that will allow us to gain deep and unbiased understanding of the cellular mechanisms triggered by ion channels nominated by human genetics in relevant cell types and models. Ultimately this work will lead to a comprehensive understanding of dysfunctional pathways involving ion channels with implications for the development of targeted therapies.

We are using the tools of molecular biology, cell biology, advanced imaging techniques, patch clamp electrophysiology and animal models to study the role of ion channels in health and disease.



Last Update: 12/5/2018



Publications

For a complete listing of publications click here.

 


 



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