Immunology
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Jean-Pierre Kinet, MD

Department of Pathology
Beth Israel Deaconess Medical Center
330 Brookline Avenue, HM-945
Boston MA 02215
Tel: (617) 667-1324
Fax: (617) 667-3520
Email: jkinet@bidmc.harvard.edu

 Jean-Pierre Kinet

Our laboratory is interested in two separate but related questions:

  1. The role of mast cells and their receptors in inflammation.
  2. The mechanisms of calcium mobilization in cells of the immune system, including mast cells, and the biological consequences of the calcium signals. The laboratory is analyzing these questions by combining a variety of approaches including molecular biology and genetics, biochemistry and cell biology. Research in my laboratory led to the identification of CRACM1 as an essential protein for store-operated Ca2+ influx and as a component of the CRAC channel. Subsequent studies have shown that CRACM1 forms multimeric assemblies that bind STIM1, a putative ER Ca2+ sensor, and that acidic residues in the transmembrane and extracellular domains of CRACM1 contribute to the ionic selectivity of the CRAC-channel pore.

 

Papers & Publications:

  1. Vig, M., Dehaven, W.I., Bird, G.S., Billingsley, J.M., Wang, H., Rao, P.E., Hutchings, A.B., Jouvin, M.-H., Putney, J.W., Kinet, J.-P. A major defect in mast cell effector functions in CRACM1-/- mice. Nat Immunol. 2008 Jan;9(1):89-96. Epub 2007 Dec 2.
  2. Peinelt C., Vig M., Koomoa D. L., Beck A., Nadler M., Koblan-Huberson M., Lis A., Andrea Fleig A., Penner R., & Kinet J.-P. Amplification of Ca2 Release-Activated Ca2 (CRAC) current by STIM1 and CRACM1 (ORAI1). Nature Cell Biol. 8:771-773, 2006
  3. Vig, M., Peinelt, C., Beck, A., Koomoa, D. L., Rabah, D., Koblan-Huberson, M., Kraft, S., Turner, H., Fleig, A., Penner, R., Kinet, J.-P. CRACM1 is a plasma membrane protein essential for store-operated Ca2 entry. Science 312:1220-1223, 2006
  4. Kraft, S., Fleming, T., Billingsley, J.M., Lin, S.-Y., Jouvin, M.-H., Storz, P., and Kinet, J.-P. Anti-CD63 antibodies suppress IgE-dependent allergic reactions in vitro and in vivo. J. Exp. Med. 201:385-396, 2005
  5. Launay, P., Cheng, H., Srivastan, S,, Penner, R., Fleig, A,, and Kinet, J.-P. TRPM4 regulates calcium oscillations after T cell activation. Science 306:1374-1377, 2004