Immunology
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Stuart F. Schlossman

Department of Medicine
Dana-Farber Cancer Institute
Mayer Building, Room 756
44 Binney Street
Boston, MA 02115
Tel: 617-632-3325
Fax: 617-632-2690
email:Stuart_Schlossman@dfci.harvard.edu
5 postdoctoral fellows

  

Within the human immune system, our understanding of the functional programs of T lymphocytes and the mechanisms involved advanced rapidly with the appreciation that antigen recognition and effector functions are intimately linked with surface phenotype. Having identified the CD3/TcR cell receptor complex and its interaction with MHC as the mechanism by which antigen specific signals are delivered to the Tcell, and that the direction of the response is determined by coexpression of CD4 or CD8, a series of other antigens have been discovered, referred to as "costimlatory molecules" which serve to modify and regulate the response. Amongst these antigens, which include CD28, CD2 and CD5, both CD26 and CD27 antigens have proved themselves to be most intriguing. In man, CD4, CD45RO and CD26 can define the primary T helper/memory cell which responds to recall antigens and provides help for B cell Ig synthesis. The reciprocal and functionally distinct CD4, CD45RA and CD27 positive e population fails to respond to recall antigens but can readily down regulate Ig synthesis. Despite the biological importance of these distinct T cell subsets, the exact nature of cellular interactions, requirement for antigen organization and presentation, and role of antagonistically acting secretory products and cell surface molecules in cellular collaboration are not well understood. My laboratory is actively exploring mechanisms by which cell surface molecules regulate a productive immune response.

 

Papers & Publications:

  1. Stuhler G, Schlossman SF. Antigen organization regulates cluster formation and induction of cytotoxic T lymphocytes by helper T cell subsets. Proc Natl Acad Sci. 1997; 94:622-7.
  2. Prasad KVS, Ao Z, Yoon Y, Wu MX, Rizk M, Jacquot S, Schlossman SF. CD27, a member of the tumor necrosis factor receptor family induces apoptosis and binds to Siva, a proapoptotic protein. Proc Natl Acad Sci. 1997; 94:6346-51.
  3. Jacquot S, Kobata T, Iwata S, Morimoto C, Schlossman SF. CD154/CD40 and CD70/CD27 interactions have different and sequential functions in T cell-dependent B cell responses. J Immunol. 1997; 159:2652-7.
  4. 4. Morimoto C, Schlossman SF. The structur and function of CD26 in the T-cell immune response. Immunological Reviews. 1998;161:55-70.