Wendy S. Garrett


Harvard School of Public Health
665 Huntington Avenue
Building 1, 9th Floor
Boston, MA 02115
Tel: 617-432-3250
Fax: 617-432-3259
Email: wgarrett@hsph.harvard.edu
Lab Members: 5 Postdoctoral Fellows, 3 Graduate Students
Visit my lab page here.




The Garrett Lab is interested in defining the dynamic interactions between the mucosal immune system and gut microbiota. Our experimental questions are grounded in understanding how interactions between intestinal microbial communities and the immune system contribute to the pathophysiology of both inflammatory bowel disease and colorectal cancer. Our lab uses a variety of genomic, cellular and molecular techniques as well as germ-free, gnotobiotic and conventional mouse models to investigate gut microbial communities, mucosal immune cell subsets, and their contribution to the development of inflammatory bowel disease and colorectal cancer.

References:

Kostic, A.D., Chun, E., Robertson, L., Glickman, J.N., Gallini, C.A., Michaud, M., Clancy, T.E., Chung, D.C., Lochhead, P., Hold, G.L., El-Omar, E.N., Brenner D., Fuchs C.S., Meyerson M., and Garrett W.S. (2013). Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor immune microenvironment. Cell Host & Microbe. 14: 207-215.

Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N. and Garrett, W. S. (2013). The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis.
Science. 341(6145): 569-573.

Kostic, A. D., Howitt, M. R. and Garrett, W. S
. (2013). Exploring host-microbiota interactions in animal models and humans. Genes & development, 27(7), 701-18.

Kostic AD, Gevers D, Pedamallu CS, Michaud M, Duke F, Earl AM, Ojesina AI, Jung J, Bass AJ, Tabernero J, Baselga J, Liu C, Shivdasani RA, Ogino S, Birren BW, Huttenhower C, Garrett WS, Meyerson M.(2012) Genomic analysis identifies association of Fusobacterium with colorectal carcinoma. Genome Research. 22(2):292-8.

Garrett WS, Gordon JI, and Glimcher LH. Homeostasis and Inflammation in the Intestine. 2010. Cell. 140, 859-70.


For a complete listing of publications click here.



Last Update: 1/6/2014