Immunology Faculty Member - Marjorie Oettinger, PhD

Marjorie Oettinger, PhD

Massachusetts General Hospital
Simches Research Ctr CPZN# 6620
185 Cambridge St.
Boston, MA 02114
Tel: 617-726-5967
Fax: 617-726-6893
Email: oettinger@frodo.mgh.harvard.edu



The Oettgen lab studies IgE and mast cell functions in the regulation of allergic sensitization and in the pathogenesis of food allergy. The group has established murine models of allergic diseases, including anaphylaxis, asthma, food allergy and allergic rhinitis and has used these along with a variety of genetic mutants with altered IgE, IgE-receptor or mast cell function to assess functions of IgE and mast cells in allergic pathogenesis. These investigations have revealed previously unknown adjuvant effects of IgE-activated mast cells in driving Th2 and ILC2 responses while suppressing Treg induction. In clinical/translational research, the lab has found that IgG antibodies induced by food ingestion block IgE-mediated activation of mast cells and basophils in a pathway involving the inhibitory Fc receptor, FcgRIIb. The Oettgen lab is part of the Food Allergy Science Initiative, based at the Broad Institute. Students working in the Oettgen lab have the opportunity to develop expertise in the study of allergic pathogenesis using animal models, genetic manipulations, cell culture systems and human study materials.



Last Update: 6/18/2018



Publications

Morshead, K. B., Ciccone, D. N., Taverna, S. D., Allis, C. D., and Oettinger, M. A. (2003). Antigen receptor loci poised for V(D)J rearrangement are broadly associated with Brg1 and flanked by peaks of histone H3 dimethylated at lysine 4. Proc. Natl. Acad. Sci. U S A. 100:11577-11582.

Clatworthy, A. E, Valencia, M. A, Haber, J. E, and Oettinger, M. A. (2003) V(D)J recombination and RAG-mediated transposition in yeast. Mol. Cell 12:489-499.

Elkin, S. K., Matthews, A. G., and Oettinger, M. A. (2003). The C-terminal portion of RAG2 protects against transposition in vitro. EMBO J. 22:1931-1938.



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