Immunology Faculty Member - Andrew Luster, MD, PhD

Andrew Luster, MD, PhD

Massachusetts General Hospital
CIID/Rheumatology, Allergy & Immunology
149 13th Street, Rm 8304
Charlestown, MA 02129
Tel: 617-726-5710
Fax: 617-726-5651
Email: aluster@mgh.harvard.edu
Visit my lab page here.



Chemokines and Lipid Chemoattractants in Normal Physiology and Disease
Research in my laboratory focuses on understanding the role of chemokines and lipid chemoattractants and their receptors in controlling the migratory behavior, cellular interactions and trafficking of leukocytes in vivo. Gene-targeted and transgenic reporter mouse strains have been developed to study the role of chemokines and chemoattractant receptors in the development and delivery of organ-specific innate and adaptive immune and inflammatory responses in mouse models of autoimmune, allergic, infectious and malignant diseases. The laboratory has become very interested in the role of chemokines in anti-tumor immunity and checkpoint blockade immunotherapy. System biology and in vivo multiphoton microscopy approaches are utilized to understand how multiple chemoattractant pathways are integrated in vivo for the positioning of immune cells in lymphoid and non-lymphoid tissue and for the fine control of leukocyte trafficking in vivo. Chemokines and chemoattractant receptors are interrogated in human diseases to determine chemokine systems relevant for disease pathogenesis. Finally, regulatory T cell subsets are being defined and studied for their specific roles in the control of the innate and adaptive immune response.



Last Update: 8/21/2018



Publications

For a complete listing of publications click here.

 


 

Sokol CL, Camire RB, Jones MC, Luster AD. The chemokine receptor CCR8 promotes the migration of dendritic cells into the lymph node parenchyma to initiate the allergic immune response. Immunity 2018; in press.

Miyabe Y, Miyabe C, Murooka TT, Kim EY, Newton GA, Kim ND, Haribabu B, Luscinskas FW, Mempel TR,
Luster AD. Complement C5a receptor is the key initiator of neutrophil adhesion igniting immune complex-induced arthritis. Science Immunology 2017; 2(7). pii: eaaj2195.

Sorensen EW, Lian J, Ozga AJ, Miyabe Y, Ji SW, Bromley SK, Mempel TR,
Luster AD. CXCL10 stabilizes T cell-brain endothelial cell adhesion leading to the induction of cerebral malaria. JCI Insight 2018; 3(8): pii: 98911.

Deruaz M, Murooka TT, Ji S, Gavin MA Vrbanac VD, Lieberman J, Tager AM, Mempel TR,
Luster AD. Chemoattractant-mediated leukocyte trafficking enables HIV dissemination from the genital mucosa. JCI Insight 2017; 2: e88533.

Cho JL, Ling MF, Adams DC, Faustino L, Islam SA, Afshar R, Griffith JW, Harris RS, Ng A, Radicioni G, Ford AA, Han AK, Xavier R, Kwok WW, Boucher R, Moon JJ, Hamilos DL, Kesimer M, Suter MJ, Medoff BD,
Luster AD. Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation. Science Translational Medicine 2016; 8: 359ra132.

Groom JR, Richmond J, Murooka TT, Sorensen EW, Sung JH, Bankert K, von Andrian UH, Moon JJ, Mempel TR,
Luster AD. CXCR3 receptor-ligand interactions in the lymph node optimize CD4+ T helper 1 differentiation. Immunity 2012; 37: 1091-103.



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of Harvard College