Andrew Lichtman
Department of Pathology
Brigham and Women's Hospital
HIM/NRB-7, Room 752N
77 Avenue Louis Pasteur
Boston, MA 02115
Tel: 617-525-4335
Fax: 617-525-4333
email:alichtman@rics.bwh.harvard.edu
5 Postdoctoral Fellows, 1 Medical Student, 1 Graduate Student
My laboratory research program focuses on T lymphocyte mediated immunity. We study the mechanisms of migration of different effector T cell subsets of into tissues, and immunologic aspects of cardiovascular disease. Our work on the mechanisms by which T cells cause damage to the cardiovascular system makes use of mouse models of atherosclerosis and myocarditis. Recent efforts in our lab have defined the impact of T cell costimulatory and regulatory pathways on these diseases.
References:
- Cai YH, Alvarez A , Alcaide P, Duramad P, Lim Y-C, Jarolim P, Lowe JB, Luscinskas FW, and Lichtman AH. Abrogation of functional selectin-ligand expression reduces migration of pathogenic CD8+ T cells into heart. Journal of Immunology. 2006; 176: 6568–6575.
- Taqueti VR, Grabie N, Colvin R, Pang H, Jarolim P, Luster A, Glimcher L, and Lichtman AH. T-bet controls pathogenicity of cytotoxic T lymphocytes in the heart by separable effects on migration and effector activity. Journal of Immunology. 2006; 177:5890-901.
- Gotsman I, Grabie N, Gupta R, Dacosta R, MacConmara M, Lederer J, Sukhova G, Witztum JL, Sharpe AH, Lichtman AH. Impaired regulatory T-cell response and enhanced atherosclerosis in the absence of inducible costimulatory molecule. Circulation 2006; 114:2047-55.
- Love VA, Grabie N, Stavrakis G, Sharpe A, and Lichtman AH. CTLA-4 ablation and IL-12-driven differentiation synergistically augment cardiac pathogenicity of CTL. Circulation Research. 2007. In Press
- Gotsman I,,Grabie N, Dacosta R, Sukhova G, Sharpe A, and Lichtman AH. Proatherogenic immune responses are regulated by the PD-1/PD-L pathway. Journal of Clinical Investigation. 2007. In Press.
Immunology webpage updated 12/02/2009