Immunology Faculty Member - Jun Huh, PhD

Jun Huh, PhD

Harvard Medical School
77 Avenue Louis Pasteur, NRB 1056E

Boston, MA 02115
Tel: 617-432-5355
Email: jun_huh@hms.harvard.edu
Visit my lab page here.



Immune cell modulation is an attractive strategy for the treatment of inflammatory conditions. Inflammation is critical to protecting us from dangers within (e.g. cancer) and without (e.g. microbes). But inflammation also drives much human pathology and diseases, including autoimmune diseases and neurodevelopmental disorders.
The Huh lab is interested in identifying host- and bacteria-derived small molecules that control inflammation in the mammalian gut. We are also interested in uncovering mechanisms by which nuclear hormone receptors control immune cell differentiation and function. Finally, we are trying to uncover the dynamic interplay between the host immune system and gut-residing bacteria in pregnant mothers and understand how such interactions dictate neural development of the developing fetus.



Last Update: 2/15/2018



Publications

For a complete listing of publications click here.

 


 

1. Choi GB, Yim YS, Wong H, Kim S, Kim H, Kim SV, Hoeffer CA*, Littman DR*, Huh JR*. The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring. Science. 2016 Feb; 351(6276):933-939. PubMed PMID: 26822608.

2. Silverstein NJ, Huh JR. Interleukin-17: Why the worms squirm. Immunity. 2017 46(3): 347-349. PMID: 28329701.

3. Guerra ES, Lee CK, Specht CA, Yadav B, Huang H, Akalin A, Huh JR, Mueller C, Levitz SM. Central Role of IL-23 and IL-17 Producing Eosinophils as Immunomodulatory Effector Cells in Acute Pulmonary Aspergillosis and Allergic Asthma. PLoS Pathogens. 2017 Jan 17;13(1):e1006175. PubMed PMID: 28095479; PubMed Central PMCID: PMC5271415

4. Kim S, Kim HJ, Yim YS, Ha S, Atarashi K, Tan TG, Longman RS, Honda K, Littman DR, Choi GB*, Huh JR*. Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring. Nature. 2017 Sep; 549(7673):528-532. PubMed PMID: 28902840.

5. Yim YS, Park A, Berrios J, Pascual L, Soares N, Kim JY, Kim S, Kim H, Waisman A, Littman D, Harnett MT, Wickersham IR, Huh JR*, Choi GB*. Reversing behavioral abnormalities in mice exposed to maternal inflammation. Nature. 2017 Sep; 549(7673):482-487. PubMed PMID: 28902835.



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