Immunology Faculty Member - Roni Nowarski

Roni Nowarski

Member of the Faculty

Evergrande Center for Immunologic Diseases
Building for Transformative Medicine, Room 9016AA
60 Fenwood Road
Boston, MA 02115
Email: rnowarski@bwh.harvard.edu
Visit my lab page here.



Tissue immunoregulation of inflammation
Our laboratory studies the immune signaling pathways that regulate tissue inflammation, and the mechanistic basis for tissue pathology in inflammatory and autoimmune disorders. The questions we pursue are grounded in understanding the interplay between tissue physiology and the innate immune system, as a central axis controlling homeostasis and disease. A major focus of the lab is the immunoregulatory roles of the non-immune cells, including epithelial, stromal and vascular cells, in the development of pathological inflammatory responses. We use advanced mouse models and imaging platforms, as well as a variety of genetic, molecular and cellular techniques to investigate immune signaling within tissues and to discover the factors that impact fundamental tissue functions in the inflammatory setting. Our mission is to identify effective therapeutic targets for restoring tissue integrity in immune-related disorders. To learn more, visit our lab website: https://www.nowarskilab.com/



Last Update: 6/20/2018



Publications

For a complete listing of publications click here.

 


 

Nowarski, R., R. Jackson, and R. A. Flavell. 2017. The Stromal Intervention: Regulation of Immunity and Inflammation at the Epithelial-Mesenchymal Barrier. Cell 168: 362-375.

Nowarski, R., R. Jackson, N. Gagliani, M. R. de Zoete, N. W. Palm, W. Bailis, J. S. Low, C. C. Harman, M. Graham, E. Elinav, and R. A. Flavell. 2015. Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis. Cell 163: 1444-1456.

Wlodarska, M., C. A. Thaiss, R. Nowarski, J. Henao-Mejia, J. P. Zhang, E. M. Brown, G. Frankel, M. Levy, M. N. Katz, W. M. Philbrick, E. Elinav, B. B. Finlay, and R. A. Flavell. 2014. NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion. Cell 156: 1045-1059.

Elinav, E., R. Nowarski, C. A. Thaiss, B. Hu, C. Jin, and R. A. Flavell. 2013. Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms. Nature reviews. Cancer 13: 759-771.



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