Shannon J. Turley
Associate Program Head, Graduate Program in Immunology
Department of Pathology
Harvard Medical School
Dept. of Cancer Immunology and AIDS
Dana Farber Cancer Institute
Dana Building, Room 1440
44 Binney Street
Boston, MA 02115
Tel: 617-632-4990
Fax: 617-582-7999
Email: shannon_turley@dfci.harvard.edu
website:The Turley Lab Page
3 Postdoctoral Fellows, 1 Graduate Student, 1 Medical Student
The Turley Lab is interested in deciphering how the interactions between antigen presenting cells and CD4 and CD8 T cells can lead to tolerance or immunity. We study molecular and cellular aspects of antigen presentation in diseases such as type-1 diabetes, enteritis, and pancreatic cancer. Combining animal models of disease, multiparameter cytofluorimetry, and high resolution imaging technologies, we explore endocytosis, transport, and/or processing of antigen by multiple lineages of antigen presenting cells including dendritic cells, macrophages, and lymph node stromal cells. The broad goal of our work is to understand how the microenvironments of healthy, inflamed, and malignant tissues influence the biology of these key antigen presenting cells and their interactions with CD4 and CD8 T cells. Ultimately, elucidating the steps leading to primary immune responses against self-antigens should provide the necessary framework for enhancing this process in cancer and dampening it in autoimmune diseases.
References:
- Magnusson FC, Liblau RS, von Boehmer H, Pittet MJ, Lee JW, Turley SJ, and Khazaie K. 2008. Direct presentation of antigen protects against CD8 T-cell mediated intestinal autoimmunity. Gastroenterol. 134(4):1028-37.
- Collier AY, Lee JW, and Turley SJ. 2008. Self-encounters of the third kind: Lymph node stroma in CD8+ T cell tolerance. Muc. Immunol. Advance online publication, May 14, 2008; doi:10.1038/mi.2008.19.
- Epardaud M, Elpek KG, Rubinstein MP, Yonekura A, Bellemare-Pelletier A, Bronson R, Hamerman JA, Goldrath AW, and Turley SJ. 2008. IL-15/IL-15Ralpha complexes promote destruction of established tumors by reviving tumor-resident CD8+ T cells. Can Res. 68(8):2972-83.
- Lee JW, Epardaud M, Sun J, Becker JE, Cheng AC, Yonekura A, Heath JK, Turley SJ. 2007. Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self. Nat. Immunol. 8;2: 181-190.
- Turley SJ, Lee JW, Dutton-Swain N, Mathis D. Benoist C. 2005. Endocrine self and gut non-self intersect in pancreatic lymph nodes. Proc. Nat. Acad. Sci. 102: 17729-17733.
Immunology webpage updated 12/02/2009