Immunology Faculty Member - Bobby Cherayil, MD

Bobby Cherayil, MD

Massachusetts General Hospital-East
Mucosal Immunology and Biology Research Center
Building 114 16th Street
Charlestown, MA 02129
Tel: 617-726-4170
Fax: 617-726-4172
Email: cherayil@helix.mgh.harvard.edu
Visit my lab page here.



Work in my laboratory is directed at understanding the factors that influence immune responses to bacterial enteropathogens. We use cell culture and mouse infection experiments to interrogate the responses of intestinal epithelial cells and macrophages to Salmonella enterica, different serovars of which cause acute food poisoning or typhoid fever in humans. One of our interests is in the role played by iron metabolism in host-pathogen interactions. We have characterized the effects of iron overload disorders such as hemochromatosis on the macrophage response to infection, and have also examined the mechanisms that dysregulate iron homeostasis in infectious and non-infectious inflammatory conditions. More recently, we have become interested in the influence of the gut microbiota on iron metabolism, both at baseline and in the context of inflammation. We expect that these studies will lead to novel insights into the bidirectional cross-talk between the pathways that regulate iron homeostasis and the immune response and, ultimately, to new strategies for the therapeutic manipulation of these two processes.



Last Update: 6/18/2018



Publications

For a complete listing of publications click here.

 


 

1. Chlosta S, Fishman DS, Harrington L, Johnson EE, Knutson MD, Wessling-Resnick M, Cherayil BJ. The iron efflux protein ferroportin regulates the intracellular growth of Salmonella enterica. Infect. Immun. 2006; 74: 3065-3067.

2. Wang L, Johnson EE, Shi HN, Walker WA, Wessling-Resnick M,
Cherayil BJ. Attenuated inflammatory responses in hemochromatosis reveal a role for iron in the regulation of macrophage cytokine translation. J. Immunol. 2008; 181: 2723-2731.

3. Wang L, Harrington L, Trebicka E, Shi HN, Kagan JC, Hong CC, Lin HY, Babitt JL,
Cherayil BJ. Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis. J. Clin. Invest. 2009; 119: 3322-3328.

4. Wang L, Trebicka E, Fu Y, Waggoner L, Akira S, Fitzgerald KA, Kagan JC,
Cherayil BJ. Regulation of lipopolysaccharide-induced translation of tumor necrosis factor α by the Toll-like receptor 4 adaptor protein TRAM. J. Innate Immun. 2011; 3: 437-446.

5. Shanmugam NKN, Ellenbogen S, Trebicka E, Wang L, Mukhopadhyay S, Gallini CA, Garrett WS, Lacy-Hulbert A,
Cherayil BJ. TNFα inhibits expression of the iron regulating hormone hepcidin in murine models of innate colitis. PLoS One 2012; 7: e38136.

6. Trebicka E, Jacob S, Pirzai W, Hurley BP,
Cherayil BJ. Role of anti-lipopolysaccharide antibodies in serum bactericidal activity against Salmonella enterica serovar Typhimurium in healthy adults and children in the United States. Clin Vaccine Immunol. 2013. In press.



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