Peter F. Weller


Beth Israel Deaconess Medical Center
CLS Building, Room 943
330 Brookline Avenue
Boston, MA 2215
Tel: 617-735-4110
Fax: 617-735-4115
Email: pweller@bidmc.harvard.edu




Research in this laboratory is centered around understanding basic mechanisms of leukocyte functioning in forms of inflammation. The two principal areas of investigation are:

1.) the immunobiology of eosinophilic leukocytes
2.) the intracellular regulation and compartmentalization of inducible mediators of inflammation in neutrophils and other leukocytes.

Studies of human eosinophils are aimed at defining mechanisms whereby eosinophils may collaboratively interact with other cellular elements of the immune system. These studies include investigations of the mechanisms whereby eosinophils may function as antigen-presenting cells in governing T-lymphocyte dependent immune responses, and include investigations of the in vivo migration and function of eosinophils and of the regulated expression of cell surface proteins involved in collaborative interactions between eosinophils and other cell types. Additional studies are focused on defining the molecular mechanisms governing the synthesis, granule storage and release mechanisms of eosinophil derived cytokines.

The second area of research involves the molecular and cellular biologic bases of inducible responses of leukocytes participating in host defense and other forms of inflammation. These are centered on a unique intracellular compartment, termed the lipid body, whose formation is rapidly inducible in leukocytes. The intracellular signaling mechanisms responsible for lipid body induction and especially the roles of lipid bodies as distinct sites of cytokine and eicosanoid mediator formation are being studied. In addition to investigating previously undefined pathways of leukocyte responses to inflammation, these studies also offer the potential to identify novel anti inflammatory therapeutic targets.

References:

Spencer LA, Melo RCN, Perez SAC, Bafford SP. Dvorak AM, Weller PF. Cytokine receptor-mediated trafficking of preformed IL-4 in eosinophils identifies an innate immune mechanism of cytokine secretion Proc Natl Acad Sci USA 2006;103:3333-3338.

Wan HC, Melo RCN, Jin Z, Dvorak AM, Weller PF. Roles and origins of leukocyte lipid bodies: proteomic and ultrastructural studies. FASEB J 2007;21:167-178.

Wang H-B, Ghiran I, Matthaei K, Weller PF. Airway eosinophils function as professional antigen-presenting cells. J Immunol. 2007;179:7585-7592.

Wang H-B, Weller PF. Pivotal Advance: Eosinophils mediate early alum adjuvant-elicited B cell priming and IgM production. J Leuko Biol 2008;83:817-821.

Rothenberg ME, Klion AD, Roufosse FE, Kahn JE, Weller PF, Simon H-U, Schwartz LB, Rosenwasser LJ, Ring J, Griffin E, Haig AE, Frewer PIH, Parkin JMM, Gleich GJ, on behalf of the Mepolizumab HES Study Group. Treatment of hypereosinophilic syndrome with mepolizumab, an anti-IL-5 antibody. New Engl J Med 2008; 358:1215-1228.



Last Update: 1/6/2014