Immunology
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Diane Mathis

Section on Immunology and Immunogenetics
Joslin Diabetes Center
Dept. of Medicine
Brigham and Women's Hospital
The Harvard Stem Cell Institute
One Joslin Place
Boston, MA 02215
Tel: 617-264-2743
Fax: 617-264-2744
email:dm@joslin.harvard.edu
18 Postdoctoral Fellows, 5 Graduate Students

 Diane Mathis

Our lab works in the fields of T cell differentiation and autoimmunity, with a special emphasis on exploiting the most advanced transgenic and gene-targeting technology to engineer new mouse models. Studies on T cell differentiation focus on selection of the T cell repertoire in the thymus and cellular and molecular influences on T cell survival in the periphery. Studies on autoimmunity explore the immunological mechanisms of diabetes, rheumatoid arthritis and APECED. Major questions tackled are what initiates these diseases, how is their progression regulated, and what are the final effector mechanisms. In addition, modern genetic and genomic approaches are used to identify disease-modifying genes in both human patients and mouse models. The application of computational and bioinformatic strategies to these and other issues is actively pursued. Lastly, we have been engaged in a collaborative effort to develop and apply novel whole-mouse imaging strategies to immunological problems.

 

Papers & Publications:

  1. S. Zucchelli, P Holler, T. Yamagata, M. Roy, C. Benoist and D. Mathis. Defective central tolerance in NOD mice: genomics and genetics. Immunity (2005) 22, 385-396.
  2. M. Anderson, E. Venanzi, W. Jiang, Z. Chen, R. Bronson, C. Benoist and D. Mathis. The cellular mechanism of aire control of T cell tolerance. Immunity (2005) 23, 227-239.
  3. S. Turvey, E. Swart, M. Denis, U. Mahmood, C. Benoist, R. Weissleder, and D. Mathis. Noninvasive imaging of pancreatic inflammation and its reversal in type 1 diabetes. J. Clin. Invest. (2005) 115, 2454-2461.
  4. B. Binstadt, P. Pate, H. Alencar, P.Nigrovic, DM Lee, U. Mahmood, R. Weissleder, D. Mathis and C. Benoist. Particularities of the vasculature can promote the organ specificity of autoimmune attack. Nature Immunol. (2006) 7, 284-292.
  5. G. Hyatt , R. Melamed , R. Park, R. Seguritan, C. Laplace, L. Poirot, S. Zucchelli, R. Obst, M. Matos, E. Venanzi, A. Goldrath, L. Nguyen, J. Luckey, T. Yamagata, A. Herman, J. Jacobs, D. Mathis, and C. Benoist. Gene-expression microarrays: glimpses at the immunological genome. Nature Immunol. (2006) 7, 686-691.